Retina 2016 Winds of Innovations

217 Pages·2016·5.8 MB·English

Retina 2016
Winds of Innovations
Program Directors
Jennifer I Lim MD and Carl D Regillo MD
In conjunction with the American Society of Retina Specialists,
the Macula Society, the Retina Society, and Club Jules Gonin

McCormick Place
Chicago, Illinois
Friday – Saturday, Oct. 14 – 15, 2016
Presented by:
The American Academy of Ophthalmology
Supported in part by an unrestricted educational grant
from Genentech.
Retina 2016 Planning Group 2007 John T Thompson MD Subspecialty Day Advisory Committee
Jennifer I Lim MD FARVO M Gilbert Grand MD Daniel S Durrie MD
Program Director 2006 Emily Y Chew MD Associate Secretary
CPraorgl rDam R eDgiirlleoc tMorD FACS 2005 JMEomhicinhly aT eY lT TCh ohTmerweps seMo MnD MD D JFuralinac Ais HS aMllaerh MMDD
Mark S Humayan MD PhD 2004 William F Mieler MD R Michael Siatkowski MD
Richard F Spaide MD Michael T Trese MD Kuldev Singh MD MPH
2003 Kirk H Packo MD Nicolas J Volpe MD
Former Program Directors William F Mieler MD
2015 Pravin U Dugel MD 2002 Mark S Blumenkranz MD Jonathan B Rubenstein MD
Jennifer I Lim MD Kirk H Packo MD Secretary for Annual Meeting
222222000000111110410329 JDTAAAPJDPTPooeeraallnaaaaattllrrnnteeeevnneeonnrriiikk ee nnWW KK llCCi SS oUFF KK HHMMHH CMMDaaaaooaiiiiullssss aapllMMsseegeerroaarrrrettn nnii DDlMMnnMM e MMM MMJDDDDrDDD DDM D 2211111999990099999005869710 GMJGSJHSHHHTuutthee aaaallaMMoiioorrnnaarrrmrrkll aayyggeeAA ccayy eeSWW KK s HHAACC BeeM laahhnnFFuWWllaa llzzllmyyAeenniiiieennrrllggea ll nnnFF iibMMaaMM rrkeJJmmeerDDrrrDDeeg assMMmm n SMMzaarDD nnMDDM MM DDDD SAMLDPMGtainieaseatnbanfrlSSPrafari kcpcRr aLnC ieie ’OeaoisREceon imi HnsdomatRtigeeslrfe iaer,naiRis ocdnntDtn ,a,uciMg crefPMreakasaer,tine neeegyS cest,Jn c eeitCrCneii n,enC rMgotCngseMvts orPie fp &rPCiD cy Do C EEMEoeASxrdse,dEih iegDtiit,nonb iiVnrairtgteisoccse rto r,
2008 M Gilbert Grand MD Paul Sternberg Jr MD
Antonio Capone Jr MD
©2016 American Academy of Ophthalmology. All rights reserved. No portion may be reproduced without express written consent of the American Academy of Ophthalmology.
ii Planning Group 2016 Subspecialty Day | Retina
2016 Retina Subspecialty Day Planning Group
On behalf of the American Academy of Ophthalmology and the American Society of Retina Specialists, the Macula Society,
the Retina Society, and Club Jules Gonin, it is our pleasure to welcome you to Chicago and Retina 2016: Winds of Innovations.
