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(cid:9) Medical Teacher, Vol. 23, No. 1, 2oo1 Simulation and new learning technologies S. Barry Issenberg,' Michael S. Gordon,' David Lee Gordon,' Robert E. Safford2 &IanR.Hart3 'Center for Research in Médical Education, University of Miami School of Medicine, Florida, USA; 2Mayo Clinic, Jacksonville, Florida, USA; 3University of Ottawa, Ontario, Canada SUMMARY Changes inmedicalpracticethatlimitpatientavail- Chinese proverb: "To prophesy is not easy. Particularly in ability and instructors' time have resulted in poor physical regard to thé future." diagnosis skills by learners at all levels. Advanced simulation technology, includingthe use of sophisticatedmultimedia computer systems, helps to address this problem. Formanyyears 'Harvey', Currentproblemsin medical skills training:a common scénario thé Cardiology Patient Simulator, and théUMedic Multimédia Computersystem have proven to be effective tools to teach and Peter Smith, a senior medical student, exited thé OSCE assess bedside cardiovascular skills when they are integrated into station with his preceptor and felt he had made thé correct thé required curriculum of medical school and postgraduate diagnosis and initial treatment plan regarding his 72year-old training. In thé future, virtual reality technology, based initially patient with exertional angina pectoris: unstable angina on data front thé Visible Human Data set, will provide thé secondary to coronary artery disease to be confirmed by an majority of simulation-based training. Models that provide a exercise stress test. To his surprise and disappointment, he high level of visualfidelity and use sophisticated haptic devices was notified that his patient's exertional angina was thé that simulate thé`touch'andfeel'ofa procédure or examination result of critical aortic stenosis, a diagnosis he missed by not are now being used in selected medicalcenters. The présence of appreciating thé long systolic murmur at thé patient's upper these tools is not enough. Evidence-based outcomes must show right sternal edge. Worse, thé patient would be at risk for these systems to be effective instruments for teaching and assess- sudden cardiac death if he were to undergo exercise stress ment, and medical educators must be willing to effect change in testing. Despite his disappointment, Peter was relieved to medical educatignto ensure thé appropriateuse of these systems learn that he would still pass and graduate from medical in thé next millennium. school. Over thé next few days, Peter reflected on thé OSCE encourlter and wondered how he, a graduating medical Introduction student, had missed an important bedside finding. He was In thé past century, there bas been an exponential growth in upset with himself for not eliciting thé finding, but then our knowledge of thé human body, its structures, its func- reflected on thé adequacy of his medical-school training in dons, what can go wrong with it and why. The major auscultatory skills. advances in diagnostic tests and imaging have been truly remarkable and, along with our ability to prevent or cure Skills training during preclinical years illness and prolong active life, have had a major impact on thé quality of thé human condition. Over thé past few After each of his first two years of medical school, Mr Smith décades, medical educators have been quick to embrace underwent an assessment of his ability to perform a complete physical examination. However, during each of these new technologies and pedagogical approaches such as infor- matics, problem-based learning and just-in-tinte learning in sessions, he really went `thoough thé motions' of thé exam an effort to help students deal with thé problem of thé and was not tested on his ability to elicit a specific finding. growing information overload. He learned about thé physical findings of aortic valve stenosis from a textbook rather chan from personal expérience. Medical knowledge, however, bas advanced more rapidly than medical éducation. Even as we unravel thé génome During his first 2 years of medical school, his mentors seemed unconcerned about his inability to perform a and begin thé era of proteomics, we use outdated and often ineffective methods to teach skills and mold attitudes. detailed, organ-specific physical examination since he and Fortunately, positive changes are on thé horizon for medical his classmates were never graded on their clinical skills (Kassebaum & Eaglen, 1999). educators. Rapid advances in technology will lead to a révolu- tion in thé teaching of both basic clinical skills and thé manual skills necessary to perform invasive procédures and Skipstrainingduring clinical years surgical interventions. Simulation technologies are available During his thirdyear clinical clerkships, Mr Smith spent today chat have a positive impact on thé acquisition and more time in conférence rooms, discussing patient care or retention of clinical skills. Virtual reality in particular is playing an increasing role in thé skills training of healthcare Correspondence: S. Barry Issenberg, M.D., Assistant Professor of Clinical professionals. It is likely that medical éducation in 2020 will Medicine Director, Educational Research&Technology, Center for Research differ greatly front medical éducation in 2000, though one in Medical Education, Univenity of Miami School of Medicine. Tel: (305) must keep in mind thé old, and probably apocryphal, 243-6491;fax:(305) 243-6136;emaiL barryi(âgniamLedu 16 ISSN 0142-159X (print)/ISSN 1466-187X(online)/01/010016-08©2001Taylor & Francis Ltd DOL 10.1080/01421590020007324 Simulation and new learning technologies related journal articles with the ward team, than he did at developed a multimedia computer-based, self-assessment patients' bedsides honing his skills (Shankel & Mazzaferri, program focusing on "physical examination and physical 1986). When the ward team did visit a patient with an diagnosis skills" (Norcini, 1993). important physical finding, there was limited time to practice his exam skills (Collins et al.,1978).This resulted from: Physical body simulators • occasional reluctance or embarrassment of patients to Simulators now available and routinely used in medical expose themselves to the large number of individuals on education vary in their complexity and ability to represent the ward team; real-patient situations. Some models permit examination • impatience of team residents eager to conclude rounds and manipulation by the student, but do not respond or quickly in order to attend afternoon clinic; provide feedback.Othersare more sophisticated and interact • impatience of attendings eager to conclude rounds quickly with die students.The simplest simulators resemble a person in order to attend a privatepatient clinic or meeting, in size and weight only, much like a mannequin in a depart- perform a procedure or experiment, etc.; ment store.Tbese types of simulators are used extensively • difficulty locating patients undergoing diagnostic tests; in trauma cases to replicate automobile accident victims. • rapid patient discharges due to efficient managed-care Learners use these simulators to practice cervical-coller caseworkers. placement, removal of patients from automobiles, and other Peter was aware of the availability of CD-ROMs and tapes ways to stabilize accident victims.These simulators typically of heart murmurs in the library. However, these were have permanent and non-modifiable `injuries' such as head optional resources with content that was never required or lacerations and contusions, a dilated pupil, or compound tested. He knew of students at other schools that had these leg fractures. Any sense of realism is due to the scenario rather than the simulator itself. The simulator does not types of resources as part of their core curriculum and wondered whether they were better skilled than he. Peter respond to any action and its sole requirement is to represent a 'body', i.e. to be the approximate size and weight of a realized that in a few months he would be seeing patients on his own who may also have important auscultatory findings. typical person. He further worried, if his auscultatory skills suffered, what Anatomic-pathologic simulators about his ability to perform a competent neurologic or ophthalmologic examination? Why did those in charge of Another type of simulator is the simple anatomical model his medical education not make sure he possessed the skills used to train students how to perform a single component necessary to be a physician before allowing him to graduate? of the physical examination. Exemples include models for Unfortunately for Peter, deficiencies in die performance of breast examination, eye examination, car examination, female clinical skills are not limited to medical students; they are pelvic examination and male rectal examination. The also prescrit among residents in internal medicine (Mangione advantage of such simulators is chat they enable teaching on & Nieman, 1997; St Clair et al.,1992), emergency medicine a practical level without any imposition on real patients, (Jones et al.,1997), and pediatrics (Gaskin et al.,2000). especially with sensitive topics such as pelvic examination. When using simulators of lower fidelity it is important to appreciate their limitations and use them in situations that Simulation technology in the core curriculum: a potentiel solution maximize their strengths (Macintosh and Chard, 1997). The above fictitious case highlights many of the problems Procedural skills simulators occurring in academic medical centers today as a result of Other simulators are used to learn, practice and assess reduced physician teaching time and reduced availability procedural and practicalskills.Thesesimulators are currently of patients as educational resources. The increased use of used to train learners in the following techniques: simulation technology to supplement skills training with repetitious, standardized training would appear to be a logical • intravenous access via cannula insertion and surgical cut solution to the problem. Despite thewidespread availability down; of simulation technology, however, its use has not yet become catheterization of the male and female bladder; part of the cote curriculum at most medical schools. This airway management, including intubation (some of these may soon change, regardless of the opinions of individual devices, including the Cricothyrotomy Simulator faculty and medical educators. Several key organizations [Armstrong Medical Industries, Inc., Uncolnshire, IL] have recognized the role of simulation technology in medical allow the learner to practice catheter oxygenation/jet education and have recently implemented guidelines or ventilation via the cricothyroid membrane in cases of programs to foster its development. The members of the laryngeal, pharyngeal, lingual tonsilar and epiglottic Medical School Objectives Project, sponsored by the pathology; this is important because die clinicalopportuni- Association of American Medical Colleges, stated in their ties for employing this kind of technique are otherwise Medical Informatics Objectives chat "the successful medical rare); school graduate should be able to . . . effectively utilize • soft tissue injection and aspiration of knee, shoulder,elbow various computer-based instructional (and self-assessment) and wrist joints; • ureteroscopy for practice of kidney stone removal. tools, including electronic tutorials and patient simula- tions" (Medical School Objectives Writing Group, 1998). Surgical simulators TheAmerican Board ofIntemalMedicine shares this view as reflected initsdecision to form the Physical Examination Surgical training is one area that seems ideally suited for the Self-Evaluation Process Committee. This committee bas use of simulators. Proficiency in surgery requires knowledge 17 S. Barry Issenberget al. of underlying anatomy, dexterity and frequent practice. hasresulted in thé recent suggestion by dieAmerican College Despite this apparent fit, there have not been many valid of Cardiology Task Force on