Serbian society for mitochondrial and free-radical physiology. Mitochondria and free radicals - the new challenge. Book of abstracts. September 21st 2009, Belgrade. PDF
Preview Serbian society for mitochondrial and free-radical physiology. Mitochondria and free radicals - the new challenge. Book of abstracts. September 21st 2009, Belgrade.
Serbian society for mitochondrial and free-radical physiology N a u (cid:31) n i su Mitochondria and free radicals -- tthhee nneeww cchhaalllleennggee -- BBOOOOKK OOFF AABBSSTTRRAACCTTSS SSeepptteemmbbeerr 2211.. 22000099.. BBeellggrraaddee Srpsko društvo za mitohondrijalnu i slobodno-radikalsku fiziologiju Ministarstvo za nauku i tehnološki razvoj Univerzitet u Beogradu, Institut za biološka istraživanja “Siniša Stanković” Univerzitet u Beogradu, Farmaceutski fakultet Univerzitet u Beogradu, Biološki fakultet Univerzitet u Beogradu, Medicinski fakultet KNJIGA SAŽETAKA Naučni simpozijum “Mitohondrije i slobodni radikali” - nov izazov - 21. septembar 2009. Beograd, Srbija SDMSRF-2009 Urednici: Bato Korać Vesna Otašević Izdavač: Srpsko društvo za mitohondrijalnu i slobodno-radikalsku fiziologiju Ministarstvo za nauku i tehnološki razvoj Univerzitet u Beogradu, Institut za biološka istraživanja “Siniša Stanković” Univerzitet u Beogradu, Farmaceutski fakultet Univerzitet u Beogradu, Biološki fakultet Univerzitet u Beogradu, Medicinski fakultet Za izdavača: Bato Korać Snežana Pajović Miodrag Petrović Nada Kovačević Gordana Cvijić Vladimir Bumbaširević Urednici: Bato Korać Vesna Otašević Tehnički urednici: Vesna Otašević Aleksandra Janković Ana Vasilijević Dizajn: Aleksandra Janković Štampa: ”Rival Copy d.o.o.“: 200 primeraka Autorska prava © 2009 od strane Srpskog društva za mitohondrijalnu i slobodno-radikalsku fiziologiju i drugih saradnika. Sva prava zadržana. Nijedan deo ove publikacije ne može biti reprodukovan u bilo kom obliku ili bilo kojim sredstvom, bez pismene dozvole izdavača. ISBN: 978-86-912893-0-0 Serbian society for mitochondrial and free-radical physiology Ministry of science and technological development University of Belgrade, Institute for biological research “Siniša Stanković” University of Belgrade, Faculty of Pharmacy University of Belgrade, Faculty of Biology University of Belgrade, Faculty of Medicine BOOK OF ABSTRACTS Scientific symposium “Mitochondria and free radicals” - the new challenge - September 21. 2009. Belgrade, Serbia SDMSRF-2009 Edited by: Bato Korać Vesna Otašević Publisher: Serbian society for mitochondrial and free-radical physiology Ministry of science and technological development University of Belgrade, Institute for biological research “Siniša Stanković” University of Belgrade, Faculty of Pharmacy University of Belgrade, Faculty of Biology University of Belgrade, Faculty of Medicine For publisher: Bato Korać Snežana Pajović Miodrag Petrović Nada Kovačević Gordana Cvijić Vladimir Bumbaširević Editors: Bato Korać Vesna Otašević Technical editors: Vesna Otašević Aleksandra Janković Ana Vasilijević Design: Aleksandra Janković Print: ”Rival Copy d.o.o.“: 200 copies Copyright © 2009 by the Serbian society for mitochondrial and free-radical physiology and others contributors. All rights reserved. No part of this publication may be reproduced, in any form or by any means, without permission in writing from the publisher. ISBN: 978-86-912893-0-0 Pozdravna reč Poštovane koleginice i kolege, Od Altmanovog otkrića bioblasta, fundamentalnih partikula života i Fentonovih eksperimenata o nastanku hidroksil radikala razgradnjom vodonik peroksida u prisustvu gvožđa, s kraja devetnaestog veka, nezavisno jedan od drugog, začinju se dva naučna pravca. Jedan u svom središtu ima mitohondrije, a drugi slobodne radikale. Oba su morala sačekati drugu polovinu dvadesetog veka da bi bila potkrepljena naučnim rezultatima. Za oba, takođe, možemo reći da su punu afirmaciju stekla početkom osamdesetih godina prošlog veka, podržana sa dva otkrića: fiziološkom ulogom azot oksida i spoznajom mitohondrijalnih oboljenja. Počeci su bili neizvesni, a o sprezi se nije moglo ni govoriti. Evolucija nas uči da su oni od rođenja zajedno, od prve redukcije kiseonika u mitohondrijama. Taj prvi udisaj