Small Wonders: Peptides for Disease Control PDF
Preview Small Wonders: Peptides for Disease Control
Small Wonders: Peptides for 1 0 0 bs.acs.org 2-1095.fw Disease Control u1 p0 p://k-2 2 | htt021/b 11 28, 20oi: 10. May 2 | d n 01 o2 35.42 pril 4, 3.A 89.16Web): ded by Date ( wnloaation Doblic u P In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. 1 0 0 g w bs.acs.or2-1095.f u1 p0 p://k-2 2 | htt021/b 11 28, 20oi: 10. May 2 | d n 01 o2 35.42 pril 4, 3.A 89.16Web): ded by Date ( wnloaation Doblic u P In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. 1095 ACS SYMPOSIUM SERIES Small Wonders: Peptides for Disease Control Kanniah Rajasekaran, Editor Southern Regional Research Center 1 0 0 U.S. Department of Agriculture g w bs.acs.or2-1095.f New Orleans, Louisiana pu01 Jeffrey W. Cary, Editor p://k-2 2 | htt021/b SoUut.hSe.rDneRpeagrtimoneanlt RoefseAagrrcihcuCltuerneter 11 28, 20oi: 10. New Orleans, Louisiana May 2 | d Jesse M. Jaynes, Editor n 01 o2 35.42 pril 4, Tuskegee University, Tuskegee, Alabama 89.163.Web): A UEnmiveirlsiiotyMofoGnirtoensai,nGoirso,nEa,dSiptoairn ded by Date ( wnloaation Sponsored by the Doublic ACSDivisionofAgriculturalandFoodChemistry,Inc. P AmericanChemicalSociety,Washington,DC DistributedinprintbyOxfordUniversityPress,Inc. In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. LibraryofCongressCataloging-in-PublicationData Smallwonders:peptidesfordiseasecontrol/KanniahRajasekaran...[etal.],editor[s]. p.;cm.-- (ACSsymposiumseries;1095) 1 "SponsoredbytheACSDivisionofAgriculturalandFoodChemistry,Inc." 0 0 Includesbibliographicalreferencesandindex. g w bs.acs.or2-1095.f FIIoS.oRBdaNCjah9se7emk8a-i0rsa-tr8ny4,.1KI2I.I,-.21S79e45r82ie--4sI:I(A.alACkm.Spesarypimcearpn)oCsihuemmsicearileSso;c1i0et9y5..D0i0v9is7i-o6n15o6fAgriculturaland pu01 [DNLM:1. AntimicrobialCationicPeptides.2. Anti-InfectiveAgents.3. PlantDiseases. p://k-2 4. Therapeutics. QU68] 2 | htt021/b 615.7′92--dc23 11 28, 20oi: 10. 2012004898 May 2 | d n 01 o2 35.42 pril 4, ThepaperusedinthispublicationmeetstheminimumrequirementsofAmericanNational 3.A Standard for Information Sciences—Permanence of Paper for Printed Library Materials, 89.16Web): ANSIZ39.48n1984. ded by Date ( Copyright©2012AmericanChemicalSociety wnloaation DistributedinprintbyOxfordUniversityPress,Inc. Doublic oAfllthReiUgh.Sts.RCeospeyrrviegdh.tRAecptriosgarllaopwhiecdcfoopryinintegrnbaelyuosnedotnhlayt,pperromviidtteeddtbhyatSaepcteiro-ncsha1p0t7erofre1e0o8f P $40.25plus$0.75perpageispaidtotheCopyrightClearanceCenter,Inc.,222Rosewood Drive,Danvers,MA01923,USA.Republicationorreproductionforsaleofpagesinthis bookispermittedonlyunderlicensefromACS.Directtheseandotherpermissionrequests toACSCopyrightOffice,PublicationsDivision,115516thStreet,N.W.,Washington,DC 20036. Thecitationoftradenamesand/ornamesofmanufacturersinthispublicationisnottobe construedasanendorsementorasapprovalbyACSofthecommercialproductsorservices referenced herein; nor should the mere reference herein to any drawing, specification, chemicalprocess, orotherdataberegardedasalicenseorasaconveyanceofanyright or permission to the holder, reader, or any other person or corporation, to manufacture, reproduce,use,orsellanypatentedinventionorcopyrightedworkthatmayinanywaybe relatedthereto. Registerednames,trademarks,etc.,usedinthispublication,evenwithout specificindicationthereof,arenottobeconsideredunprotectedbylaw. PRINTEDINTHEUNITEDSTATESOFAMERICA In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. Foreword The ACS Symposium Series was first published in 1974 to provide a mechanism for publishing symposia quickly in book form. The purpose of the series is to publish timely, comprehensive books developed from the ACS sponsoredsymposiabasedoncurrentscientificresearch. Occasionally,booksare developed from symposia sponsored by other organizations when the topic is of 1 00 keeninteresttothechemistryaudience. g w bs.acs.or2-1095.f forapBperfoopreriaatgereaenidncgotmoppruebhleisnhsiavebocookv,etrhaegeparonpdofsoerdintatebrleesottfoctohneteanutdsieisncreev.iSeowmede u1 p://pk-20 papersmaybeexcludedtobetterfocusthebook;othersmaybeaddedtoprovide 2 | htt021/b caodmdepdr.eDhernasftisveonfecshsa.ptWersheanreappeperro-prerviaiteew,eodvperrvioierwtoofirnainltarcocdeupcttaonrcyecohrarpetjeercstioarne, 11 28, 20oi: 10. andmanuscriptsarepreparedincamera-readyformat. May 2 | d As a rule, only original research papers and original review papers are n 01 included in the volumes. Verbatim reproductions of previous published papers o2 35.42 pril 4, arenotaccepted. 