Schizophrenia: the final frontier: a festschrift for Robin M. Murray PDF
Preview Schizophrenia: the final frontier: a festschrift for Robin M. Murray
THE MAUDSLEY The Maudsley Series The Maudsley Series HENRY MAUDSLEY, from whom the series of monographs takes its name, was the founder of The Maudsley Hospital and the most prominent English psychiatrist of his generation. The Maudsley Hospital was united with the Bethlem Royal Hospital in 1948 and its medical school, renamed the Institute of Psychiatry at the same time, became a constituent part of the British Postgraduate Medical Federation. It is now a school of King’s College, London, and entrusted with the duty of advancing psychiatry by teaching and research. The South London & Maudsley NHS Trust, together with the Institute of Psychiatry, are jointly known as The Maudsley. The monograph series reports high quality empirical work on a single topic of relevance to mental health, carried out at the Maudsley. This can be by single or multiple authors. Some of the monographs are directly concerned with clinical problems; others, are in scientific fields of direct or indirect relevance to mental health and that are cultivated for the furtherance of psychiatry. Editor Professor A. S. David MPhil MSc FRCP MRCPsych MD Assistant Editor Professor T. Wykes BSc PhD MPhil Previous Editors 1955–1962 P rofessor Sir Aubrey Lewis LLD DSc MD FRCP and Professor G. W. Harris MA MD DSc FRS 1962–1966 Professor Sir Aubrey Lewis LLD DSc MD FRCP 1966–1970 Professor Sir Denis Hill MB FRCP FRCPsych DPM and Professor J. T. Eayrs PhD DSc 1970–1979 Professor Sir Denis Hill MB FRCP FRCPsych DPM and Professor G. S. Brindley 1979–1981 Professor G. S. Brindley MD FRCP FRS and Professor G. F. M. Russell MD FRCP FRC(ED) FRCPsych 1981–1983 Professor G. F. M. Russell MD FRCP FRCP(ED) FRCPsych 1983–1989 Professor G. F. M. Russell MD FRCP FRCP(ED) FRCPsych and Professor E. Marley MA MD DSc FRCP FRCPsych DPM 1989–1993 Professor G. F. M. Russell MD FRCP FRCP(ED) FRCPsych and Professor B. H. Anderton BSc PhD 1993–1999 Professor Sir David Goldberg MA DM MSc FRCP FRCPsych DPM The Maudsley Series Schizophrenia The Final Frontier — A Festschrift for Robin M. Murray Edited by Anthony S. David, Shitij Kapur and Peter McGuffin First published 2011 by Psychology Press 27 Church Road, Hove, East Sussex BN3 2FA Simultaneously published in the USA and Canada by Routledge 711 Third Avenue, New York, NY 10017 Psychology Press is an imprint of the Taylor & Francis Group, an Informa Business Copyright © 2011 Psychology Press All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Cataloguing-in-Publication Data Schizophrenia : the final frontier : a festschrift for Robin M. Murray / edited by Anthony S. David, Shitij Kapur, and Peter McGuffin. p. ; cm. -- (Maudsley series) Includes bibliographical references and index. ISBN 978-1-84872-077-0 (hbk) 1. Schizophrenia. I. David, Anthony S., editor. II. Kapur, Shitij, editor. III. McGuffin, Peter, editor. IV. Murray, Robin M., 1944- , honoree. V. Series: Maudsley series. [DNLM: 1. Murray, Robin M., 1944- 2. Schizophrenia—Festschrift. WM 203] RC514.S336445 2011 616.89’8–dc22 2010044157 ISBN: 978-1-84872-077-0 (hbk) ISBN: 978-0-203-80877-1 (ebk) Typeset in Times New Roman by RefineCatch Limited, Bungay, Suffolk Printed and bound in Great Britain by TJ International Ltd, Padstow, Cornwall Contents List of plates ix List of figures x List of tables xii List of contributors xiii Foreword by Daniel R. Weinberger xvii Preface xxi Acknowledgements xxiii PART I Development 1 1 The neurodevelopmental hypothesis of schizophrenia 3 KATHERINE H. KARLSGODT, LAUREN M. ELLMAN, DAQIANG SUN, VIJAY MITTAL AND TYRONE D. CANNON 2 Is earlier intervention for schizophrenia possible? Identifying antecedents of schizophrenia in children aged 9–12 years 19 KRISTIN R. LAURENS, SHEILAGH HODGINS, ERIC A. TAYLOR AND ROBIN M. MURRAY 3 The black hole of the adolescent brain 33 MATT ALLIN AND CHIARA NOSARTI 4 The contribution of Nordic population registers to the search for the causes of schizophrenia and other psychiatric disorders 45 PETER B. JONES, MATTI