Education (Gregoratos and studies examining thé use of simulators for surgical training. Miller, 1999) Chat 'Harvey' should be integrated into thé Simulators are currently available to train learners in thé day-to-day teaching of clinical cardiology. following surgical techniques: • simple wound closure, evaluating suture tension and accuracy of placement; Computer-aided instruction: CD-ROM-based software • bowel anastomosis (closure), using sutures and staples; • laparotomy; Computer-aided instruction (CAI) appears to be an ideal • episiotomy and theed-degree tear of thé perineum (with method for teaching a cote of material repetitively. CAI ability to practice suture repair at multiple levels); programs allow for an interactive educational process, • toe surgery, including including ring block with local requiring active involvement by thé student or house off cet anesthesia and wedge resection of thé nail bed and total in thé learning process. In addition, thé students are able to ablation of thé nail; run thé programs individually, at cimes convenient to them • dermatologic surgery, including cutting, suturing, and without thé need for direct faculty supervision. Currendy, removal of sebaceous cysts, lipomas,perianalhematomas, there are hundreds of CAI CD-ROM programs available and skin tags. for learners at all levels in many areas of interest. These include programs that teach radiology and ECG interpréta- tion, advanced cardiac life support, procedure skills and Harvey, thé cardiology patient simulator physical diagnosis techniques. Harvey is a teaching device that provides a comprehensive cardiology curriculum by realistically simulatiog 27 common and rare cardiac conditions. The physical findings UMedic, Multimedia Computer System (MCS) programmed in Harvey for each disease include blood pres- The UMedic MCS has been developed over thé last 15 sure, bilateral jugular venous pulses, bilateral carotid and years with multimedia features chat include computer and peripheralarterialpulses, precordial impulses in six différent video graphics and réal-cime digitized video and audio. areas and ausçultatoryy events. The latter are heard in thé Fifteen patient-centered case based programs comprise a four classic auscultatory areas, are synchronized with thé comprehensive generalist curriculum in cardiology. Its pulses and vary with respiration when appropriate. structure and content have been described elsewhere (Waugh Harveyhasbeen subjected to rigorous testing to establish et al., 1995; Issenberg, McGaghie et al.,1999). its educational efiicacy.Themost comprehensive evaluation A recent multicenter study demonstrated chat UMedic of any simulation technology was thé multicenter study of could be integrated into thé entire four-year medical school Harvey sponsored by thé National Heart, Lung, and Blood curriculum (Petrusa et al., 1999). A total of 1586 students Institute. (Ewy et al.,1987). It involved 208 senior medical at six medical schools completed 6131 programs and rated students at five medical schools. Fourth-year medical thé educational value of thé system favorably compared students who used thé Cardiology Patient Simulator (CPS) with otherlearningmaterials.The study resulted in a recom- during their cardiology elective performed significandybetter mended four-year curriculum plan for thé UMedic system. than thé non-CPS-trained group, who learned in thé Valid pré- and post-tests were then created to measure traditional manner from real patients. This was true not outcomes in bedside skills (Issenberget al.,1998) and were only on thé CPS skills post-test (p < 0.001), but also on thé used in an additional multicenter cohort study involving live patient skills post-test (p < 0.03). In addition, there was senior medical students at five institutions that compared no statistically significant différence in thé way patients thé UMedic system with traditional methods for teaching perceived thé professional behavior of CPS-trained and bedside skills in cardiology (Issenberg, Petrusa et al.,1999). non-CPS-trained students. The latter data address thé In thé intervention group, UMedic modules replaced instruc- concern chat simulators may negatively impact physician tion in bedside skills that occurred during teaching rounds behavior. In another study involving more than 200 second- and individual patient work-ups. There was a statistically year medical students at thé University of Michigan, significant improvement in thé pré- to post-test scores of incorporation of Harvey into a required physical skills course thé UMedic trained students compared with non-UMedic significantly improved overall cardiac examination skills as students (p < 0.001). Similar results occurred in a similar measured by pré- and post-tests of unknown findings on recent study involving second- and theed-year internal thé simulator (p < 0.001) (Wooliscroft et al.,1987). medicine residents (Issenberg et al.,2000). In addition to its use as an educational cool, Harvey has The most successful application of UMedic has been in been used as a systematic and objective tool for testing its combined use with Harvey. In this way, thé learner has bedside cardiovascular examination skills (Ewy et al., 1987; thé benefit of a large `patient pool' on which to practice Jones et al., 1997; Wooliscroft et al., 1987; Gaskin et al., bedside skills along with a multimedia teaching program 2000). Testing with simulators such as Harvey is actually that provides `live' faculty presentations and feedback in an more effective than testing with actual patients. With a interactive format. While this type of learning now Cakes simulator, there is complete control over thé specific task place in defined areas such as clinical skills or learning selected, e.g. a bedside cardiac exam, as well as thé resource centers, future systems will use more advanced complexity of thé task. Exact validation of `patient' findings technology to enable universal access at any time and place leads to a standardized and more-objective skills-testing to chose who wish to learn or need to be tested. Undoubt- process.Theproven value of`Harvey' as an educational tool edly,there systems will incorporate thé use of virtual reality. 