RNA Binding Proteins: New Concepts in Gene Regulation PDF
Preview RNA Binding Proteins: New Concepts in Gene Regulation
RNA BINDING PROTEINS: New Concepts in Gene Regulation ENDOCRINE UPDATES Shlomo Melmed, MD., Series Editor 1. E.R. Levin and 1.L. Nadler (eds.): Endocrinology of Cardiovascular Function. 1998. ISBN: 0-7923-8217-X 2. 1.A. Fagin (ed.): Thyroid Cancer. 1998. ISBN: 0-7923-8326-5 3. 1.S. Adams and B.P. Lukert (eds.): Osteoporosis: Genetics, Prevention and Treatment. 1998. ISBN: 0-7923-8366-4. 4. B.-A. Bengtsson (ed.): Growth Hormone. 1999. ISBN: 0-7923-8478-4 5. C. Wang (ed.): Male Reproductive Function. 1999. ISBN 0-7923-8520-9 6. B. Rapoport and S.M. McLachlan (eds.): Graves' Disease: Pathogenesis and Treatment. 2000. ISBN: 0-7923-7790-7. 7. W. W. de Herder (ed.): Functional and Morphological Imaging of the Endocrine System. 2000. ISBN 0-7923-7923-9 8. H.G. Burger (ed.): Sex Hormone Replacement Therapy. 2001. ISBN 0-7923-7965-9 9. A. Giustina (ed.): Growth Hormone and the Heart. 2001. ISBN 0-7923-7212-3 10. W.L. Lowe, lr. (ed.): Genetics of Diabetes Mellitus. 2001. ISBN 0-7923-7252-2 11. 1.F. Habener and M.A. Hussain (eds.): Molecular Basis of Pancreas Development and Function. 2001. ISBN 0-7923-7271-9 12. N. Horseman (ed.): Prolactin. 2001 ISBN 0-7923-7290-5 13. M. Castro (ed.): Transgenic Models in Endocrinology. 2001 ISBN 0-7923-7344-8 14. R. Bahn (ed.): Thyroid Eye Disease. 2001 ISBN 0-7923-7380-4 15. M.D. Bronstein (ed.): Pituitary Tumors in Pregnancy ISBN 0-7923-7442-8 16. K. Sandberg and S.E. Mulroney (eds.): RNA Binding Proteins: New Concepts in Gene Regulation. 2001. ISBN 0-7923-7612-9 RNA BINDING PROTEINS: New Concepts in Gene Regulation Edited by Kathryn Sandberg, PhD Departments ofM edicine and Physiology & Biophysics Georgetown University School ofM edicine Washington, DC and Susan E. Mulroney, PhD Depa~tment ofP hysiology & Biophysics Georgetown University School ofM edicine Washington, DC "~. Springer Science+Business Media, LLC Library of Congress Cataloging-in-Publication Data RNA binding proteins: new concepts in gene regulation 1 edited by Kathryn Sandberg and Susan E. Mulroney. p. cm. --(Endocrine updates; 16) Includes bibliographical references and index. ISBN 978-1-4419-4935-6 ISBN 978-1-4757-6446-8 (eBook) DOI 10.1007/978-1-4757-6446-8 1. Genetic regulation. 2. RNA-protein interactions I. Sandberg, Kathryn. II. Mulroney, Susan E. III. Series. QH450 .R63 2002 572.8'65--dc21 2001054415 Copyright © 2002 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2002 Softcover reprint of the hardcover 1s t edition 2002 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photo-copying, recording, or otherwise, without the prior written permission of the publisher, Springer Science+Business Media, LLC. Printed on acid-free paper. Contents Contributors .............................................................................. vii Preface ....................................................................................... xiii Acknowledgements ..................................................................... xv Section I: Translational Control 1. The role of RNA-binding proteins in IRES-dependent translation Sung Key Jang and Eckard Wimmer... ... ... ... ... ... . . . . . . .... 1 2. Translational regulation of masked maternal mRNAs in early development Nancy Standart...... .................................... ............ 35 3. Poly-C binding proteins: Cellular regulators of mRNA fate and function Andrea V. Gamarnik and Raul Andino........................... 53 4. Autoregulation of protein synthesis by translation Guim Kwon, Guang Xu, Wilhelm S. Cruz, Connie A. Marshall and Michael L. McDaniel... ... ... ........ 71 5. Translational initiation of ornithine decarboxylase mRNA Lo Persson and Koichi Takao............... ... ................... 87 Section II: mRNA Metabolism 6. Regulation ofmRNA stability by AUFI Gerald M Wilson and Gary Brewer... ... ... ..... . . . . . . . . .. ... ... 101 7. RNA binding by members of the 70-kDa family of molecular chaperones Christine Zimmer, Eszter Nagy, John R Subjeck, and Tamas Benics.................. ... ... .......................... 119 8. Post-transcriptional control of type-l plasminogen activator inhibitor mRNA Joanne H Beaton and Thomas D. Gelehrter ................... 135 9. Post-transcriptional control of the GAP-43 mRNA by the ELAV -like protein HuD Nora Perrone-Bizzozero and Rebecca Keller .................. 157 Section III: Hormonal and Homeostatic Regulation 10. RNA-dependent protein kinases Raymond Petryshyn, Sergie Nekhai, and Evelio D. Perez-Albuerne .................................... 175 11. Regulation of messenger RNA-binding proteins by protein kinases A and C Richard A. Jungmann... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 193 12. Post-transcriptional regulation of iron metabolism Tracey A. Rouault.................................................. 213 13. Cytochrome P450 RNA-protein interactions Matti A. Lang and Franr;oise Raffalli-Mathieu ................. 