S1- alphabetical list of aging-related genes

176 Pages·2009·1.42 MB·English

Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
AARSL alanyl-tRNA synthetase like 672 +/- 50 780 +/- 24 666 +/- 26 777 +/- 38 -0.959643 0.0904189 0.04684 0.0097575 0.0922137
AASDH 2-aminoadipic 6-semialdehyde dehydrogenase 587 +/- 19 771 +/- 21 501 +/- 29 664 +/- 26 -6.83E-05 8.644E-05 0.002318 0.0046175 0.0347906
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 437 +/- 47 523 +/- 31 335 +/- 10 398 +/- 11 -0.001844 0.1582204 0.002045 0.1826101 0.0544598
ABHD14A abhydrolase domain containing 14A 1760 +/- 56 1515 +/- 91 1973 +/- 103 1818 +/- 29 0.010547 -0.048824 -0.200935 0.0371071 0.3262792
ABP1 Amiloride binding protein 1 (amine oxidase (copper-containing)) 105 +/- 10 165 +/- 23 154 +/- 17 181 +/- 18 0.021482 0.0527017 0.302632 5.18E-05 0.0770133
ABTB2 Ankyrin repeat and BTB (POZ) domain containing 2 654 +/- 122 485 +/- 39 505 +/- 32 342 +/- 18 -0.030184 -0.236531 -0.002265 0.5021444 0.0832426
ACAA2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 589 +/- 56 854 +/- 62 529 +/- 31 645 +/- 33 -0.03897 0.0097889 0.030153 0.000594 0.1078687
ACACB acetyl-Coenzyme A carboxylase beta 124 +/- 17 175 +/- 13 138 +/- 12 164 +/- 12 0.943167 0.0376355 0.152219 0.0293754 0.3358733
ACADL acyl-Coenzyme A dehydrogenase, long chain 234 +/- 12 184 +/- 12 226 +/- 9 179 +/- 19 -0.359297 -0.013599 -0.065477 0.0959391 0.0845069
ACAT1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 4099 +/- 188 3515 +/- 106 3250 +/- 137 3238 +/- 137 -0.007467 -0.027046 -0.954273 0.1128106 0.9705821
ACCN1 amiloride-sensitive cation channel 1, neuronal (degenerin) 1925 +/- 136 1421 +/- 164 1179 +/- 59 900 +/- 42 -0.000254 -0.040656 -0.004392 0.0273253 0.0121481
ACIN1 apoptotic chromatin condensation inducer 1 1859 +/- 171 1790 +/- 102 2092 +/- 94 1822 +/- 45 0.172929 -0.735092 -0.03529 0.8562892 0.0993413
ACO1 aconitase 1, soluble 964 +/- 82 811 +/- 43 950 +/- 45 803 +/- 46 -0.754764 -0.139533 -0.048938 0.1183283 0.0289747
ACOT9 acyl-CoA thioesterase 9 370 +/- 33 344 +/- 40 284 +/- 9 218 +/- 20 -0.001741 -0.63831 -0.024981 0.6715461 0.2839666
ACP1 acid phosphatase 1, soluble 2644 +/- 165 2074 +/- 157 2357 +/- 91 2031 +/- 147 -0.085298 -0.031306 -0.10182 0.009087 0.0106821
ACP6 acid phosphatase 6, lysophosphatidic 881 +/- 49 984 +/- 51 742 +/- 28 837 +/- 8 -0.002935 0.171551 0.018151 0.0355159 0.0710112
ACSS1 acyl-CoA synthetase short-chain family member 1 229 +/- 21 311 +/- 28 196 +/- 16 228 +/- 23 -0.013777 0.0442198 0.295382 0.092173 0.4151929
ACTC actin, alpha, cardiac muscle 84 +/- 15 206 +/- 35 98 +/- 11 212 +/- 35 0.021907 0.0155645 0.029736 0.0980108 0.1657953
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 6172 +/- 108 6822 +/- 248 6301 +/- 210 7510 +/- 229 0.046595 0.0483003 0.003988 0.5901922 0.0845271
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 3191 +/- 134 2571 +/- 136 2763 +/- 211 2529 +/- 81 -0.241727 -0.008683 -0.339256 0.0015617 0.5937013
ACVR1B activin A receptor, type IB 1767 +/- 140 1532 +/- 52 1675 +/- 66 1338 +/- 98 -0.117997 -0.163381 -0.023761 0.2017275 0.249096
ACY1 aminoacylase 1 493 +/- 28 523 +/- 20 435 +/- 30 520 +/- 22 -0.072713 0.3972113 0.048724 0.6064414 0.155183
ACY1L2 aminoacylase 1-like 2 224 +/- 39 230 +/- 24 450 +/- 41 321 +/- 40 0.001236 0.8951819 -0.050237 0.5937618 0.3209364
ADA adenosine deaminase 265 +/- 19 352 +/- 29 341 +/- 51 373 +/- 25 0.130605 0.0331452 0.593305 0.0330362 0.5864965
ADAM10 ADAM metallopeptidase domain 10 1557 +/- 99 1808 +/- 84 1420 +/- 70 1612 +/- 46 -0.053577 0.0837127 0.049117 0.0627916 0.3649355
ADAM15 ADAM metallopeptidase domain 15 (metargidin) 1022 +/- 24 1299 +/- 94 1046 +/- 106 1001 +/- 50 -0.089311 0.0308546 -0.711056 0.1417549 0.7624836
ADCK4 aarF domain containing kinase 4 430 +/- 24 546 +/- 40 383 +/- 31 503 +/- 38 -0.139029 0.0374119 0.039519 0.2730918 0.306371
ADD1 adducin 1 (alpha) 4262 +/- 135 3716 +/- 140 3921 +/- 116 3527 +/- 163 -0.000231 -0.018613 -0.086088 0.0313122 0.2337141
ADD3 adducin 3 (gamma) 2311 +/- 330 3058 +/- 364 3069 +/- 265 3733 +/- 91 0.020001 0.1598374 0.054267 0.1569602 0.2721863
ADI1 acireductone dioxygenase 1 841 +/- 61 1306 +/- 144 924 +/- 99 1052 +/- 80 -0.633769 0.0213659 0.342331 0.0411467 0.8502112
ADPRH ADP-ribosylarginine hydrolase 189 +/- 23 309 +/- 20 168 +/- 16 281 +/- 20 -0.015382 0.0030101 0.00234 0.0028139 0.0090525
AFF3 AF4/FMR2 family, member 3 128 +/- 17 237 +/- 14 224 +/- 20 358 +/- 44 0.000454 0.0007359 0.034613 0.0013776 0.0003071
AFTIPHILINaftiphilin protein 689 +/- 9 552 +/- 54 739 +/- 50 699 +/- 28 0.034714 -0.050685 -0.502967 0.1353892 0.6185892
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 124 +/- 10 226 +/- 20 169 +/- 8 232 +/- 26 0.32873 0.0024393 0.066576 0.0077687 0.0848176
AGXT2L1 alanine-glyoxylate aminotransferase 2-like 1 3918 +/- 414 5586 +/- 247 3574 +/- 289 4607 +/- 398 -0.017396 0.0082839 0.070131 0.0534143 0.1478785
AHCYL1 S-adenosylhomocysteine hydrolase-like 1 5935 +/- 600 7815 +/- 704 6059 +/- 511 8209 +/- 330 0.89046 0.0702645 0.007299 0.178801 0.1949046
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 3672 +/- 96 3351 +/- 98 3165 +/- 122 3121 +/- 103 -0.010338 -0.04181 -0.788981 0.0745863 0.7081707
AIM1 absent in melanoma 1 368 +/- 97 238 +/- 44 114 +/- 15 175 +/- 22 -0.04556 -0.265509 0.050898 0.4169037 0.3555645
AKAP2 A kinase (PRKA) anchor protein 2 119 +/- 16 187 +/- 25 136 +/- 11 180 +/- 30 0.449089 0.048877 0.230583 0.1043416 0.7033942
AKAP8L A kinase (PRKA) anchor protein 8-like 115 +/- 15 71 +/- 9 120 +/- 16 99 +/- 3 0.145062 -0.038473 -0.237324 0.0940107 0.464845
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 1175 +/- 77 1379 +/- 69 853 +/- 46 1153 +/- 50 -0.000463 0.0781494 0.001841 0.3070654 0.0892846
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 722 +/- 43 917 +/- 15 718 +/- 9 959 +/- 30 0.634132 0.0049548 0.000763 0.0088467 0.0075985
AKT3 V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 4120 +/- 100 3342 +/- 250 3311 +/- 184 3045 +/- 90 -0.019216 -0.025143 -0.234272 0.0121962 0.4146659
ALDH3A1 aldehyde dehydrogenase 3 family, memberA1 99 +/- 11 267 +/- 57 115 +/- 22 357 +/- 54 0.192629 0.0317146 0.008136 0.1405832 0.1298736
S1- alphabetical list of aging-related genes.xls Page 1
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 147 +/- 9 263 +/- 37 91 +/- 15 124 +/- 5 -0.002691 0.024391 0.084644 0.0284083 0.1508073
ALG5 asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosylt 601 +/- 24 662 +/- 22 529 +/- 14 623 +/- 25 -0.004397 0.089144 0.015616 0.0442575 0.0523303
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 473 +/- 41 658 +/- 40 571 +/- 39 657 +/- 38 0.100357 0.009148 0.144295 0.026047 0.1802512
ALS2CR7 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 167 +/- 14 134 +/- 8 171 +/- 14 126 +/- 13 -0.89375 -0.070817 -0.048406 0.0693331 0.0090109
AMY1A amylase, alpha 1A; salivary 217 +/- 46 706 +/- 123 210 +/- 34 692 +/- 108 -0.311506 0.0086487 0.008796 0.20853 0.1553613
ANAPC1 anaphase promoting complex subunit 1 942 +/- 48 810 +/- 32 776 +/- 30 736 +/- 25 -0.002459 -0.048252 -0.328608 0.0962622 0.410849
ANAPC10 anaphase promoting complex subunit 10 140 +/- 9 189 +/- 9 212 +/- 8 217 +/- 21 0.001658 0.003833 0.804792 0.0042811 0.1671211
ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast) 1418 +/- 65 1478 +/- 46 1036 +/- 22 1185 +/- 40 -2.42E-05 0.4651226 0.015793 0.9601436 0.2593954
ANAPC13 anaphase promoting complex subunit 13 1133 +/- 61 1351 +/- 62 1288 +/- 122 1286 +/- 100 0.659716 0.0312862 -0.989156 0.0454783 0.4677743
ANGPT1 angiopoietin 1 1046 +/- 93 1388 +/- 95 1366 +/- 231 1407 +/- 71 0.128906 0.0281217 0.870727 0.0085604 0.9933055
