SPECT and SPECT/CT: A Clinical Guide PDF
Preview SPECT and SPECT/CT: A Clinical Guide
Get t he m ost out of t he b o ok – wat ch t he vide os on Me diaCe nt e r.Thie m e.com ! Simply visit MediaCenter.thieme.com and, when prompted during the registration process, enter the code below to get started today. 247Z-NJ3Z-3VTG-32N8 SPECT and SPECT/CT A Clinical Guide Chun K. Kim , MD Clinical Director, Division of Nuclear Medicine and Molecular Imaging Department of Radiology Brigham and Women’s Hospital Associate Professor of Radiology Harvard Medical School Boston, Massachusetts Katherine A. Zukotynski, MD Associate Professor Departments of Radiology and Medicine McMaster University Hamilton, Ontario, Canada 250 illustrations Thieme New York • Stuttgart • Delhi • Rio de Janeiro Executive Editor: William Lamsback Important note: Medicine is an ever-changing science Managing Editor: J. Owen Zurhellen IV undergoing continual development. Research and clinical Editorial Assistant: Mary B. Wilson experience are continually expanding our knowledge, in Director, Editorial Services: Mary Jo Casey particular our knowledge of proper treatment and drug Production Editor: Torsten Scheihagen therapy. Insofar as this book mentions any dosage or appli- International Production Director: Andreas Schabert cation, readers may rest assured that the authors, editors, International Marketing Director: Fiona Henderson and publishers have made every effort to ensure that such International Sales Director: Louisa Turrell references are in accordance with the state ofknowledge at Director of Sales, North America: Mike Roseman the time of production of the book. Senior Vice President and Chief Operating Of cer: Nevertheless,this does not involve,imply,or express any Sarah Vanderbilt guarantee or responsibility on the part of the publishers in President: Brian D. Scanlan respect to any dosage instructions and forms of applications Printer: Everbest Printing Co. stated in the book. Every user is requested to examine carefully the manufacturers’ lea ets accompanying each Library of Congress Cataloging-in-Publication Data drug and to check, if necessary in consultation with a phy- Names: Kim,Chun K.,editor.| Zukotynski,Katherine A.,editor. sician or specialist,whether the dosage schedulesmentioned Title: SPECT and SPECT/CT : a clinical guide / [edited by] therein or the contraindications stated by the manufacturers Chun K. Kim, Katherine A. Zukotynski. differ from the statements made in the present book. Such Description: First edition. | New York, NY : Thieme, [2017] | examination is particularly important with drugs that are Includes bibliographical references and index. either rarelyused or have been newlyreleased on the market. Identi ers: LCCN 2016018886 (print) | LCCN 2016019458 Every dosage schedule or every form of application used is (ebook) | ISBN 9781626231511 (pbk.) | entirelyat the user’s own risk and responsibility.The authors ISBN 9781626233393 (eISBN) | ISBN 9781626233393 and publishers request every user to report to the publishers Subjects: | MESH: Tomography, Emission-Computed, any discrepancies or inaccuracies noticed. If errors in this Single-Photon work are found after publication, errata will be posted at Classi cation: LCCRC78.7.R4 (print)| LCCRC78.7.R4 (ebook)| www.thieme.com on the product description page. NLM WN 206 | DDC 616.07/575–dc23 Some of the product names, patents, and registered LC record available at https://lccn.loc.gov/2016018886 designs referred to in this book are in fact registered trade- marks or proprietary names even though speci c reference to this fact is not always made in the text. Therefore, the appearance of a name without designation as proprietary is Copyright © 2017 by Thieme Medical Publishers, Inc. not to be construed as a representation by the publisher that it is in the public domain. Thieme Publishers New York 333 Seventh Avenue, New York, NY 10001 USA +1 800 782 3488, [email protected] Thieme Publishers Stuttgart Rüdigerstrasse 14, 70469 Stuttgart, Germany +49 [0]711 8931 421, [email protected] Thieme Publishers Delhi A-12, Second Floor, Sector-2, Noida-201301 Uttar Pradesh, India +91 120 45 566 00, [email protected] Thieme Publishers Rio de Janeiro, Thieme Publicações Ltda. Edifício Rodolpho de Paoli, 25º andar Av. Nilo Peçanha, 50 – Sala 2508 Rio de Janeiro 20020-906 Brasil +55 21 3172-2297 / +55 21 3172-1896 Cover design: Thieme Publishing Group This book, including all parts thereof, is legally protected by Typesetting by DiTech Process Solutions copyright. Any use, exploitation, or commercialization out- side the narrow limitsset bycopyright legislation without the Printed in China by Everbest Printing Co. 5 4 3 2 1 publisher’s consent is illegal