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Retina 2015 Upping the Ante PDF

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Preview Retina 2015 Upping the Ante

Retina 2015 Upping the Ante Program Directors Pravin U Dugel MD and Jennifer I Lim MD In conjunction with the American Society of Retina Specialists, the Macula Society, the Retina Society, and Club Jules Gonin Sands Expo/Venetian Las Vegas, Nevada Friday, Nov. 13 – Saturday, Nov. 14, 2015 Presented by: The American Academy of Ophthalmology Sponsored in part by an unrestricted educational grant from Genentech Retina 2015 Planning Group 2007 John T Thompson MD Subspecialty Day Advisory Committee Pravin U Dugel MD M Gilbert Grand MD William F Mieler MD Program Director 2006 Emily Y Chew MD Associate Secretary Jennifer I Lim MD John T Thompson MD Donald L Budenz MD MPH Program Director 2005 Michael T Trese MD Daniel S Durrie MD CRaicrhl aDrd R Fe gSipllaoi dMe DMD 2 004 EWMmiilcillhiyaa meYl FTC hMTerwieesl eMer M DMDD FRNr iaMcnocilcaishs aSJe MlV Soailahpt ekM oMwDDski MD 2003 Kirk H Packo MD Former Program Directors William F Mieler MD Jonathan B Rubenstein MD 2014 Peter K Kaiser MD 2002 Mark S Blumenkranz MD Secretary for Annual Meeting Pravin U Dugel MD Kirk H Packo MD 2013 Tarek S Hassan MD 2001 George A Williams MD Staff Peter K Kaiser MD Mark S Blumenkranz MD Melanie R Rafaty CMP, Director, Scientific 2012 Joan W Miller MD 2000 Julia A Haller MD Meetings Tarek S Hassan MD George A Williams MD Ann L’Estrange, Scientific Meetings Specialist 2011 Allen C Ho MD 1999 Stanley Chang MD Christa Fernandez, Presenter Coordinator Joan W Miller MD Julia A Haller MD Debra Rosencrance CMP CAE, Vice 2010 Daniel F Martin MD 1998 Harry W Flynn Jr MD President, Meetings & Exhibits Allen C Ho MD Stanley Chang MD Patricia Heinicke Jr, Copyeditor 2009 Antonio Capone Jr MD 1997 H MacKenzie Freeman MD Mark Ong, Designer Daniel F Martin MD Harry W Flynn Jr MD Gina Comaduran, Cover Design 2008 M Gilbert Grand MD 1996 H MacKenzie Freeman MD Antonio Capone Jr MD 1995 Thomas M Aaberg Sr MD Paul Sternberg Jr MD ©2015 American Academy of Ophthalmology. All rights reserved. No portion may be reproduced without express written consent of the American Academy of Ophthalmology. ii 2015 Subspecialty Day | Retina 2015 Retina Subspecialty Day Planning Group On behalf of the American Academy of Ophthalmology and the American Society of Retina Specialists, the Macula Society, the Retina Society, and Club Jules Gonin, it is our pleasure to welcome you to Las Vegas and Retina 2015: Upping the Ante. Pravin U Dugel MD Jennifer Irene Lim MD Program Director Program Director Abbott Medical Optics: C Alcon Laboratories, Inc.: C Acucela: C Alexion: C Alcon Laboratories, Inc.: C Genentech: C,L,S Alimera Sciences, Inc.: C,O ICON Bioscience: C,S Allergan: C | Digisight: O Lumenis, Inc.: C Genentech: C Pfizer, Inc.: S Novartis Pharmaceuticals Corp.: C Regeneron Pharmaceuticals, Inc.: C,L,S Ophthotech: C,O Santen, Inc.: C Ora: C | Regeneron: C ThromboGenics: C Carl D Regillo MD FACS Richard F Spaide MD Acucela: C,S Novartis Pharmaceuticals Genentech: C Advanced Cell Corp.: C Topcon Medical Systems, Inc.: P,C Technology: S Pfizer, Inc. C Alcon Laboratories, Inc.: Regeneron C,S Pharmaceuticals, Inc.: Alimera Sciences, Inc.: C,S C,S Santen, Inc.: S Allergan: C,S Second Sight Medical Bausch + Lomb: C Products, Inc.: S Genentech: C,S ThromboGenics, Inc.: C,S NotalVision, Ltd.: C,S 2015 Subspecialty Day | Retina iii Retina 2015 Contents 2015 Retina Subspecialty Day Planning Group ii CME iv The Charles L Schepens MD Lecture vi Faculty Listing vii Program Schedule xxvii Section I: Masters of Surgery 1 Section II: Vitreoretinal Surgery, Part I 12 Advocating for Patients 35 The Charles L Schepens MD Lecture 37 Section III: The Business of Retina 38 Section IV: Late Breaking Developments, Part I 44 Section V: My Coolest Surgical Video 45 Section VI: Pediatric Retina 46 Section VII: Retinal Vein Occlusion 49 Section VIII: Diabetic Retinopathy Clinical Research Network (DRCRnet) Protocols 54 Section IX: First-time Results of Clinical Trials, Part I 58 Section X: Neovascular AMD 62 Section XI: Imaging 81 Section XII: Late Breaking Developments, Part II 110 Section XIII: Oncology Panel 111 Section XIV: Diabetes 112 Section XV: First-time Results of Clinical Trials, Part II 126 Section XVI: Uveitis 137 Section XVII: Non-neovascular AMD 138 Section XVIII: Vitreoretinal Surgery, Part II 159 Section XIX: Video Surgical Complications—What Would You Do? 174 Faculty Financial Disclosure 175 Retina Exhibitors 184 Presenter Index 186 iv 2015 Subspecialty Day | Retina CME Credit Academy’s CME Mission