Rubin's Pathology: Clinicopathologic Foundations of Medicine, 6th Edition PDF
Preview Rubin's Pathology: Clinicopathologic Foundations of Medicine, 6th Edition
RUBIN’S PATHOLOGY: Clinicopathologic Foundations of Medicine S I X T H E D I T I O N Editors Raphael Rubin, M.D., leftand David S. Strayer, M.D., Ph.D., right. Founder and Consulting Editor Emanuel Rubin, M.D. RUBIN’S PATHOLOGY: Clinicopathologic Foundations of Medicine S I X T H E D I T I O N EDITORS: Raphael Rubin, M.D. David S. Strayer, M.D., Ph.D. Professor of Pathology Professor of Pathology Department of Pathology and Cell Biology Jefferson Medical College of Thomas Jefferson University Philadelphia, Pennsylvania FOUNDER AND CONSULTING EDITOR: Emanuel Rubin, M.D. Gonzalo Aponte Distinguished Professor of Pathology Chairman Emeritus of the Department of Pathology and Cell Biology Jefferson Medical College of Thomas Jefferson University Philadelphia, Pennsylvania Acquisitions Editor: Susan Rhyner Product Manager:Sirkka Howes Marketing Manager: Joy Fisher-Williams Manufacturing Manager:Margie Orzech Designer: Steve Druding Compositor: Aptara, Inc. Sixth Edition Copyright © 2012, 2008, 2005, 2001, 1995, 1989 Lippincott Williams & Wilkins, a Wolters Kluwer business. 351 West Camden Street Two Commerce Square Baltimore, MD 21201 2001 Market Street Philadelphia, PA19103 Printed in China All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, includ- ing as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by indi- viduals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Lippincott Williams & Wilkins at 530 Walnut Street, Philadelphia, PA19106, via email at [email protected], or via website at lww.com (products and services). 9 8 7 6 5 4 3 2 1 Library of Congress Cataloging-in-Publication Data Rubin’s pathology : clinicopathologic foundations of medicine / Editors, Raphael Rubin, M.D., David S. Strayer, M.D., Ph.D., Professor of Pathology Professor of Pathology, Department of Pathology and Cell Biology, Jefferson Medical College of Thomas Jefferson University Philadelphia, Pennsyl- vania, Founder and Consulting Editor, Emanuel Rubin, M.D., Gonzalo Aponte, Distinguished Professor of Pathology, Chairman Emeritus of the Depart- ment of Pathology and Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania. — Sixth Edition. p. ; cm. Pathology : clinicopathologic foundations of medicine Includes bibliographical references and index. Summary: “The highly acclaimed foundation textbook Rubin’s Pathology: Clinicopathologic Foundations of Medicine, now in its sixth edition, pro- vides medical students with a lucid discussion of basic disease processes and their effects on cells, organs, and people. The streamlined coverage includes only what medical students need to know and provides clinical application of the chapter concepts. Icons signal discussions of pathogenesis, pathology, epidemiology, etiological factors, and clinical features. Rubin’s Pathology is liberally illustrated with full-color graphic illustrations, gross pathology pho- tos, and micrographs. The sixth edition is completely updated with expanded and revised context. Asuite of exciting online tools for students includes a fully searchable e-text with all images, 140 interactive case studies, 1500 audio review questions, summary podcast lectures, and a selection of mobile flash cards for iPhone, iPod, and BlackBerry from the new Rubin’s Pathology Mobile Flash Cards. Resources for faculty include a 600 question test gen- erator and chapter outlines and objectives”—Provided by publisher. ISBN 978-1-60547-968-2 (hardback : alk. paper) 1. Pathology. I. Rubin, Raphael, editor. II. Strayer, David S. (David Sheldon), 1949- editor. III. Rubin, Emanuel, 1928- editor. IV. Title: Pathology : clinicopathologic foundations of medicine. [DNLM: 1. Pathologic Processes. QZ 4] RB111.E856 2012 616.07—dc22 2010052493 DISCLAIMER Care has been taken to confirm the accuracy of the information present and to describe generally accepted practices. However, the authors, edi- tors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of this infor- mation in a particular situation remains the professional responsibility of the practitioner; the clinical treatments described and recommended may not be considered absolute and universal recommendations. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with the current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in this publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDAstatus of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030or fax orders to (301) 223-2320. International cus- tomers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: http://www.lww.com. Lippincott Williams & Wilkins customer service representatives are avail- able from 8:30 am to 6:00 pm, EST. The publisher specially acknowledges the past work and contributions of Professor F. Stephen Vogel to the chapter on neuropathology. Dr. Vogel appre- ciates the publisher’s previous recognition of its erroneous use of his work in the 4th and 5th editions, and wishes to publicly express his satisfaction with the authorship and content of the chapter as it appears in this 6th edition. DEDICATION We dedicate this book to our wives and families, whose tolerance, love and support sustained us throughout this endeavor; to our colleagues, from whom we have learned so much; to our chapter authors who have given so much of themselves to produce this new edition; and to students every- where, upon whose curiosity and energy the future of medical science depends. CONTRIBUTORS Michael F. Allard, MD Gregory N. Fuller, MD, PhD Professor of Pathology and Laboratory Medicine Professor of Pathology University of British Columbia Chief of Neuropathology Cardiovascular Pathologist The University of Texas M.D. Anderson Cancer Center Department of Pathology and Laboratory Medicine Houston, Texas The iCAPTURE Centre St. Paul’s Hospital Roberto A. Garcia, MD Vancouver, British Columbia, Canada Assistant Professor of Pathology The Mount Sinai School of Medicine Mary Beth Beasley, MD Chief of Orthopaedic and Soft Tissue Pathology Associate Professor of Pathology The Mount Sinai Hospital Mount Sinai Medical Center New York, New York New York, New York J. Clay Goodman, MD Thomas W. Bouldin, MD Professor of Pathology and Neurology Professor of Pathology and Laboratory Medicine Walter Henrick Moursund Chair in Neuropathology Chair for Faculty and Trainee Development Associate Dean of Undergraduate Medical Education University of North Carolina at Chapel Hill Baylor College of Medicine Director of Neuropathology Houston, Texas McLendon Clinical Laboratories University of North Carolina Hospitals Avrum I. Gotlieb, MD, CM, FRCP Chapel Hill, North Carolina Professor of Laboratory Medicine and Pathology University of Toronto Diane L. Carlson, MD Staff Pathologist Assistant Attending Laboratory Medicine Program Department of Pathology University Health Network Memorial Sloan-Kettering Cancer Center Toronto, Ontario, Canada New York, New York Philip N. Hawkins, PhD, FRCP, FRCPath, FMedSci Ivan Damjanov, MD, PhD Professor of Medicine Professor of Pathology Centre for Amyloidosis and Acute Phase Proteins The University of Kansas School of Medicine University College London Medical School Pathologist Head, National Amyloidosis Centre Department of Pathology Royal Free Hospital University of Kansas Medical Center London, England, United Kingdom Kansas City, Kansas Steven K. Herrine, MD Jeffrey M. Davidson, PhD Professor of Medicine Professor of Pathology Thomas Jefferson University Vanderbilt University School of Medicine Philadelphia, Pennsylvania Senior Research Career Scientist Medical Research Service J. Charles Jennette, MD Veterans Affairs Tennessee Valley Healthcare System Brinkhous Distinguished Professor and Chair of Nashville, Tennessee Pathology and Laboratory Medicine University of North Carolina, School of Medicine David E. Elder, MD, ChB, FRCPA Chief of Service Professor of Pathology and Laboratory Medicine Department of Pathology and Laboratory Medicine University of Pennsylvania School of Medicine University of North Carolina Hospitals Director of Anatomic Pathology Chapel Hills, North Carolina Hospital of the University of Pennsylvania Philadelphia, Pennsylvania Alina Dulau Florea, MD Assistant Professor of Pathology Thomas Jefferson University Philadelphia, Pennsylvania vi CONTRIBUTORS vii Lawrence C. Kenyon, MD, PhD Anna Marie Mulligan, MB, MSc, FRCPath Associate Professor of Pathology, Anatomy and Assistant Professor of Laboratory Medicine and Cell Biology Pathobiology Thomas Jefferson University University of Toronto Pathologist and Neuropathologist Anatomic Pathologist Department of Pathology, Anatomy and Cell Biology Department of Laboratory Medicine Thomas Jefferson University Hospital St. Michael’s Hospital Philadelphia, Pennsylvania Toronto, Ontario, Canada Robert Kisilevsky, MD, PhD, FRCPC, FRSC Hedwig S. Murphy, MD, PhD Professor Emeritus Associate Professor of Pathology Department of Pathology and Molecular Medicine University of Michigan Queen’s University Staff Pathologist Kingston, Ontario, Canada Department of Pathology and Laboratory Medicine Veterans Affairs Ann Arbor Health System