Table Of Content

Contents Volume 40, No. 1, July 1994 Immunodeficiency Virus Type-1 Infected Patients. M. C. Sirianni, I. J. Ansotegui, F. Aiuti & H. Wigzell Prolonged In Vivo IL-4 Treatment Inhibits Antigen- Abstracts of Papers Presented at the XXIVth Meeting Specific IgG, and IgE Formation. R. van Ommen, of the Scandinavian Society for Immunology and the A. E. C. M. Vredendaal & H. F. J. Savelkoul IXth Summer School Inhibition of Spontaneous and Mitogen-Induced Lym- Errata phocyte Proliferation by Murine Bone Marrow- Derived Macrophages: Role of Prostaglandins, Nitric Oxides and Cell-to-Cell Contact. G. Zwadlo-Klarwasser, Volume 40, No. 2, August 1994 S. Platen & W. Schmutzler Affinity Maturation and Isotype Switch in Clonally Scandinavian Society for Immunology—25 years. Per Related Anti-Erythrocyte Autoantibodies. B. B. Scott, Brandtzaeg, Géran Moller & Jacob B. Natvig S. Sadigh, E. M. Andrew, R. N. Maini & R. A. Mageed REVIEW. Immunoregulatory Effects of Cytokines on Anti-CD45 Augments Response of the T;,2 Clone to TCR Natural Killer Cells. B. Naume & T. Espevik Cross-Linking. H. Wolff& C. Janeway Jr The Binding of Synovial Tissue-Derived Human Mono- Cytokine Dependence of Human to Mouse clonal Immunoglobulin M Rheumatoid Factor to Graft-versus-Host Disease. W. Huppes, H. Fickenscher, Immunoglobulin G Preparations of Differing Galac- B. A. ’tHart & B. Fleckenstein tose Content. A. J. Soltys, F. C. Hay, A. Bond, Intravenous Immunoglobulins Suppress Immunoglobulin J. S. Axford, M. G. Jones, I. Randen, K. M. Thompson Productions by Suppressing Ca?*-Dependent Signal & J. B. Natvig Transduction Through Fcy Receptors in B Lympho- A RadLV-Induced 76 T Cell Lymphoma Displaying an cytes. N. Kondo, K. Kasahara, T. Kameyama, Y. Suzuki, Antitumoral Cytotoxicity. M.-T. Martin-Simonet, N. Shimozawa, S. Tomatsu, Y. Nakashima, T. Hori, V. Marini, PP. Ricciardi-Castagnoli, T. Astier-Gin, A. Yamagishi, T. Ogawa, H. Iwata, Y. Takahashi, R. Greimers, J. Boniver & N. Schaff-Lafontaine R. Takenaka, K. Watanabe, M. Haga & T. Orii Responses of Human T Cells to Dominant Discrete The Cross-Reactive Idiotopes Recognized by the Mono- Protein Antigens of Escherichia coli and Pseudomonas clonal Antibodies 9G4 and LC1 are Located in Frame- aeruginosa. C. M. Kersten, R. T. McCluskey, H. Shaw work Region | of Two Non-Overlapping Subsets of Warren & J. T. Kurnick Human V};4 Family Encoded Antibodies. K. N. Potter, Partial Amino Acid Sequence of a Novel Protozoan Y. C. Li & J. D. Capra Parasite Antigen that Inhibits Non-Specific Cytotoxic Evolutionary Conservation of a Human Function-Asso- Cell Activity. J. H. Leary III, D. L. Evans & L. Jaso- ciated Molecule on Murine Natural Killer Cells: Expres- Friedmann sion and Function. R. Kapur, D. L. Evans & D. T. Harris Cloning, Sequencing and Expression in Escherichia coli of IFN-y Inhibits Internalization of Soluble Aminated (-1,3- the Gene for a Antigen from Mycobacterium scrofula- D-Glucan by Macrophages and Thereby Down-Regu- ceum. M. Takano, N. Ohara, A. Mizuno & T. Yamada lates the Glucan Induced Release of TNF-a and IL-1/. Comparative Analysis of the Antibody Response to the Z. Konopski, R. Seljelid & T. Eskeland HTLV-I gag and env Proteins in HTLV-I Asympto- Real-Time Biospecific Interaction Analysis of a Natural matic Carriers and HAM/TSP