Table Of Content

THE ARTHITIDES: FOCUS ON RHEUMATOID AND OSTEOARTHRITIS MICHAEL PINCUS, DO RHEUMATOLOGY LAHEY HOSPITAL AND MEDICAL CENTER Disclosures No Disclosures  Approach to the Arthritic Patient History is key Monoarticular ->   Aspirate! Duration and onset  Acute acute (hours/days) or   chronic (insidious)  Inflammatory Crystal  Inflammatory or Non  Infection  Inflammatory “pseudoseptic”  presentation of a typically If Inflammatory  polyarticular disease Soft tissue  Non Inflammatory  (bursitis/myalgia) vs Trauma  Articular Hemarthrosis  Monoarticular vs Multiple  Polyarticular  Symmetric or Asymmetric  Approach to the Arthritic Patient Rash Family History   AOSD dermatographism, AS> SLE > RA   urticaria SLE ACLE, Malar, Tumid  Constitutional Sxs  Infections:  Fever  Lyme-> Erythema Chronicum  GCA, Vasculitis, SLE, AOSD, Migrans  Peroidic FeverSyndromes/FMF Reactive-> Keratoderma  Crystal, Acute Sarcoidosis Blenorrhagicum Weight Loss  Virus/AOSD Maculopapular  GCA, Paraneoplastic  Vasculitis Palpaple Purpura  Psoriatic Plaques  RA Rare  Bechet’s Pustular, Pathergy+  Sarcoid  EN, Lupus Pernio  Approach to the Arthritic Patient Organ Involvmenet  Renal  SLE, Vasculitis, Gout  Lung  Scleroderma, RA, Sjogrens, Dermatomyositis and Anti-Synthase syndromes  Heart  SLE, RA, GCA  Neuro  SLE, Sjogrens, Vasculitis, Sarcoid, Bechets, MAS/HLH  Ocular  HLA B27 related, RA, Bechets, Vasculitis  Mucosal  Bechets, Sjogren, IBD  Raynauds  Sjogrens, RA, SLE, Cryoglobulin, Antiphopholipid Syndromes  Objectives: Rheumatoid Arthritis Learn epidemiology and proposed pathogenesis  Review common and uncommon presentations of  Rheumatoid Arthritis Become familiar with some of the old and new  therapies Rheumatoid Arthritis: Pathogenesis to Treatment Epidemiology Affects all ethnicities  Female: Male 2.5:1  Peak incidence 4-5th decades  Estimated prevalence is 1%, rates are declining  Prevalence increases to 5% in females > 70  Differences in prevalence  0.1% rural Africans  5% in Pima and Chippewa Indians  Why??? Genetics  Hormonal factors  Environmental influences  Infectious exposures  Genetics Risk in first degree relative is 1.5x higher  Concordance rate is higher with monozygotic twins  (12%) as compared with dizygotic twins (3.5%) Double Take: Twins with RA Fight It Together

Description:
McInnes IB, Schett G. N Engl J Med 2011;365:2205-2219. The microbiome and rheumatoid arthritis Scher, Abramson Nat Rev Rheum Aug 2011.
ebook img

Rheumatoid Arthritis Pathogenesis PDF

74 Pages·2017·1.98 MB·English
by  Pincus, Michael D.
Save to my drive
Quick download
Download
Upgrade Premium
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.

Preview Rheumatoid Arthritis Pathogenesis

THE ARTHITIDES: FOCUS ON RHEUMATOID AND OSTEOARTHRITIS MICHAEL PINCUS, DO RHEUMATOLOGY LAHEY HOSPITAL AND MEDICAL CENTER Disclosures No Disclosures  Approach to the Arthritic Patient History is key Monoarticular ->   Aspirate! Duration and onset  Acute acute (hours/days) or   chronic (insidious)  Inflammatory Crystal  Inflammatory or Non  Infection  Inflammatory “pseudoseptic”  presentation of a typically If Inflammatory  polyarticular disease Soft tissue  Non Inflammatory  (bursitis/myalgia) vs Trauma  Articular Hemarthrosis  Monoarticular vs Multiple  Polyarticular  Symmetric or Asymmetric  Approach to the Arthritic Patient Rash Family History   AOSD dermatographism, AS> SLE > RA   urticaria SLE ACLE, Malar, Tumid  Constitutional Sxs  Infections:  Fever  Lyme-> Erythema Chronicum  GCA, Vasculitis, SLE, AOSD, Migrans  Peroidic FeverSyndromes/FMF Reactive-> Keratoderma  Crystal, Acute Sarcoidosis Blenorrhagicum Weight Loss  Virus/AOSD Maculopapular  GCA, Paraneoplastic  Vasculitis Palpaple Purpura  Psoriatic Plaques  RA Rare  Bechet’s Pustular, Pathergy+  Sarcoid  EN, Lupus Pernio  Approach to the Arthritic Patient Organ Involvmenet  Renal  SLE, Vasculitis, Gout  Lung  Scleroderma, RA, Sjogrens, Dermatomyositis and Anti-Synthase syndromes  Heart  SLE, RA, GCA  Neuro  SLE, Sjogrens, Vasculitis, Sarcoid, Bechets, MAS/HLH  Ocular  HLA B27 related, RA, Bechets, Vasculitis  Mucosal  Bechets, Sjogren, IBD  Raynauds  Sjogrens, RA, SLE, Cryoglobulin, Antiphopholipid Syndromes  Objectives: Rheumatoid Arthritis Learn epidemiology and proposed pathogenesis  Review common and uncommon presentations of  Rheumatoid Arthritis Become familiar with some of the old and new  therapies Rheumatoid Arthritis: Pathogenesis to Treatment Epidemiology Affects all ethnicities  Female: Male 2.5:1  Peak incidence 4-5th decades  Estimated prevalence is 1%, rates are declining  Prevalence increases to 5% in females > 70  Differences in prevalence  0.1% rural Africans  5% in Pima and Chippewa Indians  Why??? Genetics  Hormonal factors  Environmental influences  Infectious exposures  Genetics Risk in first degree relative is 1.5x higher  Concordance rate is higher with monozygotic twins  (12%) as compared with dizygotic twins (3.5%) Double Take: Twins with RA Fight It Together

Description:
McInnes IB, Schett G. N Engl J Med 2011;365:2205-2219. The microbiome and rheumatoid arthritis Scher, Abramson Nat Rev Rheum Aug 2011.
See more

The list of books you might like

Upgrade Premium
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.
DMCA & Copyright: Dear all, most of the website is community built, users are uploading hundred of books everyday, which makes really hard for us to identify copyrighted material, please contact us if you want any material removed.
Copyright @ PDFdrive.to, 2022 | We love our users