225 14. Site-specific cleavage of insulin-like growth factor II mRNAs Erwin L. van Dijk and P. Elly Holthuizen ...................... 239 15. Hormonal regulation of the EGF/receptor system Stephen W Spaulding and Lowell G. Shejlin .................. 255 16. The role of RNA binding proteins in tumorigenesis Sreerama Shetly., .................................................. 271 17. Regulation of G-protein coupled receptor cytosolic mRNA binding proteins Kathyrn Sandberg, Zheng Wu, Hong Ji, Eric Hernandez and Susan E. Mulroney ........................ 285 Index ............................................................................. 307 VI Contributors Raul Andino, Ph.D. Associate Professor Department ofM icrobiology and Immunology University of California at San Francisco, Box 0414 San Francisco, CA 94143-0414 Wilhelm S. Cruz, Ph.D. Instructor Biology Department Campus Box 8118 Washington University Rebstock 130 St Louis, MO 63110 Gary Brewer, Ph.D. Associate Professor Department ofM olecular Genetics and Microbiology UMDNJ-Robert Wood Johnson Medical School 675 Hoes Lane Piscataway, NJ 08854 Andrea V. Gamarnik, Ph.D. Group Leader 1nstituto de Investigaciones Bioquimicas Fundacion Campomar Av Patricias Argentinas 435 Capital Federal, Buenos Aires, Argentina Thomas D. Gelehrter, M.D. Professor and Chair Department ofH uman Genetics University ofM ichigan Medical School 4909 Buhi, Box 0618 1241 E. Catherine Street Ann Arbor, MI 48109-0618 Tamas Benies, M.D., Ph.D. Senior StajJScientist Assistant Professor Department ofM olecular Biology Dept. ofM edical Immunol and Microbiol. 1NTERCELL, Inc. Faculty ofM edicine Rennweg 95B University ofP ees, Szigeti u. 12 A-1030 Vienna, Austria 7643 Pecs, Hungary Joanne H. Heaton, M.S. Department ofH uman Genetics University ofM ichigan Medical School 4909 Buhl, Box 0618 1241 E. Catherine Street Ann Arbor, MI 48109-0618 Eric Hernandez Graduate Student Department ofM icrobiology and Immunology Georgetown University 4000 Reservoir Road, NW Washington, DC 20007-2145 P. Elly Holthuizen, Ph.D. Senior Scientist Department ofP hysiological Chemistry University Medical Center Utrecht Universiteitsweg 100 3584 CG Utrecht The Netherlands Sung Key Jang, Ph.D. Associate Professor Department ofL ife Sciences Pohang University ofS cience and Technology Hyoja-Dong San 31, Pohang Kyungbuk 790-784, Korea. Hong Ji, M.D. Assistant Professor Department ofP hySiology Georgetown University 4000 Reservoir Road, NW Washington, DC 20007-2145 Richard A. Jungmann, Ph.D. Professor Department ofC ell and Molecular Biology Northwestern University Medical School Olson Pavilion 8321 303 East Chicago Avenue Chicago,IL 60611-3008 Rebecca Keller, Ph.D. Research Assistant Professor Department ofC hemistry Clark Hall 104 University ofN ew Mexico School ofM edicine Albuquerque, NM 87131 viii Guim Kwon, Ph.D. Research Instructor Department ofP athology and Immunology Washington University School ofM edicine 660 S. Euclid Avenue St Louis, MO 63110 Matti A. Lang. Ph.D. Professor and Chair Department ofB iochemistry Faculty ofP harmacy Biomedical Centrum Box 578 University of Uppsala Uppsala, Sweden Connie A. Marshall, B.S. Research Associate Department ofP athology and Immunology Campus Box 8118 Washington University School ofM edicine 660 S. Euclid Avenue St Louis, MO 63 I1 0 Michael L. McDaniel, Ph.D. Professor Department ofP athology and Immunology Campus Box 8118 Washington University School ofM edicine 660 S. Euclid Avenue St Louis, MO 63 I1 0 Susan E. Mulroney, Ph.D. Associate Professor Department ofP hysiology & Biophysics Georgetown University School ofM edicine 3900 Reservoir Rd, NW Rm 253 Basic Science Building Washington, DC 20007 Eszter Nagy, M.D., Ph.D. Senior StaffS cientist Assistant Professor Department ofM olecular Biology Dept. ofC linical Biochemistry INTERCELL, Inc. Faculty ofM edicine Rennweg 95B University ofP ecs, Szigeti u. 12 A-J030 Vienna, Austria 7643 Pecs, Hungary Sergie Nekhai, Ph.D. Assistant Professor Sickle Cell Center Howard University 2121 Georgia Avenue, NW Washington, DC 20059 ix Evelio D. Perez-Albuerne, M.D., Ph.D. Attending Physician Department ofH ematology/Oncology Children's National Medical Center III Michigan Avenue, NW Washington, DC 20010 Nora Perrone-Bizzozero, Ph.D. Professor Department ofN euroscience University ofN ew Mexico School ofM edicine 915 Camino de Salud NE Albuquerque, NM 87131-5223 Lo Persson, Ph.D. Professor Department ofP hysiology and Neuroscience University ofL und BMC F:I3 S-22184 Lund, Sweden Raymond A. Petryshyn, Ph.D. Scientific Review Administrator Grants Review Branch Division ofE xtramural Activities National Cancer Institute Room 8133 6116 Executive Blvd. MSC 8328 Bethesda, MD 20892 Fran~oise Raffalli-Mathieu, Ph.D. Department ofB iochemistry Faculty ofP harmacy Biomedical Centrum Box 578 University of Uppsala Uppsala, Sweden Tracey A. Rouault, M.D. Chief Section on Human Iron Metabolism Cell Biology and Metabolism Branch National Institute ofC hild Health and Human Development Building 18, Room 101 Bethesda, MD 20892 x
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