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SELECTED TOPICS IN OPTICAL COHERENCE TOMOGRAPHY Edited by Gangjun Liu Selected Topics in Optical Coherence Tomography Edited by Gangjun Liu Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Romana Vukelic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Selected Topics in Optical Coherence Tomography, Edited by Gangjun Liu p. cm. ISBN 978-953-51-0034-8 Contents Preface IX Part 1 OCT Techniques 1 Chapter 1 Full-Field Optical Coherence Microscopy 3 Arnaud Dubois Chapter 2 Doppler OCT and OCT Angiography for In Vivo Imaging of Vascular Physiology 21 Vivek J. Srinivasan, Aaron C. Chan and Edmund Y. Lam Chapter 3 Phase-Resolved Doppler Optical Coherence Tomography 41 Gangjun Liu and Zhongping Chen Chapter 4 3-D Ultrahigh Resolution Optical Coherence Tomography with Adaptive Optics for Ophthalmic Imaging 65 Guohua Shi, Jing Lu, Xiqi Li and Yudong Zhang Chapter 5 Quasi–Nondiffractive Beams for OCT–Visualization: Theoretical and Experimental Investigations 83 Larisa Kramoreva, Elena Petrova and Julia Razhko Part 2 OCT Applications 107 Chapter 6 Neoatherosclerosis Within the Implanted Stent 109 Hironori Kitabata and Takashi Akasaka Chapter 7 Cellular Level Imaging of the Retina Using Optical Coherence Tomography 121 Cherry Greiner and Stacey S. Choi Chapter 8 Spectral-Domain Optical Coherence Tomography in Hereditary Retinal Dystrophies 147 Isabelle Meunier, Carl Arndt, Xavier Zanlonghi, Sabine Defoort-Dhellemmes, Isabelle Drumare, Martine Mauget-Faysse, Benjamin Wolff, Aude Affortit, Christian Hamel and Bernard Puech VI Contents Chapter 9 Study of the Effects of Aging, Refraction and Intraocular Pressure Levels on Retinal Nerve Fiber Layer Thickness of Normal Healthy Eyes 171 Maki Katai and Hiroshi Ohguro Chapter 10 Morphological Changes of Retinal Pigment Epithelial Detachment in Central Serous Chorioretinopathy 185 Ari Shinojima and Mitsuko Yuzawa Chapter 11 Clinical Applications of Optical Coherence Tomography in Ophthalmology 197 Upender K. Wali and Nadia Al Kharousi Chapter 12 Optical Coherence Tomography in Dentistry 239 Yueli L. Chen, Quan Zhang and Quing Zhu Chapter 13 Using Optical Coherence Tomography to Characterize the Crack Morphology of Ceramic Glaze and Jade 261 M.-L. Yang, A.M. Winkler, J. Klein, A. Wall and J.K. Barton Preface Optical coherence tomography (OCT) is an interferometric technique based on optical coherent gating. In OCT, imaging contrast originates from the sample inhomogeneous scattering properties that are linearly dependent on the sample’s refractive indices. OCT offers axial resolution of 2‐15 μm and penetration depth around 2 mm. Since its invention in the late 1980s and early 1990s, OCT has experienced explosive growth in both technology and application. With the development of Fourier domain OCT, the A‐line rate and the sensitivity of the OCT systems have been improved dramatically in the past few years. The potentials of OCT for real time, in‐vivo diagnostic, surgery guidance and monitoring applications have been recognized. In recent years, we have seen an increase in the number of research groups, as well as industry companies, involved in the OCT system development and application. OCT was first used clinically in ophthalmology, for the imaging and diagnosis of retinal disease. Recently, it has been applied to image subsurface structure in skin, vessels, oral cavities, as well as respiratory, urogenital and gastrointestinal tracts. The application of OCT will continue to penetrate more exciting fields in the near future. This book contains different exciting topics in the OCT fields, written by experts from all over the world. Technological developments, as well as clinical and industrial applications are covered. Some interesting topics, like the ultrahigh resolution OCT, the functional extension of OCT and the full field OCT are reviewed, and the applications of OCT in ophthalmology, cardiology and dentistry are also addressed. I believe that a broad range of readers, such as students, researchers and physicians will benefit from this book. I would like to thank all who made this project possible. Firstly, my sincere gratitude goes to the InTech staff for inviting me to participate as Editor and for providing assistance with the editing process, especially to Ms. Romana Vukelic for her professional assistance throughout the entire process. I also thank all the authors for generously sharing their knowledge and experience with the readers, and for the time they have taken to write these chapters. Most importantly, on behalf of the X Preface authors and myself, we hope that the readers will download, read and benefit from this book. Gangjun Liu Beckman Laser Institute, University of California, Irvine, California USA