ANKH ankylosis, progressive homolog (mouse) 2365 +/- 119 2794 +/- 121 2527 +/- 92 2834 +/- 84 0.309715 0.0303359 0.035778 0.1664892 0.3065043
ANKHD1 ankyrin repeat and KH domain containing 1 870 +/- 60 1083 +/- 30 945 +/- 57 1001 +/- 44 -0.975161 0.0145608 0.45834 0.0060792 0.436999
ANKIB1 ankyrin repeat and IBR domain containing 1 1928 +/- 106 2973 +/- 269 1694 +/- 82 1917 +/- 65 -0.007949 0.009743 0.063334 9E-05 0.0839082
ANKMY1 ankyrin repeat and MYND domain containing 1 80 +/- 6 123 +/- 12 89 +/- 10 110 +/- 19 -0.871513 0.0124915 0.377353 0.0331304 0.1804862
ANKRD10 ankyrin repeat domain 10 912 +/- 51 1028 +/- 46 829 +/- 38 1027 +/- 65 -0.235634 0.116825 0.035519 0.1665156 0.2166634
ANKRD11 ankyrin repeat domain 11 147 +/- 24 240 +/- 28 262 +/- 22 250 +/- 72 0.044845 0.0307121 -0.879094 0.0139103 0.3395989
ANKRD16 ankyrin repeat domain 16 117 +/- 11 155 +/- 15 124 +/- 12 175 +/- 8 0.207757 0.078603 0.005667 0.4099566 0.0824376
ANKRD20Aankyrin repeat domain 20 family, member A1 143 +/- 19 247 +/- 40 57 +/- 20 106 +/- 21 -0.004106 0.0508737 0.130608 0.0214372 0.1929429
ANKRD34 ankyrin repeat domain 34 1681 +/- 72 1443 +/- 63 1781 +/- 88 1714 +/- 34 0.039068 -0.031915 -0.501221 0.0025436 0.8755633
ANKRD37 ankyrin repeat domain 37 571 +/- 66 630 +/- 24 455 +/- 38 593 +/- 37 -0.099949 0.4327419 0.027995 0.4128942 0.0187851
ANKRD43 ankyrin repeat domain 43 1626 +/- 115 1329 +/- 135 1930 +/- 112 1590 +/- 92 0.041881 -0.125069 -0.044003 0.1207345 0.1464073
ANKRD52 ankyrin repeat domain 52 1020 +/- 66 863 +/- 45 1073 +/- 53 917 +/- 18 0.324193 -0.080713 -0.030652 0.1436219 0.1729886
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 7067 +/- 478 8852 +/- 493 7058 +/- 279 8534 +/- 485 -0.731046 0.0265886 0.035709 0.0075347 0.1131341
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 5261 +/- 630 6605 +/- 629 4342 +/- 135 4863 +/- 137 -0.020829 0.1620245 0.024182 0.065918 0.0327325
AP2B1 adaptor-related protein complex 2, beta 1 subunit 7691 +/- 354 5572 +/- 446 5527 +/- 121 4060 +/- 189 -0.000127 -0.004297 -0.000323 0.0287975 0.0273872
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 302 +/- 25 267 +/- 10 347 +/- 7 261 +/- 13 0.134526 -0.231272 -0.000873 0.8974693 0.010348
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 336 +/- 50 195 +/- 7 440 +/- 40 279 +/- 34 0.006951 -0.035594 -0.012958 0.0223472 0.0475868
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 5027 +/- 303 5203 +/- 381 4570 +/- 115 4883 +/- 59 -0.153539 0.7245922 0.044144 0.539062 0.0316903
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 146 +/- 16 200 +/- 16 146 +/- 13 166 +/- 11 -0.405789 0.0351104 0.285013 0.014208 0.6673145
API5 apoptosis inhibitor 5 1659 +/- 24 1825 +/- 54 1812 +/- 42 1906 +/- 76 0.037835 0.0265735 0.322472 0.0189811 0.0551939
APLP1 amyloid beta (A4) precursor-like protein 1 12980 +/- 687 13451 +/- 820 11777 +/- 440 13170 +/- 402 -0.27261 0.6699599 0.044232 0.6211934 0.2032392
APLP2 Amyloid beta (A4) precursor-like protein 2 397 +/- 24 319 +/- 21 448 +/- 28 403 +/- 22 0.010772 -0.037329 -0.240439 0.077951 0.5159072
APOA1BP apolipoprotein A-I binding protein 3444 +/- 146 3736 +/- 191 2627 +/- 74 3301 +/- 117 -0.000886 0.2539505 0.001861 0.2150369 0.0332909
APOD apolipoprotein D 1694 +/- 156 2698 +/- 413 1143 +/- 60 1879 +/- 176 -0.002071 0.0605189 0.011046 0.0199683 0.0099519
APRIN androgen-induced proliferation inhibitor 2075 +/- 34 1723 +/- 57 2125 +/- 61 1961 +/- 40 0.027176 -0.000695 -0.054459 7.079E-06 0.033862
AQP4 aquaporin 4 3429 +/- 247 4405 +/- 244 3780 +/- 277 3499 +/- 199 -0.351243 0.0182687 -0.431325 0.0137531 0.4163361
ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2) 1246 +/- 34 1120 +/- 36 1244 +/- 43 1245 +/- 60 0.241294 -0.029165 0.986526 0.0071719 0.5121562
ARHGAP1Rho GTPase activating protein 1 2732 +/- 133 3160 +/- 91 2618 +/- 114 2959 +/- 91 -0.087418 0.0261302 0.045362 0.1377545 0.4245211
ARHGAP2Rho GTPase activating protein 21 696 +/- 46 796 +/- 50 840 +/- 34 715 +/- 22 0.242334 0.1755294 -0.014326 0.1245424 0.0339893
ARHGAP26Rho GTPase activating protein 26 1897 +/- 171 1395 +/- 80 1867 +/- 154 1491 +/- 130 0.927036 -0.031968 -0.095828 0.0959248 0.1306623
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 11 658 +/- 70 564 +/- 45 969 +/- 43 769 +/- 57 0.000579 -0.290212 -0.023698 0.2544702 0.0498946
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12 5718 +/- 162 5133 +/- 235 5709 +/- 82 5041 +/- 202 -0.824157 -0.070928 -0.025744 0.01647 0.0003521
ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2 667 +/- 82 848 +/- 50 714 +/- 18 958 +/- 49 0.26721 0.093234 0.005343 0.1031341 0.0226937
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 3467 +/- 223 2866 +/- 102 2911 +/- 102 2790 +/- 61 -0.02838 -0.043674 -0.336368 0.0223283 0.410873
S1- alphabetical list of aging-related genes.xls Page 2
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
ARID1B AT rich interactive domain 1B (SWI1-like) 517 +/- 50 742 +/- 58 815 +/- 107 980 +/- 67 0.000873 0.0153366 0.224649 0.1181921 0.401326
ARIH1 Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) 340 +/- 7 374 +/- 9 372 +/- 17 385 +/- 27 0.253827 0.0120777 0.684705 0.0779694 0.2231039
ARIH2 ariadne homolog 2 (Drosophila) 1295 +/- 30 1073 +/- 49 1029 +/- 41 1044 +/- 54 -0.015864 -0.004513 0.829441 0.1147651 0.7756638
ARL6IP ADP-ribosylation factor-like 6 interacting protein 153 +/- 21 148 +/- 10 183 +/- 10 128 +/- 9 0.490568 -0.810586 -0.002748 0.8348318 0.1231773
ARMC2 armadillo repeat containing 2 247 +/- 26 192 +/- 9 249 +/- 6 220 +/- 6 0.279862 -0.097351 -0.008671 0.1105013 0.0027694
ARMC6 armadillo repeat containing 6 565 +/- 25 466 +/- 18 510 +/- 19 463 +/- 34 -0.266613 -0.009367 -0.270282 0.0009704 0.4644186
ARMCX1 armadillo repeat containing, X-linked 1 1267 +/- 41 1222 +/- 26 1385 +/- 38 1242 +/- 47 0.066419 -0.3784 -0.043796 0.506433 0.3617033
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 265 +/- 16 338 +/- 19 206 +/- 20 235 +/- 20 -0.001183 0.0141484 0.321994 0.0021732 0.7072972
ARPC5L actin related protein 2/3 complex, subunit 5-like 2033 +/- 80 1711 +/- 88 1873 +/- 143 1847 +/- 133 -0.931367 -0.022096 -0.8971 0.0104216 0.878848
ARRB1 arrestin, beta 1 380 +/- 17 456 +/- 27 349 +/- 27 389 +/- 28 -0.156395 0.0424103 0.331062 0.0404324 0.6828249
ARSD arylsulfatase D 461 +/- 56 623 +/- 41 464 +/- 64 612 +/- 50 -0.824537 0.043787 0.101284 0.1024168 0.15605
ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like 157 +/- 9 116 +/- 12 192 +/- 21 128 +/- 16 0.066622 -0.026696 -0.038097 0.0595455 0.0329058
ASB6 ankyrin repeat and SOCS box-containing 6 176 +/- 8 150 +/- 8 238 +/- 19 208 +/- 4 6.79E-05 -0.052557 -0.185877 0.1854066 0.3284327
ASB8 ankyrin repeat and SOCS box-containing 8 524 +/- 37 698 +/- 46 630 +/- 54 667 +/- 53 0.160758 0.015618 0.635976 0.0172022 0.3534385
ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 389 +/- 32 477 +/- 23 500 +/- 19 435 +/- 10 0.20467 0.0535443 -0.016733 0.0253333 0.0195744
ASPHD2 aspartate beta-hydroxylase domain containing 2 919 +/- 80 730 +/- 79 1141 +/- 46 992 +/- 32 0.002157 -0.122917 -0.027085 0.0684548 0.0557951
ASTN2 Astrotactin 2 149 +/- 10 185 +/- 27 178 +/- 20 260 +/- 21 0.037549 0.2540618 0.021935 0.4993867 0.2857922
ATAD2 ATPase family, AAA domain containing 2 97 +/- 15 148 +/- 7 117 +/- 7 127 +/- 8 -0.891597 0.0181211 0.41145 0.0864308 0.2851105
ATF1 Activating transcription factor 1 660 +/- 47 833 +/- 36 824 +/- 43 894 +/- 69 0.085587 0.0165201 0.413932 0.0171804 0.3602559
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 1361 +/- 96 1868 +/- 140 1316 +/- 125 1632 +/- 120 -0.087718 0.0157577 0.101921 0.0006093 0.020707
ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 489 +/- 25 632 +/- 27 517 +/- 23 734 +/- 11 0.023955 0.0030799 5.64E-05 0.0439593 0.0065325
