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Sexual Medicine Principles and Practice Karthik Gunasekaran Shah Dupesh Khan Editors 123 Sexual Medicine Karthik Gunasekaran • Shah Dupesh Khan Editors Sexual Medicine Principles and Practice Editors Karthik Gunasekaran Shah Dupesh Khan The Metromale Clinic and Fertility Center The Metromale Clinic and Fertility Center Chennai Chennai India India ISBN 978-981-13-1225-0 ISBN 978-981-13-1226-7 (eBook) https://doi.org/10.1007/978-981-13-1226-7 Library of Congress Control Number: 2018954051 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore Foreword Reproduction is the law of life. We all live to reproduce and continue to live through our offspring. Species that are able to reproduce successfully grow and thrive. Others decline and disappear. Sex is the driving force that keeps reproduction going. Sex seems to be the only way for the large majority of people to reproduce. The advent of assisted reproduc- tion and the newer reproductive technologies would hardly make any change in the reproductive lives of most of the people. They may have to and will continue to reproduce in the old fashion way—sexual intercourse-related reproduction. Sexual problems are rampant and are almost universal. They occur with equal frequencies in both men and women. As men are expected to perform, it is often felt that sexual problems are more prevalent in men. However, sexual problems in women occur with equal frequency but are often untold and often go unnoticed. Bedroom tragedies are often worse than boardroom tragedies and often lead to problems in both the fronts. Sexual medicine is an uncharted territory. There are very few qualified, trained, or self-trained practitioners of sexual medicine. The field is often dominated by sexual medicine charlatans and mavericks who continue to sell wrong ideas to peo- ple, such as “masturbation is harmful” and many other sexual myths. Medical education in India and in many other countries is bereft of formal or informal training in sexual medicine at all levels. This has not helped the situation improve any further. Neither the gynecologist who is often the primary physician for the woman, nor the urologist who may be the primary physician for men, nor the general practitioner or the family physician enquires about the sexual health of their clients. Men and women are sexual beings with varying sexual needs from puberty to, often, the grave. This need varies in different phases of life in both sexes. A proper history taking in all adolescents, adults, and elderly patients requires proper knowledge. This book edited by two eminent andrologists with contributions from experts in sexual medicine from India and abroad attempts to fulfill the lacunae in sexual med- icine education. The chapters cover a wide range of topics written by practitioners of sexual medicine, intended for general practitioners and early career gynecolo- gists, urologists, andrologists, and sexual medicine specialists. The chapters include v vi Foreword physiology of sexual response, importance of history taking, and sexual dysfunction in men and women and in the young and not so young. The book, however, does not address sex during pregnancy, sex in the postpar- tum period, and sex in special situations. I am sure the next edition of the book will address these issues. This concise book I hope would find a place in the library of all practitioners of gynecology, urology, andrology, and family medicine. Chennai, India Pandiyan Natarajan Contents 1 The Human Sexual Response . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Shah Dupesh Khan and Karthik Gunasekaran 2 How to Take a Sexual History . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Narayana Reddy and Shah Dupesh Khan 3 Erectile Dysfunction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Karthik Gunasekaran and Shah Dupesh Khan 4 Ejaculatory Dysfunction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Pandiyan Natarajan and Shah Dupesh Khan 5 Sexual Dysfunction and Infertility . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Pandiyan Natarajan and Shah Dupesh Khan 6 Female Sexual Dysfunction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 Manu Lakshmi and Shah Dupesh Khan 7 Sexual Pain Disorders in Women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 Manu Lakshmi and Shah Dupesh Khan 8 Testosterone Replacement Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 G. Rastrelli, Y. Reisman, S. Ferri, O. Prontera, A. Sforza, M. Maggi, and G. Corona 9 Psychotherapy for Sexual Dysfunctions . . . . . . . . . . . . . . . . . . . . . . . . 95 A. Sathyanarayana Reddy 10 Micropenis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 Karthik Gunasekaran and Shah Dupesh Khan 11 Sexual Paraphilia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 Shah Dupesh Khan and Karthik Gunasekaran 12 Sexual Health in the Aging Couple . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 Prashanth Baspure vii About the Editors Karthik  Gunasekaran, MS, FRCS (Glasgow), FECSM is an andrologist, embryologist, and sexual medicine specialist. Dr. Karthik graduated from Madras Medical College and completed his master’s in surgery there. During this time, he was awarded the Prof. Venugopal gold medal in urology. He completed his fellow- ship in pelvic surgery at the Cleveland Clinic Foundation, USA. His andrology and embryology training were from Chettinad University, Chennai. He completed the ESSM course in Hungary and secured the FECSM in 2014, prior to obtaining his FRCS from the Royal College of Physicians and Surgeons of Glasgow. He has been serving as Lead Andrologist and Reproductive Microsurgeon at Metromale Clinic and Fertility Center since 2013. Shah Dupesh Khan, MBBS, DCE, FASM, (PhD) is the Lead Consultant for Andrology and Sexual Medicine at the Metromale Clinic and Fertility Center. He graduated from Chengalpattu Government Medical College and finished his