Specialty Imaging: PET, 1e PDF
Preview Specialty Imaging: PET, 1e
PET Positron Emission Tomography With Correlative CT and MR Bennett ii PET Positron Emission Tomography With Correlative CT and MR Paige Bennett, MD Associate Professor Nuclear Medicine and Molecular Imaging Department of Radiology Wake Forest School of Medicine Winston-Salem, North Carolina Akiva Mintz, MD, PhD, MHA, CFA Professor and Vice Chair of Translational Research, Radiology Director, PET Center Division Chief, Nuclear Medicine and Molecular Imaging Department of Radiology Columbia University Medical Center New York, New York Brad Perry, MD Diagnostic Radiology Resident Department of Radiology Wake Forest University Health Sciences Winston-Salem, North Carolina Andrew T. Trout, MD Assistant Professor of Radiology and Pediatrics Director, Nuclear Medicine Director, Clinical Research (Radiology) Department of Radiology Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Paula Vergara-Wentland, MD Diagnostic Radiology Fellow Department of Radiology Wake Forest University Health Sciences Winston-Salem, North Carolina iii 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899 SPECIALTY IMAGING: PET ISBN: 978-0-323-52484-1 Copyright © 2018 by Elsevier. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/ permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Publisher Cataloging-in-Publication Data Names: Bennett, Paige. Title: Specialty Imaging. PET / [edited by] Paige Bennett. Other titles: PET. Description: First edition. | Salt Lake City, UT : Elsevier, Inc., [2017] | Includes bibliographical references and index. Identifiers: ISBN 978-0-323-52484-1 Subjects: LCSH: Tomography--Handbooks, manuals, etc. | Radiography--Handbooks, manuals, etc. | MESH: Radiography--methods--Atlases. | Radiography, Dual-Energy Scanned Projection--methods--Atlases. | Tomography, Emission-Computed, Single-Photon--methods--Atlases. | Tomography, X-Ray Computed--methods--Atlases. Classification: LCC RC78.S63 2017 | NLM WN 200 | DDC 616.0757’2--dc23 International Standard Book Number: 978-0-323-52484-1 Cover Designer: Tom M. Olson, BA Printed in Canada by Friesens, Altona, Manitoba, Canada Last digit is the print number: 9 8 7 6 5 4 3 2 1 iv DEDICATION For Dad, Mom, Betsy, Sidney, and Lee Andrew. Thankful for this time with you all. PB v vi CONTRIBUTING AUTHORS Ashley F. Blurton, MD, MS Jacob Blackwell, MD Assistant Professor Wake Forest School of Medicine Nuclear Medicine Winston-Salem, North Carolina Department of Radiology and Medical Imaging University of Virginia School of Medicine Adam G. Johnson, MD Charlottesville, Virginia Wake Forest School of Medicine Winston-Salem, North Carolina Angela P. Bruner, PhD, DABR Director, Radiation Safety Officer, Medical Physicist Robert M. Morgan, Jr., MD Radiation Safety & Medical Physics Wake Forest School of Medicine Baylor Scott & White Health Winston-Salem, North Carolina Dallas, Texas Eric L. Yuan, MD Erica Cohen, MD Wake Forest School of Medicine Assistant Chief of Nuclear Medicine Winston-Salem, North Carolina Edward Hines VA Medical Center Hines, Illinois Assistant Professor of Radiology Loyola University Medical Center Maywood, Illinois Additional Contributors Erin Grady, MD, CCD, FACNM Nuclear Medicine Physician John Bailey, MD Christiana Care Health System Newark, Delaware Aidan Burke, MD Abdul-Rahman Abualuz, MD Hollins Clark, MD Department of Radiology James Patrick Davidson, MD Wake Forest Health Sciences Winston-Salem, North Carolina Pushpender Gupta, MBBS Kelli Y. Ha, MD Brian L. Bones, MD Department of Radiology John M. Holbert, MD, FACR Wake Forest Health Sciences Winston-Salem, North Carolina Katarina Kesty, MD, MBA Amanda Jo Lott Marcellino, MD Todd Michael Danziger, MD Department of Radiology Ashley C. Mays, MD Wake Forest Health Sciences Bryan J. Neth, BS Winston-Salem, North Carolina Umesh D. Oza, MD Nathaniel Garrett Gray, MD Department of Radiology Virginia Barnes Planz, MD Wake Forest Health Sciences Anita Thomas, MD Winston-Salem, North Carolina Pavani Thotakura, MD Jennifer Schroeder, MD Bimal Vyas, MD, MS Department of Radiology Wake Forest Health Sciences Christopher T. Whitlow, MD, PhD, MHA Winston-Salem, North Carolina vii viii PREFACE PET has revolutionized the fields of oncology, cardiology, and neurology. The overwhelming success of F-18 FDG in clinical use has demonstrated the true power of molecular imaging and has led to additiona l regulatory approvals of molecular PET agents for clinical practice, including new tracers that target amyloid in Alzheimer disease, radiolabeled peptides that target somatostatin receptors on tumors, and radiolabeled amino acids to image prostate cancer. These developments have led to a renaissance in nuclear medicine that has changed the way patients are managed and treated. The highly sensitive F-18 FDG PET is now being augmented by PET tracers with increased specificity. PET offers physicians an early opportunity to alter therapeutics if they are not efficacious after a trial period and before adverse effects are evident. As PET research continues, it will continue to assist in personalized medicine by enabling highly specific therapies, giving patients the best chance at successful treatment. Clinicians including nuclear medicine radiologists, radiation oncologists, oncologists, oncology surgeons, trainees in nuclear medicine and oncology plus researchers in drug development and molecular imaging need to keep up with existing and emerging PET technologies currently in clinical practice. Specialty Imaging: PET, first edition is a reference text covering: • Interpretation, artifacts, and common pitfalls • Oncologic PET diagnoses with staging tables and reporting tips • CNS PET indications, including dementia, epilepsy, oncology • Cardiac PET indications including stress tests, cardiac viability, sarcoidosis • Infection and inflammation PET • PET physics and instrumentation • Clinical and research PET radiotracers and their indications The authoring team that developed this text is a group of dedicated nuclear medicine physicians and radiologists involved in both clinical practice and academic pursuits. Lead authors including myself, Dr. Paige Bennett, and Dr. Andrew Trout have worked to deliver expertise and case examples in the fields of neuroimaging, oncology, and pediatrics. In addition, over 30 contributing authors–led by Drs. Brad Perry and Paula Vergara-Wentland–have generously shared their expertise and case examples inside this book to bring the reader up-to-date on clinical PET imaging. Akiva Mintz, MD, PhD, MHA, CFA Professor and Vice Chair of Translational Research, Radiology Director, PET Center Division Chief, Nuclear Medicine and Molecular Imaging Department of Radiology Columbia University Medical Center New York, New York ix
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