O A R L OXFORD AMERICAN RHEUMATOLOGY LIBRARY Rheumatoid Arthritis 00-Weisman_Prelims.indd i 6/29/2011 8:52:12 PM This material is not intended to be, and should not be considered, a substi- tute for medical or other professional advice. Treatment for the conditions described in this material is highly dependent on the individual circumstances. While this material is designed to offer accurate information with respect to the subject matter covered and to be current as of the time it was written, research and knowledge about medical and health issues are constantly evolving, and dose schedules for medications are being revised continually, with new side effects rec- ognized and accounted for regularly. Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulation. Oxford University Press and the authors make no representations or warranties to readers, express or implied, as to the accuracy or completeness of this material, including without limitation that they make no representations or warranties as to the accuracy or effi cacy of the drug dosages mentioned in the material. The authors and the publishers do not accept, and expressly disclaim, any responsibility for any liability, loss, or risk that may be claimed or incurred as a consequence of the use and/or application of any of the contents of this material. The Publisher is responsible for author selection and the Publisher and the Author(s) make all editorial decisions, including decisions regarding content. The Publisher and the Author(s) are not responsible for any product information added to this publication by companies purchasing copies of it for distribution to clinicians. 00-Weisman_Prelims.indd ii 6/29/2011 8:52:12 PM O A R L OXFORD AMERICAN RHEUMATOLOGY LIBRARY Rheumatoid Arthritis Michael H. Weisman, MD Director, Division of Rheumatology Professor of Medicine Cedar-Sinai Medical Center Professor Emeritus of Medicine University of California (UCSD) School of Medicine San Diego, CA Executive Series Editor Daniel J. Wallace, MD, FACP, FACR Clinical Professor of Medicine Division of Rheumatology Cedars-Sinai Medical Center David Geffen School of Medicine 1 00-Weisman_Prelims.indd iii 6/29/2011 8:52:12 PM 1 Oxford University Press, Inc., publishes works that further Oxford University’s objective of excellence in research, scholarship, and education. Oxford New York Auckland Cape Town Dar es Salaam Hong Kong Karachi Kuala Lumpur Madrid Melbourne Mexico City Nairobi New Delhi Shanghai Taipei Toronto With offi ces in Argentina Austria Brazil Chile Czech Republic France Greece Guatemala Hungary Italy Japan Poland Portugal Singapore South Korea Switzerland Thailand Turkey Ukraine Vietnam Copyright © 2011 by Oxford University Press, Inc. Published by Oxford University Press, Inc. 198 Madison Avenue, New York, New York 10016 www.oup.com Oxford is a registered trademark of Oxford University Press All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Oxford University Press. Library of Congress Cataloging-in-Publication Data Weisman, Michael H. Rheumatoid arthritis / Michael H. Weisman. p. ; cm. — (Oxford American rheumatology library) Includes bibliographical references and index. ISBN 978-0-19-975421-2 (standard ed. : alk. paper) 1. Rheumatoid arthritis—Diagnosis. 2. Rheumatoid arthritis—Treatment. I. Title. II. Series: Oxford American rheumatology library. [DNLM: 1. Arthritis, Rheumatoid—diagnosis. 2. Arthritis, Rheumatoid—drug therapy. 3. Diagnosis, Differential. 4. Outcome Assessment (Health Care) WE 346 W428r 2011] RC933.W435 2011 616.7í227—dc22 2010013597 9 8 7 6 5 4 3 2 1 Printed in the United States of America on acid-free paper 00-Weisman_Prelims.indd iv 6/29/2011 8:52:12 PM Disclosures Dr. Weisman has nothing to disclose. vv 00-Weisman_Prelims.indd v 6/29/2011 8:52:15 PM This page intentionally left blank Contents Acknowledgment ix 1 History of Rheumatoid Arthritis 1 2 Defi nition and Classifi cation 5 3 Epidemiology 11 4 Pathogenesis 15 5 Clinical Signs and Symptoms 23 6 Comorbidities and Rheumatoid Arthritis 33 7 Pregnancy 43 8 Outcome Measurement 49 9 Laboratory and Imaging Assessments 55 10 Differential Diagnosis 61 11 Medications to Manage Rheumatoid Arthritis 65 12 Economic Impact and Disability Issues 75 13 Prognosis 77 Glossary 81 Appendix Rheumatoid Arthritis Resource Materials 85 HAQ-DI Disability Index 87 Index 89 00-Weisman_Prelims.indd vii 7/19/2011 4:47:37 PM This page intentionally left blank Acknowledgment I want to thank Oxford University Press for allowing me to write this very important book for physicians and would like to acknowledge Alisa Wilson for her help in preparing the manuscript. Michael Weisman, M.D. Los Angeles, CA x i 00-Weisman_Prelims.indd ix 6/29/2011 8:52:22 PM
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