Science Magazine April 15th 2011 Volume 332 Issue 6027

112 Pages·2011·13.93 MB·English

by  AAAS

15 April 2011 | $10
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4-1BBL Caspase-3 sFlt-1(D3) IL-2 MEC sRANK
4-1BBReceptor Caspase-6 sFlt-1(D4) IL-3 Mek-1 sRANKL
6Ckine CD4 sFlt-1(D5) IL-4 MIA RANTES
oo ACAD8 CD14 sFlt-1(D7) sIL-4Receptor Midkine RELM-α
ACAT2 CD22 Flt3-Ligand IL-5 MIG/CXCL9 RELM-β
gAcrp30/Adipolean CD40Ligand/TRAP sFlt-4 IL-6 MIP-1α/CCL3 Resistin
cc AAcCtYiv1inA CCDD91055//sEFnadsoLgilginand FsFolltli-s4t/aFtincChimera sILIL-7-6Receptor MMIIPP--13β//CCCCLL243 RRPPTTPPγβ
ADAT1 CHIPS FSH IL-8(72a.a.) MIP-3α/CCL20 RPTPμ
Adiponectin CNTF Fractalkine/CX3C IL-8(77a.a.) MIP-3β/CCL19 SCF
.. ADRP Collagen G-CSF IL-9 MIP-4(PARC)/CCL18 SCGF-α
ss AITRL CREB α-GalactosidaseA IL-10 MIP-5/CCL15 SCGF-β
Akt1 CTACK/CCL27 Galectin-1 IL-11 MMP-3 SDF-1α
Alpha-FetoProtein(AFP) CTGF Galectin-3 IL-12 MMP-7 SDF-1β
ee AAnlpghioap-Goiaeltainc-to1s(iAdnagse-1A) CCTTLGAF-L4//WFcISP-2 GGaCsPtr-o2intestinalCA IILL--1133analog MMyMoPs-ta1t3in SSeFc2r0etin
Angiopoietin-2(Ang-2) CXCL16 GDF-3 IL-15 Nanog SHP-2
AngiostatinK1-3 Cytokeratin8 GDF-9 IL-16(121a.a.) NAP-2 STAT1
cc Annexin-V DEP-1 GDF-11 IL-16(130a.a.) Neurturin c-Src
apo-SAA Desmopressin GDNF IL-17 NFAT-1 TACI
ApoliproteinA-1 DisulfideOxidoreductase GLP-1 IL-17B beta-NGF TARC
nn ApoliproteinE2 E-selectin Glucagon IL-17D NOGGIN TC-PTP
ApoliproteinE3 ECGF Goserelin IL-17E NOV TECK
ApoliproteinE4 EGF GM-CSF IL-17F NP-1 TFF2
ee AArPteRmILin EEMlafAinP/S-IIKALP GGRPBOBα IILL--1209 NNTT--31/BCSF-3 TTGGFF--αβ1
ATF2 ENA-78 GROβ IL-22 NT-4 TGF-β2
AuroraA Endostatin GROγ IL-31 Ocreotide TGF-β3
ii AuroraB Enteropeptidase GRO/MGSA Insulin OncostatinM Thymosinα1
cc BAFF Eotaxin GrowthHormone IP-10 Osteoprotegerin(OPG) sTIE-1/FcChimera
BAFFReceptor Eotaxin-2 GrowthHormoneBP JE OTOR sTIE-2/FcChimera
BCA-1/BLC/CXCL13 Eotaxin-3(TSC) GST-p21/WAF-1 JNK2a1 Oxytocin TL-1A
ss BBDC-M1A EEPPHHBB24 HHBC-CE-G1F JKNCK/2CaX2CL1 pP3a8ra-αthyroidHormone TTNNFF--αβ
BD-2 Eptifbatide HGF KGF PDGF-AA sTNFR1
ll BBDD-N3F EErrykt-h2ropoietin(EPO) HHiissttdreylli-ntRNAsynthetase LL-AaGsp-1araginase PPDDGGFF--ABBB sTTPNOFR2
ll Bivalirudin Exodus-2 HRG1-β1 LALFPeptide Persephin TRAIL/Apo2L
ee BMP-2 FasLigand I-309 LAR-PTP PF-4 sTRAILR-1(DR4)
BMP-4 FasReceptor I-TAC LC-1 PIGF-1 sTRAILR-2(DR5)
BMP-7 FGF-1(acidic) IFN-α LBP PIGF-2 TSH
cc BsBMMPP-1R3-1A FFGGFF--24(basic) IIFFNN--ααA2a LLDD-H78β PPKKAC-αα-subunit TTSWLEPAK
BrainNatriureticProtein FGF-5 IFN-α2b LEC/NCC-4 PKC-γ TWEAKReceptor
.. BBrReAaKstTumorAntigen FFGGFF--76/KGF IIFFNN--γβ LLIeGpHtinT PPlLeGioFtr-o1phin UVEroGkiFn1a2s1e
ww C5a FGF-8 IFN-Omega LIX PolymyxinB(PMB) VEGF145
C5L2Peptide FGF-9 IGF-I LKM PRAS40 VEGF165
C-10 FGF-10 IGF-II LL-37 PRL-1 VEGF-C
C-ReactiveProtein FGF-16 proIGF-II Lymphotactin PRL-2 VEGF-CI525
ww CCa-SlbricndinD-9K FFGGFF--1178 IIGGFFBBPP--12 sML-YCVSEF-1 PPrRoLk-in3eticin-2 EVGEG-VFE-EGF
