Springer Texts in Education Garland E. Allen Jeffrey J.W. Baker Scientific Process and Social Issues in Biology Education Springer Texts in Education More information about this series at http://www.springer.com/series/13812 Garland E. Allen Jeffrey J.W. Baker (cid:129) Scientific Process and Social Issues in Biology Education 123 Garland E. Allen Jeffrey J.W.Baker Department ofBiology WesleyanUniversity Washington University in St.Louis Middletown, CT St.Louis, MO USA USA ISSN 2366-7672 ISSN 2366-7980 (electronic) SpringerTexts inEducation ISBN978-3-319-44378-2 ISBN978-3-319-44380-5 (eBook) DOI 10.1007/978-3-319-44380-5 LibraryofCongressControlNumber:2016947760 ©SpringerInternationalPublishingSwitzerland2017 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission orinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped. 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Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerInternationalPublishingAGSwitzerland Preface This book is the product of the authors’ teaching introductory biology and related science courses at several different colleges and universities, though primarily at Wesleyan University, Middletown, Connecticut (Baker) and Washington Univer- sity, St. Louis, Missouri (Allen). One of us remembers in his earliest years of teaching having the distinct feeling that, more often than not, some of his most creativestudentsreceivedonlymediocregrades:unmotivatedbythepresentationof adazzlingarrayofdetailedfactualinformation,theywouldoftenaskunexpectedly thoughtfulandhighlyreflectivequestions.Conversely,studentsreceivingAs,while able to regurgitate biological “facts,” (e.g., details of the Krebs citric acid cycle), were often totally incapable of mapping out a strategy for investigating even the simplest of research projects. A variation on this theme was the comment of one facultycolleague that he found himself becoming increasingly uncomfortable with the recognition that a few of his students could complete a basic introductory biologycoursesatisfactorilyyetstillremainconvincedoftheintellectualvalidityof Creationism! These and other such experiences convinced us that students may do well in a science course but fail completely to comprehend the nature of science itself, the underlying reasons for its immense power as an intellectual process, and the rela- tionship between the natural sciences, social sciences, and humanities. Perhaps worse, when considering science at all, students seem to drift from one extreme to another,eitherbuying intopopularpressversionsofscienceastheultimatesource of all truth or viewing it as just one of many systems of intellectual thought, of no greaterorlesservaliditythananyother.Unfortunately,thislatterviewisoneoften found even among the ranks of college faculty in the social sciences and the humanities,inwhichmodernsciencemaybereferredtoas“justanothersystemof myths,” “the predominant myth of the twentieth century,” or other words to that effect. Such a view does a profound disservice to the meaning of both the terms “science” and “myth.” If indeed modern science is to be viewed as a myth, then clearly it is by far the most powerful one yet devised by the human imagination! Itwasinanattempttodealwiththisconfusionthat,overtheyears,webeganto incorporate material into our course designed to confront this and other such problems. Ironically, one of the anonymous reviewers of the manuscript for this v vi Preface bookwroteacommentthatreflectsbeautifullythesortofresistanceoneencounters to such efforts: Aspartofadebatewithfacultyovercurricularissuessomeyearsago,Iaskedoneofmy colleagueshowoursciencestudentswouldfareiftheywereaskedtodistinguishbetween scienceandthehumanities....Theresponseofmycolleaguewassilence.Thissilencewas born of what I believe to be a pervasive fact: that those of us who teach science rarely considered these issue so explicitly. . . . It is much easier to present the facts of normal science(whatweknow)thantoconsiderhowweknowit. In one of our earlier books we put forward what we think is the essence of a processapproachtoscience:“...itistheprocess,notmerelythecontentor“facts” ofbiology,thatshouldformthebasicthrustofintroductorycourses.Bytheprocess of science we mean how we know what we know; how experiments are designed, dataanalyzedandconclusionsdrawn—inshort,thelogicandmethodofscience.”1 Thisapproachisdesignedtostresstostudentsthattoday’sscientific“facts”maybe tomorrow’s errors. In our efforts over the past few years to produce an updated version of our approach, however, we found ourselves immersed in a publishing world far