Patients: an Isotype and Human Polyreactive Monoclonal IgM Antibody and Subclass Analysis. G. A. Dekaban, E. E. King, J. Arp, its Fab and scFv Fragments with Several Antigens. T. J. Palker & G. P. A. Rice D. Roggenbuck, H. Konig, B. Niemann, G. Schoenherr, Interleukin-6 and Interleukin-6 Receptor are Expressed by S. Jahn & T. Porstmann Cultured Glomerular Epithelial Cells. A. Moutabarrik, Cloning and Expression of the Cervine Interleukin 4 Gene. I. Nakanishi & M. Ishibashi S. M. Hook, A. M. Crawford, D. N. Chinn, J. F. T. Griffin Bacteriostatic Activity of BCG/PPD-Activated Macro- & G. S. Buchan phages Against Mycobacterium fortuitum Does Not Autoantibodies Against Ganglioside GM3 Represent a Involve Reactive Nitrogen or Oxygen Intermediates. Portion of Anti-Lymphocyte Antibodies in AIDS P. H. Nibbering, S.-I. Yoshida, M. T. van den Barselaar Patients. JT. Griggi, R. Bauer, T. Garofalo, S. Kukel, & R. van Furth L. Lenti, A. P. Massetti, C. Miiller, M. Sorice & Familial Macroglobulinaemia: Hyperactive B-Cells but G. M. Pontieri Normal Natural Killer Function. H. M. Ogsmundsdot- Natural Killer Cell Stimulatory Factor (NKSF)/IL-12 and tir, G. M. Johannesson, S. Sveinsdottir, S. Einarsdottir, Cytolytic Activities of PBL/NK Cells from Human A. Hegeman & O. Jensson iv Contents Cyclic AMP Sensitive Signalling by the CD28 Marker Sustained and Distinctive Patterns of Gene Activation in Requires Concomitant Stimulation by the T-Cell Anti- Synovial Fibroblasts and Whole Synovial Tissue gen Receptor (TCR/CD3) Complex. B. S. Skalhegg, Obtained from Inflammatory Synovitis. C. Ritchlin, A. M. Rasmussen, K. Taskén, V. Hansson, T. Jahnsen E. Dwyer, R. Bucala & R. Winchester & T. Lea The Role of B Lymphocytes in Experimental Herpes 76 and aG T Cells are Equally Susceptible to Apoptosis. Simplex Viral Retinitis. V. Arrunategui-Correa, J. Dutt T. P. Arstila, P. Toivanen, O. Vainio & O. Lassila & C. S. Foster Anti-Idiotypic B Lymphocytes in Patients with Monoclo- Inhibitory Activity of Soluble IL-2R in Sera, Ascites and nal Gammopathies. S. Bergenbrant, Q. Yi, E. Osby, Culture Supernatants from Murine Leukaemic Cells. A. Osterborg, R. Ostman, M. Bjérkholm, G. Holm & C. Waldner, C. Mongini, E. Alvarez, I. Roig & S. E. Hajos A. K. Lefvert Circulating Myeloperoxidase May Cause False Negative Lipopolysaccharide-stimulated events in B Cell Activa- Findings in the Analysis of Myeloperoxidase Antibodies tion. H. Hu & G. Moller in Systemic Vasculitis. A.-M. Haapala, E. Soppi & H. Hyéty Interactions of Opsonized Immune Complexes with Whole Blood Cells: Binding to Erythrocytes Restricts Complex A Highly Conserved Phenylalanine in the a,3-T Cell Uptake by Leucocyte Populations. C. H. Nielsen, S.-E. Receptor (TCR) Constant Region Determines the Svehag, H. V. Marquart & Integrity of TCR/CD3 Complexes. S. Caspar-Bauguil, R. G. Q. Leslie J. Arnaud, A. Huchenqg, W. R. Hein, C. Geisler & B. Rubin Fcy-Receptor Activity of Placental Annexin II. E. K. Kristoffersen, E. Ulvestad, L. Bjorge, A. Aarli & R. Matre Serum Amyloid A Protein in Mink During Endotoxin- Induced Inflammation and Amyloidogenesis. C. Foyn- Short-Term Kinetics of the Humoral Anti-Clq Response Bruun, M. Rygg, K. Nordstoga, K. Sletten & G. Marhaug in SLE Using the ELISPOT Method: Fast Decline in Production in Response to Steroids. J. Rénnelid, Characterization