18 Simulation and new learning technologies Virtualreality physiology or performing a therapeutic procedure. In the Virtual reality (VR) is a concept that is intumately familiar beginning, most learners are able to focus only on one or two and intuitively obvious to children as a consequence of of these components at a time, contributing to both risk and video-game technology but which is far less familiar to adults stress. who teach and practice medicine. Its roots are in the branch Virtual reality simulation systems allow learners to of computer science dedicated to artificial intelligence. At practice the procedure a portion at a time, without risk to a its simplest, virtual reality bas been defined as, "an artificial patient. These systems, if validated, could potentially also environment which is experienced through sensory stimuli be used to assess the learners skills for certification of provided by a computer and in which one's actions partially competence (boards, hospital credentialing, etc.) and for determine what happens in the environmenC (Merriam maintenance of skills or acquisition of new techniques once Webster Collegiate Dictionary, 1996). in practice. Invasive procedures: 'See one, do one, teach one' Computer-based anatomic models Teaching learners how to perform invasive medical For the last decade, computer based volume renderings of procedures and assessing their performance is a challenging the whole body and specific organs have been generated. task.Traditionally, learners have observed more experienced Initial efforts used the Visible Human Project (VHP) data physicians performing a procedure. After a brief apprentice- set, a databank of high-resolution digital anatomy of both ship, supplemented by reading textbooks and occasional men and women, available from the National Ubrary of practice on cadavers, the learner is then allowed to begin Medicine (Visible Human Project, 1999).First implemented doing portions of the procedure on patients under the in 1994, the VHP bas given researchers access to data in tutelage of the mentor. This process is inefficient and multiple modalities, including X-ray-based computed inevitably leads to considerable anxiety on the part of die tomography (CT) and magnetic resonance imaging (MRI). learner, die mentor and at times even the patient. These anatomic models are remarkably lifelike, and Thoracentesis, for example, is a common and relatively demonstrate realistic surface textures. straightforward procedure in which a needle is passed through the chest cavity to allow drainage of pleural fluid Virtual endoscopy surrounding the long for diagnostic and/or therapeutic purposes. Typically, a second-year medicine resident will Simply viewing the surface of an anatomic model, although demonstrate the procedure for a first-year resident with the visually pleasing in an artistic sense, accomplishes little. implied promise that the next time a patient on their service Physicians wish to look inside the body, a concept first requires the procedure, the first-year resident will perform dramatized in the 1966 movie Fantastic Voyage (Fantastic itwith the second-year resident 'talking him or her through Voyage, 1966). In that movie a physician suspected foul play it'. Inevitably, after performing the procedure once or twice when a diplomat became ill. He introduced a miniaturized himself, the inexperienced teach the even more submarine into die diplomat'sbody to make a diagnosis. In inexperienced, leading to the medical adage, 'sec one, do the 21st centuryvirtualendoscopy systems allow the learner one, teach one'. to see examples of normal patients and those with disease Invasive procedures are difficult to learn because they so that the student is able to anticipate how tissues will require an understanding of complex these-dimensional appear at the actual physical endoscopy. If the patient model anatomy and tactile skills for the manipulation of a probe is constructed using graphical data from an actual patient's (needle, scope, catheter, surgical instrument, bioptome, etc.), imaging data (CT/MRI, etc.), die virtual endoscopy bas the commonly referred to as acquiring the 'feel' for the perform- potential to replace the invasive procedure for diagnosis. ance of the procedure (Robb, 2000). 'Mis inherent And if die procedure to be performed is therapeutic, one complexity inevitably leads to a high complication rate and couldrehearse the therapeutic procedure on a VR Smulator steep learning curve. prior to performing the identical procedure on the patient. As students complete their formal training and enter This would be of particular value when unusual or practice, medical centers will require that they be 'creden- particularly challenging cases are encountered. tialed' to perform a variety of procedures. Usually this In many instances only the spatial or surface requires documentation that the physician has performed a characteristics of pathology are required (e.g. ulcer, coronary minimum number of procedures, die lirait having been set obstruction, etc.), but virtual techniques currently cannot in some cases by national professional bodies and in others replace physical biopsy when pathological examination of by the local medical center credentials committee, and a tissue is required (Blezek & Robb, 1997).Thismay change written statement from the training director of the institu- in the near future. Characterization of tissues by MRI, tion from which die practitioner bascome certifying his/her ultrasound and other techniques is progressing rapidly competence to perform the procedure. For the most part (Satava & Robb, 1997). Benign tissues may be differenti- such statements are qualitative; only in rare instances are atedfrom malignant ones in the future based on their surface they based on objective measures of assessment. characteristics as assessed by MRI. When learning