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 2029 +/- 118 1514 +/- 111 1497 +/- 112 1332 +/- 42 -0.003401 -0.009807 -0.213381 0.0042259 0.2469229
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 1719 +/- 90 1425 +/- 89 2012 +/- 103 1836 +/- 84 0.000518 -0.042683 -0.215555 0.1947563 0.6087121
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 998 +/- 141 706 +/- 35 1092 +/- 143 659 +/- 56 0.489304 -0.094192 -0.027765 0.1672911 0.1605408
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 208 +/- 7 103 +/- 11 218 +/- 21 236 +/- 128 0.419591 -0.000226 0.891766 0.0042581 0.6526729
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 5128 +/- 416 3241 +/- 499 4550 +/- 162 3067 +/- 564 -0.083263 -0.016199 -0.056256 0.0124313 0.0555702
ATP8B2 ATPase, Class I, type 8B, member 2 1260 +/- 36 1102 +/- 43 1508 +/- 74 1279 +/- 39 0.000662 -0.018718 -0.027391 0.0716008 0.1292793
ATPBD1B ATP binding domain 1 family, member B 517 +/- 51 773 +/- 37 492 +/- 40 837 +/- 27 0.822615 0.0029109 7.1E-05 0.0124511 0.0230446
ATXN2 ataxin 2 1690 +/- 104 2226 +/- 102 1668 +/- 61 2193 +/- 86 -0.80154 0.0043761 0.001322 0.0391748 0.0196687
ATXN7L1 ataxin 7-like 1 462 +/- 25 555 +/- 22 612 +/- 31 626 +/- 34 0.003912 0.0190188 0.771269 0.0840158 0.431721
ATXN7L3 ataxin 7-like 3 4182 +/- 141 3742 +/- 124 3753 +/- 122 3589 +/- 83 -0.010413 -0.041159 -0.297757 0.0055341 0.7757953
AURKA aurora kinase A 143 +/- 8 167 +/- 14 108 +/- 7 135 +/- 5 -0.003063 0.1749027 0.017575 0.0328976 0.0511261
AURKAIP1aurora kinase A interacting protein 1 1086 +/- 137 1595 +/- 169 1097 +/- 103 1678 +/- 137 0.160723 0.0426736 0.009992 0.1630108 0.0713341
AXL AXL receptor tyrosine kinase 951 +/- 51 1108 +/- 50 906 +/- 51 754 +/- 67 -0.01455 0.054106 -0.110761 0.2028006 0.0169621
AYP1 AYP1 protein 1952 +/- 156 2320 +/- 203 1716 +/- 121 2044 +/- 75 -0.127408 0.1834171 0.049916 0.0808976 0.0674348
AZI2 5-azacytidine induced 2 394 +/- 23 458 +/- 16 409 +/- 24 439 +/- 10 -0.660114 0.0482444 0.292643 0.0336147 0.3530425
B2M beta-2-microglobulin 7946 +/- 519 10622 +/- 678 6616 +/- 572 9837 +/- 646 -0.020796 0.0114966 0.005147 0.0423626 0.1051803
B3GNT1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 7168 +/- 286 6332 +/- 368 7310 +/- 119 6286 +/- 200 0.467301 -0.105163 -0.003595 0.0523104 0.0044193
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 215 +/- 11 174 +/- 8 238 +/- 21 202 +/- 7 0.016043 -0.011299 -0.156849 0.0343221 0.3937487
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 1509 +/- 46 1313 +/- 50 1304 +/- 35 1196 +/- 29 -0.000177 -0.016366 -0.043079 0.0059715 0.0109205
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2214 +/- 209 1568 +/- 99 1896 +/- 165 1568 +/- 81 -0.03683 -0.026376 -0.117469 0.0216119 0.1666359
bA16L21.2DnaJ-like protein 465 +/- 29 601 +/- 37 472 +/- 48 628 +/- 64 0.563406 0.0162922 0.086858 0.0074342 0.0212148
BAALC brain and acute leukemia, cytoplasmic 5677 +/- 195 4724 +/- 234 5418 +/- 180 4924 +/- 267 -0.971717 -0.01105 -0.167427 0.0070715 0.0303023
BAG1 BCL2-associated athanogene 642 +/- 54 817 +/- 54 829 +/- 57 905 +/- 31 0.029825 0.0459185 0.271393 0.2549285 0.394043
S1- alphabetical list of aging-related genes.xls Page 3
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
BAG5 BCL2-associated athanogene 5 1207 +/- 46 1153 +/- 44 1176 +/- 30 1285 +/- 20 0.249987 -0.41745 0.015127 0.4431129 0.0787352
BAX BCL2-associated X protein 831 +/- 23 877 +/- 24 728 +/- 13 807 +/- 21 -0.000268 0.188443 0.01614 0.3452937 0.1605293
BBS10 Bardet-Biedl syndrome 10 654 +/- 36 800 +/- 32 792 +/- 37 735 +/- 48 0.282967 0.0127777 -0.374216 0.0041161 0.3153397
BBX bobby sox homolog (Drosophila) 1408 +/- 90 1558 +/- 89 1131 +/- 18 1251 +/- 43 -0.00139 0.2635379 0.045523 0.1257724 0.0998663
BCAP31 B-cell receptor-associated protein 31 1029 +/- 88 1543 +/- 54 860 +/- 54 1436 +/- 92 -0.001081 0.0009896 0.001211 0.004477 0.0133562
BCL10 B-cell CLL/lymphoma 10 367 +/- 32 332 +/- 22 459 +/- 20 380 +/- 15 0.010289 -0.395955 -0.011414 0.3654709 0.0460348
BCL9L B-cell CLL/lymphoma 9-like 590 +/- 55 534 +/- 38 851 +/- 35 651 +/- 50 0.002662 -0.417435 -0.012774 0.3931402 0.0874792
BHLHB9 basic helix-loop-helix domain containing, class B, 9 1246 +/- 54 1079 +/- 55 1348 +/- 40 1378 +/- 74 0.00898 -0.054366 0.738951 0.0366155 0.1918358
BICC1 Bicaudal C homolog 1 (Drosophila) 484 +/- 64 390 +/- 42 763 +/- 49 466 +/- 75 0.010564 -0.249579 -0.012458 0.4693602 0.1136697
BICD2 bicaudal D homolog 2 (Drosophila) 1123 +/- 23 818 +/- 85 1051 +/- 110 902 +/- 129 0.056606 -0.014435 -0.404725 0.3535027 0.7955801
BIRC6 baculoviral IAP repeat-containing 6 (apollon) 348 +/- 15 458 +/- 21 431 +/- 7 524 +/- 30 4.21E-05 0.0020667 0.034166 0.000872 0.0185995
BOP1 block of proliferation 1 292 +/- 18 210 +/- 26 357 +/- 15 258 +/- 9 0.005846 -0.026404 -0.000564 0.0936834 0.0022434
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 161 +/- 18 269 +/- 23 210 +/- 23 267 +/- 28 0.158484 0.0048843 0.156536 0.0169403 0.0348519
BRCC2 BRCC2 260 +/- 26 370 +/- 35 220 +/- 11 242 +/- 10 -0.012762 0.0323446 0.172532 0.0087585 0.3163604
BRD2 bromodomain containing 2 683 +/- 52 469 +/- 53 945 +/- 41 572 +/- 72 0.004681 -0.016525 -0.003474 0.2800474 0.0970544
BRD8 bromodomain containing 8 2792 +/- 155 3452 +/- 144 2758 +/- 92 3162 +/- 229 -0.266079 0.0110736 0.159508 0.0100204 0.057173
BRWD2 bromodomain and WD repeat domain containing 2 564 +/- 69 382 +/- 3 593 +/- 41 404 +/- 22 0.615269 -0.046177 -0.004233 0.1376207 0.0357696
BTBD12 BTB (POZ) domain containing 12 437 +/- 23 371 +/- 26 440 +/- 20 356 +/- 19 -0.804196 -0.083174 -0.013972 0.1339189 0.2063703
BTBD2 BTB (POZ) domain containing 2 1567 +/- 138 1823 +/- 101 1620 +/- 100 2016 +/- 105 0.152705 0.1687539 0.023564 0.4501454 0.0686026
BTBD6 BTB (POZ) domain containing 6 118 +/- 4 104 +/- 8 134 +/- 8 104 +/- 6 0.312173 -0.15831 -0.015357 0.0606079 0.014503
BTF3 basic transcription factor 3 1055 +/- 87 1438 +/- 101 1121 +/- 86 1351 +/- 104 -0.899068 0.0168246 0.126083 0.001568 0.0303016
BTG4 B-cell translocation gene 4 106 +/- 9 193 +/- 31 105 +/- 8 196 +/- 11 0.585522 0.035256 0.000213 0.0939422 0.0050279
BTN2A2 butyrophilin, subfamily 2, member A2 158 +/- 20 239 +/- 24 168 +/- 18 199 +/- 14 -0.434283 0.0262197 0.201096 0.0493648 0.6504022
BTN3A1 butyrophilin, subfamily 3, member A1 194 +/- 23 323 +/- 36 209 +/- 19 260 +/- 29 -0.381616 0.0163828 0.183902 0.0577965 0.1481924
BUB3 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 4140 +/- 127 3656 +/- 142 3469 +/- 169 3052 +/- 117 -0.000718 -0.02942 -0.074618 0.2495534 0.1460212
BXDC5 brix domain containing 5 1465 +/- 71 1335 +/- 55 1579 +/- 58 1297 +/- 45 0.533917 -0.17978 -0.004051 0.3902844 0.0388022
BZRP benzodiazapine receptor (peripheral) 565 +/- 74 798 +/- 62 374 +/- 21 504 +/- 36 -0.003355 0.0377401 0.018487 0.0214934 0.1014083
BZW1 basic leucine zipper and W2 domains 1 5216 +/- 116 4624 +/- 192 4100 +/- 120 3941 +/- 258 -0.000248 -0.028896 -0.596853 0.0047402 0.2150581
C1QC complement component 1, q subcomponent, C chain 541 +/- 44 951 +/- 109 482 +/- 52 755 +/- 55 -0.028928 0.0110178 0.006202 0.0003612 0.0024066
CA10 carbonic anhydrase X 1854 +/- 361 1852 +/- 301 4062 +/- 174 3455 +/- 172 3.99E-05 -0.996745 -0.035214 0.9563537 0.1060229
CABP4 calcium binding protein 4 167 +/- 42 189 +/- 30 193 +/- 12 142 +/- 16 -0.901635 0.6781443 -0.035053 0.3978992 0.0971859
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2) 307 +/- 34 240 +/- 11 269 +/- 21 207 +/- 8 -0.089852 -0.109651 -0.032139 0.1049094 0.0171144
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 961 +/- 89 664 +/- 44 1617 +/- 110 993 +/- 119 0.000194 -0.018645 -0.004193 0.0747641 0.1216223
