Resolution of EBV+ CNS lymphoma with appearance - RePub

151 Pages·2007·6.1 MB·English

The Role of T Lymphocytes in
The Pathogenesis of Hu Antibody Associated
Paraneoplastic Neurological Syndromes
Cover: This is a photograph of a model posing as a patient with Hu-PNS. Hu-PNS usually runs a
severe and subacute course, leaving the patient with severe disability within weeks to months from
onset of symptoms. At the time of neurological presentation, approximately 70% of patients are not
known with cancer. In more than 80% of the patients, an underlying tumor is ultimately detected,
most often a small cell lung cancer.
ISBN: 978-90-8559-290-7
Cover and chapter pages: Gian van Eekelen (www.gian.nl), Hans Milikan and Janet de Beukelaar
Printed by: Optima Grafische Communicatie, Rotterdam
Copyright: Janet W.K. de Beukelaar, 2007
The Role of T Lymphocytes in
The Pathogenesis of Hu Antibody Associated
Paraneoplastic Neurological Syndromes
De rol van T lymfocyten bij de pathogenese
van paraneoplastische neurologische syndromen
die met Hu antistoffen geassocieerd zijn
Proefschrift
ter verkrijging van de graad van doctor
aan de Erasmus Universiteit Rotterdam
op gezag van de rector magnificus
Prof.dr. S.W.J. Lamberts
en volgens het besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 13 juni 2007 om 11.45 uur
door
Janet Willemien Karin de Beukelaar
geboren te Woerden
Promotiecommissie:
Promotor : Prof.dr. P.A.E. Sillevis Smitt
Overige leden : Prof.dr. M.J. van den Bent
Prof.dr. H. Hooijkaas
Dr. R.Q. Hintzen
Copromotor : Dr. J.W. Gratama
The studies described in this thesis were performed at the Departments of Neurology,
Medical Oncology and Virology from the Erasmus University Medical Center in
Rotterdam, The Netherlands.
This research project was supported by the Revolving Fund from the Erasmus MC
Rotterdam, The Netherlands.
Printing of this thesis was sponsored by BD Biosciences, Jerini Peptide Technologies,
ProImmune Ltd, Remmert Adriaan Laan fonds, TNT post, Shell Nederland and Océ N.V.
Aan mijn vader (1946-1999)
Aan mijn moeder
Aan Jelmer

Table of contents
Chapter 1 General Introduction 9
Chapter 2 Managing paraneoplastic neurological syndromes 19
Oncologist 2006;11(3):292-305
Chapter 3 Increased proportions of circulating activated T cells in Hu antibody 41
associated paraneoplastic neurological syndromes
Submitted
Chapter 4 No evidence for circulating HuD-specific CD8+ T cells in patients 53
with paraneoplastic neurological syndromes and Hu antibodies
Cancer Immunol Immunother 2007; in press
Chapter 5 Resolution of EBV+ CNS lymphoma with appearance of CSF 63
EBV-specific T cells
Ann Neurol 2005;58:788-792
Chapter 6 The cerebrospinal fluid of patients with Hu-associated paraneoplastic 73
neurological syndromes does not contain detectable numbers of
HuD-specific CD8+ T cells
Submitted
Chapter 7 The impact of impurities in synthetic peptides on the outcome of 87
T-cell stimulation assays
Rapid Comm Mass Spectrometry 2007;21:1282-1288
Chapter 8 An uncontrolled trial of rituximab for antibody associated 101
paraneoplastic neurological syndromes
J Neurol 2006;253:16-20
Chapter 9 General Discussion 111
References 117
Summary 131
Samenvatting 135
List of abbreviations 139
Dankwoord 143
Curriculum Vitae 147
List of publications 149
7

Hoofdstukken [lay-out] 04-04-2007 19:40 Page 1
Chapter 1
General Introduction