to perform an invasive procedure, the learner must simultaneously correlate the clinical assessment of an Touch, feel and haptics ill-and possibly sedated-patient, manipulation of a probe or surgical instrument, and the these-dimensional interpreta- Haptics, the study of touch, allows the incorporation of tion of a two-dimensional imaging study, all the while assessing tactile stimuli into VR systems allowing the learner to obtain 19 S. Barry Issenberget al. the`feel' of an invasive procedure (Blezek & Robb, 1999). It the scope tube, while electrical actuators provide translational is generally agreed that this is the most difficult part of and/or rotational force feedback based on the state of the teaching an invasive procedure and that improvements in endoscopy simulation. this area of instruction have the potential to steepen the Initial results of studies to assess the effectiveness of this learning curve and improve patient safety. Haptic-force system in simulating bronchoscopy have shown that the feedback devices, the simplest of which is the joystick, are device can differentiate experts (defined as individuals who commercially available (Massie, 1996). performed over 500 bronchoscopies) from those with To illustrate die use of such devices, consider die difficulty intermediate experience (defined as individuals who of teaching a learner toperformdeep nerve block techniques. performed more than 25bronchoscopies but fewer than 25) The deliveryof local anesthetics to the spinal nerves or die or beginners (defined as individuals with no experience in deep plexuses, such as die celiac, for relief of pain is the performing a bronchoscopy) (Mehta et al., 2000). Experts epitome of the learner having to get die `feel'.The teacher performed the procedure in a significandy shorter period of demonstrates and explains that as the needle passes through time and with fewer mistakes (e.g. `collisions' of scope against skin onefeels a `pop' as the resistance of the skin is overcome. mucosa wall) than the intermediate and beginner groups. Passage of the needle through the paraspinal muscles In an era where the numbers of skilled teachers are engenders less resistance. One bas to be careful not to strike declining and pressures to increase patient volumes are either die kidney which would feel `firm' or the vertebrae increasing, fewer mentors are available. VR simulation which would be `hard'. As the needle approaches the systems have die potential to greatly improve the training of descending thoracic aorta the `pulsations' can be felt on learners at all levels in various fields of medicine. The saure the tip of the needle which is tien directed away toward die technology that simulates a bronchoscopy can bc used to celiac plexus. simulate an ophthalmologic, neurologic or cardiovascular If one mounts a force transducer on a needle and passes physical examination. The potentiaI advantage of these it through the unembalmed tissues of a cadaver on the saure systems compared with die current method for testing and path discussed above, one can direcdy measure the force certification, including written and oral examinations, is required to overcome the resistance of each structure. that they allow die examinee to demonstrate clinical skillsin Delivering those sequential forces to the learner using die a controlled clinical environment while still exhibiting cogni- force-feedback device, a virtual needle, allowsdie learner to tive and language skills (Gaba et al., 1998). experience how passage of the needle into a patient feels (Martin et al., 1999). Others have calculated die relative Discussion densifies of tissues using the Houndsfield units from CT scans andtienhave assigned relative forces to various tissues Despite the availability of devices with advanced simulation to achieve the saure end (Satava & Jones, 1999). technology designed specifically for the instruction and assessment of medical students and physicians, too many medical schools fail to employ such devices to teach and Current state-of-the-artvirtual simulators evaluate learners' skills (Kassebaum & Eaglen, 1999). The presence of these tools is not enough. Evidence-based Initial VR simulation systems were crude, but improved outcomes must guide medical educators who are willing to rapidly as the speed and capacity of computers increased. effectchange. Thesenewer systems,while much more realistic in simulating In an article in the End-of-the-Millennium Special Issue die experience, were prohibitive at most medical centers ofScientific American, entitled 'The Unexpected Science to because of their high cost. Recently, a more affordable VR simulator was developed to provide multiple uses in a single Come', Sir John Maddox wrote, "The most important discoveries of the next 50 years are likely to be ones of unit. 'Me Pre0p Endoscopic Simulator (HT Medical which we cannot now even conceive" (Maddox, 1999). Systems, Gaithersberg, MD) is a realistic training simula- Foreseeing what new technologies will be in use in the year tion system that integrates force feedback, multimedia, and 2020, far less predicting their impact on the day-to-day 3D graphics on a personal computer (Tasto et al., 2000). practice of medicine and its teaching, is an exercise fraught The Pre0p simulator comprises a computer, a display with danger.Thecompilation of essays by the Pulitzer Prize- monitor and an AccuTouch Endoscopic Interface Device winning Richard Rhodes, entided `Visions of Technology', that consists of a proxy endoscope that looks like a real is replete with examples of predictions that, in retrospect, endoscope and is electrically connected to the second part missed the mark significandy. Some predictions, however, of the interface device, a robotic mannequin into which die are remarkably prescient. One essay points out that, over endoscope can be inserted. Various sensors track the state the past 100 years, die technological status of die world as of the system and send this information back to die host a whole advanced at a roughly exponential