Retina 2015 Upping the Ante

220 Pages·2015·9.26 MB·English

Retina 2015
Upping the Ante
Program Directors
Pravin U Dugel MD and Jennifer I Lim MD
In conjunction with the American Society of Retina Specialists,
the Macula Society, the Retina Society, and Club Jules Gonin
Sands Expo/Venetian
Las Vegas, Nevada
Friday, Nov. 13 – Saturday, Nov. 14, 2015
Presented by:
The American Academy of Ophthalmology
Sponsored in part by an unrestricted educational grant from
Genentech
Retina 2015 Planning Group 2007 John T Thompson MD Subspecialty Day Advisory Committee
Pravin U Dugel MD M Gilbert Grand MD William F Mieler MD
Program Director 2006 Emily Y Chew MD Associate Secretary
Jennifer I Lim MD John T Thompson MD Donald L Budenz MD MPH
Program Director 2005 Michael T Trese MD Daniel S Durrie MD
CRaicrhl aDrd R Fe gSipllaoi dMe DMD 2 004 EWMmiilcillhiyaa meYl FTC hMTerwieesl eMer M DMDD FRNr iaMcnocilcaishs aSJe MlV Soailahpt ekM oMwDDski MD
2003 Kirk H Packo MD
Former Program Directors William F Mieler MD Jonathan B Rubenstein MD
2014 Peter K Kaiser MD 2002 Mark S Blumenkranz MD Secretary for Annual Meeting
Pravin U Dugel MD Kirk H Packo MD
2013 Tarek S Hassan MD 2001 George A Williams MD Staff
Peter K Kaiser MD Mark S Blumenkranz MD Melanie R Rafaty CMP, Director, Scientific
2012 Joan W Miller MD 2000 Julia A Haller MD Meetings
Tarek S Hassan MD George A Williams MD Ann L’Estrange, Scientific Meetings Specialist
2011 Allen C Ho MD 1999 Stanley Chang MD Christa Fernandez, Presenter Coordinator
Joan W Miller MD Julia A Haller MD Debra Rosencrance CMP CAE, Vice
2010 Daniel F Martin MD 1998 Harry W Flynn Jr MD President, Meetings & Exhibits
Allen C Ho MD Stanley Chang MD Patricia Heinicke Jr, Copyeditor
2009 Antonio Capone Jr MD 1997 H MacKenzie Freeman MD Mark Ong, Designer
Daniel F Martin MD Harry W Flynn Jr MD Gina Comaduran, Cover Design
2008 M Gilbert Grand MD 1996 H MacKenzie Freeman MD
Antonio Capone Jr MD 1995 Thomas M Aaberg Sr MD
Paul Sternberg Jr MD
©2015 American Academy of Ophthalmology. All rights reserved. No portion may be reproduced without express written consent of the American Academy of Ophthalmology.
ii 2015 Subspecialty Day | Retina
2015 Retina Subspecialty Day Planning Group
On behalf of the American Academy of Ophthalmology and the American Society of Retina Specialists,
the Macula Society, the Retina Society, and Club Jules Gonin, it is our pleasure to welcome you to
Las Vegas and Retina 2015: Upping the Ante.