of Purified Protein Derivative of Tuber- Y. H. Huang, T. Norrlander. S. Rogberg, B. Nilsson, culin by Use of Monoclonal Antibodies: Isolation of a R. Gustafsson & L. Klareskog Delayed-Type Hypersensitivity Reactive Component from M. tuberculosis Culture Filtrate. J. Klausen, The Importance of Glm and 2 Allotypes for the IgG2 M. Magnusson, A. Bengard Andersen & C. Koch Antibody Levels and Avidity Against Pneumococcal Polysaccharide Type 1 Within Mono- and Dizygotic SHORT PAPER. A Human Rheumatoid Factor C304 Twin-Pairs. H. B. Konradsen, V.-A. Oxelius, M. Hahn- Shares Vy and V, Gene Usage with Antibodies Specific Zoric & L. A. Hanson for Ubiquitous Human Viral Pathogens. J. D. Rioux, Antibodies Directed Against Monomorphic and Evolu- J. Rauch, L. Silvestri & M. M. Newkirk tionary Conserved Self Epitopes may be Generated in SHORT PAPER. Resistance to Secondary Amyloidosis in ‘Knock-Out’ Mice. Development of Monoclonal Anti- A/J Mice is Not Significantly Associated with Allelic bodies Directed Against Monomorphic MHC Class I Variants Linked to the Serum Amyloid A Gene Cluster. Determinants. M. H. Claesson, B. Endel, J. Ulrik, L. @. A. Butler & A. S. Whitehead Pedersen, S. Skov & S. Buus SHORT PAPER. Activation of the Classical Pathway The Fifth Serum Amyloid A-Related Gene Sequence, of Complement by Non-Immune Complexes of GSAA4, is SAS3. G. Watson, D. J. Faulkes & P. Woo Immunoglobulins with Human Protein Fv (Fv Fragment-Binding Protein). E. Ruffet, R. Pires, SHORT PAPER. T Cell Receptor Va Gene Usage in Human T Cells Stimulated with SEE and SED. J. L. J. Pillot & J.-P. Bouvet Liu, V. L. Hodara & H. Wigzell SHORT PAPER. Vé61* Gamma/Delta T Lymphocytes Infiltrating Human Lung Cancer Express the CD8a/a A Short Account of the History of the Scandinavian Society for Immunology. J. V. Sparck Homodimer. M. Ferrarini, S. Heltai, G. Chiesa & M. G. Sabbadini SHORT PAPER. Evolutionarily Conserved Function of CD28 in a T Cell Activation. T. P. Arstila, O. Vainio & Volume 40, No. 3, September 1994 O. Lassila Lymphocyte Transformation Test in Adult Patients with Minimal Change Nephrotic Syndrome. Y. H. M. Al-Azzawi, N. G. Al-Tawil & I. A. Al-Shamaa Volume 40, No. 4, October 1994 The Intersubunit Region of the Influenza Virus Haemag- glutinin is Recognized by Antibodies During Infection. The Role of CD4* T Cells in Cell-Mediated Immunity Z. Nagy, E. Rajnavélgyi, M. Hollési, G. K. Toth, to LCMV: Studies in MHC Class I and Class II G. Varadi, B. Penke, I. Toth, A. Horvath, J. Gergely & Deficient Mice. J. P. Christensen, O. Marker & A. R. I. Kurucz Thomsen 373 Contents Vv Non-Coordinated Biosynthesis of Early Complement Secondary IgE Responses Jn Vivo are Predominantly Components in a Deficiency of Complement Proteins Generated Via +,¢-Double Positive B Cells. R. Van Clr and Cls. A. Chevailler, C. Drouet, D. Ponard, Ommen, A. E. C. M. Vredendaal & C. Alibeu, S. Suraniti, F. Carrére, G. Renier, D. Hurez H. F. J. Savelkoul & M. G. Colombi Measurement of Allergen-Specific IgD and Correlation Production and Characterization of Monoclonal Anti- with Allergen-Specific IgE. M. Zhang, J. Niehus, bodies Against the Major Cysteine Proteinase of T. Brunnee, J. Kleine-Tebbe, A. O’Connor & G. Kunkel Trypanosoma cruzi. G. Gonzalez, A. Orn, J. J. Cazzulo The Antibody MY4 Recognizes CD14 on Porcine Mono- & K.