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State-of-the-art hysteroscopic approaches to pathologies of the genital tract PDF

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STATE-OF-THE-ART HYSTEROSCOPIC APPROACHES TO PATHOLOGIES OF THE GENITAL TRACT Carmine Nappi Attilio Di Spiezio Sardo School of Medicine and Surgery University of Naples ‘Federico II’ Naples, Italy I would like to dedicate this book to the women and to the youth, and to the two Elenas of my family. CN To my wife, Anna, who has always been with me since the early days of my career, for her unconditional and generous support. To my parents who have accompanied me throughout my journey of personal and intellectual growth, who fostered my passion for academic studies and especially for medicine. To Prof. Carmine Nappi(cid:2)(cid:72)(cid:81)(cid:84)(cid:2)(cid:68)(cid:71)(cid:75)(cid:80)(cid:73)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:386)(cid:84)(cid:85)(cid:86)(cid:14)(cid:2)(cid:89)(cid:74)(cid:81)(cid:2)(cid:74)(cid:67)(cid:85)(cid:2)(cid:68)(cid:71)(cid:78)(cid:75)(cid:71)(cid:88)(cid:71)(cid:70)(cid:2) in me ever since I was a young medical student, looking out eagerly and enthusiastically at the world of gynecology, who instilled in me the attitude that with a proper mind- set and perseverance any goal can be reached, and who (cid:2)(cid:82)(cid:84)(cid:81)(cid:88)(cid:75)(cid:70)(cid:71)(cid:70)(cid:2)(cid:69)(cid:81)(cid:80)(cid:86)(cid:75)(cid:80)(cid:87)(cid:75)(cid:80)(cid:73)(cid:2)(cid:85)(cid:87)(cid:82)(cid:82)(cid:81)(cid:84)(cid:86)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2)(cid:69)(cid:81)(cid:80)(cid:386)(cid:70)(cid:71)(cid:80)(cid:69)(cid:71)(cid:14)(cid:2)(cid:86)(cid:74)(cid:87)(cid:85)(cid:2)(cid:71)(cid:80)(cid:74)(cid:67)(cid:80)(cid:69)- ing my professional development. To all those, who have encouraged me to explore the world of hysteroscopy: in particular, to Adam Magos, who guided me in the early stages of my hands-on training, to Giampietro Gubbini,(cid:2)(cid:89)(cid:74)(cid:81)(cid:2)(cid:89)(cid:67)(cid:85)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:386)(cid:84)(cid:85)(cid:86)(cid:2)(cid:86)(cid:81)(cid:2)(cid:74)(cid:67)(cid:88)(cid:71)(cid:2)(cid:2)(cid:69)(cid:81)(cid:80)(cid:386)(cid:70)(cid:71)(cid:80)(cid:69)(cid:71)(cid:2) in my abilities, to Stefano Bettocchi, for his affection and (cid:69)(cid:81)(cid:80)(cid:386)(cid:70)(cid:71)(cid:80)(cid:69)(cid:71)(cid:14)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2)for having instilled in me the passion for ambulatory surgery, and to Ivan Mazzon, for his v aluable lessons, which were instrumental in improving my surgical skills, to Maurizio Guida for constantly providing support in (cid:79)(cid:91)(cid:2)(cid:69)(cid:78)(cid:75)(cid:80)(cid:75)(cid:69)(cid:67)(cid:2) (cid:78)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2)(cid:85)(cid:69)(cid:75)(cid:71)(cid:80)(cid:86)(cid:75)(cid:386)(cid:69)(cid:2)(cid:2)(cid:71)(cid:80)(cid:70)(cid:71)(cid:67)(cid:88)(cid:81)(cid:87)(cid:84)(cid:85)(cid:14)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2)(cid:86)(cid:81)(cid:2)Luca Mencaglia, who has always been generous with advices, ceaselessly guiding and supporting me throughout the past years of my career. ADSS 8 State-of-the-Art Hysteroscopic Approaches to Pathologies of the Genital Tract Foreword Diagnostic imaging procedures and surgical absence of structured postgraduate