Role of Nutraceuticals in Cancer Chemosensitization (Volume 2) (Cancer Sensitizing Agents for Chemotherapy, Volume 2) PDF
Preview Role of Nutraceuticals in Cancer Chemosensitization (Volume 2) (Cancer Sensitizing Agents for Chemotherapy, Volume 2)
Cancer Sensitizing Agents for Chemotherapy ROLE OF NUTRACEUTICALS IN CANCER CHEMOSENSITIZATION VOLUME 2 Cancer Sensitizing Agents for Chemotherapy ROLE OF NUTRACEUTICALS IN CANCER CHEMOSENSITIZATION VOLUME 2 Edited by A C B LOK HANDRA HARTI UniversityofDelhi(NorthCampus),Delhi,andNationalInstituteofCancerPreventionandResearch- IndianCouncilofMedicalResearch(NICPR-ICMR),Noida,UP,India B B A HARAT HUSHAN GGARWAL InflammationResearchCenter,SanDiego,CA,UnitedStates AcademicPressisanimprintofElsevier 125LondonWall,LondonEC2Y5AS,UnitedKingdom 525BStreet,Suite1800,SanDiego,CA92101-4495,UnitedStates 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom ©2018ElsevierInc.Allrightsreserved. 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Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingandusingany information,methods,compounds,orexperimentsdescribedherein.Inusingsuchinformationormethodsthey shouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesforwhomtheyhaveaprofessional responsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assumeanyliabilityfor anyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability,negligenceorotherwise,orfrom anyuseoroperationofanymethods,products,instructions,orideascontainedinthematerialherein. LibraryofCongressCataloging-in-PublicationData AcatalogrecordforthisbookisavailablefromtheLibraryofCongress BritishLibraryCataloguing-in-PublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary ISSN:2468-3183 ISBN:978-0-12-812373-7 ForinformationonallAcademicPresspublications visitourwebsiteathttps://www.elsevier.com/books-and-journals Publisher:MicaHaley AcquisitionEditor:RafaelE.Teixeira EditorialProjectManager:MarianaL.Kuhl ProductionProjectManager:PunithavathyGovindaradjane CoverDesigner:GregHarris TypesetbySPiGlobal,India Contents Contributors ix Conclusion 51 ConflictofInterest 52 About the Editors xi Acknowledgment 52 About the Series Editor xiii References 52 Aims and Scope for Series “Cancer FurtherReading 60 SensitizingAgentsforChemotherapy” xv 3. Role of Resveratrol in Preface xvii Chemosensitization of Cancer 61 SABIRAMOHAMMED,KUZHUVELILB.HARIKUMAR 1. Pathways Linked to Cancer Abstract 61 Chemoresistance and Their Targeting Introduction 61 by Nutraceuticals 1 SourceandChemistryofResveratrol 62 ALOKCHANDRABHARTI,KANCHANVISHNOI, PossibleMolecularMechanismsof SUKHMAHENDRASINGH, ChemoresistanceinCancer 62 BHARATBHUSHANAGGARWAL ChemosensitizationStudiesUsingResveratrol inVitro 65 Abstract 1 ChemosensitizationStudiesUsingResveratrol Introduction 2 inVivo 68 Chemotherapy 3 HumanClinicalTrialsInvolvingResveratrol Chemoresistance:ProbleminCuringCancer 7 inCancer 70 MechanismofChemoresistance 8 ConclusionandFuturePerspective 71 Chemosensitization:AnApproachtoTarget References 71 Cancer 14 FurtherReading 76 NutraceuticalsasChemosensitizers:Opportunities andChallenges 14 4. Role of Tocotrienols in Conclusion 19 Chemosensitization of Cancer 77 ConflictofInterest 19 Acknowledgments 19 KAZIMHUSAIN,MOKENGEP.MALAFA References 19 Abstract 77 Introduction 77 2. The Potential of Curcumin: A SourceandChemistryofTocotrienols 78 Multitargeting Agent in Cancer Cell MolecularTargetsofTocotrienolsinCancer 79 Chemosensitization 31 MechanismsofAnticancerActionof Tocotrienols 81 DEVIVASHABORDOLOI,AJAIKUMARB. KUNNUMAKKARA ChemosensitizationbyTocotrienols 83 ChemosensitizationInVitro 85 Abstract 31 ChemosensitizationInVivo 90 Introduction 31 ChemosensitizationinHuman 91 ChemosensitizationStudiesofCurcuminin Conclusion 91 DifferentCancers 33 References 91 v vi CONTENTS 5. Chemosensitization by Ursolic Acid: 8. Role of Gambogic Acid in A New