Pravin U Dugel MD Jennifer Irene Lim MD
Program Director Program Director
Abbott Medical Optics: C Alcon Laboratories, Inc.: C
Acucela: C Alexion: C
Alcon Laboratories, Inc.: C Genentech: C,L,S
Alimera Sciences, Inc.: C,O ICON Bioscience: C,S
Allergan: C | Digisight: O Lumenis, Inc.: C
Genentech: C Pfizer, Inc.: S
Novartis Pharmaceuticals Corp.: C Regeneron Pharmaceuticals, Inc.: C,L,S
Ophthotech: C,O Santen, Inc.: C
Ora: C | Regeneron: C
ThromboGenics: C
Carl D Regillo MD FACS Richard F Spaide MD
Acucela: C,S Novartis Pharmaceuticals Genentech: C
Advanced Cell Corp.: C Topcon Medical Systems, Inc.: P,C
Technology: S Pfizer, Inc. C
Alcon Laboratories, Inc.: Regeneron
C,S Pharmaceuticals, Inc.:
Alimera Sciences, Inc.: C,S
C,S Santen, Inc.: S
Allergan: C,S Second Sight Medical
Bausch + Lomb: C Products, Inc.: S
Genentech: C,S ThromboGenics, Inc.: C,S
NotalVision, Ltd.: C,S
2015 Subspecialty Day | Retina iii
Retina 2015 Contents
2015 Retina Subspecialty Day Planning Group ii
CME iv
The Charles L Schepens MD Lecture vi
Faculty Listing vii
Program Schedule xxvii
Section I: Masters of Surgery 1
Section II: Vitreoretinal Surgery, Part I 12
Advocating for Patients 35
The Charles L Schepens MD Lecture 37
Section III: The Business of Retina 38
Section IV: Late Breaking Developments, Part I 44
Section V: My Coolest Surgical Video 45
Section VI: Pediatric Retina 46
Section VII: Retinal Vein Occlusion 49
Section VIII: Diabetic Retinopathy Clinical Research Network (DRCRnet) Protocols 54
Section IX: First-time Results of Clinical Trials, Part I 58
Section X: Neovascular AMD 62
Section XI: Imaging 81
Section XII: Late Breaking Developments, Part II 110
Section XIII: Oncology Panel 111
Section XIV: Diabetes 112
Section XV: First-time Results of Clinical Trials, Part II 126
Section XVI: Uveitis 137
Section XVII: Non-neovascular AMD 138
Section XVIII: Vitreoretinal Surgery, Part II 159
Section XIX: Video Surgical Complications—What Would You Do? 174
Faculty Financial Disclosure 175
Retina Exhibitors 184
Presenter Index 186
iv 2015 Subspecialty Day | Retina
CME Credit
Academy’s CME Mission Statement Scientific Integrity and Disclosure of Financial
Interest
The purpose of the American Academy of Ophthalmology’s
Continuing Medical Education (CME) program is to pres- The American Academy of Ophthalmology is committed to
ent ophthalmologists with the highest quality lifelong learning ensuring that all CME information is based on the application
opportunities that promote improvement and change in physi- of research findings and the implementation of evidence-based
cian practices, performance, or competence, thus enabling such medicine. It seeks to promote balance, objectivity, and absence of
physicians to maintain or improve the competence and profes- commercial bias in its content. All persons in a position to con-
sional performance needed to provide the best possible eye care trol the content of this activity must disclose any and all financial
for their patients. interest. The Academy has mechanisms in place to resolve all
conflicts of interest prior to an educational activity being deliv-
ered to the learners.
2015 Retina Subspecialty Day Meeting Learning
The Academy requires all presenters to disclose on their first
Objectives
slide whether they have any financial interests from the past 12
Upon completion of this activity, participants should be able to: months. Presenters are required to verbally disclose any financial
interests that specifically pertain to their presentation.
• Explain the current management of macular edema
secondary to retinal occlusive disease and diabetic
retinopathy Attendance Verification for CME Reporting
• Explain the pathobiology and management of atrophic
Before processing your requests for CME credit, the Academy
and exudative AMD and other causes of CNV
must verify your attendance at Subspecialty Day and/or at AAO
• Identify emerging developments in retinal imaging
2015. In order to be verified for CME or auditing purposes, you
• Describe new vitreoretinal surgical techniques and instru-
must either:
mentation
• Identify new developments in hereditary retinal degenera- • Register in advance, receive materials in the mail, and turn
tions, pediatric retinal diseases, and ocular oncology in the Final Program and/or Subspecialty Day Syllabus
• Summarize current and new clinical trial data for retinal exchange voucher(s) onsite;
diseases such as AMD, diabetic retinopathy, and retinal • Register in advance and pick up your badge onsite if
vein occlusion materials did not arrive before you traveled to the meeting;
• Register onsite; or
• Scan the barcode on your badge as you enter an AAO
2015 Retina Subspecialty Day Meeting Target
2015 course or session room.