education. endoscopy are among the fastest developing The European Society for Gynaecological Endo- medical procedures of the century. scopy(cid:2)(cid:10)(cid:39)(cid:53)(cid:41)(cid:39)(cid:11)(cid:2)(cid:74)(cid:67)(cid:85)(cid:2)(cid:69)(cid:81)(cid:87)(cid:80)(cid:86)(cid:71)(cid:84)(cid:71)(cid:70)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:78)(cid:67)(cid:86)(cid:86)(cid:71)(cid:84)(cid:2)(cid:70)(cid:71)(cid:386)(cid:69)(cid:75)(cid:71)(cid:80)(cid:69)(cid:91)(cid:2) by setting up the Gynaecological Endoscopic Hysteroscopy, the gold standard for the evalua- Surgical Education and Assessment (GESEA) tion and treatment of intra uterine pathologies, has Programme, comprising lectures, hands-on been experienced for a long time as an invasive (cid:86)(cid:84)(cid:67)(cid:75)(cid:80)(cid:75)(cid:80)(cid:73)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2)(cid:69)(cid:78)(cid:75)(cid:80)(cid:75)(cid:69)(cid:67)(cid:78)(cid:2)(cid:86)(cid:87)(cid:86)(cid:81)(cid:84)(cid:75)(cid:67)(cid:78)(cid:85)(cid:16)(cid:2)(cid:54)(cid:74)(cid:71)(cid:2)(cid:386)(cid:84)(cid:85)(cid:86)(cid:2)(cid:82)(cid:75)(cid:78)(cid:78)(cid:67)(cid:84)(cid:14)(cid:2)(cid:68)(cid:67)(cid:85)(cid:71)(cid:70)(cid:2) technique, characterized by a slow learning on e-learning modules, focuses on the theoretical curve. The revolutionary advances taking place in aspects of the technique. Indeed, the correct (cid:86)(cid:74)(cid:71)(cid:2)(cid:386)(cid:71)(cid:78)(cid:70)(cid:2)(cid:81)(cid:72)(cid:2)(cid:70)(cid:75)(cid:73)(cid:75)(cid:86)(cid:67)(cid:78)(cid:2)(cid:75)(cid:79)(cid:67)(cid:73)(cid:75)(cid:80)(cid:73)(cid:14)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:79)(cid:75)(cid:80)(cid:75)(cid:67)(cid:86)(cid:87)(cid:84)(cid:75)(cid:92)(cid:67)(cid:86)(cid:75)(cid:81)(cid:80)(cid:2)(cid:81)(cid:72)(cid:2) approach to diagnostic and operative hystero- (cid:74)(cid:75)(cid:73)(cid:74)(cid:15)(cid:70)(cid:71)(cid:386)(cid:80)(cid:75)(cid:86)(cid:75)(cid:81)(cid:80)(cid:2)(cid:71)(cid:80)(cid:70)(cid:81)(cid:85)(cid:69)(cid:81)(cid:82)(cid:71)(cid:85)(cid:2)(cid:67)(cid:78)(cid:81)(cid:80)(cid:73)(cid:2)(cid:89)(cid:75)(cid:86)(cid:74)(cid:2)(cid:67)(cid:2)(cid:84)(cid:71)(cid:78)(cid:71)(cid:80)(cid:86)(cid:78)(cid:71)(cid:85)(cid:85)(cid:2) scopy not only requires an adequate attitude pursuit of excellence, propelling the evolution towards intra-uterine surgery, but also a thorough of both science and technology, have made theoretical knowledge of anatomy, pathology, hysteroscopy a simple, safe and well-tolerated instruments, energy sources and complications. (cid:81)(cid:72)(cid:386)(cid:69)(cid:71)(cid:2)(cid:82)(cid:84)(cid:81)(cid:69)(cid:71)(cid:70)(cid:87)(cid:84)(cid:71)(cid:2)(cid:81)(cid:72)(cid:72)(cid:71)(cid:84)(cid:75)(cid:80)(cid:73)(cid:2)(cid:85)(cid:87)(cid:82)(cid:71)(cid:84)(cid:68)(cid:2)(cid:75)(cid:79)(cid:67)(cid:73)(cid:75)(cid:80)(cid:73)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2) It is an irrefutable truth that words can only give documentation options. an approximate impression of the information Hysteroscopy has not only helped to overcome the available. For this reason, this book with its most fallacy of simple curettage. Apart from providing (cid:69)(cid:81)(cid:79)(cid:82)(cid:84)(cid:71)(cid:74)(cid:71)(cid:80)(cid:85)(cid:75)(cid:88)(cid:71)(cid:14)(cid:2)(cid:74)(cid:75)(cid:73)(cid:74)(cid:15)(cid:70)(cid:71)(cid:386)(cid:80)(cid:75)(cid:86)(cid:75)(cid:81)(cid:80)(cid:2)(cid:75)(cid:79)(cid:67)(cid:73)(cid:71)(cid:85)(cid:2)(cid:75)(cid:85)(cid:2)(cid:81)(cid:72)(cid:2)(cid:79)(cid:67)(cid:76)(cid:81)(cid:84)(cid:2) the