rate, doubling computer.Thesimulation uses this information to compute every 20years (Rhodes, 1999). appropriate visual and tactile responses to the motions Four general predictions may be offeredon the impact of imparted by the user. These responses are transmitted to simulation and virtual reality technology on the practice of the user through visual, audio and haptic modalities, creating medicine and medical education in 2020: die illusion for the user that he/she is insertiog the endo- scope into a real patient. The robotic mannequin has been (1) Anything to do with the human body in sickness and in designed to accept proxy bronchoscopes, sigmoidoscopes, health that is `digitizable'-and thus `storable', colonoscopes, gastroscopes and ureteroscopes through the `manipulable', `clonable' and `transmissible'-will be, appropriate anatomic models.Tracking of scope motions is and the computers involved will become faster, smaller achieved with sensors that monitor insertion and rotation of and cheaper. 20 Simulation and new learning technologies (2) The présence of such stored `medical avatars', whether thé future of medical education, one thing is sure-medical originally created for diagnostic purposes or teaching educators are not `early adopters'. It took 30 years for purposes, will allow for virtual-reality learning expéri problem-based learning (PBL) to truly become mainstream ences customized for thé individual trainee for a specific in thé field. The need to inculcate a culture of lifelong case. learning is more talked about than practiced, and some (3) Simulation technology is unlikely to have a major impact medical educators still think that OSCE is an organization on thé training of history taking, and, unless we take of oil-producing nations. So we will take thé easy way out in appropriate steps to prevent it, any effect on thé promo compiling our prédictions regarding thé impact of technology tion of appropriate attitudes is more likely to be néga- on thé future face of medical education. Although we use tive than positive. thé word `will' in making thé following predictions, we are, (4) The major impact of such technologies will be on skills in truth,realIy suggesting whatshouldhappen. training through their ability to provide on-demand access to `deliberate practice'. The undergraduate curriculum will be unrecognizable in thé traditionaI sense since thé stages will be marked Skillsmaybe defined as "actions (and reactions) which an less by organ/system or discipline-based blocks or rota- individual performs in a competent way in order to achieve tions, and more by thé attainment of measurable a goal" (Ericsson, 1996). One may have no skill, some skill outcomes, thé rate of which will vary from student to or complete skill.Therefore,whenteaching or testing a skill, student. The merging of educational strategies such as thé level of acceptable mastery musc be defined depending PBL and self-directed learning with thé just-indîne on thé training level. Ericsson has demonstrated that, in availability of information through IT and thé use of competitive performance domains such as athletics, music cumulative learning portfolios of practical and clinical and chess, thé différences between individuals, from novice experiences as a major assessment cool will allow, within to champion, "are among thé largest reproducible différ- limits, students to progress through thé curriculum at ences in performance observed for normal adults". He also their own pace. suggests that similar large différences would beexpected in (2) Increasingly, in thé early years, thé acquisition of other domains of expertise (including medicine), in which knowledge and understanding will be through self- there is a long period of education followed by an apprentice- directed (but outcomes driven) learning. Information ship. to facilitate that learning will be delivered over thé The most important identifiable factor separating thé Internet, using fast broadband `pipes' to transmit text, elite performer of skills from others is thé amount of `deliber- audio, video, chat groups and, where appropriate for ate practice'.This includes practice undertaken overa long understanding, simulations and virtual reality. All of period of time in order to attain excellence, as well as thé this willbeenhancedby live group discussion and tutor amount of ongoing effort required to maintain it. Deliberate input. practice has been defined as thé opportunity to tackle "a (3) Realizing that, despite regional, national and well-defined task with an appropriate difficultylevel for thé international différences in core curriculum content, particular individual, informative feedback, and opportuni- there are overlapping commonalities, a growing amount ties for repetition and corrections of errors" (Ericsson et al., of thé learning material required for core learning will 1993). be shared between medical schools and delivered over In thé early part of thé last century, Sir William Osler thé Internet. In some cases, these would be single wrote, "Thé art of medicine is to be learned only by expéri- learning items such as texts and interactive simulations. ence, `tis not an inheritance; it cannot be revealed. Learn to In other cases, whole modules or even blocks will be sec, learn to hear, learn to feel, learn to smell, and know that used communally. by practice alone can you become expert" (Osier, 1919). (4) In thé later years, cumulative electronic learning However, it is well known Chat, during both undergraduate portfolios will map each individual students progress and postgraduate medical training, there is an inherent in meeting thé learning outcomes.Theywill ensure that capriciousness in regard to opportunities to gain deliberate all students are exposed to patients illustrating thé key practice in learning new skills or honing old ones. Even common problems faced by primary-care physicians when opportunities to practice specific skills do occur, there and that thé students have seen thé `prototype' cases is often no `informative