Regulatory Peptides

418 Pages·1989·10.32 MB·English

by  J. M. Polak, S. R. Bloom (auth.), Prof. Julia M. Polak (eds.)

EXS 56:
Experientia Supplementum,
Vol. 56
REGULATORY
PEPTIDES
Edited by
J. M. Polak
1989
Birkhauser Verlag
Basel . Boston . Berlin
Editor:
Prof. Julia M. Polak
Royal Postgraduate Medical School
Department of Histochemistry
Hammersmith Hospital
Du Cane Road
London WI2 OHS
England
Library of Congress Cataloging in Publication Data
Regulatory peptides.
(EXS; 56)
Includes index.
I. Peptide hormones. 2. Neuropeptides. I. Polak,
Julia M. II. Series: Experientia. Supplementum;
v.56.
QP572.P4R45 1989 599'.01927 88-22126
ISBN-13: 978-3-7643-1976-2 e-ISBN-13: 978-3-0348-9136-3
DOl: 10.1007/978-3-0348-9136-3
CIP-Kurztitelaufnabme der Deut!K:ben Bibliotbek
Regulatory peptides/ed. by J. M. Polak.-Basel; Boston;
Berlin: Birkhiiuser, 1989
(Experientia: Supplementum; Vol. 56)
NE: Polak, Julia M. [Hrsg.]; Experientia/Supplementum
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Contributors
Aguzzi, A., Department of Human Pathology, University of Pavia, 27100
Pavia, Italy
Allen, T. G. J., Department of Anatomy and Developmental Biology and
Centre for Neuroscience, University College London, Gower Street,
London WCIE 6BT, England
c.,
Andrews, P. Department of Biochemistry, Purdue University, West
Lafayette, Indiana 47907, USA
Barnes, P. J., Department of Medicine, Cardiothoracic Institute, Bromp
ton Hospital, London SW3, England
Bartfai, T., Department of Biochemistry, Arrhenius Laboratory, Univer
sity of Stockholm, 10691 Stockholm, Sweden
Bloom, S. R., Department of Medicine, Royal Postgraduate Medical
School, Hammersmith Hospital, Du Cane Road, London W12 OHS,
England
Brayton, K. A., Department of Biochemistry, Purdue University, West
Lafayette, Indiana 47907, USA
Buffa, R., Diagnostic Histopathology Center, University of Pavia at
Varese, 21100 Varese, Italy
Burnstock, G., Department of Anatomy and Developmental Biology and
Centre for Neuroscience, University College London, Gower Street,
London WCIE 6BT, England
Burrin, J. M., Department of Medicine, Royal Postgraduate Medical
School, Hammersmith Hospital, Du Cane Road, London W12 OHS,
England
Ceccatelli, S., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
Coghlan, J. P., Howard Florey Institute of Experimental Physiology and
Medicine, University of Melbourne Parkville, Victoria, 3052 Australia
Darby, I. A., Howard Florey Institute of Experimental Physiology and
Medicine, University of Melbourne Parkville, Victoria, 3052 Australia
VI
Darling, P. E., Howard Florey Institute of Experimental Physiology and
Medicine, University of Melbourne Parkville, Victoria, 3052 Australia
Davenport, A. P., Parke-Davis Research Unit, Addenbrookes Hospital
Site, Hills Road, Cambridge CB2 2QB, England
Dietl, M. M., Preclinical Research, Sandoz Ltd, 4002 Basel, Switzerland
Dixon, J. K, Department of Biochemistry, Purdue University, West
Lafayette, Indiana 47907, USA
Fahrenkrug, J., Department of Clinical Pathology, Bispebjerg Hospital,
Copenhagen, Denmark
Goodlad, R. A., Cancer Research Campaign Cell Proliferation Unit, De
partment of Histopathology, Royal Postgraduate Medical School,
Hammersmith Hospital, Du Cane Road, London W12 OHS, England
c.,
de Groat, W. Department of Pharmacology and Center for Neuro
science, UniversityofPittsburgh,Pittsburgh,Pennsylvania 15261, USA
Gulbenkian, S., Department of Histochemistry, Royal Postgraduate Med
ical School, Hammersmith Hospital, Du Cane Road, London W12