option of selective treatment of pathology with importance for all gynecologists opting to enter almost no risk of damage to adjacent tissues, it has into the world of advanced hysteroscopy. become the preferred mode of access to inspect Prof. C. Nappi and Dr. A. Di Spiezo Sardo have the subendometrial myometrium for abnormalities. compiled a most unique and comprehensive col- A new indication for the hystero scopist is the lection of didactically elaborated contents, which exploration of the junctional zone between myo- (cid:67)(cid:84)(cid:71)(cid:2)(cid:82)(cid:84)(cid:71)(cid:85)(cid:71)(cid:80)(cid:86)(cid:71)(cid:70)(cid:2)(cid:89)(cid:75)(cid:86)(cid:74)(cid:2)(cid:85)(cid:69)(cid:75)(cid:71)(cid:80)(cid:86)(cid:75)(cid:386)(cid:69)(cid:67)(cid:78)(cid:78)(cid:91)(cid:2)(cid:88)(cid:67)(cid:78)(cid:75)(cid:70)(cid:2)(cid:71)(cid:90)(cid:82)(cid:78)(cid:67)(cid:80)(cid:67)(cid:86)(cid:75)(cid:81)(cid:80)(cid:85)(cid:14)(cid:2) metrium and endometrium – con sidered an area of so that I highly recommend it for the essential (cid:72)(cid:87)(cid:80)(cid:69)(cid:86)(cid:75)(cid:81)(cid:80)(cid:67)(cid:78)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2)(cid:85)(cid:86)(cid:84)(cid:87)(cid:69)(cid:86)(cid:87)(cid:84)(cid:67)(cid:78)(cid:2)(cid:85)(cid:75)(cid:73)(cid:80)(cid:75)(cid:386)(cid:69)(cid:67)(cid:80)(cid:69)(cid:71)(cid:2)(cid:115)(cid:2)(cid:72)(cid:81)(cid:84)(cid:2)(cid:85)(cid:69)(cid:84)(cid:87)(cid:86)(cid:75)(cid:80)(cid:91)(cid:2) reading list of any gynaecologist. on implantation disorders and abnormal uterine This textbook on hysteroscopy gives an overview bleeding of unknown origin. Careful inspection of all major topics, from the basics to advanced of this zone receives a lot of interest since it can surgical procedures and should therefore be provide answers to important questions like those recommended for use as a reference to all (cid:84)(cid:71)(cid:78)(cid:67)(cid:86)(cid:71)(cid:70)(cid:2)(cid:86)(cid:81)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:75)(cid:80)(cid:387)(cid:87)(cid:71)(cid:80)(cid:69)(cid:71)(cid:2)(cid:81)(cid:72)(cid:2)(cid:79)(cid:91)(cid:81)(cid:79)(cid:71)(cid:86)(cid:84)(cid:75)(cid:67)(cid:78)(cid:2)(cid:69)(cid:74)(cid:67)(cid:80)(cid:73)(cid:71)(cid:85)(cid:2) colleagues preparing themselves for the GESEA on the implantation process. Also in patients with Diploma as Hysteroscopic Surgeon. abnormal uterine bleeding disorders or uterine enlargement of doubtful origin, it allows to obtain A new era in hysteroscopy has begun, and the (cid:386)(cid:84)(cid:79)(cid:2)(cid:74)(cid:75)(cid:85)(cid:86)(cid:81)(cid:78)(cid:81)(cid:73)(cid:75)(cid:69)(cid:67)(cid:78)(cid:2)(cid:85)(cid:82)(cid:71)(cid:69)(cid:75)(cid:79)(cid:71)(cid:80)(cid:85)(cid:2)(cid:86)(cid:74)(cid:67)(cid:86)(cid:2)(cid:67)(cid:84)(cid:71)(cid:2)(cid:85)(cid:87)(cid:68)(cid:76)(cid:71)(cid:69)(cid:86)(cid:71)(cid:70)(cid:2)(cid:86)(cid:81)(cid:2) successful collaboration of the authors of this a histopathological examination prior to making a book gives an excellent proof of the enriching (cid:386)(cid:80)(cid:67)(cid:78)(cid:2)(cid:70)(cid:71)(cid:69)(cid:75)(cid:85)(cid:75)(cid:81)(cid:80)(cid:2)(cid:81)(cid:80)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:86)(cid:84)(cid:71)(cid:67)(cid:86)(cid:79)(cid:71)(cid:80)(cid:86)(cid:16) combination