Statement Scientific Integrity and Disclosure of Financial Interest The purpose of the American Academy of Ophthalmology’s Continuing Medical Education (CME) program is to pres- The American Academy of Ophthalmology is committed to ent ophthalmologists with the highest quality lifelong learning ensuring that all CME information is based on the application opportunities that promote improvement and change in physi- of research findings and the implementation of evidence-based cian practices, performance, or competence, thus enabling such medicine. It seeks to promote balance, objectivity, and absence of physicians to maintain or improve the competence and profes- commercial bias in its content. All persons in a position to con- sional performance needed to provide the best possible eye care trol the content of this activity must disclose any and all financial for their patients. interest. The Academy has mechanisms in place to resolve all conflicts of interest prior to an educational activity being deliv- ered to the learners. 2015 Retina Subspecialty Day Meeting Learning The Academy requires all presenters to disclose on their first Objectives slide whether they have any financial interests from the past 12 Upon completion of this activity, participants should be able to: months. Presenters are required to verbally disclose any financial interests that specifically pertain to their presentation. • Explain the current management of macular edema secondary to retinal occlusive disease and diabetic retinopathy Attendance Verification for CME Reporting • Explain the pathobiology and management of atrophic Before processing your requests for CME credit, the Academy and exudative AMD and other causes of CNV must verify your attendance at Subspecialty Day and/or at AAO • Identify emerging developments in retinal imaging 2015. In order to be verified for CME or auditing purposes, you • Describe new vitreoretinal surgical techniques and instru- must either: mentation • Identify new developments in hereditary retinal degenera- • Register in advance, receive materials in the mail, and turn tions, pediatric retinal diseases, and ocular oncology in the Final Program and/or Subspecialty Day Syllabus • Summarize current and new clinical trial data for retinal exchange voucher(s) onsite; diseases such as AMD, diabetic retinopathy, and retinal • Register in advance and pick up your badge onsite if vein occlusion materials did not arrive before you traveled to the meeting; • Register onsite; or • Scan the barcode on your badge as you enter an AAO 2015 Retina Subspecialty Day Meeting Target 2015 course or session room. Audience The intended target audience for this program is vitreoretinal CME Credit Reporting specialists, members in fellowship training, and general ophthal- mologists who are engaged in the diagnosis and treatment of Level 2 Lobby and Academy Resource Center, Hall B – Booth vitreoretinal diseases. 2632 Attendees whose attendance has been verified (see above) at 2015 Retina Subspecialty Day Meeting CME Credit AAO 2015 can claim their CME credit online during the meet- ing. Registrants will receive an email during the meeting with the The American Academy of Ophthalmology is accredited by the link and instructions on how to claim credit. Accreditation Council for Continuing Medical Education to pro- Onsite, you may report credits earned during Subspecialty vide CME for physicians. Day and/or AAO 2015 at the CME Credit Reporting booth. The American Academy of Ophthalmology designates this Academy Members: The CME credit reporting receipt is not a live activity for a maximum of 14 AMA PRA Category 1 Cred- CME transcript. CME transcripts that include AAO 2015 cred- its™. Physicians should claim only the credit commensurate with its entered onsite will be available to Academy members on the the extent of their participation in the activity. Academy’s website beginning Dec. 10, 2015. NOTE: CME credits must be reported by Jan. 13, 2016. Teaching at a Live Activity After AAO 2015, credits can be claimed at www.aao.org. The Academy transcript cannot list individual course atten- Teaching instruction courses or delivering a scientific paper or dance. It will list only the overall credits spent in educational poster is not an AMA PRA Category 1 Credit™ activity and activities at Subspecialty Day and/or AAO 2015. should not be included when calculating your total AMA PRA Nonmembers: The Academy will provide nonmembers with Category 1 Credits™. Presenters may claim AMA PRA Category verification of credits earned and reported for a single Academy- 1 Credits™ through the American Medical Association. To sponsored CME