CalbindinD-28K FGF-19 IGFBP-3 MCP-1(MCAF) Prolactin HB-VEGF-E
CalbindinD-29K FGF-20 IGFBP-4 MCP-2 Protirelin sVEGFR-1
Calmodulin sFGFR-1(IIIc)/FcChimera IGFBP-4 MCP-3 PTHrP sVEGFR-2
ww CalcitoninAcetate sFGFR-2(IIIc)/FcChimera IGFBP-5 MCP-4 PTP1B sVEGFR-3
CarbonicAnhydraseIII sFGFR-3/ FcChimera IGFBP-6 MCP-5 PTP-IA2 WISP-1
Carcino-embryonicAntigen sFGFR-4/FcChimera IGFBP-7 MDC(67a.a.) PTP-MEG2 WISP-2
Cardiotrophin-1 sFlt-1(native) IL-1α MDC(69a.a.) PTP-PEST WISP-3
IL-1β MDH WNT-1
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CONTENTS
Volume 332 Issue 6027
EDITORIAL LETTERS
283 The Young Academy Movement 305 Putting the Ocean Under Review
Bruce Alberts P. A. Bernal
Low-Dose Radiation Knowledge: Priceless
NEWS OF THE WEEK
M. H. Barcellos-Hoff et al.
288 A roundup of the week’s top stories The Risks and Benefi ts of Re-Consent
J. S. Forsberg et al.
NEWS & ANALYSIS
Response
291 Research Holds Up Well in S. B. Trinidad et al.
Final 2011 Agreement
>> Science Podcast 306 CORRECTIONS AND CLARIFICATIONS
292 Fukushima Radiation Creates Unique Test BOOKS ET AL.
of Marine Life’s Hardiness
307 A History of Communications page 298
293 Outlook Brightens for Plastic Solar Cells M. T. Poe, reviewed by C. Kelty
294 Chinese Neurosurgeons Quietly Push 308 Genetic Justice
for Easing of Brain Operation Ban
S. Krimsky and T. Simoncelli,
295 Tennessee House Bill Opens Door to reviewed by M. A. Goldman
Challenges to Evolution, Climate Change
296 A Sign of New Particles or POLICY FORUM
General Restlessness? 309 Genomics, Biobanks, and the
297 Frightening Risk of Marfan Syndrome, Trade-Secret Model
and Potential Treatment, Elucidated R. Mitchell et al.
>> Reports pp. 358 and 361
PERSPECTIVES
NEWS FOCUS 311 Photosynthesis, Reorganized
298 Uncertain Future for Tropical Ecology M. J. West-Eberhard et al.
300 Do Jumping Genes Spawn Diversity? 312 C ytonemes Show Their Colors
M. Affolter and K. Basler
302 Lunar and Planetary Science Conference >> Report p. 354
page 309
Asteroid Model Shows Early Life Suffered a
Billion-Year Battering 313 M ake It Quantum and Continuous
Prime Science Achieved at Asteroid P. Grangier
A Badly Battered Vesta Awaits Dawn’s Arrival >> Report p. 330
Snapshots From the Meeting 315 A nother Spin on Graphene
A. H. Castro Neto
>> Report p. 328
316 A Frontal Challenge for Climate Models
R. Ferrari
>> Research Article p. 318
CONTENTS continued >>
COVER DEPARTMENTS
Schematic representations of DNA nanostructures with complex 281 This Week in Science
curvatures including two-dimensional arrangements of concentric 284 Editors’ Choice
rings and three-dimensional shapes, including a nanofl ask 286 Science Staff
70 nanometers tall and 40 nanometers wide (DNA molecule 369 New Products
is not shown to scale). On page 342, Han et al. describe the 370 Science Careers
creation of these structures using a DNA origami folding
technique in which double-helical DNA is bent to follow the
rounded contours of the target object.