feedback or opportunities for repeti- around which clinical problem solving is based. tion or correction'. Thé problem in medical éducation is Appropriate use of these learning portfolios will also that thé subjects necessary to `deliberately practice upon' ensure that thé underlying anatomical and pathophysi- are human beings, with all their diversity and variability. ological concepts are reinforced as clinical cases are Simulations and virtual reality hold out thé promise of encountered.Thiswill require more basic science input unlirnited access to deliberate practice as part of skills into thé later years of thé curriculum. training. As thé skills required for thé practice of invasive (5) Simulators and simulations will become more software medicine become more numerous and more complex, such than hardware, i.e. more virtual reality than real. access to practice and rehearsal will become more essential. (6) The réal power of VR simulations is their potential widespread accessibility. Simulations, with all their inter- activity, will be widely available over thé Internet. For Technology and medical education: what does thé many, thé limiting factor will be thé availability of thé future hold? hardware `front end'-thé controls that allow thé The year 2020 seems such a long time away, yet 1980 seems operator to interact appropriately with thé simulation. just a short timeago!Whenlearning from thé past to predict For some simulations a standardized front end will be 21 S. Barry Issenberget al. thé norm, as gaming joysticks and ports have become. Notes on contributors For thé more complex procedures special hardware will be necessary. Such hardware will be relatively S. BARRY ISSENBERG, MD is Assistant Professor of Clinical Medicine inexpensive and can and should be scattered around aCnedn tiesr tfhoér DRierseecatrocrh o ifn E Mdeudciactaiol nEadlu Rcaetsieoanrc(hC aRnMd ET)ecahinthoélo Ugynivaeirstihtyé clinical facilities and accessible round thé clock so that of Miami (Florida) School of Medicine. on-demand skills training, rehearsal or updating is avail- MICHAELS. GORDON, MD PhD is Associate Dean for Research in able. In some cases, thé hardware may be inexpensive MedicalEducation,Professor of Clinical Medicine (Cardiology) and enough to be purchased by individuals, allowing them Director of thé CRME ai thé University of Miami (Florida) School to deliberately practice or rehearse anywhere they avant of Medicine. even at home with thé kids. Regular upgrading of thé DAVID LIEGoRDoN,MD is Associate Professor ofClinicalNeurology skills appropriate to their practice using simulatorswill and Director of Emergency Medical Skills Training at thé CRME. be a normal part of continuing professional develop- IAN R HART, MB ChB MSc, is Professor Emeritus aithé University ment (i.e. continuing medical education, or CME)- of Ottawa, Canada. He is an international consultant in thé field of even for those practicing in thé community. medical education. And finally, do not forget gaming and thé gamers, who, ROBERT E. SAFFORD, MD PhD is thé Barbara Woodward Lips more than any other group, brought simulations into Professor of Medicine and Chair, Department of Internal Medicine, aithéMayo Clinic, Jacksonville (Florida). thé mainstream. If there is any challenge to their manual and décision-making skills out there, they will avant to try it and compete with others. And there will be References someone out there who will avant to sell it to them. Look to see many complex surgicaVproceduralsimula- Bi£ZEv, D.J. & RoBB, RA. (1997) Evaluating virtual endoscopy for tions available in game arcades and even at home. clinical use,JournalofDigital Imaging, 10, pp. 51-55. Medical simulations will be seen as thé ultimate game. BLEZEx, D.J. & RoBB, R.A. (1999) Haptic rendering of isosurfaces Just think about it: some 15year-0Id challenging a dMireedcictliyn ef rMomee tms Vediritcuaall iRmeaaglietys ,( Ainm: Jst.eDrd.amW,E ISOTWS OPrOeDss)e, tp apl.. 67(E-7d1s.) cardiac surgeon in a by-pass operation simulation-and CoLLBVs, G.F, CASSIE, J.M. & DAGGERT, C.J. (1978) The role of thé winning! It is inevitable, and may be appropriately attending physician in clinical training,JournalofMédical Educa- humiliating. tion, 53, pp. 429-431. ERlcssoN,K.A., KRAMFE,K.T.&TÈSCHE-RMER, C. (1993)The role of deliberate practice in thé acquisition of expert performance, PsyehologyReview, 100, pp. 3631106. Conclusion ERICSSON, K.A. (Ed.) (1996) The Road to Excellence (Mahwah, NJ, There are those who will see thé future elucidated above as LawrenceEribaumAssociates), pp. 1-50. an Orwellian nightmare of technology's dehumanizing face. Ewv,G.A., FELNER, J.M.,JtntL,D., MAYER, J.W,SyiD,A. & WAuGH, RA. (1987) Test of a cardiology patient simulator with students in They willsee only a dark picture of chips, bits, bytes, pixels fourth-yearélectives,JournalofMédicalEducation,627,pp. 738-743. and avatars obscuring thé human tragedy of illness and FANTASTICVOYAGE (1966),directedbyRichard Fleischer. disease and thé anguish they cause. But they will be wrong. GABA, D.M., HOwARD,S.K., FLANAGAN,B. & SmiTH,B.E. (1998) Doctors better trained in basic clinical skills and with Assessment of clinical performance during simulated crises using on-demand opportunities to `deliberately practice' to both technical and behavioral ratings, Anesthesiology,89, pp. 8-18. maintain them, will,as did our young student, Peter Smith, GASK:IN, PR, OwENs, S.E., TALNER, N.S., SANDERs, S.P. & Ir,J.S. corne to realize that such skills are thé gateway to thé (2000) Clinical auscultation skills in pediatric residents, Pedatrics, 105 (6),pp. 1184-1187. appropriate ordering of tests and images.Thiswill actually GREGoRATos, G. & Mn.tER, A.B. (1999) Tàsk Force 3: teaching, diminish thé need for thé unnecessary intrusion of diagnostic JournaloftheAmerican CollegeofCardiology, 33, pp. 1120-1127. technology into thé patient's life. Such imaging technolo- ISSENBERG, S.B.,McGAGHIE,WC.,BRowN, D.D., MAYER,J.W. et al. gies, despite their tendency to reveal thé présence of (1998) Development