danas je molekulski dobro razjašnjen, toliko da jedne bez drugih praktično ne razmatramo. Mitohondrije i slobodni radikali su funkcionalna celina. Tako je od postanka života, tako je i danas kada oni regulišu život i smrt ćelija, nezaobilazni su u patofiziološkim stanjima od neurodegenerativnih poremećaja, preko dijabetesa do metaboličkog sindroma, intrigantni u kloniranju, kanceru ... Želja nam je da Srpsko društvo za mitohondrijalnu i slobodno-radikalsku fiziologiju bude razvojna tačka tog kontinuiteta. Stožer koji sjedinjuje i produbljuje. Naš prvi simpozijum je ne početak, već novi lik više od pedeset godina razvoja ove problematike u Srbiji. Osmišljen je da pruži šansu mladim naučnicima da izlože svoje i rezultate grupa u kojima rade. Simbolično, započinjemo sa onima na kojima je budućnost. U ime Društva želim da se zahvalim svima koji su pomogli održavanje simpozijuma, a učesnicima da poželim plodnu naučnu aktivnost, nove ideje i kontakte, da im ovaj dan ostane u sećanju, ... želim im „nov izazov“. Bato Korać Predsednik Srpskog društva za mitohondrijalnu i slobodno-radikalsku fiziologiju Preface Dear colleagues, By the end of the 19th century, since the epochal Altman's discovery of bioblasts, fundamental particles of life and Fenton's experiments on free radicals evolvement by hydrogen peroxide de-composition in the presence of iron, two scientific fields, were initiated independently of each other, the first being concentrated on mitochodria and the second one devoted to free radicals. Both these scientific fields were somehow neglected and a long time, even untill the second half of the 20th century has elapsed before the fundamental scientific principles underlying them were enthroned. It can be claimed as well, that they achieved a full scientific affirmation only at the beginning of the '80s of the last century, thanks to a powerful flywheel of two great discoveries of nitrogen oxide physiological role and cognition of mitochondria-related diseases. The first steps were not only doubtful, but also very strenuous ones, and it was impossible to mention any coupling of the two. The Evolution is teaching us that the above two phenomena are inevitably closely connected to each other since the birth, beginning with the first oxygen reduction within the mitochondria. At present, this first inhalation is understood in detail at the molecular level and it is impossible to consider either of them separately. Mitochondria and free radicals represent a functional entirety. It was so since the Genesis and it is the same today when the fact that they act regulating both the life and death of the cells is so obvious. Mitochondria and free radicals are unavoidable in pathophysiological conditions from neurodegenerative disturbances and diabetes to metabolic syndromes, and they are intriguing and challenging in cloning procedures, malignant diseases, etc. It is our great wish that the Society for Mitochondrial and Free Radical Physiology of Serbia becomes a corner-stone of this continuity, i.e. developmental focus of this entirety which will act unifying and deepening our knowledge. Our First Symposium is not the start, but a new image of over fifty years old development of this scientific field in Serbia. It was primarily aimed at providing the chance to young scientists to present their own achievements, as well as the results of their scientific teams. Symbolizing this goal, let us start with those who represent our future because the world belongs to the young. On behalf of the Society for Mitochondrial and Free Radical Physiology of Serbia, I feel obliged and pleased to express our gratitude to all those who contributed and enabled in any way to organize this Symposium. I would like also to welcome all colleagues and guests and to the participants I am sending my sincere desires for their fruitful scientific activity, new leading ideas and contacts to remember for ever this day significant for all of us, another words, I wish them, ... „the new challenge“. On Behalf of the Organizing Committee Bato Korać President of Serbian society for mitochondrial and free radical physiology
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