Jennifer Irene Lim MD FARVO Carl D Regillo MD FACS
Program Director Program Director
AbbVie: C Abbott: C | Acucela: C,S
Alcon Laboratories Inc.: C Aerpio: C
Genentech: C,L,S Alcon Laboratories Inc.: C,S
Icon Bioscience: C,S Allergan: C,S | Bausch+Lomb: C
Lumenis Inc.: C Bayer Healthcare Pharmaceuticals: C
Pfizer Inc.: S Genentech: C,S | GlaxoSmithKline: S
Regeneron Pharmaceuticals Inc.: C,L,S NotalVision Ltd.: C,S
Santen Inc.: C Novartis Pharmaceuticals Corp.: C,S
Regeneron Pharmaceuticals Inc.: C,S
ThromboGenics Inc.: S
Mark S Humayun MD PhD Richard F Spaide MD
1Co. Inc.: C,O,P Bausch+Lomb: C
Alcon Laboratories Inc.: C,L Topcon Medical Systems Inc.: P,C
Aquesys: C | Clearside: C,O
Eyemedix: C,O,P,S
InnFocus: C,O | Iridex: P
oProbe: C,O,P | Reflow: C,O,P
Regenerative Patch Technologies (RPT):
C,O,P
Replenish: C,O,P
Second Sight: C,O,P
22001166 SSuubbssppeecciiaallttyy DDaayy || RReettiinnaa PlanningS Gecrtoioupn iiiiii
2016 SubSPeCIALty DAy R Michael Siatkowski MD AAO StAFF
ADVISORy COMMIttee (Pediatric Ophthalmology)
National Eye Institute: S Ann L’estrange
Daniel S Durrie MD, Chair None
(Refractive Surgery) Kuldev Singh MD MPH
Abbott Medical Optics: L,S (Glaucoma) Melanie Rafaty
AcuFocus Inc.: C,L,O,S Abbott Medical Optics Inc.: C None
Alcon Laboratories Inc.: S Aerie: C
Allergan: S | Alphaeon: C,L,O Alcon Laboratories Inc.: C Lisa Romero
Avedro: L,O,S Allergan: C None
Hoopes Durrie Rivera Research Carl Zeiss Meditec: C
Center: C ForSight Vision 5: C Debra Rosencrance
Strathspey Crown LLC: C,L,O InnFocus: C | Ivantis: C None
Wavetec: O Mynosys: C
National Eye Institute: S beth Wilson
Julia A Haller MD (Retina) National Space Biomedical Research None
Celgene: O | Janssen: C Institute: C
KalVista: C | Merck & Co. Inc.: C Santen Inc.: C | Shire: C
ThromboGenics Inc.: S Thieme Medical Publishers: C
Transcend: C
Francis S Mah MD (Cornea) U.S. Food and Drug
Abbott Medical Optics Inc.: S,L,C Administration: C
Aerie: C
Alcon Laboratories Inc.: L,S,C Nicholas J Volpe MD
Allergan: S,L,C (Neuro-Ophthalmology)
Bausch+Lomb: C,L Opticent Inc.: O
CoDa: C | ForeSight: C
NovaBay: C | Ocular Science: O,C
Ocular Therapeutix: C,S
PolyActiva: C | Shire: C
Slack Publishing: C
Sun Pharma: C
Sydnexis: C | TearLab: C

2016 Subspecialty Day | Retina Contents v
Retina 2016 Contents
Retina Subspecialty Day Planning Group ii
CME vii
The Charles L Schepens MD Lecture ix
Faculty Listing x
Program Schedule xxxi
Section I: Masters of Surgery 1
Section II: Vitreoretinal Surgery, Part I 7
The Charles L Schepens MD Lecture 28
Section III: The Business of Retina 33
Section IV: Therapies for Macular and Retinal Vascular Diseases 40
Section V: Retinal Degenerations 51
Section VI: Uveitis Panel, Part I 61
Advocating for Patients 62
Section VII: My Coolest Surgical Video 64
Section VIII: Pediatric Retina 65
Section IX: Late Breaking Developments, Part I 69
Section X: First-time Results of Clinical Trials, Part I 74
Section XI: Neovascular AMD 80
Section XII: Imaging 93
Section XIII: Late Breaking Developments, Part II 100
Section XIV: Debates 104
Section XV: Oncology 110
Section XVI: Diabetes 115
Section XVII: First-time Results of Clinical Trials, Part II 129
Section XVIII: Uveitis, Part II 136
Section XIX: Non-neovascular AMD 141
Section XX: Vitreoretinal Surgery, Part II 147
Section XXI: Retinal Vein Occlusion 156
vi Contents 2016 Subspecialty Day | Retina
Section XXII: Video Surgical Complications: What Would You Do? 161
Faculty Financial Disclosure 167
Presenter Index 177
Retina Exhibits 179
2016 Subspecialty Day | Retina CMe Credit vii
CMe Credit
Academy’s CMe Mission Statement Portion of the meeting not eligible for credit include attend-
ing Break with the Experts.
The purpose of the American Academy of Ophthalmology’s
Continuing Medical Education (CME) program is to present
ophthalmologists with the highest quality lifelong learning Self-Assessment Credit
opportunities that promote improvement and change in physi-
This activity meets the Self-Assessment CME requirements
cian practices, performance, or competence, thus enabling such
defined by the American Board of Ophthalmology (ABO).
physicians to maintain or improve the competence and profes-
Please be advised that the ABO is not an accrediting body for
sional performance needed to provide the best possible eye care
purposes of any CME program. The ABO does not sponsor this
for their patients.
or any outside activity, and the ABO does not endorse any par-
ticular CME activity. Complete information regarding the ABO
2016 Retina Subspecialty Day Meeting Learning Self-Assessment CME Maintenance of Certification require-
Objectives ments is available at http://abop.org/maintain-certification/
part-2-lifelong-learning-self-assessment/sacme/.
