Role of Capsaicin in Oxidative Stress and Cancer

183 Pages·2013·3.45 MB·English

by  Kartick C. Pramanik (auth.), Sanjay K. Srivastava (eds.)

Diet and Cancer 3
Series Editor: Adriana Albini
Sanjay K. Srivastava Editor
Role of Capsaicin
in Oxidative Stress
and Cancer
Diet and Cancer
Series Editor
Adriana Albini
Head Oncology Research, IRCCS MultiMedica, Via Fantoli 15/16,
20138 Milano, Italy
and
MultiMedica Castellanza
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For further volumes:
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Sanjay K. Srivastava
Editor
Role of Capsaicin in Oxidative
Stress and Cancer
Editor
Sanjay K. Srivastava
Biomedical Sciences
Texas Tech University Health Sciences Center
Amarillo, TX, USA
ISBN 978-94-007-6316-6 ISBN 978-94-007-6317-3 (eBook)
DOI 10.1007/978-94-007-6317-3
Springer Dordrecht Heidelberg New York London
Library of Congress Control Number: 2013936405
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Dedicated to my loving family, my wife
Rekha and adoring kids Sameer and Suyash,
who provided me constant love and support.

Preface
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a principal pungent ingredient
of red chili peppers that was isolated by Christian Friedrich Bucholz (1770–1818)
from the plant C apsicum (S olanaceae ). It is widely consumed as food additive in
South Asian and Latin American countries. Capsaicin has been used to treat pain and
infl ammation associated with a variety of diseases including rheumatoid arthritis,
diabetic neuropathy, postmasectomy pain syndrome, cluster headaches, herpes zoster
etc. Several recent studies evaluated capsaicin as a novel anti-cancer agent against
pancreatic, prostate, melanoma and colon cancers. Various mechanisms of capsaicin
in preventing cancer have been described sporadically but a comprehensive idea of
capsaicin as a chemo-preventive agent in the literature is lacking. R ole of Capsaicin
in Oxidative Stress and Cancer discusses preventive and therapeutic effects of capsaicin
in different cancer models such as melanoma, pancreatic cancer, colon cancer, gastric
cancer, breast cancer, prostate cancer, skin cancer, leukemia, multiple myeloma and
glioma. Various molecular and cellular targets of capsaicin have been identifi ed and
how mitochondria plays a critical role in capsaicin-m ediated therapeutic effects. All the
chapters have been written by well established internationally recognized researchers
in this fi eld. The reader will be provided with an understanding of how capsaicin prevents
or may treat cancer, how different cells respond differentially to capsaicin, how
environmental carcinogen induced carcinogenesis can be prevented by capsaicin and
the mechanism of oxidative stress caused by capsaicin. The book will serve as a sound
basis for cancer researchers in different countries. It will be invaluable for students
of medical sciences, oncologists, and cancer researchers in all parts of the world.
This book describes the mechanism of the anti-cancer effects of capsaicin
including the involvement of cytochrome P-450 in the bioactivation; identifi cation
of mitochondria as the key target site for oxidative stress; involvement of mitochon-
drial respiratory chain in the production of ROS; prevention of chemically-induced
carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti- cancer
effects; identifi cation of p53 activation as a possible mechanism; involvement of
Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3;
inhibition of cell survival pathways including PI3K/Akt; and the involvement of
intrinsic mitochondrial cell death pathway.
vii
viii Preface
Several aspects of capsaicin in causing oxidative stress and its role as an anti- cancer
agent have been discussed. Overall, the chapters focus on
• How capsaicin causes oxidative stress in cancer cells leading to cell death
• The details of how capsaicin prevents chemical carcinogenesis
• Elucidating the molecular mechanism of the anti-cancer effects of capsaicin in
various cancer cells targeting signal transduction pathways
We hope that this book will be helpful to the researchers, scientists and patients,
providing invaluable information of the basic and translational aspects of capsaicin.
Department of Biomedical Sciences Sanjay K. Srivastava, Ph.D.
Texas Tech University Health Sciences Center
Amarillo, TX, USA
SKS Biography
Dr. Sanjay K. Srivastava is a Professor of Biomedical Sciences at Texas Tech
University Health Sciences Center (TTUHSC), Amarillo, Texas, specializing in
cancer biology, cell signaling and nutritional chemoprevention. Dr. Srivastava
served as an Assistant Professor in the Department of Pharmacology, University of
Pittsburgh School of Medicine, and did his post-doc from University of Texas
Medical Branch at Galveston, Texas. He received an M.S. in Biochemistry from
Lucknow University and a Ph.D. in Biochemical Toxicology from Industrial
Toxicology Research Center, India. Dr. Srivastava is funded by grants from the
National Cancer Institute, NIH. He has authored/co-authored more than 100
research papers and is in the editorial board of several journals. Dr. Srivastava has
been the recipient of several awards including TTUHSC “President’s Excellence in
Research Award”. His research has been featured by news agencies including BBC,
MSNBC, CBS, ABC, Science News etc.
Contents
1 Role of Capsaicin in Cancer Prevention ................................................. 1
Kartick C. Pramanik and Sanjay K. Srivastava
2 Role of Death Receptors Belonging to the TNF Family
in Capsaicin-Induced Apoptosis of Tumor Cells .................................... 19
Giorgio Santoni, Sara Caprodossi, Valerio Farfariello,
Sonia Liberati, and Consuelo Amantini
3 Role of Capsaicin in Prostate Cancer ...................................................... 47
Inés Díaz-Laviada
4 Capsaicin and the Urinary Bladder ........................................................ 67
Robert S. Svatek and Rita Ghosh
5 Inhibition of Pancreatitis and Carcinogenesis by Capsaicin ................ 89
Wanying Zhang, Jie Liao, Haonan Li, Allison Yang,
Sanjay K. Srivastava, and Guang-Yu Yang
6 Cytochrome P450-Dependent Modifi cation of Capsaicinoids:
Pharmacological Inactivation and Bioactivation Mechanisms ............. 107
Christopher A. Reilly
7 The Cancer-Suppressing and -Promoting Actions of Capsaicin .......... 131
Pin Ju Chueh
8 Oxidative Stress by Capsaicin in Cancer ................................................ 149
Kartick C. Pramanik, Palika Datta, and Sanjay K. Srivastava
Index ................................................................................................................. 173
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