Respiratory System PDF
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Monographs on Pathology of Laboratory Animals Sponsored by the International Life Sciences Institute Editorial Board J. D. Burek, West Point· J. S. Campbell, Ottawa C. C. Capen, Columbus . A. Cardesa, Barcelona RG.Carison, Kalamazoo· D. de Paola, Rio de Janeiro G. Della Porta, Milan . J. L. Emerson, Atlanta F. M. Garner, Rockville . L. Golberg, Research Triangle Park H. C. Grice, N epean . C. C. Harris, Bethesda . R Hess, Basel C. F. Hollander, Rijswijk· G. H. Hottendorf, Syracuse RD. Hunt, Southborough . T. C. Jones, Southborough Y. Konishi, Nara . D. Krewski, Ottawa· R Kroes, Bilthoven H. Luginbuhl, Bern . U. Mohr, Hannover . P. Olsen, Soborg J. A. Popp, Research Triangle Park· J. R Schenken, Omaha R A. Squire, Baltimore· J. Sugar, Budapest S. Takayama, Tokyo . G. C. Todd, Greenfield L. Tomatis, Lyon . B. F. Trump, Baltimore· J. M. Ward, Frederick Officers - ILSI Alex Malaspina, Atlanta - President Peter B. Dews, Boston - Vice President Ulrich Mohr, Hannover - Vice President Roger D. Middlekauff, Washington - Secretary/Treasurer Respiratory System Edited by T.e.Jones V.Mohr R.D.Hunt With 279 Figures and 20 Tables Springer-Verlag Berlin Heidelberg New York Tokyo 1985 Thomas Carlyle Jones, D. V. M., D. Sc. Professor of Comparative Pathology, Emeritus Harvard Medical School New England Regional Primate Research Center One Pine Hill Drive, Southborough, MA 01772, USA Ulrich Mohr, M. D. Professor of Experimental Pathology Medizinische Hochschule Hannover Institut fur Experimentelle Pathologie Konstanty-Gutschow-Strasse 8 3000 Hannover 61, Federal Republic of Germany Ronald Duncan Hunt, D. V. M. Professor of Comparative Pathology Harvard Medical School New England Regional Primate Research Center One Pine Hill Drive, Southborough, MA 01772, USA ISBN-13: 978-3-642-96848-8 e-ISBN-13: 978-3-642-96846-4 DOl: 10.1007/978-3-642-96846-4 Library of Congress Cataloging in Publication Data. Main entry under title: Respiratory system. (Monographs on pathology oflaboratory animals) Bibliography: p. Includes index. 1. Laboratory animals-Diseases. 2. Respiratory organs-Diseases. 3. Ro- dents-Diseases. 4. Rodents as laboratory animals. 5. Pathology, Comparative. I. Jones, Thomas Carlyle. II. Mohr, U. (Ulrich) III. Hunt, Ronald Duncan. IV. Series. SF996.5.R47 1985 599.32'3 84-14048 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use a fee is payable to 'Verwertungsgesellschaft Wort', Munich. © Springer-Verlag Berlin Heidelberg 1985 The use of registered names, trademarks, etc. in the publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protec- tive laws and regulations and therefore free for general use. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 2123/3140-543210 Foreword The International Life Sciences Institute (ILSI) was creat- ed to promote cooperative efforts toward solving critical health and safety questions involving foods, drugs, cosmet- ics, chemicals, and other aspects of the environment. The Officers and Trustees believe that questions regarding health and safety are best resolved when government and industry rely on scientific investigations, analyses, and re- views by independent experts. Further, the scientific aspects of an issue should be examined and discussed on an international basis, separate from the political concerns of individual companies. ILSI is pleased to sponsor this set of monographs on the pathology of laboratory animals. This project will be use- ful in improving the scientific basis for the application of pathologic techniques to health and safety evaluation of substances in our environment. The world wide distribu- tion of the authors, editors, and Editorial Board who are creating these monographs strengthens the expectation that international communication and cooperation will al- so be strengthened. Alex Malaspina President International Life Sciences Institute Preface This book on the respiratory system is the second volume of a set pre- pared under the sponsorship of the International Life Sciences Insti- tute (ILSI). One aim of this set on the Pathology of Laboratory Ani- mals is to provide information which will be useful to pathologists, especially those involved in studies on the safety of foods, drugs, chemicals, and other substances in the environment. It is expected that this and future volumes will contribute to better communication on an international