Robbins Essential Pathology

447 Pages·2020·75.633 MB·English

by  Vinay Kumar, Abul K. Abbas, Jon C. Aster, Andrea T. Deyrup

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2015v1.0
RO B B I N S
ESSENTIAL
PATHOLOGY
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RO B B I N S
ESSENTIAL
PATHOLOGY
Vinay Kumar,
MBBS, MD, FRCPath
Alice Hogge and Arthur A. Baer Distinguished Service Professor
Department of Pathology
Biologic Science Division
The Pritzker School of Medicine
The University of Chicago
Chicago, Illinois
Abul K. Abbas,
MBBS
Professor and Chairman Emeritus
Department of Pathology
University of California San Francisco
San Francisco, California
Jon C. Aster,
MD, PhD
Professor of Pathology
Brigham and Women’s Hospital
Harvard Medical School
Boston, Massachusetts
Andrea T. Deyrup,
MD, PhD
Associate Professor
Department of Pathology
Duke University Medical Center
Durham, North Carolina
1600 John F. Kennedy Blvd.
Ste 1600
Phladelpha, PA 19103-2899
ROBBINS ESSENTIAL PATHOLOGY ISBN: 978-0-323-64025-1
Copyright © 2021 by Elsevier, Inc. All rights reserved.
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P R E FA C E
We are pleased o presen a new member o e Robbns amly con- • Morethan600USMLE-style,multiple-choicequestionsareavail-
neced o e roos. able o renorce mporan conceps n e capers and cases and
In e preace o e rs edon o Textbook of Patoogy–Wt o ad n board preparaon. We ope a e organ sysem-based
Cnca Appcatons (publsed n 1957), Sanley Robbns lad down cases,linkedtoboththetextandthequestions,willfacilitatean
e gudng prncples o s new book: “te subject matter s to be pre- organc assmlaon o crcal normaon necessary or negraed
sented n a ogca, concse, readabe fason, devod of dstractng deta currcula.
and wt consderabe empass on reatng patoogy to cnca med- An all-elecronc orma enables neracve negraon o ex,
cne.” Wle ese me-onored undamenals ave remaned embed- casesandquestionstopromoteactivelearning.ecaseschallengethe
ded n medcal educaon, wo major canges ave ad an mpac on suden o apply wa as been learned rom ex and classwork. In
ow e dscplne s aug now and ow sudens learn . Frs, n efec, ese are uorals a allow sudens o learn a er own pace
mos medcal scools, e basc and clncal scences are aug n an a a me and place o er coosng. Ho-spong o gross and so-
negraed, organ sysem-based currculum a blends basc prncples logc eaures brngs an exper paologs o e suden’s sde. Suc
w clncal relevance. Second, because o early clncal exposure, e neracvy s possble only n an elecronc orma. In addon, an
me devoed o paology (and oer basc scences) as progressvely exensve lbrary o mages (Supplemenal eFgures) rom e Robbns
decreased. Robbns Essenta Patoogy s nended o sasy e needs poo collecon aclaes vsual learnng syles and augmens e key
o oday’s medcal sudens by dsllng basc conceps o paogene- mages n e ex.
ss and morpology and provdng clncal vgnees o glg e Althoughthetextisavailableinprintform,thecases,questions,and
relevance o paology o e undersandng o dsease. To mee ese expanded mage collecon are ofered only n e neracve elecronc
goals, s new addon o e Robbns amly consss o ree ne- orm. We srongly encourage e readers o ake advanage o e ree
graed componens: componens o Essenta Patoogy.
• Nineteentextchaptersinwhichthesubjectmatterispresentedin We ope a we ave succeeded n provdng a book a as
