Report of the Advisory Committee on Research on Women's Health, Fiscal Years 2011-2012

774 Pages·2013·6.25 MB·English

F I SCAL YEARS 2 011-2012
Report of the Advisory
Committee on Research
on Women’s Health
Office of Research
on Women’s Health
and
NIH Support for Research
on Women’s Health
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2011–2012
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Office of Research on Women’s Health. (2013). Report of the Advisory Committee on Research on
Women’s Health, Fiscal Years 2011–2012: Office of Research on Women’s Health and NIH Support
for Research on Women’s Health. Bethesda, MD: U.S. Department of Health and Human
Services, Public Health Service, National Institutes of Health.
NIH Publication No. 13-7995
Copies of this report and other publications of the Office of Research on Women’s Health are
available:
Office of Research on Women’s Health
National Institutes of Health
6707 Democracy Blvd., Suite 400, MSC 5484
Bethesda, Maryland 20892-5484
Voice: 301-402-1770
http://orwh.od.nih.gov
FFiissccaall YYeeaarrss 22001111 && 22001122
Preface
The Advisory Committee on Research on Women’s Health (ACRWH), in collaboration with the
Office of Research on Women’s Health (ORWH) and the National Institutes of Health (NIH)
Coordinating Committee on Research on Women’s Health (CCRWH), submits to the Director
of NIH this biennial report for fiscal years (FYs) 2011 and 2012, which details NIH activities car-
ried out in fulfillment of the core mission of ORWH, as defined in the NIH Revitalization Act of
1993. That mission is to strengthen and enhance NIH basic, translational, and clinical research:
• To increase the understanding of the diseases and conditions that affect women, includ-
ing investigation and elucidation of the role of sex and gender factors in health and
disease;
• To build NIH programs to develop a cadre of researchers, both women and men, who are
trained to conduct interdisciplinary research in these areas;
• To ensure the appropriate representation of women in NIH research; and
• To support the advancement of women in biomedical careers.
The ACRWH has reviewed the information contained in this biennial report, and finds that
it reflects the breadth and depth of research and related activities through which ORWH has
achieved its mission in FY 2011 and FY 2012. The report also provides highlights from women’s
health and sex/gender research supported by NIH Institutes, Centers (ICs), and Offices in the
Office of the NIH Director (OD). In addition, the report presents information on NIH budget
allocations for women’s health research during FY 2011 and FY 2012 using criteria supplied
by the NIH Office of Financial Management and the U.S. Department of Health and Human
Services (HHS) Office on Women’s Health. Finally, the report contains information document-
ing the inclusion of women and minorities in NIH-funded clinical research during the same
time period.
The ACRWH wishes to acknowledge the work of the CCRWH representatives, whose efforts
ensured the timely preparation of reports from the ICs and Offices they represent. The ACRWH
also wishes to acknowledge the work of the NIH staff members who assisted in the continued
implementation and analysis of the inclusion of women and minorities in NIH-funded research,
and the work of staff who collected and tabulated the budgetary data presented in this report.
Finally, the ACRWH wishes to acknowledge the work of ORWH staff in meeting the mandates
underlying the establishment of ORWH by providing leadership, both within NIH and with the
extramural research community, to accomplish the many outstanding and important advances
in NIH-funded science and in career support that are described herein.