basis among people in government, industry, and acade- mia who are involved in the protection of the public health. The arrangement of this volume is based, in part, upon the philosophy that the first step toward understanding a pathologic lesion is its pre- cise and unambiguous identification. The microscopic and ultrastruc- tural features of a lesion that are particularly useful to the pathologist for definitive diagnosis are therefore considered foremost. Diagnostic terms preferred by the author and editors are used as the subject head- ing for each pathologic lesion. Synonyms are listed although most are not preferred and some may have been used erroneously in prior pub- lications. The problems arising in differential diagnosis of similar le- sions are considered in detail. The biologic significance of each patho- logic lesion is considered under such headings as etiology, natural history, pathogenesis, and frequency of occurrence under natural or experimental conditions. Comparison of information available on similar lesions in man and other species is valuable as a means to gain broader understanding of the processes involved. Knowledge of this nature is needed to form a scientific basis for safety evaluations and experimental pathology. Ref- erences to pertinent literature are provided in close juxtaposition to the text in order to support conclusions in the text and lead toward addi- tional information. Illustrations are an especially important means of non verbal communication, especially among pathologists, and there- fore constitute important features of each volume. The subject under each heading is covered in concise terms and is ex- pected to stand alone, but in some instances it is important to refer to other parts of the volume. A comprehensive index is provided to en- hance the use of each volume as a reference. Some omissions are inevitable and we solicit comments from our col- leagues to identify parts which need strengthening or correction. We have endeavored to include important lesions which a pathologist might encounter in studies involving the rat, mouse, or hamster. Newly recognized lesions or better understanding of old ones may make revised editions necessary in the future. The editors wish to express their deep gratitude to all of the individuals who have helped with this enterprise. We are indebted to each author and member of the Editorial Board whose names appear elsewhere in the volume. We are especially grateful to the Officers and Board of Trustees of the International Life Sciences Institute for their support and understanding. Several people have worked directly on important details in this venture. These include Nina Murray, Executive Secre- VIII Preface tary; Beverly Blake, Editorial Assistant; June Armstrong, Medical Il- lustrator; and Virginia Werwath, Administrative Assistant. Sharon K. Coleman, ILSI Coordinator for External Affairs, was helpful on many occasions. We are particularly grateful to Dr. Dietrich Gotze and his staff at Springer-Verlag for the quality of the published product. November 1984 T.C.Jones V.Mohr R.D.Hunt Table of Contents The Upper Respiratory System (Nares, Larynx, Trachea) . 1 Histology, Ultrastructure, Embryology . . . . . . . . . . . . 3 Macrosopic, Microscopic, and Ultrastructural Anatomy of the Nasal Cavity, Rat J. A. POPP and N. A. MONTEIRO-RIVIERE ........... 3 Development of Syrian Golden Hamster Tracheal Epithelium During Prenatal and Immediate Postnatal Stages M.EMURA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Epithelial Alterations in Explant Cultures of Fetal Tracheae of Syrian Golden Hamsters M.EMURA. . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 27 Neoplasms . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Response to Carcinogens of Respiratory Epithelium, Syrian Golden Hamster (Mesocricetus Auratus) H.-B. RICHTER-REICHHELM, W. BONING, and J. ALTHOFF. 33 Polypoid Adenoma, Nasal Mucosa, Rat W.D.KERNS .................. . 41 Neoplasms, Mucosa, Ethmoid Turbinates, Rat S. F. STINSON and H. M. REZNIK-SCHOLLER . 47 Squamous Cell Carcinoma, Nasal Mucosa, Rat W.D.KERNS .................. . 54 Squamous Cell Carcinoma, Upper Respiratory Tract, Syrian Hamster P. M. POUR. . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 Adenocarcinoma, Anterior Nasal Epithelium, Rat S. F. STINSON and G. REZNIK ........... . 67 Hemangiosarcoma, Nasal Cavity, Mouse W. E. GIDDENS Jr. and R. A. RENNE .... 