Cover Page: i Title Page Page: i Copyright Page Page: ii Contents Page: iii Authors Page: v Preface Page: vii Acknowledgments Page: ix How to Use This Book Page: xi PART I BASIC BACTERIOLOGY Page: 1 1. Bacteria Compared With Other Microorganisms Page: 1 2. Structure of Bacterial Cells Page: 4 3. Growth Page: 15 4. Genetics Page: 18 5. Classification of Medically Important Bacteria Page: 24 6. The Human Microbiome Page: 26 7. Pathogenesis Page: 31 8. Host Defenses Page: 51 9. Laboratory Diagnosis Page: 59 10. Antibacterial Drugs: Mechanism of Action Page: 68 11. Antibacterial Drugs: Resistance Page: 85 12. Bacterial Vaccines Page: 94 13. Sterilization & Disinfection Page: 99 PART II CLINICAL BACTERIOLOGY Page: 105 14. Overview of the Major Pathogens & Introduction to Anaerobic Bacteria Page: 105 15. Gram-Positive Cocci Page: 108 16. Gram-Negative Cocci Page: 127 17. Gram-Positive Rods Page: 134 18. Gram-Negative Rods Related to the Enteric Tract Page: 146 19. Gram-Negative Rods Related to the Respiratory Tract Page: 167 20. Gram-Negative Rods Related to Animal Sources (Zoonotic Organisms) Page: 172 21. Mycobacteria Page: 179 22. Actinomycetes Page: 190 23. Mycoplasmas Page: 193 24. Spirochetes Page: 195 25. Chlamydiae Page: 204 26. Rickettsiae Page: 208 27. Minor Bacterial Pathogens Page: 213 PART III BASIC VIROLOGY Page: 219 28. Structure Page: 220 29. Replication Page: 226 30. Genetics & Gene Therapy Page: 239 31. Classification of Medically Important Viruses Page: 243 32. Pathogenesis Page: 248 33. Host Defenses Page: 256 34. Laboratory Diagnosis Page: 262 35. Antiviral Drugs Page: 266 36. Viral Vaccines Page: 277 PART IV CLINICAL VIROLOGY Page: 283 37. Herpesviruses, Poxviruses, & Human Papilloma Virus Page: 285 38. Respiratory Viruses Page: 305 39. Important Childhood Viruses Page: 318 40. Viruses That Infect the Enteric Tract Page: 327 41. Hepatitis Viruses Page: 335 42. Arboviruses, Rabies Virus, & Ebola Virus Page: 348 43. Tumor Viruses Page: 359 44. Slow Viruses & Prions Page: 371 45. Human Immunodeficiency Virus Page: 377 46. Minor Viral Pathogens Page: 390 PART V MYCOLOGY Page: 395 47. Basic Mycology Page: 395 48. Cutaneous & Subcutaneous Mycoses Page: 403 49. Systemic Mycoses Page: 407 50. Opportunistic Mycoses Page: 414 PART VI PARASITOLOGY Page: 423 51. Intestinal & Urogenital—Protozoa Page: 424 52. Blood & Tissue Protozoa Page: 433 53. Minor Protozoan Pathogens Page: 450 54. Cestodes Page: 453 55. Trematodes Page: 463 56. Nematodes Page: 470 PART VII IMMUNOLOGY Page: 489 57. Overview of Immunity Page: 489 58. Innate Immunity Page: 495 59. Adaptive Immunity: Lymphocyte Antigen Receptors Page: 507 60. Adaptive Immunity: T-Cell–Mediated Immunity Page: 518 61. Adaptive Immunity: B Cells & Antibodies Page: 532 62. Major Histocompatibility Complex & Transplantation Page: 544 63. Complement Page: 552 64. Antigen–Antibody Reactions in the Laboratory Page: 556 65. Hypersensitivity (Allergy) Page: 567 66. Tolerance & Autoimmune Disease Page: 578 67. Tumor Immunity Page: 588 68. Immunodeficiency Page: 591 PART VIII ECTOPARASITES Page: 599 69. Ectoparasites That Cause Human Disease Page: 599 PART IX INFECTIOUS DISEASES Page: 607 70. Bone & Joint Infections Page: 607 71. Cardiac Infections Page: 612 72. Central Nervous System Infections Page: 618 73. Gastrointestinal Tract Infections Page: 627 74. Pelvic Infections Page: 635 75. Upper Respiratory Tract Infections Page: 643 76. Lower Respiratory Tract Infections Page: 649 77. Infections of the Skin & Skin Structures Page: 655 78. Urinary Tract Infections Page: 662 79. Sepsis & Septic Shock Page: 666 80. Eye Infections Page: 670 PART X BRIEF SUMMARIES OF MEDICALLY IMPORTANT ORGANISMS Page: 677 PART XI CLINICAL CASES Page: 717 PART XII PEARLS FOR THE USMLE Page: 727 PART XIII USMLE (NATIONAL BOARD) PRACTICE QUESTIONS Page: 735 PART XIV USMLE (NATIONAL BOARD) PRACTICE EXAMINATION Page: 777 INDEX Page: 787
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