Upon completion of this activity, participants should be able to:
NOTE: Credit designated as “self-assessment” is AMA PRA
■ Present the established and innovative approaches to man- Category 1 Credit™ and is also preapproved by the ABO for the
agement of retinal vascular and surgical retinal conditions Maintenance of Certification (MOC) Part II CME requirements.
■ Explain the current management of macular edema sec-
ondary to retinal occlusive disease and diabetic retinopa-
teaching at a Live Activity
thy as well as the newly proven therapies for proliferative
diabetic retinopathies Teaching instruction courses or delivering a scientific paper or
■ Explain the pathobiology and management of atrophic poster is not an AMA PRA Category 1 Credit™ activity and
and exudative AMD and other causes of ocular neovas- should not be included when calculating your total AMA PRA
cularization Category 1 Credits™. Presenters may claim AMA PRA Cat-
■ Identify imaging tests most helpful in the diagnosis and egory 1 Credits™ through the American Medical Association.
management of retinal conditions and discuss emerging To obtain an application form please contact the AMA at
developments in retinal imaging www.ama-assn.org.
■ Describe new vitreoretinal surgical techniques and
instrumentation
Scientific Integrity and Disclosure of Financial
■ Identify new developments in hereditary retinal degenera-
Interest
tions, pediatric retinal diseases, and ocular oncology
■ Describe newly discovered ocular manifestations of sys- The American Academy of Ophthalmology is committed to
temic medications and diseases ensuring that all CME information is based on the application
■ Discuss effective treatments to manage complications of research findings and the implementation of evidence-based
from medical and surgical interventions medicine. It seeks to promote balance, objectivity, and absence
■ Summarize current and new clinical trial data for retinal of commercial bias in its content. All persons in a position to
diseases such as AMD, diabetic retinopathy, hereditary control the content of this activity must disclose any and all
retinal conditions, and retinal vein occlusion financial interests. The Academy has mechanisms in place to
resolve all conflicts of interest prior to an educational activity
being delivered to the learners.
2016 Retina Subspecialty Day Meeting target
The Academy requires all presenters to disclose on their first
Audience
slide whether they have any financial interests from the past 12
The intended target audience for this program is vitreoretinal months. Presenters are required to verbally disclose any finan-
specialists, members in fellowship training, and general oph- cial interests that specifically pertain to their presentation.
thalmologists who are engaged in the diagnosis and treatment
of vitreoretinal diseases.
Control of Content
The Academy considers presenting authors, not co-authors, to
2016 Retina Subspecialty Day CMe Credit
be in control of the educational content. It is Academy policy
The American Academy of Ophthalmology is accredited by and traditional scientific publishing and professional courtesy
the Accreditation Council for Continuing Medical Education to acknowledge all people contributing to the research, regard-
(ACCME) to provide continuing medical education for physi- less of CME control of the live presentation of that content. This
cians. acknowledgement is made in a similar way in other Academy
The American Academy of Ophthalmology designates this CME activities. Though they are acknowledged, co-authors do
live activity for a maximum of 14 AMA PRA Category 1 Cred- not have control of the CME content and their disclosures are
its™. Physicians should claim only the credit commensurate not published or resolved.
with the extent of their participation in the activity.
viii CMe Credit 2016 Subspecialty Day | Retina
Attendance Verification for CMe Reporting After AAO 2016, credits can be claimed at www.aao.org/
cme.
Before processing your requests for CME credit, the Academy
The Academy transcript cannot list individual course atten-
must verify your attendance at Subspecialty Day and/or AAO
dance. It will list only the overall credits spent in educational
2016. In order to be verified for CME or auditing purposes, you
activities at Subspecialty Day and/or AAO 2016.
must either:
Nonmembers: The Academy will provide nonmembers
■ Register in advance, receive materials in the mail, and with verification of credits earned and reported for a single
turn in the Subspecialty Day Syllabi exchange voucher(s) Academy-sponsored CME activity, but it does not provide CME
onsite; credit transcripts. To obtain a printed record of your credits,
■ Register in advance and pick up your badge onsite if mate- you must report your CME credits onsite at the CME Credit
rials did not arrive before you traveled to the meeting; Reporting booths.
■ Register onsite; or
■ Scan the barcode on your badge as you enter an AAO
Proof of Attendance
2016 course or session room.
The following types of attendance verification will be available
during AAO 2016 and Subspecialty Day for those who need it
CMe Credit Reporting
for reimbursement or hospital privileges, or for nonmembers
who need it to report CME credit:
South Level 2.5 and Academy Resource Center, Booth 508
Attendees whose attendance has been verified (see above) at ■ CME credit reporting/proof-of-attendance letters
AAO 2016 can claim their CME credit online during the meet- ■ Onsite registration receipt
ing. Registrants will receive an email during the meeting with ■ Instruction course and session verification
the link and instructions on how to claim credit.