more concerned with the commercial success of encyclopedic and fact-driven textbooks and much less in scientific process. Beyond that, the intro- ductionoffullcolortobothartandphotographshasdriventhecosttothestudentof suchtextbookstoastronomicalheights,insomecases,wellover$100!Aslovelyas these books may appear, in this day and age of widespread student access to color TV,photographyandtheInternet,onecannothelpbutwonderifsuchanexpenseis justifiable. Thus when the Fitzgerald Science Press originally expressed interest in the underlying philosophy of our work and in publishing it as a series of low cost yet high quality, two-color volumes, we felt that a genuine meeting of the minds had occurred. Theformatofthisbookisdesignedspecificallytoaddressthenatureofscience in general and of the biological sciences in particular. Chapter 1 deals with the historical development of the life sciences and looks ahead towhat the field might be like in the next century. It also uses examples of current research in the field to stress that biology, like all the natural sciences, has many unsolved problems researchers today are still trying to understand and is therefore a field no less dynamic now than in the past. Chapter2beginswithanin-depthlook atbiologyasascienceinthecontextof hypothesis formulationandtheunderlying inductive and deductivelogicinvolved. Here we stress the differing types of hypotheses, the role that conscious and unconscious bias may play in both formulating questions and evaluating answers, as well as the strengths and limitations of science as an intellectual discipline. Chapter 3 deals with how scientific hypotheses are tested and how the logic involved may be analyzed in terms of its inductive and deductive framework. We have often elected here and elsewhere in this book to use older studies from the 1Preface,TheStudyofBiology,4th,edition,Baker,JeffreyJ.W.,andAllen,GarlandE.Reading, MA.AddisonWesleyPublishingCompany,1982,p.v. Preface vii seventeenth, eighteenth, and nineteenth centuries. So doing enables us to avoid having to provide a great deal of subject matter background and, since the student reader more than likely already knows the “answer,” he or she is forced to con- centrate instead on the underlying intellectual structure involved. We then apply insights from these older case studies to contemporary issues: e.g., conflicting hypotheses concerning the cause of the AIDS epidemic now sweeping many developed and developing nations. For those instructors interested in introducing early the concept of statistical analysis in hypotheses evaluation, we provide an appendix dealing with some of the essential concepts and techniques and means used to illustrate experimentally established correlation. Chapter 4 compares three case studies, the first an example of research carried outinthelaboratoryandthesecondanexampleofresearchinthefield,withallthe difficulties in terms of controlling variables that such studies entail. The third case study deals with problems inherent in evolutionary studies in which events have occurred that cannot be observed directly. Finally, Chapter 5 is concerned with the interrelationship of science and the society within which it develops and the social responsibility of scientists to the society that funds their research. Using Creationism as our example, we end with issuesraisedbythestillall-too-powerfulattractionofpseudoscienceanditsmisuse tofurtheraparticularpoliticalagenda.Doubtlesshereinstructorsmaywishtobring in other examples of their own. It is only appropriate here that we express our gratitude for the assistance pro- videdusbythelateIrmaMorose,TeresaL.Tate(néeLowe),andCindyMarks.All too often such valuable input goes unrecognized, despite the fact that little or nothing could be accomplished without it. It would be difficult to find greater justification for this book. St. Louis, MO, USA Garland E. Allen Ivy, VA, USA Jeffrey J.W. Baker March 2014 Contents 1 Biology as a Process of Inquiry. . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.2 The Growth of Biological Thought: The Nineteenth Century. . . . 2 1.3 The Twentieth Century Revolution in Biology. . . . . . . . . . . . . . 7 1.4 The Spirit of Inquiry: Some Unsolved Problems in Biology . . . . 13 1.4.1 The Excitement of Unexpected Discovery . . . . . . . . . . . 13 1.4.2 Butterfly Migration . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 1.4.3 Hen’s Teeth and Evolution. . . . . . . . . . . . . . . . . . . . . . 20 1.4.4 The Chemical Origin of Life. . . . . . . . . . . . . . . . . . . . . 22 1.5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 Further Reading. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 2 The Nature and Logic of Science . . . . . . . . . . . . . . . . . . . . . . . . . 29 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 2.2 Science as an Intellectual Discipline. . . . . . . . . . . . . . . . . . . . . 30 2.3 The Logic of Science. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 2.4 The Logic of Science: Induction and Deduction. . . . . . . . . . . . . 44 2.5 The “Dissection” of an Experiment . . . . . . . . . . . . . . . . . . . . . 48 2.6 The Logic of Science: Hypotheses as Explanations . . . . . . . . . . 52 2.7 Bias in Science . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 2.8 The Concept of Paradigms . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 2.9 Modern Science, Materialism and Idealism . . . . . . . . . . . . . . . . 71 2.10 Conclusion: The Strengths and Limitations of Science . . . . . . . . 77 2.11 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 Further Reading. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 3 The Nature and Logic of Science: Testing Hypotheses . . . . . . . . . . 83 3.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 3.2 Testing Hypotheses: Some General Principles . . . . . . . . . . . . . . 83 3.2.1 Testing Hypotheses by Observation. . . . . . . . . . . . . . . . 83 3.2.2 Testing Hypotheses by Experiments. . . . . . . . . . . . . . . . 84 3.2.3 The Importance of Uniformity and Sample Size . . . . . . . 86 ix x Contents 3.3 A Case Study in Hypothesis Formulation and Testing: How Is Cholera Transmitted? . . . . . . . . . . . . . . . . . . . . . . . . . 88 3.3.1 Disease: The Early Views. . . . . . . . . . . . . . . . . . . . . . . 88 3.3.2 Snow’s Observations. . . . . . . . . . . . . . . . . . . . . . . . . . 89 3.3.3 An Alternative Hypothesis . . . . . . . . . . . . . . . . . . . . . . 90 3.3.4 The Case of the Broad Street Pump. . . . . . . . . . . . . . . . 92 3.3.5 Objections to Snow’s Water-Borne Hypothesis . . . . . . . . 93 3.3.6 The Critical Test. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 3.3.7 A Wider Applicability and the Role of Chance. . . . . . . . 95 3.3.8 The Mechanism of Cholera Action: A Modern Perspective. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96 3.4 A Modern-Day Epidemic: The AIDS Crisis, 1981–2000. . . . . . . 96 3.4.1 Background: The Origin of the AIDS Crisis. . . . . . . . . . 96 3.4.2 The Nature of HIV Infection. . . . . . . . . . . . . . . . . . . . . 100 3.4.3 Treatment and/or Cure for AIDS. . . . . . . . . . . . . . . . . . 104 3.5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 3.5.1 Questions for Critical Thinking. . . . . . . . . . . . . . . . . . . 106 Further Reading. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 4 Doing Biology: Three Case Studies. . . . . . . . . . . . . . . . . . . . . . . . 109 4.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 4.2 Formulating and Testing Hypotheses in the Laboratory: The Discovery of Nerve Growth Factor . . . . . . . . . . . . . . . . . . 110 4.3 Research in the Field: Homing in Salmon. . . . . . . . . . . . . . . . . 115 4.3.1 The Organism. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116 4.3.2 Two Possible Hypotheses. . . . . . . . . . . . . . . . . . . . . . . 118 4.3.3 Tabulating the Results . . . . . . . . . . . . . . . . . . . . . . . . . 119 4.3.4 Further Questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 4.3.5 Testing the Pheromone Hypothesis Further. . . . . . . . . . . 124 4.3.6 “Dissecting” the Experiments . . . . . . . . . . . . . . . . . . . . 126 4.3.7 Statistical Significance. . . . . . . . . . . . . . . . . . . . . . . . . 127 4.4 An Evolutionary Historical Case: Mass Extinctions and the End of the Dinosaurs: The Nemesis Affair. . . . . . . . . . . 129 4.4.1 Testing the Impact Hypothesis . . . . . . . . . . . . . . . . . . . 131 4.4.2 Extinctions and the Paleontological Record. . . . . . . . . . . 132 4.4.3 Periodic Mass Extinctions . . . . . . . . . . . . . . . . . . . . . . 133 4.4.4 The Nemesis Hypothesis . . . . . . . . . . . . . . . . . . . . . . . 135 4.5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 136 Further Reading. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 5 The Social Context of Science: The Interaction of Science and Society . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139 5.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140 5.2 Science and Technology—The Public Confusion. . . . . . . . . . . . 140 5.3 The Social Construction of Science . . . . . . . . . . . . . . . . . . . . . 141