3.A ded by 89.16Date (Web): ACSBooksDepartment wnloaation Doblic u P In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. Preface The human tendency to regard little things as important has produced very manygreatthings. -GeorgC.Lichtenberg 1 s.org 95.pr00 agricTuhlteurualseapopfliacnattiiomniscriosbinaelarpienpgtidreeaslit(yA.MFPrso)masthaegeenatrslieisnt tchhearraapceteurtiizcataionnd http://pubs.ac1/bk-2012-10 htophifrgeevhtdhe-trnehiitvrraoitniuavggnehtfipommurecticdesrioccbirbeneiheeainslnidnaasgctthwiaveseistldialeeyasvsse,ltiootnhpimtsnhoeecvnlecatlososnfmtornoefelthxaoont-fdtgispmelnaifecnorrtraotbditoiihasneeliartashgeesesry.nantpstMehuheotasiriscessbtahaenneandnd 012 | 0.102 1700 natural AMPs from a wide range of life forms ranging from prokaryotes 21 to humans have been characterized to date and many of these have served as May 28, 2 | doi: tsepmecpilfiacteitsy,fosrtatbhielitrya,tiaonndalbdioesaivganilaobfilsiytyn.theOtinccepetphtoiduegshtwtiothbiemvperoryveudnipfootremnciyn, 1 2 on 4, 20 their antimicrobial activity as membrane disruptants, research is now revealing 3.35.4April hthoestm’suilntinfautnecitmiomnaulnnitaytubruetoaflstoheassemmoodlueclautloerssaosfcthrieticaadlapptliavyeerismnmoutnoenrlyesipnonthsee 9.16eb): in mammals or as elicitors of defense responses in plants. Several AMPs not wnloaded by 8ation Date (W omaimnenlpmyoonbrfdtruaeannsntctertbsuioicobntluiovtsgeoaicllmesalolaynfhuntanhevcrreotiauotnghndhesiaaninbntdeitlerilarteaycactdttiowioningcthrtoaosinnscdtertalhdlceidesrlepluaaupttlhhtai.orognteanrog’fsetcpseailtnlhtomegrefeemnribncrgealnlweuiltiahnr Doblic AMPtechnologyhastremendousimplicationsforthedevelopmentofnovel u P therapeuticsandplantprotectivestrategies. Thisbookassemblescontributionsby internationally acclaimed scientists with a focus on therapeutic and agricultural applications. Promising medical applications of peptide technology include treatmentsforbacterial,fungalandviralinfections. Productionofmoreeffective peptides,targetingthetreatmentofcancer,utilizesnovelstrategiesfordesigning peptide immunogens to elicit specific antibodies. In humans, peptides that modulate the host’s adaptive immune response will not be recognized by the invading pathogen as a defense factor and therefore will not be prone to development of resistance by the pathogen. Agricultural applications include control of devastating plant diseases caused by microbial pathogens, some of them resulting in mycotoxin contamination of food and feed products. Though plants and their various pathogens wage a continuous war of resistance against one another, transgenic strategies that utilize AMPs with different modes of action (both extra- and intracelluarly) against target pathogens should provide a ix In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. selfdefensemechanismthatwillbemuchharderforthepathogentocircumvent anddevelopresistance. This book is the result of the symposium “Small Wonders: Peptides for Disease Control” held at the 240th National Meeting of the American Chemical Society in Boston, MA, August 22-26, 2010. To our knowledge, this is the first bookthatcoversabroadrangeofpeptidetechnologyanditspracticalapplication intheagricultural,medical,andpharmaceuticalfields. Theup-to-datereviewsand original research presented in this book will be of interest to a diverse audience including scientists in the medical, pharmaceutical, agricultural, chemical and biotechnological fields. Biochemists, molecular biologists, microbiologists and graduatestudentsengagedinresearchandthedevelopmentofpeptideswillfind this book a useful reference tool. In summary, this book will represent a timely and much-needed comprehensive update of the literature in the field of peptides 01 fordiseasecontrol,animportantandfast-movingsubjectarea. s.org 95.pr0 sympWoesiuamreatnhdantkifmuellytoctohnetraibuuthtioorns tfoorththiseivroelunmtheu.siasWtiec wpaorutilcdipbaetiorneminissthief c0 http://pubs.a1/bk-2012-1 wuAseCiSndiDedxivpnieosdtioitanicnkognftoAhweglretihdcogurelotuutrhgeehapinmedemFreornoesvdeieCwhheelppmroioscftersysse.