Audience
The intended target audience for this program is vitreoretinal
CME Credit Reporting
specialists, members in fellowship training, and general ophthal-
mologists who are engaged in the diagnosis and treatment of
Level 2 Lobby and Academy Resource Center, Hall B – Booth
vitreoretinal diseases.
2632
Attendees whose attendance has been verified (see above) at
2015 Retina Subspecialty Day Meeting CME Credit AAO 2015 can claim their CME credit online during the meet-
ing. Registrants will receive an email during the meeting with the
The American Academy of Ophthalmology is accredited by the
link and instructions on how to claim credit.
Accreditation Council for Continuing Medical Education to pro-
Onsite, you may report credits earned during Subspecialty
vide CME for physicians.
Day and/or AAO 2015 at the CME Credit Reporting booth.
The American Academy of Ophthalmology designates this
Academy Members: The CME credit reporting receipt is not a
live activity for a maximum of 14 AMA PRA Category 1 Cred-
CME transcript. CME transcripts that include AAO 2015 cred-
its™. Physicians should claim only the credit commensurate with
its entered onsite will be available to Academy members on the
the extent of their participation in the activity.
Academy’s website beginning Dec. 10, 2015.
NOTE: CME credits must be reported by Jan. 13, 2016.
Teaching at a Live Activity After AAO 2015, credits can be claimed at www.aao.org.
The Academy transcript cannot list individual course atten-
Teaching instruction courses or delivering a scientific paper or
dance. It will list only the overall credits spent in educational
poster is not an AMA PRA Category 1 Credit™ activity and
activities at Subspecialty Day and/or AAO 2015.
should not be included when calculating your total AMA PRA
Nonmembers: The Academy will provide nonmembers with
Category 1 Credits™. Presenters may claim AMA PRA Category
verification of credits earned and reported for a single Academy-
1 Credits™ through the American Medical Association. To
sponsored CME activity, but it does not provide CME credit
obtain an application form please contact the AMA at
transcripts. To obtain a printed record of your credits, you must
www.ama-assn.org.
2015 Subspecialty Day | Retina CME Credit v
report your CME credits onsite at the CME Credit Reporting
booths.
Proof of Attendance
The following types of attendance verification will be available
during AAO 2015 and Subspecialty Day for those who need it
for reimbursement or hospital privileges, or for nonmembers
who need it to report CME credit:
• CME credit reporting/proof-of-attendance letters
• Onsite registration receipt
• Instruction course and session verification
Visit www.aao.org for detailed CME reporting information.
vi 2015 Subspecialty Day | Retina
The Charles L Schepens MD Lecture
Digital Medicine: Implications for Retina and Beyond
Friday, Nov. 13, 2015
10:07 AM – 10:27 AM
Mark S Blumenkranz MD
Mark S Blumenkranz MD MMS is H. J. Smead Professor of university corporate technology transfer and early stage biomedi-
Ophthalmology in the Department of Ophthalmology at Stan- cal company development, having either founded or served on
ford University. He received his undergraduate degree, a graduate the boards of directors of a number of successful medical drug
degree in biochemical pharmacology, and his medical education and device companies.