ONN, England
Haralambidis, J., Howard Florey Institute of Experimental Physiology
and Medicine, University of Melbourne Parkville, Victoria, 3052
Australia
Hassall, C. J. S., Department of Anatomy and Developmental Biology
and Centre for Neuroscience, University College London, Gower
Street, London WCIE 6BT, England
Hill, R. G., Parke-Davis Research Unit, Addenbrookes Hospital Site,
Hills Road, Cambridge CB2 2QB, England
Hokfelt, T., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
Hughes, J., Parke-Davis Research Unit, Addenbrookes Hospital Site,
Hills Road, Cambridge CB2 2QB, England
Jorgensen, J., Department of Clinical Pathology, Bispebjerg Hospital,
Copenhagen, Denmark
Kuwayama, Y., Department of Ophthalmology, Osaka University Medi
cal School, Osaka, Japan
Laties, A. M., Department of Ophthalmology, University of Pennsylvania
School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania,
USA
vii
Lindh, B., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
LleweUyn-Smith, I. J., Department of Anatomy and Histology and
Centre for Neuroscience, School of Medicine, Flinders University,
Bedford Park, S.A. 5042, Australia
McGregor, G. P., Department of Medicine, Royal Postgraduate Medical
School, Hammersmith Hospital, Du Cane Road, London W12 OHS,
England
Meister, B., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
Melander, T., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
MiUhom, D., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
Ottesen, B., Department of Clinical Pathology, Bispebjerg Hospital,
Copenhagen, Denmark
Palacios, J. M., Preclinical Research, Sandoz Ltd, 4002 Basel, Switzer
land
PaUe, C., Department of Clinical Pathology, Bispebjerg Hospital,
Copenhagen, Denmark
Penschow, J. D., Howard Florey Institute of Experimental Physiology
and Medicine, University of Melbourne Parkville, Victoria, 3052 Aus
tralia
Pittam, B. S., Department of Anatomy and Developmental Biology and
Centre for Neuroscience, University College London, Gower Street,
London WCIE 6BT, England
Polak, J. M., Department of Histochemistry, Royal Postgraduate Medi
cal School, Hammersmith Hospital, Du Cane Road, London W12
ONN, England
Rindi, G., Department of Human Pathology, University of Pavia, 27100
Pavia, Italy
Schalling, M., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
Seroogy, K., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
Silini, E., Department of Human Pathology, University of Pavia, 27100
Pavia, Italy
viii
Solcia, E., Department of Human Pathology, University of Pavia, 27100
Pavia, Italy
Stone, R. A., Department of Ophthalmology, University of Pennsylvania
School of Medicine, Scheie Eye Institute, Phi lidel phi a, Pennsylvania,
USA
Su, H.C., Department of Histochemistry, Royal Postgraduate Medical
School, Hammersmith Hospital, Du Cane Road, London W12 OHS,
England
Terenius, L., Department of Pharmacology, Biomedicum, Uppsala Uni
versity, P.O. Box 573, 75123 Uppsala, Sweden
Tregear, G. W., Howard Florey Institute of Experimental Physiology and
Medicine, University of Melbourne Parkville, Victoria, 3052 Australia
Tsuruo Y., Department of Histology, Karolinska Institute, P.O. Box
60400, 10401 Stockholm, Sweden
Usellini, L., Diagnostic Histopathology Center, University of Pavia at
Varese, 21100 Varese, Italy
Uttenthal, L. 0., Department of Medicine, Royal Postgraduate Medical
School, Hammersmith Hospital, Du Cane Road, London W12 OHS,
England
Van Noorden, S., Histochemistry Unit, Histopathology Department,