72 Clear Cell Carcinoma, Larynx, Syrian Hamster P.M. POUR .................... . 75 Lesions Due to Infections. . . . . . . . . . . . . . . . . . . . . .. 78 Murine Respiratory Mycoplasmosis, Upper Respiratory Tract, Rat T. R. SCHOEB and J. R. LINDSEY. . . . . . . . . . . . . . . . . 78 Sialodacryoadenitis Virus Infection, Upper Respiratory Tract, Rat D. G. BROWNSTEIN ....................... 84 X Table of Contents The Lung (Bronchi, Bronchioles, Alveolar Ducts, Alveoli, Pleura) . 87 Histology and Ultrastructure . . . . . 89 Structure and Function of the Lung C. KUHN III ............ . 89 Neoplasms. 99 Bronchiolar/Alveolar Adenoma, Lung, Rat G. A. BOORMAN ............... . 99 Alveolar Type II Cell Adenoma, Lung, Mouse S. L. KAUFFMAN and T. SATO ........ . 102 Bronchiolar Adenoma, Lung, Mouse S. L. KAUFFMAN and T.SATO ..... 107 Bronchiolar/Alveolar Carcinoma, Lung, Rat G. A. BOORMAN ................ . 112 Squamous Cell Carcinoma, Lung, Syrian Hamster P. M. POUR and H. M. REZNIK-SCHULLER. 117 Squamous Cell Carcinoma, Lung, Rat G. A. BOORMAN ............... . 124 Radiation-Induced Squamous Cell Carcinoma, Lung of Rodents F. F. HAHN. . . . . . . . . . . . . . . . . . . . . . . . . . 127 Pleural Mesothelioma, Syrian Hamster A.CARDESAandJ.A.BOMBI ... 133 Metastatic Tumors, Lung, Mouse B. SASS and A. G. LIEBELT 138 Nonneoplastic Lesions . . . 160 Bleomycin-Induced Injury, Mouse: A Model for Pulmonary Fibrosis D. H. BOWDEN .... . . . . . . . . . . . . . . . . . . 160 Endogenous Lipid Pneumonia in Female B6C3Fl Mice Y. EMI and Y. KONISHI ................. . 166 Pulmonary Lipidosis, Rat Y. EM I, R. HIGASHIGUCHI, and Y. KONISHI . 169 Alveolar Lipoproteinosis, Rat W.WELLER .................. . 171 Bronchiolar/Alveolar Hyperplasia, Lung, Rat G. A. BOORMAN ................ . 177 Fly Ash Pneumoconiosis, Hamster G. E. DAGLE and A. P. WEHNER 180 Asbestosis, Hamster G. E. DAGLE and A. P. WEHNER 183 Pulmonary Hair Embolism A. KAST ............ . 186 Table of Contents XI Lesions Due to Infection . . . . . . . . . . . . . 195 Sendai Virus Infection, Lung, Mouse and Rat D. G. BROWNSTEIN ......... . 195 Rat Coronavirus Infection, Lung, Rat D. G. BROWNSTEIN ......... . 203 Pneumonia Virus of Mice Infection, Lung, Mouse and Rat D. G. BROWNSTEIN ................. 206 Sialodacryoadenitits Virus Infection, Lung, Mouse D. G. BROWNSTEIN .............. . 210 Murine Respiratory Mycoplasmosis, Lung, Rat T. R. SCHOEB and J. R. LINDSEY ........ . 213 Pneumocystosis, Lung, Rat J. K. FRENKEL ......... . 218 Aspergillosis and Mucormycosis, Lung, Rat J. K. FRENKEL ............... . 224 Toxoplasmosis, Lung, Mouse and Hamster J. K. FRENKEL 227 Subject Index . . 231 List of Contributors llirgen Althoff, M. D. Professor of Experimental Pathology, Hannover Medical School, 3000 Hannover 61, Federal Republic of Germany Josep Antoni Bombi, M. D. Assistant Professor, Department of Pathology, University of Barcelona, Medical School, Barcelona, Spain W. Boning, Dr. rer. nat. Hannover Medical School, Hannover, Federal Republic of Germany Gary A. Boorman, D. V. M., Ph. D. Head, Tumor Pathology, Chemical Pathology Branch, NIEHS, Research Triangle Park, North Carolina, USA Drummond H. Bowden, M. D. Professor and Head, Department of Pathology, University of Manitoba, Manitoba, Canada David G. Brownstein, D. V. M. Associate Professor of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA A. Cardesa, M. D. Patologica Facultad de Medicina, Universidad de Barcelona, Barcelona, Spain Gerald E. Dagle, D. V. M., Ph. D. Staff Pathologist, Battelle, Pacific Northwest Laboratory, Richland, Washington, USA Yohko Emi, D.V.M. Department of Oncological Pathology, Cancer Center, Nara Medical College, Nara, Japan Makito Emura, Priv. Doz. Dr. rer. nat. Head, Tissue Culture Unit, Institute of Experimental Pathology, Hannover Medical College, Hannover, Federal Republic of Germany J. K. Frenkel, M. D., Ph. D. Professor of Pathology and Oncology, Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA W. Ellis Giddens, Jr., D. V. M., Ph. D. Associate Professor, Division of Animal Medicine, Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, USA Fletcher F. Hahn, D. V. M., Ph. D. Head, Pathology Group, Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico, USA Ryuichi Higashiguchi, M. D. Assistant, Department of Oncological Pathology, Cancer Center, Nara Medical College, Nara, Japan
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