(vAeTCrhaSla-nArkeGsviFaerDwe)earfslosrowsdhpuooenhsteoolrpitnhegde 012 | 0.102 tahned sAygmrpooMsieudmLLanCd. fWore tahlesogaepnperreocuisatefintahnecifaollloaswsiinstganmceemfrboemrs AofCtSh-eAGAFCDS 21 28, oi: Publication Division for the editorial assistance - Tim Marney, Bob Hauserman, May 2 | d ArleneFurman,andMaryCalvertandforthecoverdesignbyPamelaKame. 1 2 on 4, 20 35.4pril KanniahRajasekaran 89.163.Web): A RFoeosedaarcnhdBFeioeldogSiasftetyResearchUnit ded by Date ( SUoSuDthAerAngRriecguilotnuarallRReesseeaarcrchhCSeenrtveirce wnloaation 1100RobertE.LeeBlvd. Doblic NewOrleans,LA70124,U.S.A. u +1(504)286-4482(telephone) P +1(504)286-4533(fax) [email protected](e-mail) JeffreyW.Cary MolecularBiologist FoodandFeedSafetyResearchUnit SouthernRegionalResearchCenter USDAAgriculturalResearchService 1100RobertE.LeeBlvd. NewOrleans,LA70124,U.S.A. +1(504)286-5264(telephone). [email protected](e-mail) x In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. JesseM.Jaynes ProfessorofBiochemistry TuskegeeUniversity Tuskegee,AL36088,U.S.A. +1(678)787-2416(telephone) [email protected](e-mail) EmilioMontesinos ProfessorofCropScience(PlantPathology) InstituteofFoodandAgriculturalTechnology UniversityofGirona CampusMontilivi,s/n 01 17071Girona,Spain s.org 95.pr0 e+m34ili9o7.m24o1n8te4s2in7o([email protected]) (e-mail) c0 http://pubs.a1/bk-2012-1 012 | 0.102 21 28, oi: May 2 | d 1 2 on 4, 20 35.4pril 3.A 9.16eb): 8W ded by Date ( wnloaation Doblic u P xi In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. Editors’ Biographies Kanniah Rajasekaran KanniahRajasekaranisaResearchBiologistwiththeFoodandFeedSafety Research Unit, Agricultural Research Service, USDA in New Orleans, LA. He is an international authority on application of aseptic cell/tissue culture and recombinant DNA technologies towards genetic improvement of food and feed crops. HereceivedhisB.S.andM.S.inAgriculturalSciencesfromTamilNadu g 01 s.acs.or095.ot0 AthgerUicnuilvtuerraslitUynoivfeSrysidtyn,eCy,oAimubstartaolriea,.InHdeiamaonvdePdht.Do.hiinsCcurorrpeBntioptoescihtinoonlowgyithfrothme b1 USDA, ARS in 1996 after a considerable industry experience with Phytogen, a pu2- p://201 plantbiotechnologycompanyinPasadena,California. Currentresearchinterests 2 | htt1/bk- oinfclturadneshgoesnti-cpacthoottgoenn/croerlant/ipoenasnhuipt,vaanrtiiefutinegsalwpirtohterienssisatnadncpeepttoidepsh,ydteovpealtohpomgeennst 12 00 21 includingmycotoxin-producingfungi,andtissue-ororganelle-specificexpression V on May 29, 2012 | doi: 10. of transgenes. Jeffrey W. Cary NI4, L Upril JeffreyW.CaryisaMolecularBiologistintheFoodandFeedSafetyResearch RNELeb): A UthneietliuncNideawtioOnrolefathnes,gwenheicshinhvaoslvreecdeiinveadflaintotexrinnabtiioonsaylnrtheceosigsnaintidonthfeoirrritesgwuloartikoinn. OW ded by Con Date ( aHCnledosestaurribndseieudqmuheainsctelPythop.bDeur.tfyoilnricmMuemdicaprocoebsttiodonoloecg/tboyuratfarlonremoslefLaerorcmuhiesoinnatnatathieoSnmtaaotteleRUciucnleiavrUebrnisioivtlyeorgsiynitoy1.f9tH8h6ee DownloaPublicati 1jo9i8n9edwthheereUhSeDhAa,sAbeReSn,sStuoduythinegrnthReergeigounlaaltiRonesoefarfcuhngCaelndteevrealtopNmewentOarnledatnosxiinn production as well as engineering plants for expression of novel antimicrobial peptides/proteinsasameanstocontrolaflatoxincontaminationinfoodandfeed crops. Dr. Caryhasappearedasanauthorin110publicationsandservedasChair of (2003−04) of the Fermentation and Biotechnology Division of the American SocietyforMicrobiology. Jesse M. Jaynes JesseM.JaynesisaProfessorofBiochemistryatTuskegeeUniversitywhere hedoesresearchandteachesbiochemistryintheIntegrativeBiosciencesProgram. He received his associate degree in anthropology from College of Eastern Utah, B.S.degreeinbiologyfromSouthernUtahStateCollegeandPh.D.inchemistry fromBrighamYoungUniversitymentoredbyLeoVernon. HereceivedanNSF ©2012AmericanChemicalSociety In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
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