of multimedia computerbased measures of unknown benign lesions and raise patients' fears falsely, cfnical skills in bedside cardiology, in: D.E. MELNIc:K (Ed.) The still, on balance, advance thé early diagnosis of less benign Eighth International Ottawa Conférence on Médical Education and Assessment Proceedings, EwlvingAssessment: Protecring thé Human but curable pathologies. Simulation and virtual-reality Dimension, Vol. 2, pp. 821-829. technology have thé ability to allow practice and rehearsal ISSENBERG, S.B., McGAGHIE,WC., HART, I.R, MAYER,J.W. et al. of invasive procédures specific to an individual patient's (l 999) Simulation technology for health professional skills training anatomyand pathology, thus saving thé patient unnecessary and assessment, Journal of théAmericanMédical Association, 282, surgical exploration and diminishing thé risk of insertion, pp. 861-866. ablation or incision errors. ISSENBERG, S.B., PETRusA, E.R.,MCGAGHIE,WC., FELNER,J.M. et al. (1999)Efectivenessofa computer-basedsystemto teach bedside Finally, one thing is certain. Although there will be cardiology, Academic Medicine, 74(Suppl.), pp. S93-95. advances in thé médical sciences and technology over thé ISSENBERG, S.B., GoRDoN, M.S., GoRDoN, D.L. et al. (2000) A next 20 years "of which we cannot now even conceive", thé remediation program in cardiology bedside skills for internal innate nature ofhumankindwill not change. Illness, real or medicine résidents, JournalofGeneral InternalMedicine, 15(Suppl. imagined, will still engender fear and anxiety and require 1), p. 215. explanation, reassurance and succor. Earlier and more JoNEs, J.S., HuNT, S.J., CARLsoN, S.A. & SEAmoN, J.P. (1997) efficient diagnosis brought about by better diagnostic Assessing bedside cardiologic examination skills using 'Harvey', a cardiology patient simulator, Academic Emergency Medicine, 4, pp. technologies and better skills training of doctors can free up 980-985. more of our time for communication, discussion and KASSEBAUM, D.G. & EAGLEN, R.H. (1999) Shortcomings in thé compassionate care. Ensuring that thé latter occurs is thé evaluation of students' clinical skills and behaviors in médical School, realchallenge.Thetechnology has proven itself. Academic Medicine, 74, pp. 842-849. 22 Simulation and new learning technologies MAciNTOSH,M.C.M. & CHARD,T(1997) Pelvic manikins as learning RoBB, R.A. (2000) Virtual endoscopy: development and evaluation aids,MedicalEducation,31,pp.194-196. using the visible human datasets, Computerized Medical Imaging MADDox, R (1999) 'Me unexpected science to come, Scientific and Graphics,in press. American, December, pp.62-67. RHODES, R (1999) Visions of the Future (NewYork, Simon & Schus- MANGt0NE,S. & NIEMAN, L.Z. (1997) Cardiac auscultatory skills of ter). internal medicine and family practice trainees: a comparison of ST CLAIR, E.W, ODDONE, E.Z., WAUGH, RA., COREY G.R. & diagnostic proficiency, Journal of the American Medical Association, FÉusSNEx,J.K (1992) Assessing housestaffdiagnostic skills using a 278,pp. 717 722. cardiology patient simulator, Annals of Internal Medicine, 117, pp. MARTIN, D.P., BLEZEK, D.J. & Ross, R.A. (1999) Simulating lower 751-756. extremity nerve blocks with virtual reality, Techniques of Regional SATAVA,R.M.& JoNEs, S.B. (1999)Thefuture is now: virtual reality Anesthesia Pain Management,3, pp. 58-61. technologies, in: A.UKIAN, C.H. MCGUME&W.C. MCGAGHIE MASSIE,TH.(1996) InitialHaptic Explorations with the PHANTOM: (Eds) Innovative Simulations forAssessing Professional Competence: Virtual Touch Through Point Interaction (Cambridge, MA, Depart- Paper-and-penciltoVirtualReality(Chicago, University of Illinois at ment of Electrical Engineering and Computer Science, Chicago Department of Medicine), pp. 179-193. Massachusetts InstituteofTechnology, MSTherry). SATAVA, R.M. & ROBB, R.A. (1997) Virtual endoscopy: application MEDIcALSCHOOLOBgF--rtvFsWRmNGGROUF(1998) Medical school of 3D visualization to medical diagnosis, Presence,6, pp. 179-197. objectives project: medical informatics objectives. <http:// SHANKEL,S.W & MAzzAFERnE.L. (1986)Teachingthe resident in www.aamc.org.htnt> accessed 10 January 1999. Association of internal medicine: present practices and suggestions for the future, American Medical Colleges. Journal oftheAmerican Medical Association, 256, pp. 725-729. MEHTA, A.C., OsT, D., SAUNAS, S.G., SANcHE4 D.E. et al.(2000) Objective assessment of bronchoscopy skills by bronchoscopy TASTo, J.L., VERSTREKEN, K., BROwN J.M. & BAuER, J.J. (2000) training simulator,American Journal ofRespiratoryandCriticalCare Pre0pEndoscopic Simulator: frombronchoscopy to ureteroscopy, Medicine, 161, p. A234. in: J.D.WEs'rwooqH.M. HOFFMAN,G.T.MoGEL, R-A.RoBB& D. MERRIAMnBSTERCOLLF,GIATE DICTIONARY (1996) 1Othedn (Spring- STREDNEY(Eds) Medicine Meets Virtual Reality2000 (Amsterdam, field,MerriamWebster). IOS Press), pp. 344-349. NORciNI,J. (1999) Computer-based testing will soon be a reality, VISIBLE HUMANPRojFcr (1999) wwwnlm.nih.gov/pubs/factsheets/ Perspectives, American Board of Internal Medicine Newsletter for visiblehuman.html, Accessed 10 December 1999. Diplomates, Summer, p. 3. WAUGH, RA., MAYER, J.W, Ewy, G.A., Fm-NER, J.M.,ISSENBERG, OSLER,W, (1919) Osler, theTeacher,JohnsHopkins Hospital Bulletin, B.S., GEssNER, I.H. et al. (1995) Multimedia computer-assisted 30,p.198. instruction in cardiology, Archives of Internal Medicine, 155, pp. PETRusA, E.R., ISSENBERG, S.B., MAYER,J.W, FEL.NER, J.M.et al. 197-203. (1999) Implementation of a four-year multimedia computer WoouLscRoFr,J.O., CALHOUN,J.G.,TENHAKENJ.D. &JuDGE,RD. curriculum in cardiology at six medical schools,Academic Medicine, (1987) Harvey: the impact of a cardiovascular teaching simulator 74 (2),pp. 123-129. on student skill acquisition,Medical Teacher,9, pp. 53-57. 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must keep in mind thé old, and probably apocryphal,. 16 ophthalmologic examination? .. simulate an ophthalmologic, neurologic or cardiovascular.
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