of traditional skills and young scien- (cid:86)(cid:75)(cid:386)(cid:69)(cid:2)(cid:86)(cid:67)(cid:78)(cid:71)(cid:80)(cid:86)(cid:16) Unfortunately, we have to admit that, even though I like to congratulate Prof. Carmine Nappi and we have at our disposal the most advanced Dr. Attilio Di Spiezo Sardo for this very remarkable (cid:75)(cid:80)(cid:85)(cid:86)(cid:84)(cid:87)(cid:79)(cid:71)(cid:80)(cid:86)(cid:85)(cid:14)(cid:2)(cid:74)(cid:75)(cid:73)(cid:74)(cid:15)(cid:70)(cid:71)(cid:386)(cid:80)(cid:75)(cid:86)(cid:75)(cid:81)(cid:80)(cid:2)(cid:88)(cid:75)(cid:70)(cid:71)(cid:81)(cid:2)(cid:71)(cid:83)(cid:87)(cid:75)(cid:82)(cid:79)(cid:71)(cid:80)(cid:86)(cid:14)(cid:2)(cid:80)(cid:71)(cid:89)(cid:2) book ! indications and a comprehensive armamentarium of techniques, hysteroscopy is still not widely Leuven, April 2014 used in daily practice. The main cause for this Rudi Campo situation is the lack of teaching in hysteroscopy President of the European Society of during conventional medical training and the Gynaecological Endoscopy (ESGE) State-of-the-Art Hysteroscopic Approaches to Pathologies of the Genital Tract 9 Preface Technical and technological advances, ever more and therapeutic options in the management of erratic and fast-paced, are continuously revolu- intrauterine pathologies, and, more recently, of tionizing our everyday life, at times forcing us to those seen in the cervix and vagina. race ahead just to keep up with the times. This Therefore, these days, state-of-the art hystero- (cid:75)(cid:85)(cid:2)(cid:80)(cid:81)(cid:89)(cid:74)(cid:71)(cid:84)(cid:71)(cid:2)(cid:79)(cid:81)(cid:84)(cid:71)(cid:2)(cid:86)(cid:84)(cid:87)(cid:71)(cid:2)(cid:86)(cid:74)(cid:67)(cid:80)(cid:2)(cid:75)(cid:80)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:386)(cid:71)(cid:78)(cid:70)(cid:2)(cid:81)(cid:72)(cid:2)(cid:85)(cid:87)(cid:84)(cid:73)(cid:71)(cid:84)(cid:91)(cid:14)(cid:2) scopy should constitute an integral part of the which in recent decades has been all but reborn cultural and professional armamentarium not only through modern technologies, leading to results for the select few, but indeed of every gynecolo- that are both thrilling and astonishing, even in the gist, including those belonging to the younger eyes of the most skeptical. generation, and including even those who trained (cid:43)(cid:80)(cid:2)(cid:73)(cid:91)(cid:80)(cid:71)(cid:69)(cid:81)(cid:78)(cid:81)(cid:73)(cid:91)(cid:14)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:86)(cid:84)(cid:87)(cid:71)(cid:85)(cid:86)(cid:2)(cid:84)(cid:71)(cid:387)(cid:71)(cid:69)(cid:86)(cid:75)(cid:81)(cid:80)(cid:2)(cid:81)(cid:72)(cid:2)(cid:86)(cid:74)(cid:75)(cid:85)(cid:2)(cid:72)(cid:84)(cid:71)(cid:80)(cid:71)(cid:86)(cid:75)(cid:69)(cid:2) at traditional surgical facilities. and burgeoning progress is without doubt that Such is the ambitious goal of this textbook, seen in gynecologic endo scopy, and particularly intended as an instructive, practical guide, for (cid:75)(cid:80)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:386)(cid:71)(cid:78)(cid:70)(cid:2)(cid:81)(cid:72)(cid:2)(cid:74)(cid:91)(cid:85)(cid:86)(cid:71)(cid:84)(cid:81)(cid:85)(cid:69)(cid:81)(cid:82)(cid:91)(cid:16)(cid:2) quick and easy reference, concise yet replete with During the forty years of my career, I have pictures and detailed references, and meant to