activity, but it does not provide CME credit obtain an application form please contact the AMA at transcripts. To obtain a printed record of your credits, you must www.ama-assn.org. 2015 Subspecialty Day | Retina CME Credit v report your CME credits onsite at the CME Credit Reporting booths. Proof of Attendance The following types of attendance verification will be available during AAO 2015 and Subspecialty Day for those who need it for reimbursement or hospital privileges, or for nonmembers who need it to report CME credit: • CME credit reporting/proof-of-attendance letters • Onsite registration receipt • Instruction course and session verification Visit www.aao.org for detailed CME reporting information. vi 2015 Subspecialty Day | Retina The Charles L Schepens MD Lecture Digital Medicine: Implications for Retina and Beyond Friday, Nov. 13, 2015 10:07 AM – 10:27 AM Mark S Blumenkranz MD Mark S Blumenkranz MD MMS is H. J. Smead Professor of university corporate technology transfer and early stage biomedi- Ophthalmology in the Department of Ophthalmology at Stan- cal company development, having either founded or served on ford University. He received his undergraduate degree, a graduate the boards of directors of a number of successful medical drug degree in biochemical pharmacology, and his medical education and device companies. at Brown University. He completed his internship in surgery and Dr. Blumenkranz has served on the editorial boards of the his ophthalmic residency training at Stanford, and in 1980 a fel- American Journal of Ophthalmology, Retina, Ophthalmology, lowship in vitreoretinal diseases at the Bascom Palmer Eye Insti- and Graefe’s Archives for Ophthalmology. He is a past recipient tute, where he subsequently served on the faculty for five years. of the Heed Award, the Rosenthal Award in Visual Sciences, the After leaving Bascom Palmer Dr. Blumenkranz joined Associated American Academy of Ophthalmology Lifetime Achievement Retinal Consultants in Royal Oak, Michigan, and became the Award, the Alcon Research Institute Award, ARVO Fellows founding director of the vitreoretinal fellowship program at Wil- designation, and the Gertrude Pyron Award from the Ameri- liam Beaumont Hospital, before returning to Stanford in 1992 to can Society of Retina Specialists for lifetime contributions in lead the retinal service and then the department as chairman from vitreoretinal surgery. He has delivered multiple named award 1997 until 2015. He spearheaded the development of the Byers lectures over the past thirty-five years, including most recently Eye Institute at Stanford and served as its founding director from the Jackson Memorial Lecture at the Academy’s Annual Meeting the time of its opening in 2010 until 2015. in 2013. He is a past president of the American University Pro- Dr. Blumenkranz was an early innovator in vitrectomy fessors of Ophthalmology (AUPO), the Retina Society, and the techniques to treat complex forms of retinal detachment, and Macula Society. He is a member of the Steering Committee of the he helped to usher in the modern era of intravitreal, gene, and Audacious Goals Initiative of the NEI, and he is a Fellow of the surgical adjuvant drug therapy. He has also published exten- Corporation of Brown University, where he is the long-serving sively in the area of new lasers and laser tissue interactions. He chair of the Medical School Committee. has published more than 150 papers in peer-reviewed journals Dr. Blumenkranz and his wife, Recia Kott Blumenkranz MD, and multiple book chapters, abstracts, and patents in the field. are the parents of three children, Carla, Scott, and Erik, and live Dr. Blumenkranz has a long-standing interest and expertise in in Portola Valley, California. 2015 Subspecialty Day | Retina vii Faculty Thomas M Aaberg Jr MD Jayakrishna Ambati MD Marcos P Avila MD Ada, MI Lexington, KY Goiania, GO, Brazil Founder and President Professor and Vice Chair Professor of Ophthalmology Retina Specialists of Michigan Ophthalmology and Visual Sciences Head of the Ophthalmology Department Assistant Clinical Professor of University of Kentucky Universidade Federal de Goiás Ophthalmology Professor of Physiology Michigan State University University of Kentucky No photo available Carl C Awh MD Nashville, TN Anita Agarwal MD J Fernando Arevalo MD FACS President, Tennessee Retina, PC Nashville, TN Riyadh, Saudi Arabia Professor of Ophthalmology Edmund F and Virginia Ball Professor of Vanderbilt Eye Institute Ophthalmology Vanderbilt University School of Wilmer Eye Institute and Johns Hopkins Medicine University School of Medicine Chief of Vitreoretina Division The King Khaled Eye