Avenue for Chemosensitization of Cancer 151 Cancer Therapy 99 VIJAYP.KALE,PATRICKJ.GILHOOLEY,SANGITA PHADTARE,ALINABAVIZADEH,MANOJK.PANDEY SAHDEOPRASAD,AMITK.TYAGI, BHARATBHUSHANAGGARWAL Abstract 151 Abstract 99 Introduction 151 Introduction 99 SourceandChemistryofGA 155 ChemosensitizationofCancerCells 101 MolecularTargetsofGA 155 SafetyandEfficacy 106 Chemo-SensitizationbyGA 159 ConclusionandFutureDirection 106 Conclusion 161 Acknowledgment 107 References 161 References 107 9. Role of Catechins in Chemosensitization 169 6. Role of Fisetin in ANANDSWAROOPSHUKLA,ABHIMANYUKUMAR Chemosensitization 111 JHA,RANIKUMARI,KAVITARAWAT,SAIMASYEDA, ANJUSHRIVASTAVA BOKYUNGSUNG Abstract 169 Abstract 111 Introduction 171 Introduction 112 SourcesofCatechins 172 ChemistryandSourcesofFisetin 113 MolecularTargetsofFisetin 115 StructureandChemistryofCatechins 173 MolecularTargetsoftheCatechin 177 ChemosensitizationbyFisetin 126 ChemosensitizationinVitro 182 Conclusion 133 ConflictofInterest 134 ChemosensitizationinVivo 186 HumanTrials 188 References 134 ImplicationofCatechinsinOtherDiseases 189 Conclusion 192 7. Role of Celastrol in ConflictofInterest 193 Chemosensitization Acknowledgment 193 References 193 of Cancer 141 FurtherReading 198 NURS.AMIRRUDDIN,ALANP.KUMAR, ADRIANK.K.TEO,GAUTAMSETHI 10. Anticancer Attributes of Silibinin: Abstract 141 Chemo- and Radiosensitization of Introduction 141 Cancer 199 BiologicalSourceofCelastrolandIts ARPITDHEERAJ,DHANIRTAILOR,SURYAP.SINGH, Chemistry 142 RANAP.SINGH MolecularTargetsofCelastrol andItsPotentialMechanism(s) Abstract 199 ofAction 143 Introduction 200 AnticancerandChemosensitizing StructuralCompositionandBioavailabilityof EffectsofCelastrol 145 Silymarin/Silibinin 202 Conclusions 148 TargetingofVariousAttributesofCancer ConflictofInterest 148 GrowthandProgression 203 Acknowledgments 148 SilibininasChemosensitizerforCancer References 148 Cells 210 vii CONTENTS SilibininasRadiosensitizerfor SourcesandChemistryofPiperine 260 CancerCells 213 PiperineExtractionandQuantification 261 Conclusions 214 Medicinal&PharmacologicalActivitiesof References 215 Piperine 262 MechanismofActionofPiperine 264 11. Berberine as an Adjuvant and Chemoresistanceand Sensitizer to Current Chemosensitisation 270 Chemotherapy 221 InteractionsofPiperineWith ChemotherapeuticDrugs 275 ALOKCHANDRABHARTI,PRIYANKARAJAN, Conclusion 279 MOHITJADLI,DEEPTIPANDE,TEJVEERSINGH, References 280 ANJALIBHAT FurtherReading 286 Abstract 221 Introduction 222 SourceandChemistry 222 14. Role of Deguelin in EvidenceShowingthePotentialof Chemoresistance 287 BerberineasaChemosensitizer 223 SANKARJAGADEESHAN,M.MANUPRASAD, HormeticEffectsofBerberineinInVitro SHIVAKUMARIASHANAIR Studies 232 ChemosensitizationInVivoandOther Abstract 287 BeneficialProperties 232 Introduction 287 BerberineinHumanTrials 233 SourceandChemistryofDeguelin 288 Conclusion 234 MolecularTargetsofDeguelin 288 ConflictofInterest 235 ChemosensitizationbyDeguelin 288 Acknowledgments 235 Conclusion 292 References 235 Acknowledgements 293 References 294 12. Role of Emodin in Chemosensitization of Cancer 241 15. Garcinol: Preclinical Perspective SUBASHCHANDRAGUPTA,VIPINRAI Underpinning Chemo- and Abstract 241 Radiosensitization of Cancer 297 Introduction 243 SANJEEVBANERJEE,MANSIA.PARASRAMKA, Anti-cancerActivitiesofEmodin 243 SHIVANIB.PARUTHY Anti-cancerActivitiesofEmodin Analogues 249 Abstract 297 ChemosensitizationofTumorsbyEmodin 250 Introduction 297 Conclusions 254 GarcinolBioavailability 299 Acknowledgments 255 Garcinol:TherapeuticTargets 299 References 255 SystemicAnticancerandChemo-Sensitizing EffectsofGarcinol 310 13. Role of Piperine in GarcinolandTRAILSensitization 318 Chemoresistance 259 GarcinolandRadiosensitization 319 GarcinolCombinationWithOther SANDEEPKUMAR,CHETNABHANDARI,PRERNA NaturalAgents’onCancer SHARMA,NAVNEETAGNIHOTRI Therapy 319 Abstract 259 Conclusion 