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 1084 +/- 79 825 +/- 44 1214 +/- 70 1044 +/- 36 0.009523 -0.021979 -0.065895 0.0056008 0.145536
CALCOCOcalcium binding and coiled-coil domain 1 1651 +/- 65 1696 +/- 88 1450 +/- 9 1669 +/- 54 -0.151045 0.6944536 0.014307 0.3147448 0.1743436
CALCOCOcalcium binding and coiled-coil domain 2 135 +/- 14 182 +/- 16 231 +/- 15 267 +/- 26 0.000718 0.0542604 0.274321 0.0064576 0.2571646
CALD1 caldesmon 1 84 +/- 6 130 +/- 15 132 +/- 8 136 +/- 6 0.005626 0.0251705 0.710226 0.0022 0.752043
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2835 +/- 306 2109 +/- 116 2217 +/- 96 1716 +/- 125 -0.024082 -0.065712 -0.012947 0.0168465 0.0277705
CAMSAP1calmodulin regulated spectrin-associated protein 1 1864 +/- 55 1556 +/- 68 1653 +/- 70 1442 +/- 53 -0.000838 -0.005929 -0.039507 0.036372 0.1589263
CAMTA1 calmodulin binding transcription activator 1 3071 +/- 288 2648 +/- 114 3284 +/- 169 2656 +/- 62 0.5964 -0.218065 -0.011943 0.1678939 0.0245317
CAPN2 calpain 2, (m/II) large subunit 2440 +/- 204 3016 +/- 132 1931 +/- 137 2492 +/- 70 -0.000223 0.0430506 0.00757 0.0562623 0.0767471
CAPN7 calpain 7 580 +/- 29 674 +/- 27 693 +/- 37 800 +/- 39 0.004627 0.039422 0.081336 0.0466246 0.266771
CAPNS1 calpain, small subunit 1 7708 +/- 486 6177 +/- 323 7211 +/- 399 6252 +/- 282 -0.353239 -0.028383 -0.082827 0.0128554 0.156197
CAPZB capping protein (actin filament) muscle Z-line, beta 8247 +/- 582 6857 +/- 252 6783 +/- 248 5959 +/- 245 -0.006127 -0.065542 -0.0425 0.1260651 0.0938284
S1- alphabetical list of aging-related genes.xls Page 4
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
CARD9 caspase recruitment domain family, member 9 119 +/- 10 107 +/- 15 126 +/- 10 91 +/- 8 -0.759742 -0.509165 -0.024558 0.6904611 0.1781829
CARF collaborates/cooperates with ARF (alternate reading frame) protein 269 +/- 10 254 +/- 13 331 +/- 17 273 +/- 18 0.037888 -0.405664 -0.042435 0.9848762 0.2328383
CASP6 Caspase 6, apoptosis-related cysteine peptidase 345 +/- 21 260 +/- 29 301 +/- 24 283 +/- 18 -0.233104 -0.040368 -0.566645 0.0229999 0.2626178
CAST calpastatin 990 +/- 127 1424 +/- 112 822 +/- 41 1048 +/- 19 -0.011634 0.0287645 0.00158 0.0161794 0.0076301
CAST1 CAZ-associated structural protein 3281 +/- 360 2648 +/- 269 4391 +/- 181 3526 +/- 194 0.000442 -0.19195 -0.010196 0.208326 0.0276119
CBARA1 calcium binding atopy-related autoantigen 1 1698 +/- 52 1549 +/- 37 1445 +/- 72 1507 +/- 58 -0.017109 -0.04407 0.517737 0.1406721 0.701145
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1129 +/- 118 865 +/- 92 1148 +/- 81 844 +/- 74 -0.828443 -0.109053 -0.021736 0.1314337 0.0102932
CBR4 Carbonyl reductase 4 86 +/- 10 138 +/- 8 105 +/- 19 109 +/- 10 -0.882959 0.0021832 0.871819 0.0006885 0.9016726
CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila) 2091 +/- 138 2460 +/- 88 2478 +/- 74 2807 +/- 90 0.000466 0.0528484 0.021609 0.0976501 0.0574181
CCAR1 Cell division cycle and apoptosis regulator 1 149 +/- 19 225 +/- 17 200 +/- 14 216 +/- 12 0.277002 0.0143201 0.403649 0.0202498 0.8580945
CCDC109Acoiled-coil domain containing 109A 569 +/- 44 445 +/- 19 621 +/- 31 560 +/- 29 0.009885 -0.036178 -0.189661 0.0297814 0.12063
CCDC28A coiled-coil domain containing 28A 2372 +/- 140 2508 +/- 155 2361 +/- 84 2730 +/- 55 0.347593 0.5291304 0.005847 0.829815 0.0865784
CCDC44 coiled-coil domain containing 44 792 +/- 36 669 +/- 27 578 +/- 22 598 +/- 31 -0.00364 -0.021618 0.607391 0.0106531 0.7380396
CCDC46 coiled-coil domain containing 46 98 +/- 13 159 +/- 31 208 +/- 13 282 +/- 17 0.000554 0.1194535 0.009056 0.2527666 0.1569679
CCDC49 coiled-coil domain containing 49 276 +/- 18 313 +/- 20 246 +/- 12 319 +/- 21 -0.229076 0.2021114 0.019118 0.0975286 0.0471031
CCDC72 coiled-coil domain containing 72 4579 +/- 407 4039 +/- 229 3214 +/- 212 2593 +/- 139 -0.000493 -0.281026 -0.038621 0.5045182 0.0746598
CCDC74A coiled-coil domain containing 74A 613 +/- 51 646 +/- 93 640 +/- 36 1150 +/- 118 0.030966 0.7647319 0.010155 0.4369118 0.0075341
CCDC8 coiled-coil domain containing 8 394 +/- 24 308 +/- 20 374 +/- 23 310 +/- 19 -0.800822 -0.020152 -0.059179 0.1357534 0.1935142
CCDC84 coiled-coil domain containing 84 574 +/- 64 492 +/- 41 476 +/- 29 359 +/- 41 -0.004905 -0.311384 -0.049202 0.5339314 0.2964875
CCDC85A coiled-coil domain containing 85A 92 +/- 15 41 +/- 10 189 +/- 13 169 +/- 26 9.68E-05 -0.0203 -0.516734 0.0450543 0.794482
CCDC86 coiled-coil domain containing 86 471 +/- 31 440 +/- 12 478 +/- 9 411 +/- 12 -0.745525 -0.386079 -0.002237 0.3407222 0.0276324
CCDC95 coiled-coil domain containing 95 936 +/- 37 859 +/- 28 1082 +/- 28 950 +/- 21 0.002123 -0.12682 -0.004763 0.0487537 0.0046589
CCDC98 coiled-coil domain containing 98 121 +/- 10 163 +/- 15 95 +/- 14 126 +/- 13 -0.036337 0.0442752 0.141438 0.0179696 0.319486
CCDC99 Coiled-coil domain containing 99 843 +/- 108 1220 +/- 192 518 +/- 27 688 +/- 24 -0.003641 0.1255292 0.001168 0.0422772 0.0247073
CCL27 chemokine (C-C motif) ligand 27 350 +/- 36 242 +/- 23 335 +/- 21 227 +/- 16 -0.621527 -0.034547 -0.002895 0.0368565 0.0037534
CCNA1 cyclin A1 165 +/- 10 276 +/- 37 154 +/- 14 177 +/- 31 -0.03939 0.0301126 0.505994 0.0100349 0.5542809
CCNDBP1cyclin D-type binding-protein 1 1466 +/- 70 1579 +/- 106 1288 +/- 57 1562 +/- 89 -0.009416 0.3968733 0.035355 0.750233 0.1385804
CCNF cyclin F 133 +/- 13 125 +/- 9 143 +/- 17 196 +/- 13 0.025337 -0.623944 0.034926 0.3664781 0.1488046
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 357 +/- 52 222 +/- 9 332 +/- 36 323 +/- 35 0.395085 -0.048061 -0.855937 0.0351474 0.6185892
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 2068 +/- 138 2872 +/- 102 1999 +/- 97 2727 +/- 72 -0.051148 0.0010854 0.000218 0.0758965 0.0618846
CCT7 chaperonin containing TCP1, subunit 7 (eta) 926 +/- 48 785 +/- 35 940 +/- 51 822 +/- 54 0.409169 -0.039817 -0.146651 0.0916866 0.8382603
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 434 +/- 27 533 +/- 24 382 +/- 9 508 +/- 28 -0.052734 0.0224622 0.007719 0.1918141 0.0223613
CD44 CD44 molecule (Indian blood group) 390 +/- 49 579 +/- 97 642 +/- 74 919 +/- 44 0.000529 0.1243777 0.012964 0.2130658 0.0386421
CD47 CD47 molecule 2438 +/- 231 1877 +/- 56 2572 +/- 107 2131 +/- 78 0.068634 -0.059507 -0.009186 0.1748846 0.0110473
CD5 CD5 molecule 143 +/- 6 90 +/- 18 125 +/- 19 122 +/- 17 0.702718 -0.034031 -0.906423 0.2326028 0.6804172
CD52 CD52 molecule 303 +/- 58 621 +/- 52 251 +/- 51 388 +/- 37 -0.01515 0.0023325 0.057454 0.0100072 0.2205889
CD58 CD58 molecule 179 +/- 17 277 +/- 45 140 +/- 9 195 +/- 13 -0.021073 0.0842023 0.010655 0.0174593 0.0055731
CD63 CD63 molecule 3961 +/- 565 4903 +/- 297 3173 +/- 139 3664 +/- 165 -0.011074 0.1803626 0.050996 0.198092 0.4036024
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1810 +/- 283 3714 +/- 547 1215 +/- 171 2317 +/- 340 -0.016033 0.016153 0.027629 0.0079133 0.1049361
CD81 CD81 molecule 13811 +/- 551 15425 +/- 255 12732 +/- 477 14927 +/- 743 -0.099974 0.0323751 0.041803 0.1944335 0.4250111
CD99 CD99 molecule 895 +/- 110 1907 +/- 171 1138 +/- 143 2051 +/- 28 0.143353 0.0009003 0.001141 0.0008603 0.0179078
CDC16 CDC16 cell division cycle 16 homolog (S. cerevisiae) 1071 +/- 33 1180 +/- 23 991 +/- 39 1063 +/- 17 -8.94E-05 0.0248663 0.13443 0.1310045 0.324503
CDC25A cell division cycle 25A 235 +/- 35 330 +/- 18 224 +/- 25 264 +/- 25 -0.041807 0.0419309 0.285905 0.2069823 0.6622406
CDC42EP1CDC42 effector protein (Rho GTPase binding) 1 483 +/- 70 667 +/- 95 446 +/- 30 548 +/- 33 -0.229542 0.1502334 0.047948 0.0722411 0.0967348
S1- alphabetical list of aging-related genes.xls Page 5
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