Specialist Hospital, Riyadh Sophie J Bakri MD Rochester, MN Professor of Ophthalmology Mayo Clinic Thomas A Albini MD Miami, FL Associate Professor of Clinical Ophthalmology Robert L Avery MD Bascom Palmer Eye Institute Santa Barbara, CA Codirector, California Retina Research Foundation Founder, California Retina Consultants viii Faculty Listing 2015 Subspecialty Day | Retina Francesco M Bandello MD FEBO Audina M Berrocal MD Mark S Blumenkranz MD Milano, Italy Miami, FL Palo Alto, CA Full Professor and Chairman Professor of Clinical Ophthalmology H J Smead Professor and Chairman Department of Ophthalmology Bascom Palmer Eye Institute Stanford University School of Medicine University Scientific Institute San University of Miami Director, Byers Eye Institute at Stanford Raffaele Staff Physician Miami Children’s Hospital Francesco Boscia MD Caroline R Baumal MD Bari, Italy Boston, MA Maria H Berrocal MD Associate Professor and Chairman Associate Professor San Juan, PR Department of Ophthalmology Tufts University School of Medicine Faculty, Department of Ophthalmology University of Sassari Vitreoretinal Surgeon University of Puerto Rico New England Eye Center Director, Berrocal & Associates David S Boyer MD Los Angeles, CA Paul S Bernstein MD PhD Susanne Binder MD Clinical Professor of Ophthalmology Salt Lake City, UT Vienna, Austria University of Southern California / Keck Professor of Ophthalmology and Visual Professor, Department of School of Medicine Sciences Ophthalmology Partner, Retina Vitreous Associates Moran Eye Center Rudolf Foundation Clinic Medical Group University of Utah Professor of Ophthalmology The Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery 2015 Subspecialty Day | Retina Faculty Listing ix Neil M Bressler MD Gary C Brown MD Antonio Capone Jr MD Baltimore, MD Plymouth Meeting, PA Royal Oak, MI Chief, Retina Division Professor of Ophthalmology Professor of Ophthalmology The James P Gills Professor of Director Emeritus, Retina Service William Beaumont Hospital / Oakland Ophthalmology Wills Eye Hospital, Jefferson Medical University School of Medicine Wilmer Eye Institute College Copresident, Partner, Owner Johns Hopkins University School of Chief Medical Officer and Director of Associated Retinal Consultants Medicine Pharmacoeconomics Editor-in-Chief Center for Value-Based Medicine JAMA Ophthalmology Usha Chakravarthy MBBS PhD Belfast, Northern Ireland David J Browning MD PhD Professor of Ophthalmology and Vision Susan B Bressler MD Charlotte, NC Science Baltimore, MD Retina Service Queen’s University of Belfast The Julia G Levy PhD Professor of Charlotte Eye, Ear, Nose, and Throat Ophthalmology Associates Wilmer Eye Institute Johns Hopkins University School of Medicine Wiley Andrew Chambers MD McLean, VA Peter A Campochiaro MD Clinical Professor of Ophthalmology Baltimore, MD The George Washington University Eccles Professor of Ophthalmology and David M Brown MD Neuroscience Houston, TX John Hopkins University School of Clinical Professor of Ophthalmology Medicine Baylor College of Medicine Director of Clinical Research Retina Consultants of Houston x Faculty Listing 2015 Subspecialty Day | Retina R V Paul Chan MD Emily Y Chew MD Carl C Claes MD New York, NY Bethesda, MD Schilde, Belgium St. Giles Associate Professor of Pediatric Deputy Director Head of Vitreoretinal Surgery Retina Division of Epidemiology and Clinical Saint Augustinus Hospital (Wilrijk/ Weill Cornell Medical College Applications Antwerp) National Eye Institute / National Director, Ophthalmology Medical Institutes of Health Center Vlaamse Kaai 29 Antwerp/ Belgium Stanley Chang MD New York, NY KK Tse and KT Ying Professor of David R Chow MD Ophthalmology North York, ON, Canada Borja F Corcóstegui MD Columbia University Assistant Professor of Ophthalmology Barcelona, Spain University of Toronto Professor of Ophthalmology Codirector, Toronto Retina Institute University Autònoma of Barcelona Institut de Microcirurgía Ocular Steven T Charles MD Memphis, TN Clinical Professor of Ophthalmology Thomas A Ciulla MD University of Tennesee, Memphis Indianapolis, IN Scott W Cousins MD Retina Service Durham, NC Midwest Eye Institute Vice Chair for Research Professor of Ophthalmology and Immunology Duke University No photo available Nauman A Chaudhry MBBS New London, CT Clinical Professor Yale New Haven Hospital

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Pravin U Dugel MD and Jennifer I Lim MD. In conjunction with the . Continuing Medical Education (CME) program is to pres- Retinal Outcome Measures . Dose-Escalation Study of MTP-131 in Subjects with Diabetic Macular.
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