320 Introduction 259 References 320 viii CONTENTS 16. ChemopreventiveandAnticancerEffects SourceandChemistryofZerumbone 345 ofPlumbagin:NovelMechanism(s) ZerumbomePromotestheChemosensitization ofPaclitaxelandCisplatininCancer viaModulationofCellular Cells 345 Redox 325 ZerumboneisaDualInhibitorofJAK/STAT3 RAHULCHECKER,RAGHAVENDRA andNF-κBSignaling 346 S.PATWARDHAN,DEEPAKSHARMA, Zerumbone-MediatedChemosensitization SANTOSHK.SANDUR InVitroandInVivo 347 Conclusion 347 Abstract 325 References 348 Introduction 325 OccurrenceandIsolationofPlumbagin 327 18. Multitalented Ginger and Its Clinical AntioxidantPropertiesofPlumbagin 328 ChemopreventiveandAntitumor Development for Cancer PropertiesofPlumbagin 328 Treatment 351 AntiangiogenicPropertyofPlumbagin 335 ROOPALISAXENA,RITUANEJA PlumbaginNano-ParticlePreparations 336 Anti-inflammatoryPropertiesof Abstract 351 Plumbagin 337 Introduction 352 ChemosensitizingPropertiesofPlumbagin 337 AlmightyGingertoTreatMightyCancer 353 Conclusion 338 ClinicalTranslationofGinger:Major References 338 Roadblocks 360 InnovativeModernConceptsto 17. Role of Zerumbone in the FurtherClinicalTranslationof Chemosensitization of Cancer Ginger 361 Cells 343 Conclusion 364 ConflictofInterest 365 ARUPCHAKRABORTY References 365 Abstract 343 Index 371 Introduction 343 Contributors Bharat Bhushan Aggarwal Inflammation Re- Mohit Jadli University of Delhi (North Cam- searchCenter,SanDiego,CA,UnitedStates pus),Delhi,India Navneet Agnihotri Panjab University, Chandi- Sankar Jagadeeshan Rajiv Gandhi Centre for garh,India Biotechnology, Thiruvananthapuram, KL; Nur S. Amirruddin National University of UniversityofMadras,Chennai,TN,India Singapore; Institute of Molecular and Cell Abhimanyu Kumar Jha IMS Engineering Col- Biology,Singapore,Singapore lege,Ghaziabad,UP,India Ritu Aneja Georgia State University, Atlanta, Vijay P. Kale Battelle Memorial Institute, West GA,UnitedStates Jefferson,OH,UnitedStates Sanjeev Banerjee Wayne State University, Alan P. Kumar National University of Singa- Detroit,MI,UnitedStates pore; National University Health System, Sin- Chetna Bhandari Panjab University, Chandi- gapore, Singapore; Curtin University, Perth, WA, Australia; University of North Texas, garh,India Denton,TX,UnitedStates AlokChandraBharti UniversityofDelhi(North SandeepKumar PanjabUniversity,Chandigarh, Campus), Delhi; National Institute of Cancer India Prevention and Research - Indian Council of Medical Research (NICPR - ICMR), Noida, RaniKumari UniversityofDelhi,Delhi,India UP,India Ajaikumar B. Kunnumakkara Indian Institute Anjali Bhat University of Delhi (North Cam- ofTechnologyGuwahati,Guwahati,AS,India pus),Delhi,India SukhMahendraSingh BanarasHinduUniver- DevivashaBordoloi IndianInstituteofTechnol- sity,Varanasi,UP,India ogyGuwahati,Guwahati,AS,India Mokenge P. Malafa Moffitt Cancer Center, Arup Chakraborty Roseman University of Tampa,FL,UnitedStates HealthSciences,Henderson,NV,UnitedStates SabiraMohammed RajivGandhiCentreforBio- Rahul Checker Bhabha Atomic Research Cen- technology,Thiruvananthapuram,KL,India tre,Mumbai,MH,India Ali Nabavizadeh Cooper Medical School of Arpit Dheeraj Jawaharlal Nehru University, RowanUniversity,Camden,NJ,UnitedStates NewDelhi,India Shivakumari Asha Nair Rajiv Gandhi Centre Patrick J. Gilhooley Cooper Medical School of for Biotechnology, Thiruvananthapuram, KL, RowanUniversity,Camden,NJ,UnitedStates India SubashChandraGupta BanarasHinduUniver- DeeptiPande UniversityofDelhi(NorthCam- sity,Varanasi,UP,India pus),Delhi,India KuzhuvelilB.Harikumar RajivGandhiCentre Manoj K. Pandey Cooper Medical School for Biotechnology, Thiruvananthapuram, KL, of Rowan University, Camden, NJ, United India States Kazim Husain Moffitt Cancer Center, Tampa, MansiA.Parasramka MayoClinic,Jacksonville, FL,UnitedStates FL,UnitedStates ix
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