iii
Report of the Advisory Committee on Research on Women’s Health
Advisory Committee on Research on
Women’s Health, FY 2013
Janine A. Clayton, M.D., Chair Valerie Latona (2015)
Associate Director for Research on Women’s Health & Fitness Writer/Editor
Health New York, NY
Director, Office of Research on Women’s
Health Jon Levine, Ph.D. (2015)
National Institutes of Health Director
Wisconsin National Primate Research Center
Susan E. Maier, Ph.D., Executive Secretary
Deputy Director Afaf I. Meleis, Ph.D., Dr.P.S. (hon.),
Office of Research on Women’s Health F.A.A.N., F.R.C.N. (2016)
National Institutes of Health Margaret Bond Simon Dean of Nursing
Professor of Nursing and Sociology
Richard Besdine, M.D. (2015) University of Pennsylvania School of Nursing
Director, Center for Gerontology and
Healthcare Research Heidi D. Nelson, M.D., M.P.H. (2016)
Director of the Division of Geriatrics, Research Professor, Departments of Medical
Department of Medicine Informatics & Clinical Epidemiology, and
Greer Professor of Geriatric Medicine Medicine
Alpert Medical School Medical Director, Providence Women and
Brown University Children’s Program and Research Center
Co-Director, V.A. Women’s Health Fellowship
John O. DeLancey, M.D. (2015) Oregon Health & Science University
Norman F. Miller Professor
Obstetrics and Gynecology Claire Pomeroy, M.D., M.B.A. (2014)
University of Michigan Vice Chancellor, Human Health Sciences
Dean, School of Medicine
Francisco Garcia, M.D., M.P.H. (2014) Professor of Internal Medicine and
Distinguished Outreach Professor of Obstetrics Microbiology/Immunology
and Gynecology and Public Health University of California, Davis
Director, Center of Excellence in Women’s
Health Judith G. Regensteiner, Ph.D. (2017)
The University of Arizona Professor of Medicine
Division of General Internal Medicine
Ronda S. Henry-Tillman, M.D. (2014) Denver School of Medicine
Practice Director, Ladies’ Oncology Clinic University of Colorado
Director, Cancer Control
Winthrop P. Rockefeller Cancer Institute Paul F. Terranova, Ph.D. (2014)
University of Arkansas for Medical Sciences Vice Chancellor for Research
Senior Associate Dean for Research and
Karen Kim, M.D., M.S. (2014) Graduate Education, University of Kansas
Associate Professor of Medicine School of Medicine
The University of Chicago The University of Kansas Medical Center
Susan Kornstein, M.D. (2015) Gerson Weiss, M.D. (2016)
Director and Professor of Psychiatry and Professor and Chair
Obstetrics-Gynecology Department of Obstetrics, Gynecology and
Institute for Women’s Health Women’s Health
Virginia Commonwealth University University of Medicine & Dentistry of
New Jersey—New Jersey Medical School
iv
Fiscal Years 2011 & 2012
Table of Contents
Preface � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � iii
Advisory Committee on Research on Women’s Health, FY 2013 � � � � � � � � � � � � � � � � � � � � � � � iv
Table of Contents � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �v
Introduction � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �1
• Organization of the FY 2011–FY 2012 Biennial Report of the ACRWH . . . . . . . . . . . . . . . .1
Report of the Office of Research on Women’s Health � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �5
A Historical Perspective: The Development of the Office of
Research on Women’s Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
• References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6
NIH Strategic Plan for Women’s Health Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
• Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7
• Identifying the Goals for the New NIH Agenda for Women’s Health Research . . . . . . . . . .7
• Developing Success Metrics and a Toolkit to Collect and Visualize Data
for the Strategic Plan Implementation Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8
• Summary: Guiding Tomorrow’s Research on Women’s Health . . . . . . . . . . . . . . . . . . . . .12
I. ORWH Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
• ORWH and NIH Priorities for Women’s Health Research . . . . . . . . . . . . . . . . . . . . . . . . . .13
• Overview of ORWH-Cofunded Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13
• Highlights of Long-Term ORWH-Cofunded Research Initiatives . . . . . . . . . . . . . . . . . . . .16
• Summary: ORWH Research Programs Support the Implementation
of the NIH Strategic Plan for Women’s Health Research . . . . . . . . . . . . . . . . . . . . . . . . . .17
II.ORWH Interdisciplinary Research and Career Development Programs . . . . . . . . . . . 29
• Building Interdisciplinary Research Careers in Women’s Health . . . . . . . . . . . . . . . . . . . .29
• Highlights of BIRCWH Principal Investigators and Accomplishments
of the Programs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31
• Specialized Centers of Research on Sex and Gender Factors
Affecting Women’s Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .46
• Highlights of BIRCWH and SCOR Activities at the Annual NIH Interdisciplinary
Women’s Health Research Symposium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .57
• Summary: ORWH Interdisciplinary Research and Career Development
Programs Support the Implementation of the NIH Strategic Plan for
Women’s Health Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .58
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Report of the Advisory Committee on Research on Women’s Health
III. ORWH Biomedical Career Development Activities . . . . . . . . . . . . . . . . . . . . . . . . . . . 61