Michael J. Klein, MD Ann Arbor, Michigan Professor of Pathology and Laboratory Medicine Weill Medical College of Cornell University George L. Mutter, MD Pathologist-in-Chief and Director of Pathology and Associate Professor of Pathology Laboratory Medicine Harvard Medical School Hospital for Special Surgery Pathologist New York, New York Department of Pathology Brigham and Women’s Hospital David S. Klimstra, MD Boston, Massachusetts Chief of Surgical Pathology Department of Pathology Victor J. Navarro, MD Memorial Sloan-Kettering Cancer Center Professor of Medicine, Pharmacology and Experimental New York, New York Therapeutics Medical Director, Liver Transplantation Gordon K. Klintworth, MD, PhD Director, Transplant Hepatology Fellowship Professor of Pathology Departments of Gastroenterology and Hepatology Joseph A.C. Wadsworth Research Professor of Thomas Jefferson University Ophthalmology Philadelphia, Pennsylvania Duke University Durham, North Carolina Frances P. O’Malley, MB, FRCPC Professor of Laboratory Medicine and Pathobiology Amber Chang Liu, MSc University of Toronto University of Toronto Staff Pathologist Toronto, Ontario, Canada Department of Pathology and Laboratory Medicine Mount Sinai Hospital Peter A. McCue, MD Toronto, Ontario, Canada Professor of Pathology Thomas Jefferson University Stephen Peiper, MD Director of Anatomic Pathology Peter A. Herbut Professor and Chairman of Pathology, Thomas Jefferson University Hospital Anatomy and Cell Biology Philadelphia, Pennsylvania Thomas Jefferson University, Jefferson Medical College Philadelphia, Pennsylvania Bruce McManus, MD, PhD, FRSC Professor of Pathology and Laboratory Medicine Jaime Prat, MD, PhD, FRCPath University of British Columbia Professor of Pathology Director, Providence Heart and Lung Institute Director of Pathology St. Paul’s Hospital Autonomous University of Barcelona Vancouver, British Columbia, Canada Director of Pathology Hospital de la Santa Creu i Sant Pau Maria J. Merino, MD Barcelona, Spain Chief of Translational Pathology Department of Pathology Martha Quezado, MD National Cancer Institute Staff Pathologist Bethesda, Maryland Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda, Maryland viii CONTRIBUTORS Jeffrey E. Saffitz, MD, PhD Riccardo Valdez, MD Mallinckrodt Professor of Medicine Assistant Professor of Pathology Harvard Medical School Section Head, Hematopathology Chairman, Department of Pathology Department of Laboratory Medicine and Pathology Beth Israel Deaconess Medical Center Mayo Clinic Boston, Massachusetts Scottsdale, Arizona Alan L. Schiller, MD Jeffrey S. Warren, MD Professor of Pathology Aldred S. Warthin Endowed Professor of Pathology Mount Sinai School of Medicine Director, Division of Clinical Pathology Chairman, Department of Pathology University of Michigan Medical School Mount Sinai Hospital University of Michigan Hospitals New York, New York Ann Arbor, Michigan David A. Schwartz, MD, MSHyg, FCAP Bruce M. Wenig, MD Associate Clinical Professor of Pathology Professor of Pathology Vanderbilt University School of Medicine Albert Einstein College of Medicine Nashville, Tennessee Bronx, New York Chairman Gregory C. Sephel, PhD Department of Pathology and Laboratory Medicine Associate Professor of Pathology Beth Israel Medical Center Vanderbilt University School of Medicine St. Luke’s and Roosevelt Hospitals Nashville, Tennessee New York, New York Elias S. Siraj, MD Kevin Jon Williams, MD Associate Professor of Medicine Professor of Medicine Section of Endocrinology Chief, Section of Endocrinology, Diabetes, and Temple University School of Medicine Metabolism Program Director, Endocrinology Fellowship Temple University School of Medicine Temple University Hospital Philadelphia, Pennsylvania Philadelphia, Pennsylvania Robert Yanagawa, MD, PhD Edward B. Stelow, MD Resident in Surgery Associate Professor of Pathology Division of Cardiac Surgery University of Virginia University of Toronto, Faculty of Medicine Charlottesville, Virginia Toronto, Ontario, Canada Craig A. Storm, MD Mary M. Zutter, MD Assistant Professor of Pathology Professor of Pathology and Cancer Biology Dartmouth Medical School Vanderbilt University Hanover, New Hampshire Director of Hematopathology Staff Dermatopathologist Vanderbilt University Medical Center Department of Pathology Nashville, Tennessee Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire William D. Travis, MD Professor of Pathology Weill Medical College of Cornell University Attending Thoracic Pathologist Memorial Sloan Kettering Cancer Center New York, New York
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