ISOHANNI, JAANA SUVISAARI, JARI HAUKKA AND JOUKO MIETTUNEN PART II Neuroscience 69 5 The search for madness: A metaphasical trip through the basal ganglia 71 PAUL D. MORRISON vi Contents 6 Neurophysiological endophenotypes for psychosis 87 MADIHA SHAIKH AND ELVIRA BRAMON 7 Glutamate and GABA transmitter systems: Post-mortem studies and the neuropathology of amino acids in schizophrenia 103 PAUL J. HARRISON 8 Animal models of schizophrenia revisited 115 TREVOR W. ROBBINS PART III Neuroimaging 129 9 Application of neuroimaging to the study of psychosis 131 PHILIP MCGUIRE 10 Brain networks and schizophrenia 139 ED BULLMORE 11 Neuroimaging and psychosis: Are brain changes in individuals with psychosis neurodevelopmental for some and progressive for others? 147 PAOLA DAZZAN, KEVIN MORGAN, JULIA LAPPIN AND PAUL FEARON 12 Gray matter alterations in schizophrenia: Are they reversible? 155 MATCHERI S. KESHAVAN AND TEJAS BHOJRAJ PART IV Genetics 177 13 A short (and partial) history of genetics at the Institute of Psychiatry 179 PETER MCGUFFIN 14 From first contact to the final frontier: A star trek along the DISC1 pathway to schizophrenia 193 DAVID PORTEOUS 15 Dopamine gene variants and schizophrenia: A scheme for investigating nominally significant or discrepant associations 205 VISHWAJIT L. NIMGAONKAR, KODAVALI V. CHOWDARI, KONASALE M. PRASAD, ANNIE M. WATSON, HADER MANSOUR, JOEL A. WOOD AND A. JAVIER LOPEZ 16 Ebb and flow in biological psychiatry 219 TIM J. CROW Contents vii PART V Cognition 233 17 Cognitive models of psychosis, the jumping to conclusions reasoning bias and improving psychological treatment for delusions 235 PHILIPPA GARETY, DANIEL FREEMAN, SUZANNE JOLLEY, KERRY ROSS, HELEN WALLER AND GRAHAM DUNN 18 Giftedness and psychosis 247 JAMES H. MACCABE PART VI Social psychiatry 257 19 Towards a social aetiology of psychosis: The case of child sexual abuse 259 PAUL BEBBINGTON 20 Does urban density matter? 273 JANE BOYDELL AND JUDITH ALLARDYCE 21 Does higher potency cannabis mean higher risk for psychosis? 281 MARTA DI FORTI, ALESSANDRA PAPARELLI AND PAOLA CASADIO 22 The social determinants of psychosis in migrant and minority ethnic populations 289 CRAIG MORGAN, GERARD HUTCHINSON, PAOLA DAZZAN, KEVIN MORGAN AND PAUL FEARON 23 Stress and psychosis: Professor Murray’s contribution (so far) to the vulnerability–stress model 303 VALERIA MONDELLI AND CARMINE M. PARIANTE 24 Chasing gene–environment interactions across the psychiatric universe 313 JIM VAN OS, BART P. F. RUTTEN, RUUD VAN WINKEL AND MARIEKE WICHERS PART VII Treatment 325 25 How antipsychotics work: Examining trans-synaptic realities 327 SRIDHAR NATESAN AND SHITIJ KAPUR 26 Metabolic disturbance and schizophrenia 343 EMMA NICHOLSON AND DAVID J. CASTLE viii Contents 27 Clinical trials and schizophrenia 357 SHÔN LEWIS 28 What new evidence tells us about dopamine’s role in schizophrenia 365 OLIVER D. HOWES PART VIII Afterword 373 29 Robin M. Murray: A biographical note 375 ANTHONY S. DAVID 30 Robin M. Murray: Top 12 publications 381 ANTHONY S. DAVID AND ROBIN M. MURRAY Index 385 Plates Colour section between pages 32 and 38 3.1 Decreased and increased grey matter and white matter volume in VPT adolescents compared to controls 3.2 Increased and decreased regional brain activation in preterm-born young adults compared to controls 9.1 Acute induction of psychotic symptoms by tetrahydrocannabidiol 9.2 Altered hippocampal function in subjects with prodromal signs of psychosis 9.3 Neurochemical dysfunction in subjects with prodromal signs of psychosis 9.4 Correlation between subcortical dopamine dysfunction and altered cortical activation in subjects with prodromal symptoms of psychosis 9.5 Brain areas in subjects with prodromal symptoms where grey matter volume was related to thalamic glutamate levels 10.1 Disease-related disorganization of brain anatomical networks derived from structural MRI data 10.2 Developmental antecedents of adult human brain structure 11.1 Brain changes in subjects on (A) typical and (B) atypical antipsychotics versus drug-free subjects
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