Image: Dongran Han and Hao Yan, The Biodesign Institute and
Department of Chemistry and Biochemistry, Arizona State University
www.sciencemag.org SCIENCE VOL 332 15 APRIL 2011 275
reserved.CopyrightsinandtothescientistsimageareduseonlytoThermoFisherScientificbyGettyImages.
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rili
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moFisherScientificInc.thirdpartyandlicensed
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Moving science forward
CONTENTS
RESEARCH ARTICLES 346 Phonemic Diversity Supports a Serial
Founder Effect Model of Language
318 E nhanced Turbulence and Energy
Expansion from Africa
Dissipation at Ocean Fronts
Q. D. Atkinson
E. D’Asaro et al.
Analysis of word sounds suggests that
Energy in surface ocean currents can dissipate
language originated once, in central
into deep water via enhanced turbulence at
and southern Africa.
the boundaries between water masses.
>> Perspective p. 316 349 I nterplay Between Changing Climate and
Species’ Ecology Drives Macroevolutionary
322 Structure of an Agonist-Bound
Dynamics
Human A Adenosine Receptor
2A T. H. G. Ezard et al.
F. Xu et al.
Fossil records show that speciation and
Changes associated with conformationally
extinction are infl uenced by interaction with
selective agonist binding shed light on
other species and with the environment.
G protein-–coupled receptor activation.
352 p H-Dependent Gating in a FocA
pages 315 & 328
REPORTS Formate Channel
W. Lü et al.
328 Giant Nonlocality Near the Dirac Point Transport of formate through a pentameric
in Graphene
channel is gated by pH-dependent
D. A. Abanin et al. conformational changes.
Unusual transport in graphene may be a
consequence of the propagation of long-range 354 Specifi city of Drosophila Cytonemes
for Distinct Signaling Pathways
charge-neutral currents.
>> Perspective p. 315 S. Roy et al.
Signaling protein receptors are segregated
330 Teleportation of Nonclassical into different cell protrusions in Drosophila
Wave Packets of Light cells.
N. Lee et al. >> Perspective p. 312
Teleportation is demonstrated with 358 Noncanonical TGFβ Signaling Contributes
bunches of photons.
to Aortic Aneurysm Progression in
>> Perspective p. 313 page 339
Marfan Syndrome Mice
333 Enhanced Enantioselectivity in Excitation T. M. Holm et al.
of Chiral Molecules by Superchiral Light
361 Angiotensin II Type 2 Receptor
Y. Tang and A. E. Cohen
Signaling Attenuates Aortic Aneurysm
Light waves tuned to rotate more sharply
than circularly polarized light can better in Mice Through ERK Antagonism
discriminate between chiral molecules. J. P. Habashi et al.
Transforming growth factor–β promotes aortic
336 D eterministic Preparation of a Tunable aneurysm formation through activation of its
Few-Fermion System
“noncanonical” signaling pathway.
F. Serwane et al. >> News story p. 297
Optical traps are used to prepare up to
10 cold lithium atoms to be used for 365 Sequential Synaptic Excitation and
simulating few-body fermionic systems. Inhibition Shape Readiness Discharge
for Voluntary Behavior
339 A Bicycle Can Be Self-Stable Without
K. Kagaya and M. Takahata
Gyroscopic or Caster Effects
In crayfi sh, specifi c neurons produce electrical
J. D. G. Kooijman et al.
activity in synchrony with different phases
A new bicycle design points to the importance
of the walking pattern.
of mass distribution for stability.
>> Science Podcast
CONTENTS continued >>
342 DNA Origami with Complex Curvatures
in Three-Dimensional Space
D. Han et al.
Rationally introduced crossover positions
bend networks of double-helical DNA strands
into complex shapes.
page 352
www.sciencemag.org SCIENCE VOL 332 15 APRIL 2011 277

CONTENTS
SCIENCE
ONLINE
SCIENCEXPRESS SCIENCESIGNALING
www.sciencexpress.org www.sciencesignaling.org
Nocturnality in Dinosaurs Inferred from The Signal Transduction Knowledge Environment
Scleral Ring and Orbit Morphology 12 April issue: http://scim.ag/ss041211
L. Schmitz and R. Motani RESEARCH ARTICLE: Estrogen Regulates Tumor
Comparison of eye structures between fossils Growth Through a Nonclassical Pathway that
and modern species suggests that Mesozoic Includes the Transcription Factors ERβ and KLF5
archosaurs were active day and night.
