Scientific and ethical approaches for observational exposure studies

2008·11.3 MB·English

by  National Exposure Research Laboratory (U.S.)

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vvEPA
EPA 600/R-08/062 | May 2008 | www.epa.gov/ord
United States
Environmental Protection
Agency
Scientific and Ethical
Approaches for
Observational Exposure Studies
Office of Research and Development
National Exposure Research Laboratory

EPA 600/R-08/062
May 2008
Scientific and Ethical Approaches for
Observational Exposure Studies
National Exposure Research Laboratory
Office of Research and Development
U.S. Environmental Protection Agency
Research Triangle Park, NC 27711

Notice
This document has been subjected to the Agency’s peer and administrative review and has
been approved for publication as an EPA document. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
Abstract
Researchers conduct observational human exposure studies to understand how and the extent
to which people come into contact with chemicals and environmental stressors in their everyday
lives, through the air they breathe, the food and liquids they consume, and the things they touch.
The U.S. Environmental Protection Agency’s (EPA’s) National Exposure Research Laboratory
(NERL) has conducted observational human exposure studies for several decades and uses the
information and data from these studies to improve the Agency’s understanding of human
exposures to chemicals and other stressors and ultimately to support efforts to improve public
health. Because these studies involve people as research participants, they are complex and raise
numerous scientific and ethical issues that have to be addressed prior to and during their design
and implementation. To ensure that EPA’s research continues to be based on the most up-to-date
science and the highest ethical standards, the Agency has developed this document that contains
state-of-the-science approaches for conducting observational human exposure studies. This
document is not meant to represent an official Agency “guidance document” but, rather, serves as
a resource tool and source of information for NERL and other researchers on which to rely as
they develop and conduct observational human exposure studies.
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