and liable to prosecution. This applies in particular to photostat reproduction, copying, ISBN 978-1-62623-151-1 mimeographingor duplication ofany kind,translating,prep- Also available as an e-book: aration of micro lms, and electronic data processing and eISBN 978-1-62623-339-3 storage. We dedicate this book to our respective families, who are our inspiration and the foundation of our being, as well as to our friends, who have been wonderful company along the road of life. Cont ent s Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . viii Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x I The Fundamentals 1 Basic Principles of SPECT and SPECT/CT and Quality Control . . . . . . . . . . . . . . . . . . . . . . . . 3 Frederic H. Fahey 2 Radiopharmaceuticals for Clinical SPECT Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Shankar Vallabhajoshula II Clinical Applications 3 SPECT and SPECT/CT in Neuroscience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Tarun Singhal and Chun K. Kim 4 SPECT/CT for the Thyroid and Parathyroid Glands with Cases . . . . . . . . . . . . . . . . . . . . . 48 Elisa Franquet-Elía and Kevin J. Donohoe 5 SPECT and SPECT/CT for the Cardiovascular System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 Stephen J. Horgan and Sharmila Dorbala 6 SPECT and SPECT/CT for the Respiratory System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92 Paul J. Roach and Geo rey P. Schembri 7 SPECT and SPECT/CT in Neoplastic Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114 Katherine A. Zukotynski, Victor H. Gerbaudo, and Chun K. Kim 8 SPECT and SPECT/CT for the Skeletal System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127 Hyewon Hyun, Chun K. Kim, and Katherine A. Zukotynski 9 SPECT/CT for Infection and Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 Christopher J. Palestro 10 SPECT in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 Frederick D. Grant 11 Selected Interesting SPECT and SPECT/CT Cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 Samuel E. Almodóvar, Padma Manapragada, Katherine A. Zukotynski, and Chun K. Kim Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198 vii Pre face With the advent ofhybrid imaging,the eld ofnuclear glands, the cardiovascular system, the respiratory medicine has evolved signi cantly in recent years. In system, neoplastic disease, the skeletal system, infec- particular, single-photon emission computed tomog- tion/ in ammation, and pediatrics. Illustrative case raphy (SPECT) and SPECT/CT have come into their examples focusing on each clinical area are included own as important diagnostic tools in routine clinical throughout the chapters. The nal chapter of this practice. Indeed, SPECT and SPECT/CT are often tou- book presents a compilation of interesting cases tar- ted as game changers in the way clinical nuclear geting topics not otherwise reviewed in the preceding medicine is performed today. When we initially con- chapters. sidered writing this book, we realized there were We have tried to write a book that is a concise, several books available covering the general topics easy-to-read review of SPECT and SPECT/CT as it is of nuclear medicine and PET. However, we felt there currently used in the clinic. Information is presented was a lack of a concise book discussing the utility of in an accessible format with concise bullet points SPECTand SPECT/CTin the imaging eld and that this highlighting key imaging ndings and teaching pearls could be helpful primarily to residents, technologists throughout. We do not intend for this book to be a and practicing physicians. comprehensive reference on the topic; rather, we The goal of this book is to address a timely clinical hope it will provide a strong foundation, improved need by providing a basic yet broad understanding of understanding ofthese techniques,and focused high- and practical approach to SPECT and SPECT/CT that yield material for successful clinical practice in the will be useful to a spectrum ofclinicians and technol- world of today. ogists.The book begins with two chapters focusing on Leading experts in the eld ofhybrid imaging have the technological foundation of SPECT and SPECT/CT contributed to this book,and it is a pleasure to feature as well as the radiochemistry used in association with their work. We hope that you will enjoy reading our these imaging techniques. This is followed by nine book and that you will nd it to be a valuable addition chapters, each of which details the utility of SPECT to your library as well as a tool that will further your and SPECT/CTfor imaging in a speci cclinicalcontext, success! including neuroscience, the thyroid and parathyroid viii
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