witnes sed, sometimes with a skeptical attitude, be a useful source to all gynecologists, whether a remarkable development in this technique, young or old, in their clinical practice. which I have followed with the greatest interest But for the youngest of these, we recommend this and curiosity ever since I was a young assistant, book in the spirit for which it has been designed: and up until the present time, whereupon I have for the attainment of the required skill, for building both the honor and the privilege of directing the prudence, moderation and responsibility in the Department of Obstetrics and Gynecology of the sober use of techniques and technologies, without University of Naples ‘Federico II’, which today takes excess, and without yielding to the insidious pride in having a unit of diagnostic and operative temptations of technological idolatry. Indeed, hysteroscopy of real international standing. hysteroscopy is a reliable and indispensable Hysteroscopy, in its early days, was considered technique, conquering as it captivates, having the the ‘Cinderella’ sub-specialty of gynecologic greatest potential and future prospects, and yet it endo scopy, a modality that was both laborious remains but one formidable weapon in the arsenal (cid:67)(cid:80)(cid:70)(cid:2)(cid:70)(cid:75)(cid:72)(cid:386)(cid:69)(cid:87)(cid:78)(cid:86)(cid:2)(cid:86)(cid:81)(cid:2)(cid:79)(cid:67)(cid:85)(cid:86)(cid:71)(cid:84)(cid:14)(cid:2)(cid:68)(cid:71)(cid:69)(cid:67)(cid:87)(cid:85)(cid:71)(cid:2)(cid:81)(cid:72)(cid:2)(cid:75)(cid:86)(cid:85)(cid:2)(cid:69)(cid:81)(cid:80)(cid:85)(cid:75)(cid:70)(cid:71)(cid:84)(cid:67)(cid:68)(cid:78)(cid:71)(cid:2) of clinical reasoning, of which it must remain only (cid:86)(cid:71)(cid:69)(cid:74)(cid:80)(cid:75)(cid:69)(cid:67)(cid:78)(cid:2)(cid:69)(cid:74)(cid:67)(cid:78)(cid:78)(cid:71)(cid:80)(cid:73)(cid:71)(cid:85)(cid:2)(cid:67)(cid:80)(cid:70)(cid:2)(cid:70)(cid:71)(cid:386)(cid:69)(cid:75)(cid:71)(cid:80)(cid:69)(cid:75)(cid:71)(cid:85)(cid:2)(cid:75)(cid:80)(cid:2)(cid:86)(cid:71)(cid:84)(cid:79)(cid:85)(cid:2)(cid:81)(cid:72)(cid:2) a part, and which – purely and simply – it cannot instrumentation – indeed it was rarely used in the replace. routine clinical practice, which, for the purposes (cid:43)(cid:80)(cid:2)(cid:86)(cid:74)(cid:71)(cid:2)(cid:68)(cid:75)(cid:81)(cid:79)(cid:71)(cid:70)(cid:75)(cid:69)(cid:67)(cid:78)(cid:2)(cid:386)(cid:71)(cid:78)(cid:70)(cid:14)(cid:2)(cid:67)(cid:85)(cid:2)(cid:75)(cid:80)(cid:2)(cid:81)(cid:86)(cid:74)(cid:71)(cid:84)(cid:2)(cid:84)(cid:71)(cid:67)(cid:78)(cid:79)(cid:85)(cid:2)(cid:81)(cid:72)(cid:2) of diagnosis and treatment of intrauterine patholo- human activity, technological development is gies, relied almost exclusively upon curettage. transformed into real clinical progress only when Over the past twenty years, continuous and rapid governed and attuned by a professional endowed advances in technologies and techniques, along with critical awareness. If science becomes (cid:89)(cid:75)(cid:86)(cid:74)(cid:2)(cid:67)(cid:80)(cid:2)(cid:71)(cid:90)(cid:82)(cid:67)(cid:80)(cid:70)(cid:75)(cid:80)(cid:73)(cid:2)(cid:386)(cid:71)(cid:78)(cid:70)(cid:2)(cid:81)(cid:72)(cid:2)(cid:67)(cid:82)(cid:82)(cid:78)(cid:75)(cid:69)(cid:67)(cid:86)(cid:75)(cid:81)(cid:80)(cid:85)(cid:14)(cid:2)(cid:84)(cid:71)(cid:78)(cid:71)(cid:80)(cid:86)(cid:78)(cid:71)(cid:85)(cid:85)(cid:2) subjugated to technologies, the bonds