Table Of Content

Thank you for purchasing this e-book. To receive special offers and news about our latest products, sign up below. Or visit LWW.com NINTH EDITION Skeel’s Handbook of Cancer Therapy Samir N. Khleif, MD Director Georgia Cancer Center Immuno-Oncology Therapeutics Program Professor of Medicine Professor of Biochemistry and Molecular Biology Medical College of Georgia Professor of Graduate Studies Augusta University Augusta, Georgia Olivier Rixe, MD, PhD Professor Division of Hematology-Oncology The Dana Wood Endowed Chair in Cancer Therapeutics and Early Phase Clinical Research University of New Mexico Comprehensive Cancer Center Albuquerque, New Mexico Roland T. Skeel, MD Professor and Interim Chair Department of Medicine Division of Hematology-Oncology University of Toledo College of Medicine and Life Sciences Attending Physician University of Toledo Medical Center Toledo, Ohio Acquisitions Editor: Julie Goolsby Senior Product Development Editor: Emilie Moyer Senior Editorial Assistant: Brian Convery Production Project Manager: Priscilla Crater Design Coordinator: Holly McLaughlin Manufacturing Coordinator: Beth Welsh Marketing Manager: Rachel Mante Leung Prepress Vendor: S4Carlisle Publishing Services Ninth Edition Copyright © 2016 Wolters Kluwer. Copyright © 2011 Wolters Kluwer Health / Lippincott Williams & Wilkins. Copyright © 2007 Lippincott Williams & Wilkins, a Wolters Kluwer business. Copyright © 2003, 1999 by Lippincott Williams & Wilkins. Copyright © 1995 by Lippincott-Raven Publishers. Copyright © 1991, 1987, 1982 by Little, Brown & Company. Previously titled “Handbook of Cancer Chemotherapy” edited by Roland T. Skeel, All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at lww.com (products and services). 9 8 7 6 5 4 3 2 1 Library of Congress Cataloging-in-Publication Data Names: Khleif, Samir N., editor. | Rixe, Olivier, editor. | Skeel, Roland T., editor. Title: Skeel’s handbook of cancer therapy/[edited by] Samir N. Khleif, Olivier Rixe, Roland T. Skeel. Other titles: Handbook of cancer chemotherapy. Description: Ninth edition. | Philadelphia: Wolters Kluwer Health, 2016. | Preceded by Handbook of cancer chemotherapy/edited by Roland T. Skeel, Samir N. Khleif. Eighth edition. 2011. | Includes bibliographical references and index. Identifiers: LCCN 2015051073 | 9781496305558 | 9781496353399 Subjects: | MESH: Neoplasms—therapy | Antineoplastic Agents—administration & dosage | Handbooks Classification: LCC RC271.C5 | NLM QZ 39 | DDC 616.99/4061—dc23 LC record available at http://lccn.loc.gov/2015051073 This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based on healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data, and other factors unique to the patient. The publisher does not provide medical advice or guidance, and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work, including all medical judgments, and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made, and healthcare professionals should consult a variety of sources. 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CONTRIBUTORS Olivia Bally, MD Associate Professor Department of Medical Oncology Centre Léon Bérard Université Claude Bernard Lyon I Lyon, France Rachid Baz, MD Associate Member Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Associate Professor Department of Oncologic Sciences University of South Florida Tampa, Florida Al B. Benson III, MD Professor of Medicine Division of Hematology-Oncology Associate Director for Cooperative Groups Robert H. Lurie Comprehensive Cancer Center of Northwestern University Chicago, Illinois Michael J. Birrer, MD, PhD Professor Department of Medicine Harvard Medical School Physician Division of Hematology-Oncology Massachusetts General Hospital Boston, Massachusetts Jean-Yves Blay, MD, PhD Professor of Medicine Department of Medical Oncology Centre Léon Bérard Université Claude Bernard Lyon 1 Lyon, France Jad Chahoud, MD Resident Physician Department of Internal Medicine The University of Texas Health Science Center at Houston McGovern Medical School Houston, Texas Shruti Chaturvedi, MBBS Clinical Fellow Vanderbilt University Nashville, Tennessee Bruce D. Cheson, MD, FACP, FAAAS, FASCO Professor of Medicine and Deputy Chief Division of Hematology-Oncology Head of Hematology Georgetown University Hospital Lombardi Comprehensive Cancer Center Washington, District of Columbia Muhammad O. Chohan, MD Director Neurosurgical Oncology Department of Neurosurgery Co-leader Neuro-Oncology Multidisciplinary Program University of New Mexico Comprehensive Cancer Center Albuquerque, New Mexico Jean-Michel Coindre, MD Professor Department of Pathology Institut Bergonié Bordeaux, France Marcela G. del Carmen, MD, MPH Professor Division of Gynecologic Oncology Department of Obstetrics and Gynecology Massachusetts General Hospital Harvard Medical School Boston, Massachusetts Jaydira del Rivero, MD Medical Oncology Fellow Adult Clinical Endocrinology National Cancer Institute National Institutes of Health Bethesda, Maryland Don S. Dizon, MD, FACP Associate Professor of Medicine Harvard Medical School Clinical Co-Director Gynecologic Oncology Director The Oncology Sexual Health Clinica Massachusetts General Hospital Cancer Center Boston, Massachusetts Robert Dreicer, MD, MS, FACP, FASCO Section Head Medical Oncology Deputy Director University of Virginia Cancer Center Associate Director for Clinical Research Professor of Medicine and Urology University of Virginia School of Medicine Charlottesville, Virginia Robert A. Figlin, MD, FACP Professor of Medicine and Biomedical Sciences Steven Spielberg Family Chair in Hematology Oncology Director Division of Hematology-Oncology Deputy Director, Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles, California Antonio Tito Fojo, MD, PhD Medical Oncology Branch and Affiliates Head Experimental Therapeutics Section Senior Investigator Center for Cancer Research National Cancer Institute Bethesda, Maryland Olga Frankfurt, MD Associate Professor in Medicine Division of Hematology-Oncology Northwestern University Feinberg School of Medicine Chicago, Illinois Gregory N. Gan, MD, PhD Assistant Professor Director of Basic Research in Radiation Oncology Division of Medical Oncology Section of Radiation Oncology University of New Mexico Comprehensive Cancer Center Albuquerque, New Mexico Guillermo Garcia-Manero, MD Professor Chief Section of MDS Deputy Chair Translational Research Department of Leukemia The University of Texas MD Anderson Cancer Center Houston, Texas David E. Gerber, MD Associate Professor Division of Hematology-Oncology Department of Internal Medicine Harold C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas, Texas David M.J. Hoffman, MD, FACP Associate Clinical Professor of Medicine University of California Clinical Associate Professor of Medicine Cedars Sinai Medical Center Los Angeles, California Clifford A. Hudis, MD, FACP Chief Breast Medicine Service Department of Medicine Vice President for Government Relations and Chief Advocacy Officer Memorial Sloan Kettering Cancer Center Professor of Medicine Weill Cornell Medical College New York, New York Mohamad A. Hussein, MD, MB, BCh Professor of Medicine and Oncology University of South Florida Morsani College of Medicine Tampa, Florida Elias Jabbour, MD Associate Professor Department of Leukemia The University of Texas MD Anderson Cancer Center Houston, Texas John E. Janik, MD Director Immune Therapy Clinical Trials Program Leader Melanoma Multi-Disciplinary Clinic Professor of Medicine Georgia Cancer Center Augusta University