at Brown University. He completed his internship in surgery and Dr. Blumenkranz has served on the editorial boards of the
his ophthalmic residency training at Stanford, and in 1980 a fel- American Journal of Ophthalmology, Retina, Ophthalmology,
lowship in vitreoretinal diseases at the Bascom Palmer Eye Insti- and Graefe’s Archives for Ophthalmology. He is a past recipient
tute, where he subsequently served on the faculty for five years. of the Heed Award, the Rosenthal Award in Visual Sciences, the
After leaving Bascom Palmer Dr. Blumenkranz joined Associated American Academy of Ophthalmology Lifetime Achievement
Retinal Consultants in Royal Oak, Michigan, and became the Award, the Alcon Research Institute Award, ARVO Fellows
founding director of the vitreoretinal fellowship program at Wil- designation, and the Gertrude Pyron Award from the Ameri-
liam Beaumont Hospital, before returning to Stanford in 1992 to can Society of Retina Specialists for lifetime contributions in
lead the retinal service and then the department as chairman from vitreoretinal surgery. He has delivered multiple named award
1997 until 2015. He spearheaded the development of the Byers lectures over the past thirty-five years, including most recently
Eye Institute at Stanford and served as its founding director from the Jackson Memorial Lecture at the Academy’s Annual Meeting
the time of its opening in 2010 until 2015. in 2013. He is a past president of the American University Pro-
Dr. Blumenkranz was an early innovator in vitrectomy fessors of Ophthalmology (AUPO), the Retina Society, and the
techniques to treat complex forms of retinal detachment, and Macula Society. He is a member of the Steering Committee of the
he helped to usher in the modern era of intravitreal, gene, and Audacious Goals Initiative of the NEI, and he is a Fellow of the
surgical adjuvant drug therapy. He has also published exten- Corporation of Brown University, where he is the long-serving
sively in the area of new lasers and laser tissue interactions. He chair of the Medical School Committee.
has published more than 150 papers in peer-reviewed journals Dr. Blumenkranz and his wife, Recia Kott Blumenkranz MD,
and multiple book chapters, abstracts, and patents in the field. are the parents of three children, Carla, Scott, and Erik, and live
Dr. Blumenkranz has a long-standing interest and expertise in in Portola Valley, California.
2015 Subspecialty Day | Retina vii
Faculty
Thomas M Aaberg Jr MD Jayakrishna Ambati MD Marcos P Avila MD
Ada, MI Lexington, KY Goiania, GO, Brazil
Founder and President Professor and Vice Chair Professor of Ophthalmology
Retina Specialists of Michigan Ophthalmology and Visual Sciences Head of the Ophthalmology Department
Assistant Clinical Professor of University of Kentucky Universidade Federal de Goiás
Ophthalmology Professor of Physiology
Michigan State University University of Kentucky
No photo
available
Carl C Awh MD
Nashville, TN
Anita Agarwal MD J Fernando Arevalo MD FACS President, Tennessee Retina, PC
Nashville, TN Riyadh, Saudi Arabia
Professor of Ophthalmology Edmund F and Virginia Ball Professor of
Vanderbilt Eye Institute Ophthalmology
Vanderbilt University School of Wilmer Eye Institute and Johns Hopkins
Medicine University School of Medicine
Chief of Vitreoretina Division
The King Khaled Eye Specialist Hospital,
Riyadh
Sophie J Bakri MD
Rochester, MN
Professor of Ophthalmology
Mayo Clinic
Thomas A Albini MD
Miami, FL
Associate Professor of Clinical
Ophthalmology Robert L Avery MD
Bascom Palmer Eye Institute Santa Barbara, CA
Codirector, California Retina Research
Foundation
Founder, California Retina Consultants
viii Faculty Listing 2015 Subspecialty Day | Retina
Francesco M Bandello MD FEBO Audina M Berrocal MD Mark S Blumenkranz MD
Milano, Italy Miami, FL Palo Alto, CA