Y. Nakajima et al.
10.1126/science.1200043 PERSPECTIVE: Estrogen Receptor β—Switching to SCIENCESIGNALING
Industrial Melanism in British Peppered Moths Estrogen receptors in a prostate tumor.
a New Partner and Escaping from Estrogen
Has a Singular and Recent Mutational Origin
Y.-K. Leung and S.-M. Ho
A. E. van’t Hof et al. ERβ promotes apoptosis in prostate cancer cells
The locus responsible for the dark form through an estrogen-independent mechanism.
of the peppered moth is identifi ed. RESEARCH ARTICLE: IL-25 Causes Apoptosis
RESEARCH ARTICLE: PI3Kβ Plays a Critical Role
10.1126/science.1203043 of IL-25R–Expressing Breast Cancer Cells
in Neutrophil Activation by Immune Complexes
Chlorinated Indium Tin Oxide Electrodes Without Toxicity to Nonmalignant Cells
S. Kulkarni et al.
with High Work Function for Organic The β isoform of phosphoinositide 3-kinase may be an S. Furuta et al.
Mammary epithelial cells secrete an anticancer
Device Compatibility effective therapeutic target in infl ammatory diseases.
cytokine, suggesting a new therapeutic approach
M. G. Helander et al.
GLOSSARY for breast cancer.
Closer matching of the energy levels of
Find out what c-Yes, Lyn, and R-Smad mean in the
transparent electrodes and active materials in RESEARCH ARTICLE: Targeting Nrf2 Signaling
world of cell signaling.
organic light-emitting diodes improves effi ciency. Improves Bacterial Clearance by Alveolar
10.1126/science.1202992 SCIENCECAREERS Macrophages in Patients with COPD
Probing Asthenospheric Density, Temperature, and in a Mouse Model
www.sciencecareers.org/career_magazine
and Elastic Moduli Below the Western C. J. Harvey et al.
Free Career Resources for Scientists
Lung macrophages take up bacteria better
United States
Tooling Up: Two Choke Points after stimulation of the Nrf2 antioxidant
T. Ito and M. Simons
D. Jensen signaling pathway.
Monitoring the response to ocean tidal loads reveals
When moving away from the bench and into industry,
detailed variations in Earth’s internal structure.
it is important to realize that there is not just one SCIENCEPODCAST
10.1126/science.1202584
gaping chasm to cross, but two. www.sciencemag.org/multimedia/podcast
Ethical Framework for Biofuels http://scim.ag/chokepoints
Free Weekly Show
A. Buyx and J. Tait
A Very Visual Scientist On the 15 April Science Podcast: budgeting
10.1126/science.1206064
>> Science Podcast SN.i cWkeoblbay Hristov is building a career at the froe-re sxcpielonrcien,g a bni ceythcliec aslt afrbaimliteyw, oarnkd fmoro breio.fuels,
intersection of science and visual art.
SCIENCENOW http://scim.ag/hristov_visual SCIENCEINSIDER
N
Y, JAPA wHiwgwhl.isgchietsn cFeronmow O.ourrg D aily News Coverage Canodn tTernatn Csloaltlieocntiaol nR: eCsaeraerechrs in Clinical nSeciwens.csec iPeonlciceym Nagew.osr ga/nsdc iAenncaelyinsissider
RSIT Melting Antarctic Ice Causing Penguins Science Careers Staff
E
NIV to Starve Articles on clinical and translational science careers,
U U As global warming kills off ice-loving krill, produced with generous support from the Burroughs
OK penguins may be losing food supply. Wellcome Fund.
OH http://scim.ag/ice-penguins http://scim.ag/translational_collection
Y/T
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OLO A new study shows why the brains of older adults SCIENCETRANSLATIONAL MEDICINE SwCeIeEkN CinE D(IeScSeNm 0be0r3, 6b-8y 0t7h5e) Aism peuribclaisnh eAds swoceieaktliyo no nf oFrr itdhaey ,A edxvcaenpcte mtheen tl aostf
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ME PERSPECTIVE: Community Health Care— use provisions of the Copyright Act is granted by AAAS to libraries and other users
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www.sciencemag.org SCIENCE VOL 332 15 APRIL 2011 279
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