Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page i Sleep Disorders Diagnosis and Therapeutics Edited by SR Pandi-Perumal MSc President and CEO Somnogen Inc. New York, NY USA Joris C Verster PhD Utrecht University, Utrecht Institute for Pharmaceutical Sciences Faculty of Science Section Psychopharmacology Utrecht, The Netherlands Jaime M Monti MD Department of Pharmacology and Therapeutics University of the Republic School of Medicine Montevideo Uruguay Malcolm Lader MD PhD Emeritus Professor of Clinical Psychopharmacology Institute of Psychiatry London UK Salomon Z Langer MD Vice President Research Alpha-2 Pharmaceutica AB Tel Aviv Israel Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page ii © 2008 Informa UK Ltd First published in the United Kingdom in 2008 by Informa Healthcare, Telephone House, 69–77 Paul Street, London EC2A 4LQ. Informa Healthcare is a trading division of Informa UK Ltd. Registered Office: 37/41 Mortimer Street, London W1T 3JH. 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Although every effort has been made to ensure that drug doses and other information are presented accurately in this publication, the ultimate responsibility rests with the prescribing physician. Neither the publishers nor the authors can be held responsible for errors or for any consequences arising from the use of information contained herein. For detailed prescribing information or instructions on the use of any product or procedure discussed herein, please consult the prescribing information or instructional material issued by the manufacturer. A CIP record for this book is available from the British Library. Library of Congress Cataloging-in-Publication Data Data available on application ISBN 10: 0 415 43818 7 ISBN 13: 978 0 415 43818 6 Distributed in North and South America by Taylor & Francis 6000 Broken Sound Parkway, NW, (Suite 300) Boca Raton, FL 33487, USA Within Continental USA Tel: 1 (800) 272 7737; Fax: 1 (800) 374 3401 Outside Continental USA Tel: (561) 994 0555; Fax: (561) 361 6018 Email: [email protected] Book orders in the rest of the world Paul Abrahams Tel: +44 207 017 4036 Email: [email protected] Composition by C&M Digitals (P) Ltd, Chennai, India Printed and bound in India by Replika Press Pvt Ltd Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page iii To our wives and families. Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page iv Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page v Contents List of contributors xi Preface xvii Credits and acknowledgments xx 1. Classification of sleep disorders 1 Imran M Ahmed and Michael J Thorpy 2. Sleep loss and sleepiness 11 Thomas J Balkin and Nancy J Wesensten 3. Approach to the patient with a sleep complaint 21 Michael J Thorpy and Imran M Ahmed 4. Manifestations of hypersomnia 34 Michel Billiard 5. Neuropsychology of sleep disorders 43 Christian Bellebaum and Irene Daum 6. Receptor mechanisms in sleep and wakefulness 52 Christopher M Sinton and Robert W McCarley 7. Transient insomnia: a behavioral sleep medicine perspective 70 Gregory S Vander Wal, Megan E Ruiter and Kenneth L Lichstein 8. Chronic insomnia 80 Michael H Bonnet and Donna L Arand 9. Rebound with hypnotic medication 90 Malcolm Lader 10. Benzodiazepines: an overview 96 Dimitris Dikeos, Christos G Theleritis and Constantin R Soldatos 11. Benzodiazepines: effects on memory functioning 105 Danièle Bentué-Ferrer and Yvette Akwa 12. Behavioral therapy, sleep hygiene, and psychotherapy 115 Chien-Ming Yang and Matthew R Ebben 13. Sleep factors 124 Fabio García-García and René Drucker-Colín 14. CYP enzyme system and its relevance to the pharmacology of sleep 133 Inna D’Empaire and Sheldon H Preskorn 15. Pharmacokinetics: basic concepts for dosage regimen considerations 140 Saeed A Qureshi 16. Chronopharmacology: principles and applications in sleep medicine 153 SR Pandi-Perumal, Perumal Subramanian, Ilya Trakht and Daniel P Cardinali 17. Sleep and geriatric psychopharmacology 163 David J Greenblatt 18. Antihistamines and sleep 174 Michael Grözinger, Birte Huth and Ashish Sharma 19. First-generation hypnotics and sedatives 187 Paulo R Shiroma and Milton Kramer 20. GABA -benzodiazepine receptors as targets for new hypnotics 206 A Hanns Möhler Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page vi vi CONTENTS 21. Benzodiazepines: effects on sleep 220 Dimitris G Dikeos, Christos G Theleritis and Constantin R Soldatos 22. Indiplon 223 David N Neubauer 23. Serotonergic drugs as sleep medications 230 Alessandro Serretti and Antonio Drago 24. Prostaglandins and sleep–wake regulation 246 Yoshihiro Urade and Osamu Hayaishi 25. Function of endocannabinoids and related compounds in sleep 259 Oscar Prospéro-García, Andrea Herrera-Solís, Aldebarán Prospéro-García and Vincenzo Di Marzo 26. Sleep medications: when to prescribe and rationale for use 268 Sarah M Richey and Andrew D Krystal 27. Stimulants: mechanisms and therapeutic prospects 281 Elemer Szabadi and Ebony R Samuels 28. Zolpidem: its use in the treatment of sleep disorders 295 Jaime M Monti, SR Pandi-Perumal and Salomon Z Langer 29. Eszopiclone: efficacy and safety 324 Jadwiga Najib