CDH24 cadherin-like 24 969 +/- 98 925 +/- 70 890 +/- 56 690 +/- 25 -0.060269 -0.726266 -0.014013 0.6436917 0.0086368
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 3358 +/- 206 3149 +/- 168 3343 +/- 117 2839 +/- 95 -0.40566 -0.451126 -0.008778 0.3661446 0.0872679
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 3649 +/- 206 3034 +/- 85 4001 +/- 116 3504 +/- 169 0.04031 -0.029702 -0.043974 0.0157937 0.3073854
CDK5RAP3CDK5 regulatory subunit associated protein 3 2040 +/- 139 2326 +/- 68 1983 +/- 100 2344 +/- 76 -0.912757 0.1059012 0.018858 0.2761314 0.1281429
CDKL1 Cyclin-dependent kinase-like 1 (CDC2-related kinase) 246 +/- 38 126 +/- 18 235 +/- 31 154 +/- 10 0.544474 -0.02498 -0.045552 0.0374047 0.079404
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 1595 +/- 115 1240 +/- 71 1433 +/- 53 1337 +/- 51 -0.531545 -0.029208 -0.225029 0.0016399 0.2668989
CDO1 cysteine dioxygenase, type I 3039 +/- 285 2226 +/- 153 2318 +/- 87 2399 +/- 90 -0.153675 -0.037331 0.537165 0.0164488 0.9143342
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 2137 +/- 201 1588 +/- 146 1255 +/- 83 1183 +/- 110 -0.001244 -0.054361 -0.618529 0.0098995 0.1633426
CENPJ centromere protein J 96 +/- 18 264 +/- 61 97 +/- 12 311 +/- 82 0.110635 0.0401782 0.058315 0.0072099 0.0049012
CEP170 centrosomal protein 170kDa 1001 +/- 123 1338 +/- 117 981 +/- 72 1209 +/- 49 -0.23448 0.0753206 0.029525 0.1319576 0.3466277
CEP27 centrosomal protein 27kDa 292 +/- 19 350 +/- 15 317 +/- 12 384 +/- 28 0.123998 0.0392293 0.075453 0.0522933 0.4491202
CEP63 centrosomal protein 63kDa 153 +/- 12 107 +/- 16 136 +/- 25 82 +/- 13 -0.08455 -0.045694 -0.097117 0.4379545 0.3680895
CEPT1 choline/ethanolamine phosphotransferase 1 157 +/- 10 233 +/- 10 158 +/- 12 186 +/- 14 -0.098759 0.0003531 0.177277 0.0027786 0.2984887
CES2 carboxylesterase 2 (intestine, liver) 171 +/- 23 239 +/- 16 196 +/- 22 188 +/- 19 -0.767725 0.0366105 -0.781637 0.006473 0.9958296
CETN3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast) 1063 +/- 34 1071 +/- 46 1089 +/- 38 984 +/- 18 -0.731738 0.8895652 -0.040433 0.2173904 0.2261738
CFL2 cofilin 2 (muscle) 1198 +/- 120 1807 +/- 334 1128 +/- 106 1503 +/- 117 -0.245685 0.1350858 0.042518 0.017426 0.0658383
CGI-38 brain specific protein 1185 +/- 160 1693 +/- 328 699 +/- 44 901 +/- 69 -0.01281 0.2043037 0.04339 0.1728503 0.1358712
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2026 +/- 56 2199 +/- 30 2231 +/- 90 2360 +/- 104 0.004669 0.0263417 0.377636 0.0127559 0.5219367
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 566 +/- 39 497 +/- 32 476 +/- 27 398 +/- 11 -9.49E-05 -0.201579 -0.032704 0.2495831 0.0645877
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 1443 +/- 50 1660 +/- 71 1485 +/- 74 1658 +/- 34 0.228951 0.0341582 0.071556 0.1225051 0.1170426
ChGn Chondroitin beta1,4 N-acetylgalactosaminyltransferase 117 +/- 12 160 +/- 11 80 +/- 9 120 +/- 16 -0.010554 0.0304215 0.074225 0.0509525 0.0348366
CHKA choline kinase alpha 607 +/- 41 586 +/- 44 764 +/- 36 646 +/- 32 0.030471 -0.738949 -0.035292 0.8615465 0.0564405
CHL1 cell adhesion molecule with homology to L1CAM (close homolog of L1) 5666 +/- 319 6673 +/- 332 5043 +/- 360 5085 +/- 214 -0.004389 0.0537679 0.922984 0.26906 0.9666862
CHM choroideremia (Rab escort protein 1) 1904 +/- 130 2177 +/- 95 1862 +/- 132 2272 +/- 98 0.989552 0.1232673 0.035472 0.0876603 0.0370802
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 639 +/- 84 773 +/- 125 385 +/- 5 482 +/- 26 -0.005146 0.3983593 0.019465 0.1758969 0.0445424
CHSY1 carbohydrate (chondroitin) synthase 1 921 +/- 62 844 +/- 26 927 +/- 31 833 +/- 17 -0.880999 -0.289489 -0.031812 0.4493441 0.0670205
CHURC1 churchill domain containing 1 2879 +/- 78 3384 +/- 118 2472 +/- 75 2873 +/- 90 -0.000854 0.006514 0.008507 0.0013983 0.0100486
CIC capicua homolog (Drosophila) 2030 +/- 162 2055 +/- 125 3575 +/- 166 3066 +/- 138 3.82E-05 0.9079011 -0.042879 0.6272452 0.1751269
CKAP1 cytoskeleton associated protein 1 1486 +/- 142 1105 +/- 70 1406 +/- 119 962 +/- 130 -0.374152 -0.045645 -0.033776 0.2838992 0.2017971
CKLF chemokine-like factor 686 +/- 32 579 +/- 45 611 +/- 22 492 +/- 40 -0.011824 -0.086706 -0.037465 0.2042547 0.0197104
CKMT1B creatine kinase, mitochondrial 1B 6947 +/- 213 5592 +/- 354 5522 +/- 246 4526 +/- 212 -0.00021 -0.010828 -0.013362 0.013891 0.1270608
CKS1B CDC28 protein kinase regulatory subunit 1B 822 +/- 24 945 +/- 35 686 +/- 28 763 +/- 14 -0.000153 0.0180419 0.041455 0.0451127 0.2475416
CLCC1 chloride channel CLIC-like 1 332 +/- 29 441 +/- 25 310 +/- 14 395 +/- 5 -0.051789 0.0179946 0.001145 0.066525 0.011344
CLDN15 claudin 15 352 +/- 48 618 +/- 92 272 +/- 21 393 +/- 56 -0.005536 0.0355177 0.099515 0.0144859 0.0386216
CLEC14A C-type lectin domain family 14, member A 139 +/- 9 108 +/- 10 129 +/- 11 111 +/- 13 -0.617085 -0.040997 -0.334514 0.2255612 0.8329779
CLEC4A C-type lectin domain family 4, member A 101 +/- 9 155 +/- 10 108 +/- 13 131 +/- 18 -0.499229 0.0027728 0.334357 0.0041785 0.8807759
CLK4 CDC-like kinase 4 2680 +/- 52 2262 +/- 87 2336 +/- 119 1847 +/- 72 -1.37E-05 -0.003237 -0.00787 0.0890823 0.0935707
CLN3 ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) 69 +/- 19 166 +/- 24 72 +/- 18 167 +/- 36 0.962825 0.0104739 0.059108 0.1621091 0.4560878
CLUAP1 clusterin associated protein 1 364 +/- 28 271 +/- 19 359 +/- 25 394 +/- 15 0.11188 -0.021404 0.266993 0.0150513 0.3768423
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 684 +/- 73 783 +/- 21 553 +/- 20 645 +/- 18 -0.004933 0.2413487 0.007506 0.1880707 0.0672783
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2631 +/- 293 3487 +/- 483 1346 +/- 59 1861 +/- 191 -0.000853 0.1669512 0.051693 0.069623 0.0709191
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 1872 +/- 548 3446 +/- 569 974 +/- 183 2032 +/- 172 -0.014765 0.0742997 0.002279 0.0431478 0.006867
CNNM3 Cyclin M3 133 +/- 9 173 +/- 11 136 +/- 17 194 +/- 15 0.464066 0.0157123 0.030455 0.0124335 0.0476581
CNOT1 CCR4-NOT transcription complex, subunit 1 385 +/- 33 315 +/- 9 372 +/- 26 289 +/- 15 -0.133131 -0.091373 -0.022823 0.1665445 0.0437044
S1- alphabetical list of aging-related genes.xls Page 6
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 8116 +/- 1232 11141 +/- 2317 4506 +/- 307 5837 +/- 379 -0.0058 0.2839787 0.025495 0.0954527 0.0080065
CNTN1 contactin 1 1106 +/- 69 1435 +/- 87 1088 +/- 58 1302 +/- 69 -0.267859 0.0149104 0.043579 0.0089787 0.2068081
CNTNAP2 contactin associated protein-like 2 4333 +/- 298 3178 +/- 404 3580 +/- 316 3606 +/- 414 -0.141527 -0.046274 0.961217 0.0642769 0.6630139
CNTNAP4 contactin associated protein-like 4 870 +/- 94 1300 +/- 106 849 +/- 67 946 +/- 93 -0.138096 0.0126049 0.424398 0.0022063 0.720818
COG2 Component of oligomeric golgi complex 2 120 +/- 4 171 +/- 15 148 +/- 17 181 +/- 22 0.046117 0.0163734 0.26106 0.035707 0.4117899
COL11A2 collagen, type XI, alpha 2 262 +/- 34 231 +/- 38 308 +/- 19 229 +/- 25 0.500008 -0.556716 -0.038334 0.7123472 0.2080446
COL1A2 collagen, type I, alpha 2 214 +/- 68 127 +/- 38 73 +/- 10 162 +/- 21 -0.348965 -0.29204 0.010048 0.1030026 0.0184288
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 155 +/- 10 113 +/- 13 122 +/- 13 100 +/- 15 -0.148307 -0.027497 -0.29067 0.0468679 0.1000085
COL8A1 Collagen, type VIII, alpha 1 97 +/- 13 150 +/- 14 69 +/- 14 113 +/- 15 -0.023159 0.0164826 0.061623 0.0556603 0.0055949
COMT catechol-O-methyltransferase 2761 +/- 143 3402 +/- 147 2879 +/- 124 3569 +/- 121 0.377137 0.0106563 0.003185 0.0050392 0.0255997
COPB coatomer protein complex, subunit beta 2361 +/- 106 2533 +/- 108 2354 +/- 49 2670 +/- 101 0.534294 0.2794018 0.030977 0.6419051 0.2110135
COPS6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) 4767 +/- 72 4463 +/- 89 4638 +/- 109 4477 +/- 61 -0.502475 -0.024833 -0.232491 0.0048395 0.3377716
COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 2132 +/- 50 2760 +/- 207 2135 +/- 183 2910 +/- 174 0.733772 0.0276805 0.013514 0.3529859 0.252015
COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) 3844 +/- 259 2904 +/- 248 3403 +/- 232 3169 +/- 263 -0.338675 -0.025702 -0.521506 0.0037733 0.1955366
COQ3 coenzyme Q3 homolog, methyltransferase (S. cerevisiae) 962 +/- 18 1137 +/- 65 967 +/- 22 1098 +/- 25 -0.817125 0.0430001 0.003824 0.3347873 0.1330829
CORO7 coronin 7 1060 +/- 57 830 +/- 78 1137 +/- 43 970 +/- 97 0.053474 -0.040219 -0.170909 0.1279173 0.5328214
COTL1 coactosin-like 1 (Dictyostelium) 2231 +/- 123 2629 +/- 248 2186 +/- 97 2676 +/- 151 0.623129 0.1921305 0.0291 0.1506062 0.0805398
COX4NB COX4 neighbor 1259 +/- 72 1292 +/- 57 1207 +/- 23 1340 +/- 34 -0.99451 0.7250127 0.012696 0.9854078 0.2731861
COX5B cytochrome c oxidase subunit Vb 6825 +/- 788 9221 +/- 528 4736 +/- 885 7292 +/- 122 -3.18E-05 0.0331089 0.03388 0.0665571 0.0655704
COX6C cytochrome c oxidase subunit VIc 7080 +/- 300 8976 +/- 497 6419 +/- 237 8142 +/- 260 -0.027156 0.0110211 0.000959 0.2042941 0.0616353
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 526 +/- 47 668 +/- 60 737 +/- 35 880 +/- 49 0.000273 0.0943332 0.046656 0.0480927 0.0324146
CRAMP1L Crm, cramped-like (Drosophila) 799 +/- 22 1083 +/- 81 759 +/- 43 853 +/- 75 -0.02985 0.0158006 0.319566 0.109389 0.8164495
CREBBP CREB binding protein (Rubinstein-Taybi syndrome) 1537 +/- 76 1340 +/- 29 1670 +/- 25 1368 +/- 90 0.074631 -0.047722 -0.026138 0.2182167 0.2380851
CRI1 CREBBP/EP300 inhibitor 1 2595 +/- 106 2983 +/- 108 2958 +/- 141 2891 +/- 157 0.256251 0.0281349 -0.757243 0.0258302 0.9845123
CRI2 CREBBP/EP300 inhibitor 2 2677 +/- 69 2462 +/- 64 2961 +/- 148 2988 +/- 133 0.001303 -0.045566 0.896077 0.0134155 0.9560909
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1767 +/- 44 1717 +/- 67 1489 +/- 11 1401 +/- 15 -2.12E-05 -0.547481 -0.001865 0.9929446 0.0092549
CRNKL1 Crn, crooked neck-like 1 (Drosophila) 267 +/- 89 512 +/- 56 270 +/- 68 595 +/- 45 0.440492 0.0464274 0.003683 0.1024379 0.0595626
CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa 197 +/- 12 461 +/- 85 228 +/- 18 391 +/- 98 -0.925572 0.0257398 0.174308 0.0019702 0.0537538
CRYBA2 crystallin, beta A2 197 +/- 9 153 +/- 13 189 +/- 23 170 +/- 6 0.902374 -0.022757 -0.458026 0.0053405 0.7632027
CRYZL1 crystallin, zeta (quinone reductase)-like 1 1205 +/- 66 921 +/- 78 933 +/- 90 851 +/- 78 -0.062757 -0.019966 -0.505096 0.0043641 0.4585828
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 151 +/- 7 191 +/- 15 133 +/- 12 133 +/- 8 -0.007943 0.0451243 -0.994117 0.0008691 0.7750291
CSNK1D casein kinase 1, delta 809 +/- 36 702 +/- 20 866 +/- 60 764 +/- 92 0.264375 -0.031334 -0.386764 0.02211 0.3344333
CSNK1G2 casein kinase 1, gamma 2 464 +/- 48 332 +/- 27 622 +/- 27 496 +/- 28 0.001863 -0.044697 -0.010409 0.0355452 0.0068422
CSPP1 centrosome and spindle pole associated protein 1 281 +/- 13 401 +/- 33 322 +/- 36 395 +/- 48 0.278161 0.0126706 0.257417 0.0001077 0.0824303
CSTB cystatin B (stefin B) 6756 +/- 454 7724 +/- 450 6112 +/- 199 7133 +/- 147 -0.030487 0.1610221 0.002746 0.2614149 0.0407972
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 433 +/- 12 380 +/- 8 395 +/- 17 398 +/- 24 -0.558682 -0.006234 0.926065 0.0463695 0.9418725
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 2715 +/- 105 2657 +/- 150 2420 +/- 54 2153 +/- 92 -0.000546 -0.758013 -0.04211 0.7117736 0.1471537
CTNNB1 Catenin (cadherin-associated protein), beta 1, 88kDa 80 +/- 20 240 +/- 38 98 +/- 21 283 +/- 59 0.202088 0.0064958 0.031256 0.0103942 0.0012334
CTSL cathepsin L 1295 +/- 116 1543 +/- 70 1117 +/- 86 1413 +/- 26 -0.105945 0.1024043 0.01727 0.2179043 0.1827795
CTSS cathepsin S 157 +/- 19 238 +/- 20 157 +/- 21 194 +/- 33 -0.257341 0.0137798 0.371198 0.0343246 0.5160115
CTTNBP2 cortactin binding protein 2 537 +/- 51 438 +/- 37 539 +/- 47 360 +/- 32 -0.362999 -0.154618 -0.012403 0.3916878 0.0872516
CUGBP2 CUG triplet repeat, RNA binding protein 2 1263 +/- 229 2289 +/- 319 1772 +/- 270 3161 +/- 347 0.008986 0.028023 0.013492 0.2405286 0.0448164
CUL5 cullin 5 2810 +/- 145 3330 +/- 140 3029 +/- 94 3332 +/- 99 0.370153 0.0273875 0.054928 0.0355529 0.0386436
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 145 +/- 13 207 +/- 12 192 +/- 13 214 +/- 15 0.140158 0.0065434 0.297556 0.0100324 0.9857923
S1- alphabetical list of aging-related genes.xls Page 7
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 477 +/- 43 740 +/- 86 434 +/- 31 541 +/- 30 -0.053544 0.0270477 0.035306 0.0017024 0.0346302
CXADR Coxsackie virus and adenovirus receptor 2582 +/- 321 1752 +/- 139 2109 +/- 65 1507 +/- 97 -0.07616 -0.050205 -0.00121 0.0443685 0.0132856
CXXC4 CXXC finger 4 336 +/- 31 432 +/- 16 266 +/- 21 359 +/- 24 -0.004324 0.0253939 0.01767 0.098273 0.053262
CYB561 cytochrome b-561 156 +/- 15 132 +/- 15 162 +/- 7 131 +/- 10 0.939814 -0.284122 -0.034607 0.4861141 0.1017238
CYCS cytochrome c, somatic 1114 +/- 69 1523 +/- 105 1124 +/- 93 1485 +/- 52 -0.99493 0.0103416 0.010191 0.1836039 0.1321904
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 588 +/- 29 675 +/- 23 522 +/- 14 543 +/- 13 -0.000203 0.0432777 0.29925 0.0939982 0.3473348
CYR61 cysteine-rich, angiogenic inducer, 61 179 +/- 15 130 +/- 13 126 +/- 20 128 +/- 12 -0.105469 -0.034656 0.939443 0.0150256 0.8075061
D21S2056EDNA segment on chromosome 21 (unique) 2056 expressed sequence 941 +/- 105 1138 +/- 59 786 +/- 44 1023 +/- 84 -0.012674 0.1404877 0.04602 0.2599288 0.1698107
DAK dihydroxyacetone kinase 2 homolog (S. cerevisiae) 169 +/- 11 116 +/- 13 159 +/- 13 126 +/- 13 -0.883429 -0.009758 -0.113635 0.007527 0.0237072
DBF4B DBF4 homolog B (S. cerevisiae) 88 +/- 14 172 +/- 19 93 +/- 13 170 +/- 27 0.81417 0.0066193 0.043191 0.0433228 0.0069601
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 6719 +/- 435 8157 +/- 929 5664 +/- 297 6675 +/- 313 -0.029077 0.2029886 0.044247 0.0499254 0.0076164
DBT dihydrolipoamide branched chain transacylase E2 462 +/- 33 608 +/- 51 504 +/- 30 557 +/- 59 -0.412108 0.0398338 0.4561 0.1623017 0.9693144
DCAMKL2 doublecortin and CaM kinase-like 2 1543 +/- 280 1165 +/- 201 1470 +/- 91 1163 +/- 35 -0.698962 -0.30095 -0.017705 0.4026001 0.0526574
DCTN4 dynactin 4 (p62) 2167 +/- 114 1786 +/- 115 2057 +/- 72 1769 +/- 87 -0.235129 -0.039592 -0.033853 0.4393145 0.3276353
DCTN6 dynactin 6 2538 +/- 127 2919 +/- 63 2668 +/- 126 2992 +/- 196 0.155899 0.0299498 0.207326 0.24043 0.7900069
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 2306 +/- 41 1936 +/- 62 1971 +/- 52 1884 +/- 74 -0.002173 -0.00083 -0.365085 0.000397 0.2125893
DDB2 damage-specific DNA binding protein 2, 48kDa 98 +/- 11 160 +/- 9 88 +/- 9 129 +/- 8 -0.122515 0.0015318 0.005825 0.0023322 0.0568833
DDHD1 DDHD domain containing 1 1480 +/- 235 2265 +/- 180 1320 +/- 221 1767 +/- 178 -0.001847 0.0253805 0.151224 0.1292407 0.5710365
DDX48 DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 1505 +/- 88 1696 +/- 45 1343 +/- 72 1561 +/- 54 -0.030789 0.0917214 0.038878 0.0217036 0.228826
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 600 +/- 31 706 +/- 25 583 +/- 35 620 +/- 21 -0.077657 0.0259954 0.387283 0.0095351 0.5212467
DEDD2 death effector domain containing 2 610 +/- 25 569 +/- 23 643 +/- 21 576 +/- 15 0.190941 -0.256153 -0.027965 0.8402068 0.2988356
DENND1CDENN/MADD domain containing 1C 279 +/- 20 236 +/- 9 241 +/- 20 176 +/- 16 -0.018819 -0.089721 -0.034211 0.1710881 0.0882096
DENR density-regulated protein 231 +/- 38 119 +/- 19 238 +/- 27 245 +/- 52 0.136663 -0.031448 0.908312 0.0089864 0.8710639