“ogca, concse, readabe fason, devod of dstractng detas.” Core adaped o e modern eacng o paology. We welcome, and ndeed
maeral s dslled o e normaon essenal or every medcal apprecae, commens and eedback rom sudens and er nsruc-
suden, w an empass on mecansms o dsease. ors. Parnersp beween auors and e readers s essenal or excel-
• Eachchapterisassociatedwithvetosixclinicalcasesthatrelate lence n educaon.
“patoogy to cnca medcne.” Cases glg e scenc oun- Vnay Kumar
daon o e pracce o medcne and underscore e clncal rel- Abul K. Abbas
evance o paogenc mecansms. Clncal-paologc correlaons Jon C. Aster
ave always been e sreng o e Robbns’ amly o books, and Andrea T. Deyrup
s core plosopy s woven no e abrc o Robbns Essenta
Patoogy.
v
A C K N O W L E D G M E N T S
Wrng a new book s a sgncan efor. We ave underaken s ask e book developed as we wroe  rom conen o desgn. Several
n response o numerous colleagues wo asked or a sor, clncally people a Elsever worked relessly and paenly w us on e produc-
orened exbook or negraed currcula n wc paology s no a on o s ex. Specal menon sould be made o Execuve Conen
sandalone course Sraegs Jm Merr; Drecor, Conen Developmen Rebecca Grulow;
Several ndvduals provded us e mpeus o develop s book. Senor Projec Manager Kae Mannx; Desgner Bran Salsbury; and
ey are oo numerous o menon ndvdually bu prncpal among Senor Manager Ebooks and Clncal Key Paul Dever.
em are Dr. Raga Ramacandran, UCSF, and Dr. Sco Lovc, BWH. Las bu no leas, we owe a deep deb o graude o our amles:
Jm Merr, our edor a Elsever, camponed s book so a  Ramnder Kumar, Ann Abbas, Ern Malone, and Tony Wllamson.
could see e lg o e day. Wou er unwaverng suppor, we could no ave added one more
We are graeul o ose wo advsed us on e conen o ndvdual book o e several w wc we are already nvolved. Andrea T. Dey-
capers. ey nclude Dr. Tony Cang, Unversy o Ccago (kdney), rup wses o acknowledge e endurng m enorsp and suppor o
Dr. Ryan Gll, UCSF (lver), and Dr. Mara Margea, UCSF (nervous e lae Dr Tony Monag (1954–2018). Fnally, we ws o acknowledge
sysem). Several ndvduals a Duke Unversy Scool o Medcne eac oer or complemenng and ndeed enancng our ndvdual
advsed n e developmen o e clncal cases. ey nclude Dr. Anna conrbuons.
Lsa Crowley (cardac), Dr. E. Wayne Massey (neurology), and Dr. Jon Vnay Kumar
K. Robers (kdney). Many o our colleagues provded us w mages Abul K. Abbas
rom er collecons. ese gems ave been acknowledged were e Jon C. Aster
mages ave been used n e book. Andrea T. Deyrup
Some o e mulple-coce quesons were orgnally publsed n
Robbns Revew of Patoogy by Vnay Kumar and Ed Kla, wom we
ws o acknowledge.
vi
To our sudens, wo connually nspre and callenge us.
C O N T E N T S
1 Cell Injury and Cell Death, 1
2 Inflammation and Repair, 14
3 Hemodynamic Disorders, Thromboembolism, and Shock, 30
4 Diseases of the Immune System, 41
5 Neoplasia, 63
6 Genetic Diseases, 88
7 Diseases of Blood Vessels, 105
8 Heart, 118
9 Hematopoietic and Lymphoid Systems, 137
10 Lung and Upper Respiratory Tract, 163
11 Kidney, 186
12 Gastrointestinal System, 205
13 Liver, Biliary System, and Pancreas, 222
14 Male Genital Tract, Prostate, and Bladder, 240
15 Female Genital Tract and Breast, 250
16 Endocrine System, 264
17 Disorders of the Nervous System, 280
18 Musculoskeletal System and Skin, 296
19 Environmental Disease, 314
Index, 327
viii