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Sexual differentiation of the brain PDF

338 Pages·2018·87.14 MB·English
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Sexual Differentiation o f the Brain Sexual Differentiation o f the Brain edited by Akira Matsumoto, Ph.D. First published 1999 by CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 Reissued 2018 by CRC Press © 1999 by Taylor & Francis CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www. copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organiza-tion that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. A Library of Congress record exists under LC control number: 99037571 Publisher's Note The publisher has gone to great lengths to ensure the quality of this reprint but points out that some imperfections in the original copies may be apparent. Disclaimer The publisher has made every effort to trace copyright holders and welcomes correspondence from those they have been unable to contact. ISBN 13: 978-1-138-10540-9 (hbk) ISBN 13:978-0-203-71036-4 (ebk) Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Preface This monograph is dedicated to Dr. Yasumasa Arai who retired from the pro­ fessorship in anatomy at the Juntendo University School of Medicine in March 1998. He is an internationally established scientist, contributing to the advance of neuroendocrinology and neuroscience for more than 30 years. He is a member of the Editorial Boards of Hormones and Behavior and the Journal of Neuroendocrinology. He has conducted important research in the under­ standing of sexual differentiation of the brain and sex steroid influences on neural and behavioral functions. Sex steroids exert influences on modulating neural development and neu­ ral circuit formation in developing the sex steroid-sensitive neuroendocrine brain. Estrogen or aromatizable androgen can act as a neurotrophic factor on neural tissues, stimulating axonal and dendritic growth and synapse forma­ tion. The development of sexual dimorphism in neural structures such as nuclear volume and synaptic organization may reflect sex steroid-modulat­ ing neural development and synapse formation during the perinatal period. Recent neurobiological and molecular biological studies in this field have provided new information about mechanisms underlying sexual differentia­ tion of the brain. Moreover, attempts have been made to clarify sex differ­ ences in the human brain by using anatomical and noninvasive techniques such as MRI or PET. Psychological studies also have contributed in revealing the difference. All of the contributors, leading scientists in this field, have reviewed the most recent advances in studies on sexual differentiation of the brain. The monograph will provide a valuable insight into the current state of knowledge about this field. Akira Matsumoto Editor Akira Matsumoto, Ph.D., is an associate professor in the Department of Anatomy, Juntendo University School of Medicine, Tokyo (Japan). Dr. Mat­ sumoto received a B.S. degree (biology, 1968) and a Ph.D. degree (biology, 1974) from the University of Tokyo, Tokyo (Japan). He has served on the fac­ ulty of the Department of Anatomy, Juntendo University School of Medicine from 1974 to present. He received an International Society of Andrology Award (1993) and a Zoological Science Award (1997). He served as coeditor of the Atlas of Endocrine Organs (Springer-Verlag, 1992). He is a member of the Society of Neuroscience, the International Brain Research Organization, the International Society of Neuroendocrinology, the Society of Behavioral Neu­ roendocrinology, the International Society of Andrology, the Japanese Asso­ ciation of Anatomists, the Japanese Association of Endocrinology, the Japan Neuroscience Society, the Japanese Society for Comparative Endocrinology, and the Zoological Society of Japan. His research interests concern the orga­ nizational and activational effects of sex steroids on neural function and structures in the mammalian neuroendocrine brain. He has a number of pub­ lications on topics in this field in prominent journals. Contributors Laurie A. Abler, B.S., Wisconsin Regional Primate Research Center, Univer­ sity of Wisconsin, Madison, Wisconsin Paola Agrati, Center Milano Molecular Pharmacology Laboratory, Institute of Pharmacological Sciences, University of Milan, Milan, Italy Yasumasa Arai, Ph.D., Laboratory of Medical Education, Juntendo Universi­ ty School of Medicine, Tokyo, Japan Arthur P. Arnold, Ph.D., Departments of Physiological Science and Neurobi­ ology, Laboratory of Neuroendocrinology of the Brain Research Institute, Mental Retardation Research Center, University of California, Los Ange­ les, California Laura Bolzoni, Center Milano Molecular Pharmacology Laboratory, Institute of Pharmacological Sciences, University of Milan, Milan, Italy S. Marc Breedlove, Ph.D., Department of Psychology, University of Califor­ nia, Berkeley, California Alessia Brusadelli, Center Milano Molecular Pharmacology Laboratory, In­ stitute of Pharmacological Sciences, University of Milan, Milan, Italy Gloria Patricia Cardona-Gomez, Instituto Cajal, Consejo Superior de Inves­ tigaciones Cientificas, Madrid, Spain Julie Ann Chowen, Ph.D., Instituto Cajal, Consejo Superior de Investiga­ ciones Cientificas, Madrid, Spain Scott E. Christensen, M.A., Department of Psychology, University of Califor­ nia, Berkeley, California Paolo Ciana, Ph.D., Center Milano Molecular Pharmacology Laboratory, In­ stitute of Pharmacological Sciences, University of Milan, Milan, Italy David Crews, Ph.D., Institute of Reproductive Biology, Section of Integrative Biology, University of Texas, Austin, Texas

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"Sexual difference in the brain has long been one of the more intriguing research areas in the field of neuroscience. This thorough and comprehensive text uncovers and explains recent neurobiological and molecular biological studies in the field of neuroscience as they relate to the mechanisms under
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