-O. Grénvik cytes and Macrophages. H. W. L. Ziegler-Heitbrock, Differential Role of Protein Kinase C in Cytokine Induced B. Appl, E. Kafferlein, T. Léffler, H. Jahn-Henninger, Lymphocyte-Endothelium Interaction Jn Vitro. G. Eissner, W. Gutensohn, J. R. Nores, K. McCullough, B. Passlick, W. Koélch, H. Mischak, G. W. Bornkamm & E. Holler M. O. Labeta & J. Izbicki Interleukin-10 Inhibits Antimicrobial Activity Against Activation of Protein Kinase C Induces De Novo Synthesis Leishmania major in Murine Macrophages. M. Vieth, of the Soluble Interleukin-6 Receptor in Human A. Will, K. Schréppel, M. Roéllinghoff& A. Gessner B Cells. D. Kérholz, P. Nussbaum, B. Pafferath, C. Mauz-Korholz, L. Hempel & S. Burdach Analysis of the Capacity to Produce IL-3 in Murine AIDS. A. U. Neuenschwander, O. Marker & A. R. Thomsen An In Vitro Model for the Expansion of V7962 T Lympho- Molecular Characterization of Immunoglobulin Variable cytes During Development. M. Wilhelm & H.-P. Tony Regions from Murine Monoclonal Antibodies Specific Human Th0-Type T Helper-Cell Clone Supports Antigen- for Simian Virus 40 Large Tumour Antigen. M. H. Specific Immunoglobulin Production in Shearer, R. K. Bright & R. C. Kennedy Scid/beige-hu Mice. L.-T. Chin, P. Ifversen, K. Kristens- son, B. Wahren, R. Carlsson & C. A. K. Borrebaeck Differences within Mono- and Dizygotic Twin-Pairs in Spectrotypes and Clones of IgG2 Antibodies . Immunostimulatory Effect of Thalidomide in Normal to Pneumococcal Polysaccharide Type | and C-Poly- CS57BL/6 Mice is Compatible with Stimulation of a saccharide After Vaccination. H. B. Konradsen, Highly Connected Central Immune System. M. Arala- M. Hahn-Zoric, A. T. Nagao & L. A. Hanson Chaves, M. Vilanova, A. Ribeiro & J. Pinto Interleukin-4 Induces /n Vitro Migration in Naive B Cells II. The Effects of Thalidomide Treatment on Autoim- Through Direct Mechanisms. B. Clinchy & G. Moller mune-Prone NZB and MRL Mice are Consistent with Stimulation of the Central Immune System. Expression of CD43 Epitopes on NK and T Cells. S. Hoyseter, W. Jensen & S. Fossum M. Vilanova, A. Ribeiro, J. Carneiro & M. Arala-Chaves The Effects of Thymopentin on the Development of SLE- Rheumatoid-Factor-Reactive Sites on CH, Established by Analysis of Overlapping Peptides of Primary Sequence. Like Syndrome in the MRL/Ipr-lpr Mouse. F. Nicoletti, P. Zaccone, G. Magro, W. Barcellini, V. Cavallaro, R. C. Williams, Jr & C. C. Malone G. Belli, C. Cocuzza, R. Di Marco & P. L. Meroni Catabolism of the Murine IgGl Molecule: Evidence that GD2 Ganglioside-Specific Monoclonal Antibody Reacts Both CH2-CH3 Domain Interfaces are Required with Murine Cytotoxic T Lymphocytes Reactive with for Persistence of IgGl in the Circulation of Mice. FBL-3N Erythroleukaemia. S. Yoshimura, K. Taka- J.-K. Kim, M.-F. Tsen, V. Ghetie & E. S. Ward miya, I. Kato, E. Nakayama, H. Shiku & D. Furukawa Letters to the Editor Identification of the Site of Uptake of the E. coli Heat- Erratum Labile Enterotoxin, LTB. J. Lindner, A. F. Geczy & G. J. Russell-Jones Volume 40, No. 5, November 1994 Volume 40, No. 6, December 1994 Kinetics of Somatic Mutation in Lymph Node Germinal Centres. E.Kdllberg, D. Gray & T. Leanderson OBITUARY. Niels Jerne Correlations of Monocyte Phagocytic Receptor Expres- EDITORIAL. Twenty-Five Years