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 632 +/- 34 537 +/- 27 694 +/- 27 593 +/- 28 0.028154 -0.054305 -0.031207 0.1962728 0.2976787
DGCR6 DiGeorge syndrome critical region gene 6 979 +/- 27 906 +/- 45 1037 +/- 42 905 +/- 24 0.277388 -0.196474 -0.026268 0.1973073 0.0392253
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 670 +/- 35 550 +/- 12 568 +/- 33 500 +/- 24 -0.001543 -0.01723 -0.127297 0.0113765 0.3034065
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 2428 +/- 119 3034 +/- 236 2322 +/- 107 2271 +/- 112 -0.0288 0.0537281 -0.750334 0.0091283 0.7833466
DIP13B DIP13 beta 720 +/- 55 858 +/- 45 786 +/- 23 921 +/- 33 0.241895 0.0820758 0.010297 0.1216435 0.2661512
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 336 +/- 30 418 +/- 15 445 +/- 23 481 +/- 54 0.02934 0.0454459 0.56088 0.0322439 0.2303166
DKFZP779PRO0845 1349 +/- 59 1055 +/- 62 1202 +/- 31 955 +/- 46 -0.002435 -0.006254 -0.002851 0.1175901 0.0847625
DLEU8 deleted in lymphocytic leukemia 8 330 +/- 44 467 +/- 42 228 +/- 18 277 +/- 20 -0.002854 0.0495718 0.100475 0.0142841 0.0960935
DLG3 discs, large homolog 3 (neuroendocrine-dlg, Drosophila) 3182 +/- 238 2326 +/- 174 2460 +/- 135 2233 +/- 59 -0.069466 -0.017401 -0.167811 0.0156181 0.4314197
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 5343 +/- 423 4150 +/- 339 3362 +/- 229 2932 +/- 190 -0.000264 -0.053687 -0.182775 0.0176151 0.2355429
DMRTA2 DMRT-like family A2 171 +/- 21 95 +/- 12 262 +/- 37 117 +/- 11 0.057533 -0.012484 -0.009962 0.0533963 0.0209679
DMRTC1 DMRT-like family C1 490 +/- 23 258 +/- 25 324 +/- 18 327 +/- 38 -0.19937 -4.48E-05 0.951774 0.0086286 0.75672
DMTF1 cyclin D binding myb-like transcription factor 1 2324 +/- 160 2497 +/- 93 2237 +/- 55 2007 +/- 60 -0.025523 0.3743629 -0.021051 0.1431864 0.1538993
DNAJA5 DnaJ homology subfamily A member 5 145 +/- 11 219 +/- 23 120 +/- 15 134 +/- 16 -0.006805 0.0223379 0.546184 0.0218671 0.9701908
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 249 +/- 44 273 +/- 40 286 +/- 16 415 +/- 45 0.048566 0.6888496 0.042426 0.6548772 0.1443555
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 1205 +/- 78 888 +/- 41 1163 +/- 41 974 +/- 62 0.797996 -0.007385 -0.038186 0.0029897 0.0444014
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 3673 +/- 317 2730 +/- 233 3649 +/- 170 3344 +/- 450 0.519018 -0.039542 -0.553794 0.0553449 0.4061838
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2338 +/- 63 1862 +/- 122 2348 +/- 84 2059 +/- 107 0.18815 -0.009345 -0.065691 0.0345218 0.3819805
DNAPTP6 DNA polymerase-transactivated protein 6 3467 +/- 109 3025 +/- 90 3104 +/- 157 3123 +/- 114 -0.13326 -0.011511 0.925008 0.0015741 0.6415894
DNM2 dynamin 2 623 +/- 66 744 +/- 63 541 +/- 14 626 +/- 29 -0.040153 0.2143312 0.04064 0.1455557 0.0790072
DNPEP aspartyl aminopeptidase 711 +/- 27 636 +/- 18 663 +/- 42 616 +/- 40 -0.34376 -0.044533 -0.436049 0.0926153 0.3497293
S1- alphabetical list of aging-related genes.xls Page 8
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
DOC2B double C2-like domains, beta 258 +/- 27 166 +/- 20 253 +/- 19 182 +/- 20 0.994989 -0.023575 -0.030196 0.0071815 0.0204606
DOCK4 dedicator of cytokinesis 4 83 +/- 24 256 +/- 47 145 +/- 31 379 +/- 38 0.004588 0.0118613 0.001341 0.0689508 0.102621
DOK4 docking protein 4 476 +/- 29 384 +/- 21 433 +/- 40 391 +/- 20 -0.35646 -0.031212 -0.376148 0.0008963 0.4148033
DOK6 docking protein 6 1184 +/- 243 182 +/- 52 1228 +/- 38 204 +/- 68 0.238116 -0.00839 -6.71E-06 0.0219247 0.0162108
DPF1 D4, zinc and double PHD fingers family 1 1631 +/- 91 1083 +/- 88 1997 +/- 111 1529 +/- 115 0.001532 -0.001498 -0.017396 0.0084248 0.1077978
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 870 +/- 18 1041 +/- 46 787 +/- 41 847 +/- 24 -0.004586 0.0119429 0.24205 0.0784903 0.3300363
DRG2 developmentally regulated GTP binding protein 2 573 +/- 52 606 +/- 35 521 +/- 31 660 +/- 42 0.740595 0.6166757 0.031427 0.9007961 0.1741451
DST dystonin 236 +/- 21 370 +/- 38 341 +/- 33 339 +/- 42 0.136939 0.0151058 -0.977158 0.0064604 0.3652233
DTX3L deltex 3-like (Drosophila) 251 +/- 13 312 +/- 18 280 +/- 11 256 +/- 22 -0.422602 0.0240969 -0.357979 0.0931643 0.3178735
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) 283 +/- 16 306 +/- 11 221 +/- 15 291 +/- 20 -0.028388 0.273665 0.024862 0.3718957 0.1447019
DUSP14 dual specificity phosphatase 14 990 +/- 110 838 +/- 108 1439 +/- 43 1252 +/- 51 0.001272 -0.347324 -0.021931 0.3335945 0.1388966
DUSP16 dual specificity phosphatase 16 390 +/- 59 565 +/- 40 382 +/- 19 384 +/- 22 -0.062438 0.0381487 0.953696 0.0353272 0.8840471
DYM dymeclin 885 +/- 42 957 +/- 31 771 +/- 20 925 +/- 49 -0.025964 0.2012926 0.030225 0.5115503 0.0192984
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 508 +/- 62 728 +/- 72 644 +/- 82 957 +/- 115 0.003354 0.0439453 0.060176 0.2626924 0.3443156
DYNC2LI1dynein, cytoplasmic 2, light intermediate chain 1 663 +/- 56 564 +/- 36 662 +/- 33 520 +/- 17 -0.601184 -0.174754 -0.005517 0.3367994 0.0729974
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 831 +/- 140 590 +/- 62 593 +/- 37 489 +/- 19 -0.081726 -0.160623 -0.040427 0.1266689 0.1330754
DZIP1 DAZ interacting protein 1 1130 +/- 99 875 +/- 66 1406 +/- 101 904 +/- 129 0.050224 -0.060364 -0.015726 0.1075366 0.0672343
DZIP1L DAZ interacting protein 1-like 133 +/- 14 134 +/- 14 213 +/- 16 147 +/- 7 0.00727 0.975474 -0.006561 0.9479433 0.0103985
E2F3 E2F transcription factor 3 813 +/- 106 594 +/- 60 697 +/- 22 526 +/- 21 -0.190626 -0.111154 -0.000359 0.0884421 0.0277415
EBF2 early B-cell factor 2 119 +/- 5 103 +/- 3 119 +/- 8 91 +/- 19 -0.58918 -0.028084 -0.241927 0.0820613 0.4058296
ECD ecdysoneless homolog (Drosophila) 625 +/- 49 805 +/- 64 622 +/- 29 839 +/- 52 0.495522 0.0518555 0.009974 0.0080625 0.0248749
ECHDC1 enoyl Coenzyme A hydratase domain containing 1 1796 +/- 60 1599 +/- 72 1651 +/- 62 1404 +/- 53 -0.003041 -0.061427 -0.013714 0.6316257 0.1433039
ECRG4 esophageal cancer related gene 4 protein 529 +/- 11 661 +/- 53 803 +/- 58 778 +/- 126 0.00793 0.0538984 -0.863526 0.0081832 0.3276857
EDD1 E3 ubiquitin protein ligase, HECT domain containing, 1 880 +/- 28 980 +/- 21 1000 +/- 50 955 +/- 46 0.269351 0.0177322 -0.513782 0.0471093 0.4856002
EDF1 endothelial differentiation-related factor 1 2924 +/- 89 3195 +/- 140 2664 +/- 103 3111 +/- 63 -0.081532 0.1393159 0.006026 0.0524779 0.0028085
EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 2404 +/- 126 2634 +/- 244 2878 +/- 139 2330 +/- 117 0.202934 0.4293595 -0.014497 0.4495916 0.0176538
EDG2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 5091 +/- 735 6481 +/- 945 2992 +/- 289 3972 +/- 198 -0.006517 0.2741158 0.022002 0.0528127 0.027661
EDG4 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 173 +/- 16 166 +/- 12 211 +/- 12 168 +/- 8 0.169011 -0.730366 -0.014332 0.8755287 0.0104144
EDG7 Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7 906 +/- 85 1108 +/- 56 920 +/- 115 1256 +/- 85 0.270578 0.0789611 0.044672 0.0544164 0.1609179
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 11705 +/- 649 13512 +/- 606 11114 +/- 370 12852 +/- 588 -0.195276 0.0694277 0.041287 0.3456743 0.4914076
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 12229 +/- 451 10754 +/- 445 11925 +/- 233 11098 +/- 267 0.93132 -0.042274 -0.046167 0.0143564 0.3813578
EFCAB2 EF-hand calcium binding domain 2 1046 +/- 47 1331 +/- 56 1121 +/- 95 1272 +/- 82 0.705551 0.0031117 0.260353 0.0092354 0.7531719
EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 5116 +/- 149 5852 +/- 332 4920 +/- 274 5811 +/- 259 -0.968883 0.0863104 0.042475 0.0222773 0.1553735
EFHA2 EF-hand domain family, member A2 3623 +/- 194 3050 +/- 248 4234 +/- 119 3864 +/- 96 0.006972 -0.100358 -0.038748 0.0544414 0.2160947