• Research Supplements to Promote Reentry into Biomedical
and Behavioral Research Careers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .61
• Women’s Reproductive Health Research Career Development Program . . . . . . . . . . . . . .62
• NIH Working Group on Women in Biomedical Careers . . . . . . . . . . . . . . . . . . . . . . . . . . .65
• NIH Intramural Program on Research on Women’s Health . . . . . . . . . . . . . . . . . . . . . . . .69
• Office of Intramural Training and Education Programs . . . . . . . . . . . . . . . . . . . . . . . . . . .69
• ORWH Support for Other Summer Programs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .72
• ORWH Support for Other NIH Career Development Programs and Activities . . . . . . . . .73
• ORWH Support for Professional Society Activities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .73
• Summary: Biomedical Career Development Program Activities Support the
Implementation of the NIH Strategic Plan for Women’s Health Research . . . . . . . . . . . .74
IV. ORWH Research Dissemination and Outreach Activities . . . . . . . . . . . . . . . . . . . . . . . 75
• ORWH and the National Library of Medicine Partnership:
Women’s Health Resources Web Portal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .75
• NIH Vulvodynia Awareness Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .76
• NIH Pain Consortium Centers of Excellence in Pain Education . . . . . . . . . . . . . . . . . . . .76
• ORWH-Cofunded Research Conferences and Workshops . . . . . . . . . . . . . . . . . . . . . . . . .76
• ORWH Women’s Health Seminar Series . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .81
• Women’s Health Scientific Interest Group Lecture Series . . . . . . . . . . . . . . . . . . . . . . . . . .83
• Anita B. Roberts Lecture Series: Distinguished Women Scientists at NIH . . . . . . . . . . . . .83
• Association of Women in Science Seminar Series—Bethesda Chapter . . . . . . . . . . . . . . . .84
• Special Events and Meetings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .85
• ORWH Exhibit Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .86
• National Women’s Health Week at NIH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .86
• ORWH Pinn Point on Women’s Health Podcasts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .87
• ORWH Publications and Resources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .87
V. Monitoring Adherence to the NIH Policy on the Inclusion of
Women and Minorities as Subjects in Clinical Research . . . . . . . . . . . . . . . . . . . . . . . . . . 89
• NIH Monitoring Compliance Efforts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .89
• Summary Report of NIH Inclusion Data:
Comparison of FY 2011 and FY 2012 and 5- and 10-Year Trend Data . . . . . . . . . . . . . . . .93
• Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 110
VI. NIH Budget for Women’s Health Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .111
• NIH Budgetary Expenditures for Research on Women’s Health,
FY 2011 and FY 2012 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
vi
Fiscal Years 2011 & 2012
VII. Committee Members and ORWH Staff, FY 2011–2012 . . . . . . . . . . . . . . . . . . . . . . . 123
• Advisory Committee on Research on Women’s Health, FY 2011 . . . . . . . . . . . . . . . . . . .123
• Advisory Committee on Research on Women’s Health, FY 2012 . . . . . . . . . . . . . . . . . . .124
• NIH Coordinating Committee on Research on Women’s Health, FY 2011 . . . . . . . . . . .125
• NIH Coordinating Committee on Research on Women’s Health, FY 2012 . . . . . . . . . . .129
• ORWH Staff, FY 2011. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .132
• ORWH Staff, FY 2012 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .133
Report of the NIH Institutes and Centers � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �135
National Cancer Institute . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135
National Eye Institute . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
National Heart, Lung, and Blood Institute . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158
National Institute on Aging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
National Institute on Alcohol Abuse and Alcoholism . . . . . . . . . . . . . . . . . . . . . . . . . . . 184
National Institute of Allergy and Infectious Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . 198
National Institute of Arthritis and Musculoskeletal and Skin Diseases . . . . . . . . . . . . . . 219
National Institute of Biomedical Imaging and Bioengineering . . . . . . . . . . . . . . . . . . . 232
Eunice Kennedy Shriver National Institute of Child Health
and Human Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
National Institute on Deafness and Other Communication Disorders . . . . . . . . . . . . . . 261
National Institute of Dental and Craniofacial Research . . . . . . . . . . . . . . . . . . . . . . . . . . 263
National Institute of Diabetes and Digestive and Kidney Diseases . . . . . . . . . . . . . . . . 275
National Institute on Drug Abuse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 292
National Institute of Environmental Health Sciences . . . . . . . . . . . . . . . . . . . . . . . . . . . .311
National Institute of General Medical Sciences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325
National Institute of Mental Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327