between efforts on the part of the surgeons to improve development and progress can break apart, and their performance, and to overcome obstacles harmony between technological development once deemed insurmountable, have opened up and clinical progress will be subverted into an new horizons for hysteroscopic modalities, often antinomy. feasible in an ambulatory setting, and which today Carmine Nappi are considered the gold standard of diagnostic Naples, March 2014 10 State-of-the-Art Hysteroscopic Approaches to Pathologies of the Genital Tract State-of-the-Art Hysteroscopic Approaches to Pathologies of the Genital Tract Carmine Nappi1 and Attilio Di Spiezio Sardo2 1) Full Professor of Gynecology and Obstetrics Director of Department of Integrated Practice in Obstetrics, Gynecology and Urology, School of Medicine and Surgery, University of Naples ‘Federico II’ 2) Assistant Professor of Gynecology and Obstetrics affiliated with the School of Medicine and Surgery of the University of Naples ‘Federico II’ Address for correspondence: Dott. Attilio Di Spiezio Sardo AOU ‘Federico II’ Via Pansini 5, 80131 Napoli, Italy E-mail: [email protected] © 2014 ® Tuttlingen, Germany Printed in Germany, ISBN 978-3-89756-450-3 P.O. Box, D-78503 Tuttlingen, Germany Phone: +49 / 7461 / 14590 Fax: +49 / 7461 / 708-529 E-mail: [email protected] Editions in languages other than English and German are in preparation. For up-to-date information, please contact ®, Tuttlingen, at the address mentioned above. Typesetting and Image Processing: ® Tuttlingen, Germany Printed by: Straub-Druck+Medien AG, D-78713 Schramberg, Germany 06.14-0.5 Please note: Medical knowledge is ever changing. As new research and clinical experience broaden our knowledge, changes in treatment and therapy may be required. The authors and editors of the material herein have consulted sources believed to be reliable in their efforts to provide information that is complete and in accordance with the standards accepted at the time of publication. However, in view of the possibility of human error by the authors, editors, or publisher of the work herein, or changes in medical knowledge, neither the authors, editors, publisher, nor any other party who has been involved in the preparation of this work, warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from use of such information. The information contained within this brochure is intended for use by doctors and other health care professionals. This material is not intended for use as a basis for treatment decisions, and is not a substitute for professional consulta- tion and/or use of peer-reviewed medical literature. Some of the product names, patents, and registered designs referred to in this All rights reserved. No part of this publication may be translated, reprinted or book are in fact registered trademarks or proprietary names even though spe- reproduced, transmitted in any form or by any means, electronic or mechanic cific reference to this fact is not always made in the text. Therefore, the appear- al, now known or hereafter invented, includ ing photocopying and recording, or ance of a name without designation as proprietary is not to be construed as a utilized in any informa tion storage or retrieval system without the prior written representation by the publisher that it is in the public domain. permission of the copyright holder.

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