Full Professor and Chairman Professor of Clinical Ophthalmology H J Smead Professor and Chairman
Department of Ophthalmology Bascom Palmer Eye Institute Stanford University School of Medicine
University Scientific Institute San University of Miami Director, Byers Eye Institute at Stanford
Raffaele Staff Physician
Miami Children’s Hospital
Francesco Boscia MD
Caroline R Baumal MD Bari, Italy
Boston, MA Maria H Berrocal MD Associate Professor and Chairman
Associate Professor San Juan, PR Department of Ophthalmology
Tufts University School of Medicine Faculty, Department of Ophthalmology University of Sassari
Vitreoretinal Surgeon University of Puerto Rico
New England Eye Center Director, Berrocal & Associates
David S Boyer MD
Los Angeles, CA
Paul S Bernstein MD PhD Susanne Binder MD Clinical Professor of Ophthalmology
Salt Lake City, UT Vienna, Austria University of Southern California / Keck
Professor of Ophthalmology and Visual Professor, Department of School of Medicine
Sciences Ophthalmology Partner, Retina Vitreous Associates
Moran Eye Center Rudolf Foundation Clinic Medical Group
University of Utah Professor of Ophthalmology
The Ludwig Boltzmann Institute for
Retinology and Biomicroscopic Laser
Surgery
2015 Subspecialty Day | Retina Faculty Listing ix
Neil M Bressler MD Gary C Brown MD Antonio Capone Jr MD
Baltimore, MD Plymouth Meeting, PA Royal Oak, MI
Chief, Retina Division Professor of Ophthalmology Professor of Ophthalmology
The James P Gills Professor of Director Emeritus, Retina Service William Beaumont Hospital / Oakland
Ophthalmology Wills Eye Hospital, Jefferson Medical University School of Medicine
Wilmer Eye Institute College Copresident, Partner, Owner
Johns Hopkins University School of Chief Medical Officer and Director of Associated Retinal Consultants
Medicine Pharmacoeconomics
Editor-in-Chief Center for Value-Based Medicine
JAMA Ophthalmology
Usha Chakravarthy MBBS PhD
Belfast, Northern Ireland
David J Browning MD PhD Professor of Ophthalmology and Vision
Susan B Bressler MD Charlotte, NC Science
Baltimore, MD Retina Service Queen’s University of Belfast
The Julia G Levy PhD Professor of Charlotte Eye, Ear, Nose, and Throat
Ophthalmology Associates
Wilmer Eye Institute
Johns Hopkins University School of
Medicine
Wiley Andrew Chambers MD
McLean, VA
Peter A Campochiaro MD Clinical Professor of Ophthalmology
Baltimore, MD The George Washington University
Eccles Professor of Ophthalmology and
David M Brown MD Neuroscience
Houston, TX John Hopkins University School of
Clinical Professor of Ophthalmology Medicine
Baylor College of Medicine
Director of Clinical Research
Retina Consultants of Houston
x Faculty Listing 2015 Subspecialty Day | Retina
R V Paul Chan MD Emily Y Chew MD Carl C Claes MD
New York, NY Bethesda, MD Schilde, Belgium
St. Giles Associate Professor of Pediatric Deputy Director Head of Vitreoretinal Surgery
Retina Division of Epidemiology and Clinical Saint Augustinus Hospital (Wilrijk/
Weill Cornell Medical College Applications Antwerp)
National Eye Institute / National Director, Ophthalmology Medical
Institutes of Health Center
Vlaamse Kaai 29 Antwerp/ Belgium
Stanley Chang MD
New York, NY
KK Tse and KT Ying Professor of David R Chow MD
Ophthalmology North York, ON, Canada Borja F Corcóstegui MD
Columbia University Assistant Professor of Ophthalmology Barcelona, Spain
University of Toronto Professor of Ophthalmology
Codirector, Toronto Retina Institute University Autònoma of Barcelona
Institut de Microcirurgía Ocular
Steven T Charles MD
Memphis, TN
Clinical Professor of Ophthalmology Thomas A Ciulla MD
University of Tennesee, Memphis Indianapolis, IN Scott W Cousins MD
Retina Service Durham, NC
Midwest Eye Institute Vice Chair for Research
Professor of Ophthalmology and
Immunology
Duke University
No photo
available
Nauman A Chaudhry MBBS
New London, CT
Clinical Professor
Yale New Haven Hospital