National Institute on Minority Health and Health Disparities . . . . . . . . . . . . . . . . . . . . 343
National Institute of Neurological Disorders and Stroke . . . . . . . . . . . . . . . . . . . . . . . . 355
National Institute of Nursing Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 362
National Library of Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 375
Fogarty International Center . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 381
National Center for Complementary and Alternative Medicine. . . . . . . . . . . . . . . . . . . . 385
Office of Behavioral and Social Sciences Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 390
Office of Disease Prevention—Office of Dietary Supplements . . . . . . . . . . . . . . . . . . . . 396
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Report of the Advisory Committee on Research on Women’s Health
Appendices � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �401
Appendix A: ORWH-Cofunded Research Summaries, FY 2011 . . . . . . . . . . . . . . . . . . . . . 401
Appendix B: ORWH-Cofunded Research Summaries, FY 2012 . . . . . . . . . . . . . . . . . . . . 517
Appendix C: Trans-NIH Myalgic Encephalomyelitis/Chronic Fatigue
Syndrome (ME/CFS) Research Working Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 603
Appendix D: Selected BIRCWH Scholar Publications, FY 2011–FY 2012 . . . . . . . . . . . . . 605
Appendix E: Selected FY 2011–FY 2012 SCOR Publications,
Including Sex and Gender Analyses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 649
Appendix F: NIH Working Group on Women in Biomedical Careers . . . . . . . . . . . . . . . 659
Appendix G: Intramural Program on Research on
Women’s Health Steering Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 661
Appendix H: NIH Policy and Guidelines on the Inclusion of
Women and Minorities as Subjects in Clinical Research,
Amended October 2001 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 663
Appendix I: NIH Policy on Reporting Race and Ethnicity Data:
Subjects in Clinical Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 673
Appendix J: Aggregate Enrollment Tables and Trend Data . . . . . . . . . . . . . . . . . . . . . . . . 679
Acronyms and Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 723
Index � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � �741
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Fiscal Years 2011 & 2012
Introduction
This report of the Advisory Committee on Research on Women’s Health (ACRWH) for FYs 2011
and 2012 provides a summary of the accomplishments of NIH to address women’s health over
the past 2 years. The report documents the expansive growth of women’s health and sex differ-
ences research, along with many other significant programs and activities across the NIH. As
requested in the NIH Revitalization Act of 1993, the ACRWH, a chartered group composed of
non-Federal experts, submits a report to the NIH Director every 2 years, describing its findings
related to the mandates for ORWH and NIH support of women’s health research. This docu-
ment fulfills that directive.
In 2010, ORWH introduced a new strategic plan and research agenda for the NIH, “Moving
into the Future with New Dimensions and Strategies: A Vision for 2020 for Women’s Health
Research” (NIH Publication No. 10-7606), which provided a blueprint for future NIH wom-
en’s health and sex differences research and career advancement in biomedical sciences for the
coming decade. This “NIH Strategic Plan for Women’s Health Research” identified six major
goals for new research and other funding initiatives. In 2011 and 2012, the NIH community took
steps to further these goals and to track the progress toward their achievement. These efforts are
described in the ORWH section, as well as in the women’s health and sex/gender differences
research initiatives reported on by NIH ICs and Program Offices, also contained in this report.
Organization of the FY 2011–FY 2012 Biennial Report of the ACRWH
This FY 2011–FY 2012 biennial report bears witness to the phenomenal growth in women’s
health research and related programs that has occurred since the formation of the Office in
1990. It reflects major ORWH research programs, initiatives, activities, and highlights that were
reported from the NIH ICs and Program Offices. This report is not a comprehensive listing of
all NIH research on women’s health, which would necessarily be encyclopedic; the report does
serve, however, to summarize, under a single cover, examples of the wealth of NIH advances
in women’s health research. This report also provides information on and analyses of support
for women’s health research and related activities. The budget figures for NIH expenditures on
women’s health research and programs during FY 2011–FY 2012 are included as well.
This biennial report is divided into two major parts: Part 1 presents ORWH programs, and part 2
provides individual reports on women’s health research from the NIH ICs and Program Offices
in the Office of the NIH Director. Information about ORWH programs in part 1 is organized
into the following seven sections:
I. ORWH Research
II. ORWH Interdisciplinary Research and Career Development Programs
III. ORWH Biomedical Career Development Activities
IV. ORWH Research Dissemination and Outreach Activities
V. Monitoring Adherence to the NIH Policy on the Inclusion of Women and Minorities as
Subjects in Clinical Research
VI. NIH Budget for Women’s Health Research
VII. Committee Members, FY 2011–FY 2012
1