of Germinal Centre sions with Serum Immune Complex Level in Systemic Physiology: Implications for Tolerance in the Second- Lupus Erythematosus. G. Sztics, M. Kavai, P. Suranyi, ary B Cell Repertoire. G. J. V. Nossal E. Kiss, I. Csip6 & G. Szegedi Expression of CD28 on CD8* and CD4* Lymphocytes EDITORIAL. The Integrative Activity of the Immune System. M. C. Brunner, N. A. Mitchison & S. C. Schneider During HIV Infection. A. Caruso, A. Cantalamessa, S. Licenziati, L. Peroni, E. Prati, F. Martinelli, A. D. Identical Vjz;D and DJ, Junctions in Monoclonal Anti- Canaris, S. Folghera, R. Gorla, A. Balsari, R. Cattaneo bodies Derived in Response to Dextran B512 Could be & A. Turano the Result of Developmental Selection. C. Fernandez vi Contents Characterization of T-Cell Receptor VG Repertoire in Direct Evidence for SAA Deposition in Tissues During Ovarian Tumour-Reacting CD3°CD8"CD4 CTL Murine Amyloidogenesis. S. Yakar, B. Kaplan, A. Lines. B. Fisk, C. N. Flytzanes, M. S. Pollack, J. T. Livneh, B. Martin, K. Miura, Z. Ali-Khan, S. Shtrasburg Wharton & C. G. Ioannides & M. Pras Immunological Abnormalities in Patients with Chronic Non-Diabetogenic Insulitis in NOD-B10.GD Allophenic Fatigue Syndrome. U. Tirelli, G. Marotta, S. Improta & Mice in Spite of Permissive Class I MHC Antigens. A. Pinto F. Colucci, U. Dahl, L. O'Reilly, A. Cooke, P. Chandler, E. Simpson & T. Matsunaga The Influence of Branched Polypeptide Carriers on the Immunogenicity of Predicted Epitopes of HSV-1 Gly- Structural Specificity of MHC-Unrestricted Recognition coprotein D. A. Hilbert, F. Hudecz, G. Mezé, I. Mucsi, J. of HCMV-Infected Target Cells by Human CD56" NK Kajtar, I. Kurucz, J. Gergely & E. Rajnavolgyi and LAK Cells. M. Steinmassl & F. A. Anderer IgG Subclass-Associated Differences in Anti-Schistosomal Characterization of a Functional Null Cell Line Derived Antibody Specificity. B. Evengard, I. Wolowczuk, M. from (NZBxNZW) FI Mice. T. Iwasaki, T. Hamano, Marguerite, L. Hammarstrom, E. Smith & C. Auriault K. Aizawa, K. Kobayashi & E. Kakishita T Cells from Children with IDDM are Sensitized to Effects of Human Calprotectin (L1) on In Vitro Immuno- Bovine Serum Albumin. R. Cheung, J. Karjalainen, globulin Synthesis. J. G. Brun, E. Ulvestad, M. K. J. Vandermeulen, D. P. Singal & H.-M. Dosch Fagerhol & R. Jonsson T,1-Like Human T-Cell Clones Recognizing Leishmania Three New Cross-Reacting Idiotopes as Markers for the gp63 Inhibit Leishmania major in Human Macrophages. Products of Two Distinct Human V},;3 Genes Expressed M. Kemp, A. S. Hey, K. Bendtzen, A. Kharazmi & in the Early Repertoire. S. Suleyman, K. M. Thompson, T. G. Theander M. Sioud, I. Randen, R. A. Mageed, J. B. Natvig & The Expression of Carbohydrate Antigens in Activated Q. Forre T Cells and in Autoimmune Diseases. F. Fortune, Abstracts from the XX Vth Meeting of the Scandinavian J. Walker, M. Lefrancois & T. Lehner Society for Immunology and the Xth Summer School Reykjavik, Iceland, 13-17 August, 1994 IgG Humoral Response Against the Antigen 85 Complex Homologues in Leprosy. A. Drowart, K. Huygen, Referees P. Launois, E. Jann, J. Nyabenda & J. P. Van Vooren Author Index Role of the Bowel Flora for Development of Immunity to hsp 65 and Arthritis in Three Experimental Models. J. Bjork, S. Kleinau, T. Midtvedt, L. Klareskog & G. Smedegard