EFHC2 EF-hand domain (C-terminal) containing 2 234 +/- 19 266 +/- 17 174 +/- 10 237 +/- 7 -0.003752 0.235678 0.000755 0.3789393 0.0642173
EFNB2 ephrin-B2 1795 +/- 111 1406 +/- 118 910 +/- 113 742 +/- 59 -4.69E-06 -0.03715 -0.223194 0.0464358 0.3631596
EGLN1 egl nine homolog 1 (C. elegans) 599 +/- 67 426 +/- 24 799 +/- 81 561 +/- 31 0.013278 -0.050058 -0.031492 0.0742366 0.0520918
EGLN2 egl nine homolog 2 (C. elegans) 198 +/- 34 157 +/- 24 231 +/- 12 268 +/- 10 0.022033 -0.34357 0.04326 0.445131 0.4164312
EI24 etoposide induced 2.4 mRNA 1967 +/- 197 2517 +/- 46 2093 +/- 202 2274 +/- 91 -0.648435 0.0374714 0.441747 0.0391908 0.2101078
EID-3 EID-2-like inhibitor of differentiation-3 1170 +/- 82 1234 +/- 63 1297 +/- 45 1499 +/- 44 0.003591 0.5512022 0.010926 0.8176413 0.0879027
EIF1AX eukaryotic translation initiation factor 1A, X-linked 237 +/- 22 1333 +/- 96 475 +/- 143 1352 +/- 99 0.415428 4.71E-05 0.00082 0.0002253 0.0525047
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 413 +/- 20 484 +/- 18 343 +/- 27 326 +/- 8 -0.000295 0.0263662 -0.570408 0.0087158 0.5093347
EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa 2662 +/- 54 2791 +/- 67 2401 +/- 59 2691 +/- 31 -0.004037 0.1657818 0.002838 0.2860517 0.0059068
EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa 3204 +/- 180 2481 +/- 170 2961 +/- 100 2491 +/- 175 -0.387142 -0.01553 -0.055559 0.1213205 0.4933105
S1- alphabetical list of aging-related genes.xls Page 9
Young vs Aged MSI Correlations
Symbol Description Young CA Aged CA Young DG Aged DG CA v DG in CA in DG in CA in DG
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 3958 +/- 161 4220 +/- 172 3636 +/- 92 4030 +/- 135 -0.153024 0.2921752 0.045357 0.4686162 0.0015409
EIF5A2 eukaryotic translation initiation factor 5A2 834 +/- 58 677 +/- 46 773 +/- 40 626 +/- 24 -0.107501 -0.062435 -0.013845 0.2520963 0.0887465
EIF5B eukaryotic translation initiation factor 5B 746 +/- 19 848 +/- 36 734 +/- 20 791 +/- 15 -0.252486 0.0371269 0.052223 0.0020477 0.0552854
ELAC1 elaC homolog 1 (E. coli) 257 +/- 16 328 +/- 22 295 +/- 19 351 +/- 12 0.005793 0.0277609 0.037583 0.0035732 0.0142275
ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 189 +/- 16 110 +/- 15 287 +/- 18 170 +/- 21 0.001759 -0.005034 -0.002436 0.013616 0.031892
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 129 +/- 10 68 +/- 11 136 +/- 10 86 +/- 15 0.139917 -0.002287 -0.022561 0.0009517 0.0674202
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 355 +/- 29 436 +/- 19 346 +/- 23 388 +/- 29 -0.207108 0.0421148 0.281535 0.0275506 0.4790472
ELOVL4 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 1955 +/- 115 1623 +/- 79 1858 +/- 101 1621 +/- 69 -0.630383 -0.04206 -0.086909 0.0266101 0.5416739
ELTD1 EGF, latrophilin and seven transmembrane domain containing 1 216 +/- 15 319 +/- 20 190 +/- 19 228 +/- 17 -0.026701 0.0022995 0.16525 0.0005254 0.2394358
EMD emerin (Emery-Dreifuss muscular dystrophy) 883 +/- 36 950 +/- 27 898 +/- 19 978 +/- 23 0.544975 0.1708619 0.026642 0.7273092 0.3835798
EML4 echinoderm microtubule associated protein like 4 276 +/- 12 333 +/- 21 362 +/- 36 401 +/- 18 0.002134 0.0464792 0.35486 0.0068409 0.5067077
EMP2 epithelial membrane protein 2 131 +/- 20 209 +/- 17 138 +/- 17 214 +/- 16 0.498061 0.0133384 0.011268 0.0207786 0.0159111
EMP3 epithelial membrane protein 3 385 +/- 23 473 +/- 25 311 +/- 21 374 +/- 24 -0.001739 0.0295194 0.081156 0.0951945 0.7970266
EMX2 empty spiracles homolog 2 (Drosophila) 860 +/- 116 836 +/- 85 1476 +/- 75 1238 +/- 46 0.000166 -0.874806 -0.027446 0.900048 0.0081431
ENO1 enolase 1, (alpha) 7846 +/- 333 9198 +/- 336 6480 +/- 135 7880 +/- 253 -0.000391 0.0169672 0.00252 0.0783902 0.0568711
EP400 E1A binding protein p400 812 +/- 48 952 +/- 33 925 +/- 77 961 +/- 76 0.115793 0.0389664 0.741597 0.0088177 0.300628
EPB41L5 erythrocyte membrane protein band 4.1 like 5 80 +/- 8 128 +/- 8 94 +/- 11 112 +/- 3 -0.815495 0.002337 0.173636 0.0012424 0.3634233
EPHB6 EPH receptor B6 1193 +/- 220 1171 +/- 59 814 +/- 60 1044 +/- 67 -0.122707 -0.925675 0.032399 0.7972843 0.1634836
EPS15 epidermal growth factor receptor pathway substrate 15 6961 +/- 240 6152 +/- 333 6822 +/- 320 5815 +/- 233 -0.582912 -0.079764 -0.032351 0.5176281 0.1514397
EPS8 epidermal growth factor receptor pathway substrate 8 1375 +/- 55 1537 +/- 28 1326 +/- 75 1257 +/- 47 -0.015856 0.0333534 -0.451632 0.0403725 0.1494764
ERBB2IP erbb2 interacting protein 1656 +/- 204 2474 +/- 294 1821 +/- 122 2048 +/- 58 -0.515613 0.0485273 0.137143 0.0054073 0.2314574
ERGIC3 ERGIC and golgi 3 2303 +/- 107 2433 +/- 73 2054 +/- 51 2319 +/- 42 -0.015545 0.3425289 0.003142 0.8177734 0.1119695
ETF1 eukaryotic translation termination factor 1 243 +/- 4 206 +/- 11 313 +/- 29 253 +/- 16 0.004699 -0.015712 -0.113144 0.0736888 0.1713913
ETFA electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) 763 +/- 80 635 +/- 93 926 +/- 45 580 +/- 121 0.182268 -0.323308 -0.043134 0.653015 0.1909163
ETFDH electron-transferring-flavoprotein dehydrogenase 382 +/- 17 463 +/- 16 356 +/- 16 395 +/- 22 -0.011825 0.0066056 0.190975 0.1096217 0.4593126
EXOC7 exocyst complex component 7 228 +/- 32 391 +/- 33 285 +/- 12 351 +/- 36 0.513132 0.004969 0.144338 0.0761158 0.2113179
EXOSC10 exosome component 10 957 +/- 62 1170 +/- 42 800 +/- 35 895 +/- 36 -0.000661 0.0202287 0.092599 0.0296892 0.1904323
EXOSC5 exosome component 5 648 +/- 33 544 +/- 16 532 +/- 31 483 +/- 14 -0.008 -0.025109 -0.20146 0.0251747 0.4908932
FA2H fatty acid 2-hydroxylase 1088 +/- 162 1680 +/- 349 622 +/- 81 901 +/- 73 -0.012014 0.1668608 0.030927 0.0274475 0.011596
FADD Fas (TNFRSF6)-associated via death domain 417 +/- 17 322 +/- 14 411 +/- 35 337 +/- 8 0.802694 -0.001535 -0.090736 0.0364948 0.3206309
FADS3 fatty acid desaturase 3 1186 +/- 74 995 +/- 86 1240 +/- 69 944 +/- 62 0.720485 -0.123483 -0.010979 0.1789204 0.0811987
FAIM Fas apoptotic inhibitory molecule 608 +/- 41 920 +/- 63 711 +/- 51 974 +/- 37 0.112615 0.0027375 0.00246 0.0032731 0.0292477
FANCM Fanconi anemia, complementation group M 187 +/- 20 162 +/- 14 232 +/- 6 158 +/- 16 0.195764 -0.347211 -0.007508 0.511436 0.0197887
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 387 +/- 68 1140 +/- 179 336 +/- 59 910 +/- 114 -0.005662 0.0066696 0.004169 0.1398067 0.0912823
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 207 +/- 32 348 +/- 65 210 +/- 30 315 +/- 16 -0.555578 0.0929471 0.015546 0.0052674 0.0183646
FASTK Fas-activated serine/threonine kinase 625 +/- 37 797 +/- 40 549 +/- 14 706 +/- 35 -0.014604 0.010554 0.0082 0.048923 0.0043773
FAT3 FAT tumor suppressor homolog 3 (Drosophila) 802 +/- 78 532 +/- 31 691 +/- 50 625 +/- 62 -0.85823 -0.016377 -0.430341 0.0445128 0.8837028
FAT4 FAT tumor suppressor homolog 4 (Drosophila) 293 +/- 14 306 +/- 33 708 +/- 23 485 +/- 48 0.000342 0.734089 -0.005929 0.523441 0.1234583
FBLN1 fibulin 1 358 +/- 58 415 +/- 18 289 +/- 15 381 +/- 10 -0.114801 0.3817661 0.000674 0.2249587 0.0110259
FBP1 fructose-1,6-bisphosphatase 1 89 +/- 10 125 +/- 32 81 +/- 8 136 +/- 13 0.759081 0.3232018 0.009196 0.8116737 0.0144975
FBXL12 F-box and leucine-rich repeat protein 12 183 +/- 11 198 +/- 17 225 +/- 11 184 +/- 12 0.303886 0.4935119 -0.040901 0.2257533 0.1786531
FBXL14 F-box and leucine-rich repeat protein 14 1117 +/- 114 749 +/- 52 1272 +/- 40 979 +/- 38 0.01286 -0.022121 -0.000484 0.07579 0.0310178
FBXL3 F-box and leucine-rich repeat protein 3 2062 +/- 73 1887 +/- 100 2305 +/- 53 1970 +/- 46 0.072848 -0.188586 -0.000995 0.1538691 0.0055467
FBXL5 F-box and leucine-rich repeat protein 5 281 +/- 17 233 +/- 9 307 +/- 13 264 +/- 18 0.037003 -0.036268 -0.084253 0.1025076 0.2376194
S1- alphabetical list of aging-related genes.xls Page 10