Visit www.aao.org/cme for detailed CME reporting informa-
Onsite, you may report credits earned during Subspecialty
tion.
Day and/or AAO 2016 at the CME Credit Reporting booth.
Academy Members: The CME credit reporting receipt is not
a CME transcript. CME transcripts that include AAO 2016
credits entered onsite will be available to Academy members on
the Academy’s website beginning Nov. 10, 2016.
2016 Subspecialty Day | Retina the Charles L Schepens MD Lecture ix
the Charles L Schepens MD Lecture
Management Options for Vitreomacular traction:
use an Individualized Approach
Friday, Oct. 14, 2016
9:49 AM – 10:09 AM
Harry W Flynn Jr MD
Harry W Flynn Jr MD is the J Donald M Gass MD Distin- for the Academy. He serves on the editorial boards of numerous
guished Chair in Ophthalmology at the University of Miami journals, including the American Journal of Ophthalmology,
School of Medicine. He is professor of Ophthalmology at the Retina, Ophthalmic Surgery, Lasers and Imaging Retina, and
Bascom Palmer Eye Institute and specializes in medical and Evidence-Based Ophthalmology. He has served on the Data
surgical treatment of diseases of the retina and vitreous. He and Safety Monitoring Committees for the Diabetic Retinopa-
received a bachelor of science degree at Wake Forest University thy Clinical Research Network, the SCORE (Standard Care vs.
in 1967 and his doctor of medicine degree at the University of COrticosteroid for REtinal Vein Occlusion) Study, Regeneron
Virginia School of Medicine in 1971. After an internship at the VIEW 1 and VIEW 2 Studies (VEGF Trap-Eye), and the Neuro-
Pacific Medical Center in San Francisco, Dr. Flynn had two tech MacTel (Macular Teleangiectasia) Study.
years of active duty in the U.S. Army at the Brook Army Medi- Dr. Flynn received the Academy’s Life Achievement Honor
cal Center in San Antonio (1976-1978). Award in 2008, and in 2011 he received the Shaler Richardson
Dr. Flynn has been author or coauthor of more than 500 MD Service to Medicine Award from the Florida Society of
publications, as well as 88 book chapters. He has edited or Ophthalmology. He received the Hermann Wacker Award from
coedited 4 books, including Diabetes and Ocular Diseases: the Club Jules Gonin in 2012. Dr. Flynn was voted Professor of
Past, Current, and Future Therapies and Vitreoretinal Disease: the Year by the Bascom Palmer Eye Institute Residents in 2012.
The Essentials. In 2014, he received the Honorary Alumnus recognition from
Dr. Flynn has held numerous administrative positions, the Alpha Omega Alpha chapter of the University of Virginia
including president of the Vitreous Society (1992-1993), presi- School of Medicine. He has delivered 28 named lectures, includ-
dent of the Miami Ophthalmological Society (1999), and presi- ing the J Donald M Gass Lecture at the Retina Society meeting
dent of the Retina Society (2002-2003). Dr. Flynn has served as in 2012.
senior editor for Section 12 (Retina) of the Basic and Clinical Dr. Flynn has been married to his wife, Dr. Donna Flynn, for
Science Course for the American Academy of Ophthalmology. 42 years. They have two children, Mollie and Patrick, and two
He has also served as codirector of the Retina Subspecialty Day grandchildren, Parker and Lily.
x Faculty Listing 2016 Subspecialty Day | Retina
Faculty
Gary W Abrams MD Lloyd P Aiello MD PhD Jayakrishna Ambati MD
Detroit, MI Boston, MA Charlottesville, VA
Professor of Ophthalmology Professor of Ophthalmology Professor and Vice Chair for Research
Kresge Eye Institute Harvard Medical School Ophthalmology
Wayne State University Director, Beetham Eye Institute Director, Center for Advanced Vision
Head, Section of Eye Research Science
Joslin Diabetes Center University of Virginia
Anita Agarwal MD
Nashville, TN
Professor of Ophthalmology thomas A Albini MD Rajendra S Apte MD PhD
Vanderbilt Eye Institute Miami, FL Saint Louis, MO
Vanderbilt University School of Associate Professor of Clinical Paul A Cibis Distinguished Professor of
Medicine Ophthalmology Ophthalmology
Bascom Palmer Eye Institute Director of Education
Professor of Developmental Biology
Washington University in Saint Louis
School of Medicine
No photo
available
Hamid Ahmadieh MD
Tehran, Iran David Almeida MD PhD MbA
Minneapolis, MN
Surgery and Diseases of the Retina,
Vitreous & Macula
VitreoRetinal Surgery, PA
Cofounder
Citrus Therapeutics