Royal Postgraduate Medical School, Hammersmith Hospital, Du
Cane Road, London W12 ONN, England
Varndell, I. M., Histochemistry Unit, Histopathology Department,
Royal Postgraduate Medical School, Hammersmith Hospital, Du
Cane Road, London W12 ONN, England
Villani, L., IRCCS Policlinico S. Matteo, 27100 Pavia, Italy
Wharton, J., Department of Histochemistry, Royal Postgraduate Medi
cal School, Hammersmith Hospital, Du Cane Road, London Wl2
ONN, England
Wintour, E. M., Howard Florey Institute of Experimental Physiology
and Medicine, University of Melbourne Parkville, Victoria, 3052 Aus
tralia
Wright, N. A., Cancer Research Campaign Cell Proliferation Unit, De
partment of Histopathology, Royal Postgraduate Medical School,
Hammersmith Hospital, Du Cane Road, London W12 OHS, England
Contents
Abbreviations for peptides used in the following reviews. . . . . . . . .. Xl
J. M. Polak and S. R. Bloom
Introduction ................................................ 1
Techniques
S. Van Noorden and I. M. Varndell
Regulatory peptide immunocytochemistry at light and electron
microscopical levels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 11
J. M. Burrin, L. O. Uttenthal, G. P. McGregor and S. R. Bloom
Aspects of measurement and analysis of regulatory peptides 34
J. D. Penschow, J. Haralambidis, P. E. Darling, I. A. Darby,
E. M. Wintour, G. W. Tregear and J. P. Coghlan
Hybridisation histochemistry ................................. 51
J. M. Palacios and M. M. Dietl
Regulatory peptide receptors: visualization by autoradiography 70
H. C. Su and J. M. Polak
Combined axonal transport tracing and immunocytochemistry
for mapping pathways of peptide-containing nerves in the
peripheral nervous system ................................. 98
C. J. S. Hassall, T. G. J. Allen, B. S. Pittam and G. Burnstock
The use of cell and tissue culture techniques in the study of
regulatory peptides ...................................... 113
P. Davenport, R. G. Hill and J. Hughes
Quantitative analysis of auto radiograms ...................... 137
General aspects
T. Hokfelt, D. Millhorn, K. Seroogy, Y. Tsuruo, S. Ceccatelli,
B. Lindh, B. Meister, T. Melander, M. Schalling, T. Bartfai and
L. Terenius
Coexistence of peptides with classical neurotransmitters ......... 154
x
R. A. Goodlad and N. A. Wright
Peptides and epithelial growth regulation 180
P. C. Andrews, K. Brayton and J. E. Dixon
Post-translational proteolytic processing of precursors to
regulatory peptides ...................................... 192
G. Rindi, E. Solcia and J. M. Polak
Transgenic mouse models and peptide producing endocrine
tumours: morpho-functional aspects ....................... 210
Individual organs
E. So/Cia, L. Usellini, R. Buffa, G. Rindi, L. Villani, A. Aguzzi
and E. Silini
Endocrine cells producing regulatory peptides ................. 220
I. J. Llewellyn-Smith
Neuropeptides and the microcircuitry of the enteric nervous
system ................................................. 247
R. A. Stone, Y. Kuwayama and A. M. Laties
Neuropeptides and the ocular innervation . . . . . . . . . . . . . . . . . . . .. 266
J. Wharton and S. Gulbenkian
Peptides in the mammalian cardiovascular system .............. 292
P. J. Barnes
Regulatory peptides in the respiratory system . . . . . . . . . . . . . . . . .. 317
W. C. de Groat
Neuropeptides in pelvic afferent pathways . . . . . . . . . . . . . . . . . . . .. 334
J. Fahrenkrug, C. Pal/e, J. Jurgensen and B. Ottesen
Regulatory pep tides in the mammalian urogenital system . . . . . . .. 362