and Gary K Zammit 30. Zaleplon 352 Joseph Barbera and Colin M Shapiro 31. Z-drugs: comparative tolerability 364 Mario Giovanni Terzano, Giulia Milioli, Fernando De Paolis and Liborio Parrino 32. Rationale for the development of the Z–drugs 379 David Nutt and Sue Wilson 33. Melatonin 385 Nava Zisapel 34. Ramelteon: a melatonin receptor agonist 394 Richard J Wurtman 35. The rationale for the development of melatonin receptor ligands 402 Gilberto Spadoni, Annalida Bedini, Marco Mor and Silvia Rivara 36. Schizophrenia, sleep, and antipsychotic drugs 417 Luc Staner, Nadine Noël and Rémy Luthringer 37. Interrelationships between sleep, depression, and antidepressant drugs 427 Sohrab Zahedi, Jayesh Kamath and Andrew Winokur 38. Antiepileptic drugs: effects on sleep and wakefulness 443 Silvia Neme, Nancy F Foldvary-Schaefer and Madeleine Grigg-Damberger 39. Hormones and sleep 457 Axel Steiger 40. Time-zone travel, jet lag, and sleep disturbances 467 Thomas Reilly and Jim Waterhouse 41. Alcohol, sleep, sleep disorders, and consequent daytime impairment 480 Timothy A Roehrs and Thomas Roth 42. Sleep medication and traffic safety 487 Joris C Verster, Monique AJ Mets, Lieke M de Senerpont Domis and Edmund R Volkerts 43. Effects of hypnotic drugs on body balance and standing steadiness 493 Monique AJ Mets, Lieke M de Senerpont Domis Berend Olivier, Edmund R Volkerts and Joris C Verster 44. Neuropharmacology of opioids 518 Christian Zöllner Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page vii CONTENTS vii 45. Sleep and breathing disorders in adults 526 Mandy Jones and Mary J Morrell 46. Continuous positive airway pressure therapy 536 John Garvey and Walter McNicholas 47. Pharmacological treatment of obstructive sleep apnea 545 Vivien C Abad and Christian Guilleminault 48. Surgical options in snoring and obstructive sleep apnea 558 Kenny P Pang and David J Terris 49. Restless legs syndrome: treatment options 567 Lynn Marie Trotti, Donald L Bliwise and David B Rye 50. Restless legs syndrome: effects on cognitive functioning, memory, and psychomotor performance 577 Federica Provini, Roberto Vetrugno and Pasquale Montagna 51. Pharmacological treatment of narcolepsy 587 Victoria Y Zvonkina and Jed E Black 52. Modafinil and neuropharmacology of narcolepsy 597 Seiji Nishino 53. Narcolepsy: effects on cognitive functioning, memory, and psychomotor performance 608 John M Shneerson and Delia C Randall 54. Dreams: physiology, pharmacology, and psychology 618 Milton Kramer, Rashi Aggarwal and Sosunmolu Shoyinka 55. Sleep and dreaming – medication effects and side-effects 627 JF Pagel 56. Appendix I: The subjective measurement of excessive daytime sleepiness 643 Murray W Johns 57. Appendix II: The Multiple Sleep Latency Test and Maintenance of Wakefulness Test: use and procedures 658 Donna L Arand and Michael H Bonnet 58. Appendix III: The OSLER test 669 Giuseppe Liistro and Daniel Rodenstein 59. Appendix IV: The Pittsburgh Sleep Quality Index 671 Wendy M Troxel and Daniel J Buysse 60. Appendix V: Scoring rules and general guidelines for the Pittsburgh Insomnia Rating Scale 680 Douglas E Moul and Daniel J Buysse 61. Appendix VI: The Athens Insomnia Scale 687 Dimitris Dikeos, Christos G Theleritis and Constantin R Soldatos 62. Appendix VII: The Leeds Sleep Evaluation Questionnaire for psychopharmacology research 689 AC Parrott and I Hindmarch 63. Appendix VIII: Sleep Hygiene Practice Scale 694 Chien-Ming Yang and Matthew R Ebben 64. Appendix IX: Cyclic Alternating Pattern 695 Mario Giovanni Terzano, Arianna Smerieri, Fernando De Paolis, Giulia Milioli and Liborio Parrino 65. Appendix X: Body mass index 701 Index 713 Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page viii Prelims-Pandi-8044:Prelims-Pandi-8044.qxp 5/6/2008 6:54 PM Page ix Contributors Vivien C Abad MDMBA Annalida Bedini PhD Stanford University Sleep Disorders Center Istituto di Chimica Farmaceutica e Tossicologica Camino Medical Group Università degli Studi di Urbino Palo Alto Medical Foundation Urbino Cupertino, CA Italy USA Christian Bellebaum PhD Rashi Aggarwal MD Institute of Congnitive Neuroscience Department of Psychiatry Department of Neuropsychology Maimonides Medical Center Ruhr-University of Bochum Brooklyn, NY Bochum USA Germany Imran M Ahmed MD Danièle Bentué-Ferrer PhD Sleep-Wake Disorders Center Service de Pharmacologie Montefiore Medical Centre Faculté de Médecine Bronx, NY Rennes USA France Yvette Akwa PhD Michel Billiard MD Faculté de Médecine Department of Neurology Université Paris-Sud Gui de Chauliac Hospital Paris Montpellier France France Donna L Arand PhD Jed E Black MD Kettering Hospital Sleep Disorders Center Stanford Sleep Disorders Clinic Dayton, OH Stanford, CA USA USA Thomas J Balkin PhD Donald L Bliwise PhD Chief, Department of Behavioral Biology Department of Neurology Walter Reed Army Institute of Research Emory University School of Medicine Silver Spring, MD Atlanta, GA USA USA Joseph Barbera MD Michael H Bonnet PhD The Youthdale Child and Adolescent Sleep Centre Dayton Department of Veterans Affairs Medical Center Department of Psychiatry Dayton, OH University of Toronto USA Toronto, Ontario Canada