Role of Proteases in Cellular Dysfunction PDF
Preview Role of Proteases in Cellular Dysfunction
Advances in Biochemistry in Health and Disease Naranjan S. Dhalla Sajal Chakraborti E ditors Role of Proteases in Cellular Dysfunction Advances in Biochemistry in Health and Disease Series Editor: Naranjan S. Dhalla Winnipeg, Manitoba, Canada Volume 1: S. K. Cheema (ed), Biochemistry of Atherosclerosis Volume 2: S. W. Schaffer and M-Saadeh Suleiman (eds), Mitochondria: The Dynamic Organelle Volume 3: A. K. Srivastava and M. B. Anand-Srivastava (eds), Signal Transduction in the Cardiovascular System in Health and Disease Volume 4: B. Ostadal and N. S. Dhalla (eds), Cardiac Adaptations-Molecular Mechanisms Volume 5: B. I. Jugdutt and N. S. Dhalla (eds), Cardiac Remodeling-Molecular Mechanisms Volume 6: Jawahar L. Mehta and N. S. Dhalla (eds), Biochemical Basis and Therapeutic Implications of Angiogenesis Volume 7: S. Chakraborti and N. S. Dhalla (eds), Proteases in Health and Disease Volume 8: S. Chakraborti and N. S. Dhalla (eds), Role of Proteases in Cellular Dysfunction For further volumes: http://www.springer.com/series/7064 Naranjan S. Dhalla (cid:129) Sajal Chakraborti Editors Role of Proteases in Cellular Dysfunction Editors Naranjan S. Dhalla Sajal Chakraborti Institute of Cardiovascular Sciences Department of Biochemistry and Biophysics St. Boniface Hospital Research University of Kalyani University of Manitoba Kalyani , WB Winnipeg , MB India Canada ISBN 978-1-4614-9098-2 ISBN 978-1-4614-9099-9 (eBook) DOI 10.1007/978-1-4614-9099-9 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013953330 © Springer Science+Business Media New York 2014 This work is subject to copyright. 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Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) This book is dedicated to Prof. Ranbir C. Sobti, Vice Chancellor, Babasaheb Bhimrao Ambedkar University, Lucknow, India, for his untiring efforts to promote excellence in science throughout the Indian subcontinent. Prof. Sobti served the Punjab University with great distinction, fi rst as Professor and Head and then as Vice Chancellor. In view of his outstanding record as scientist in the fi eld of Biotechnology as well as high commitment for developing scientifi c culture and promoting young investigators, he was elected President of the 101st Indian Science Congress. Dr. Sobti was bestowed the great honor “Padmashree” by the Government of India. Pref ace This book entitled “Role of Proteases in Cellular Dysfunctions” is the second book on Proteases for the Series “Advances in Biochemistry in Health and Disease.” It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal, and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, and development to senescence and death. Under physiological conditions the ability of proteases is regulated by endog- enous inhibitors. However, when the activity of proteases is not regulated appropri- ately, disease processes can result in, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, infl ammation, and atherosclerosis. Thus it is evi- dent that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. For scientists working on proteases, it is important to consider the components that are intimately involved in the activation/inhibition of proteases. Additionally, proteases regulate a plethora of cell functions via interactions with other enzymes/ proteins in cells. Effi cacy of protease inhibitors to treat diseases has also been rec- ognized and is currently an important fi eld of research. This book is the result of the commendable effort by a large group of world leading experts to provide excellent, comprehensive, and up-to-date reviews on the subjects in the fi eld. It contains 23 chapters contributed by experts in their respective fi elds and elucidates the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined for new strategies for the development of therapeutic interventions. The book consists of three parts in specifi ed topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The fi rst section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases, and matrix metalloproteases (MMPs). The second section covers the deadly disease, cancer, and its relation to ubiquitin–proteasomal system, MMPs, and serine proteases. The last section is about the role of proteases such as calpains, MMPs, and serine protease as well as urokinase-type plasminogen activator receptor (uPAR) in causing cardiovascular vii viii Preface defects. The readers will fi nd these chapters both stimulating and interesting. We hope that this book will prove useful for graduate students and also researchers, who have an interest in cellular proteolytic events. As editors of this book, we are greatly indebted to the authors for the time and effort they spent in making the book as an advancement of knowledge in this fi eld. We would also like to thank Prof. Dilip Kumar Mohanta, Vice Chancellor, University of Kalyani, West Bengal, India, and Prof. Bimal K Ray, University of Missouri, Columbia, Missouri, USA, for their encouragement. The time and efforts of Dr. Vijayan Elimban and Mrs. Eva Little (St. Boniface Hospital Research) during the editing of this book are highly appreciated. We are also grateful to Ms. Melanie Tucker and Ms. Rita Beck (Springer, New York) for their understanding as well as patience for the preparation of this book. Winnipeg, MB, Canada Naranjan S. Dhalla Kalyani , WB , India Sajal Chakraborti Contents Part I Proteases and Neural Disorders 1 Role of Calpain in Immunobiology of Neurodegenerative Diseases ............................................................... 3 Nicole Trager, Azizul Haque, Swapan K. Ray, Arabinda Das, and Naren L. Banik 2 Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration ........................................................ 17 Christopher M. Norris 3 Involvement of Caspases in the Pathophysiology of Neurodegeneration and Stroke .......................................................... 47 Alakananda Goswami, Prosenjit Sen, Kuladip Jana, and Sanghamitra Raha 4 Matrix Metalloproteinases in Ischemia–Reperfusion Injury in Brain: Antioxidants as Rescuer ............................................. 67 Sibani Sarkar, Somnath Chatterjee, and Snehasikta Swarnakar 5 The Role of Matrix Metalloproteinases in Neurovascular Injury ...... 93 Ji Hae Seo, Shuzhen Guo, Josephine Lok, Deepti Navaratna, Changhong Xing, and Eng H. Lo 6 The Role of Proteases in Embryonic Neural Crest Cells ..................... 103 Avi Bar, Irit Shoval, Efrat Monsonego-Ornan, and Dalit Sela-Donenfeld Part II Proteases and Cancer 7 Proteases and Cancer Development ...................................................... 129 Shudong Zhu and Zhoufang Li ix
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