post- graduation in embryology, which he passed with honors. He then pursued his fel- lowship in andrology and sexual medicine at the Department of Reproductive Medicine, Chettinad Health City, completing it with double honors. He also received the Rajah Muthiah award for his academic achievements. He has filed for a patent on human sperm lyophilization and was shortlisted for the 2014 Medical Healthcare Innovation award in recognition of his contributions. Dr. Shah has presented four prize-winning papers at the ISAR (Indian Society of Assisted Reproduction) and Chettinad International Fertility colloquiums. He has eight publications and one textbook on Male Infertility to his credit and is currently investigating stem cells and cryobiology. ix The Human Sexual Response 1 Shah Dupesh Khan and Karthik Gunasekaran Introduction Sex remains highly controversial and is a major driving force for the human brain [1]. The brain is the master seat control for all sexual behaviour. Human beings are sexual through a better part of their entire lives [1]. Sexuality of humans manifests in different ways with increasing age. Despite the controversies that surround human sex, for a majority of us, sex is a highly pleasurable process [2]. In the boarder context things, good sexual health definitely goes hand in hand with general wellness and good health [2]. But why engage in sex in the first place? Sex is defi- nitely more wasteful compared to asexual modalities of reproduction [3]. Moreover sex and sexual reproduction are far less efficient in propagating a species as com- pared to asexual reproduction [3]. The exact answer however has eluded researchers for years despite excellent studies on animal sexual behaviour. Human beings seem to engage in sex for a variety of reasons. In a study by Meston and Buss, that involved over 1500 young men and women, a total of 237 unique reasons were found that motivated participants to engage in sexual activity [4, 5]. The reasons could be broadly categorized as physical needs, emotional, attainment of a goal and lastly insecurity. Emotional reasons were love and/or com- mitment along with the need to express it. Physical reasons included pleasure seek- ing and fulfilment [4, 5]. Goals included resources, status and even revenge. Insecurity included ‘guarding the mate’ and fulfilling a sense of duty. Emotional reasons predominated over all other reasons for partnered sex, closely followed by physical needs [4, 5]. S. D. Khan · K. Gunasekaran, MS, FRCS (Glasgow), FECSM (*) The Metromale Clinic and Fertility Center, No 1, Crescent Park Street, T-Nagar, Chennai, India © Springer Nature Singapore Pte Ltd. 2019 1 K. Gunasekaran, S. D. Khan (eds.), Sexual Medicine, https://doi.org/10.1007/978-981-13-1226-7_1 2 S. D. Khan and K. Gunasekaran Human Sexual Behaviour and Culture Sexual behaviour definitely plays an important role in species survival, yet it is highly influenced by an individual’s society and cultural context of the individual’s upbringing. Unlike other species where sexual behaviour is adaptive, higher brain functions like ‘morality’ constantly affect sexual behaviour [6]. Across cultures and societies in different parts of the world, human sex is not always tailored towards reproduction as compared to other animals [7]. Human sex and biological reproduction share a complex yet intricate relationship that is non-linear [6, 7]. Sexual behaviour is intensely social and is influenced by culture, biology and/or one’s own fantasies and/or beliefs. Sexual behaviour also changes through the years depending on the individual’s health, social interaction and choice of part- ners. Sex is influenced by an individual’s social boundaries along the frameworks of his or her past sexual experience. A good example would be the shame felt by a woman when she is sexually abused [8]. This shame and guilt are strongly linked to the individual’s sexuality and can affect the person’s current and/or future sexual relationship throughout her sex life. Clearly, there are multiple routes to human sexual response and multiple cues to which human beings can sexually respond. Sex and social behaviour share a tangible link [9]. Understanding and responding to both sexual and non-sexual cues in day-to-day species interaction and watching porn and getting aroused suggest the presence of ‘sexual mirror neurons’ in the human brain. Although not directly proven, same regions of the brain are shown to fire while ‘doing’ as well as ‘observing’ the act [10–13]. The functionality of this neural network definitely varies among individuals and this variance also decides the individual’s sexual susceptibility to sexual stimuli, for example watching por- nography [12, 13]. The development of sexual response in the context of social interaction starts as early as the infant–parent relationship [14]. Male infants get erections and female infants lubricate as early as 24 h after birth. Infants are frequently found fondling their genitals and also showing curiosity in the genitals of adults and other infants [14]. With increasing age and brain development, the child learns to recognize the erotic nature of sexual interactions. Puberty and release of gonadal hormones play a cardinal role in this aspect. The complexity of sex is best viewed in terms of brain development both functionally and morphologically in terms of size with respect to human development and/or evolution [15]. Pitfalls of the Masters and Johnson’s Model of Human Sexual Response Masters and Johnson introduced the four-stage cycle of the human sexual response (HSRC) to describe the physiological sequence of changes that they observed dur- ing lab-performed sexual activities of coitus and masturbation [16]. One of the big- gest pitfalls of the model was that it omitted the concept of sexual drive which was well emphasized in the much simpler two-phase model of sexual response proposed

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