Regenerative Medicine Brochure - Harvard Apparatus

48 Pages·2011·3.81 MB·English

your strategic partners in developing
physiologically advanced technologies for
Regenerative
Medicine
from Research
to Clinical
Applications
Treatment, Preparation &
Harvesting
Engineering & Modification
Culturing & Growth
Physiological Assessment &
Condition Monitoring
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Regenerative
Medicine
Electro- Behavioral Harvard Electro- Molecular
physiology Research Apparatus poration Sample
& Pumps & Preparation
CellBiology Electrofusion
Research
Table of Contents
Regenerative Medicine
Introduction................................................................................................................................................................................................2-5
s OverviewofTechnicalDocuments................................................................................................................................................................6-9
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NewProductSummary&Phases................................................................................................................................................................10-11
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t
n TableofContentsforPhases1-4 ................................................................................................................................................................12
o
C Phase1:Preparation&HarvestingOverview
f Introduction ........................................................................................................................................................................................13-14
o
e DrugDelivery/Infusion,NanomiteSyringePump ....................................................................................................................................15
l
b
StemCellCooledInjection,NanoCoolDeliverySystem ............................................................................................................................16
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T
FastBolusInjectionSystem ..................................................................................................................................................................17
PulsatilePerfusion,PulsatileBloodPump ..............................................................................................................................................18
Electrospinning,AdvancedPolymerMixingDeliverySystem......................................................................................................................19
CellCulturePerfusion,PHDULTRA™Push/PullSyringePump ..................................................................................................................20
PressureControlledInjectionPump........................................................................................................................................................21
ComplexMixture/DoseDelivery,PHDULTRA™GradientSystem................................................................................................................22
Accessories:SyringeWarmers ..............................................................................................................................................................23
Accessories:MicrofluidicValves,Circuits,Chips&Tubing ........................................................................................................................24
VentilatorsforAllSpecies......................................................................................................................................................................25
ee
nn Phase2:EngineeringandModificationOverview
cici
didi
ee Introduction ........................................................................................................................................................................................26-27
MM
CellularGeneDeliverySystems..............................................................................................................................................................27
ee
vv
titi •Electroporation,Electrofusion,CellInjectionSystem,Lipsomat-LiposomeProduction........................................................................27
aa
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nn Phase2Examples................................................................................................................................................................................28
ee
gg •MolecularBiology,SamplePreparation........................................................................................................................................28
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RR
oror •Protein-DrugBindingSystems ....................................................................................................................................................28
ff
nsns Phase3:Culturing&GrowthOverview
oo
utiuti Introduction ........................................................................................................................................................................................29
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SS InBreath3DBioreactorforHollowOrgansBronchus,Trachea&BloodVessels ..........................................................................................30-31
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cc LB-2LungBioreactor............................................................................................................................................................................32-33
nn
aa HPC-3,HydrostaticPerfusionChamberforOrganandTissue ..................................................................................................................34
vv
dd
AA CellandTissuePerfusion,Imaging&AssayChambers............................................................................................................................35
||
ss ToxinandChemicalCompoundRemoval,FLOW-ThruDialyzer..................................................................................................................36
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Phase4:PhysiologicalAssessment&ConditionMonitoringOverview
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pp
pp Introduction ........................................................................................................................................................................................37-38
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dd BloodGasandIonMeasurements,pH,CO ,O ,&GlucoseProbes ..........................................................................................................39-40
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vv GuideforAdvancedMetabolicandPhysiologicalEvaluationofOrganisms,Organs,Tissues&CellsusingIRContrastImaging(IR-CI)............41-43
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HH VisibleLightImaging,DigitalMagnificationSystem..................................................................................................................................44
References ................................................................................................................................................................................................45-46
ContactUs..................................................................................................................................................................................................47
Note:ForResearchUseOnly.Notforuseinhumansunlessproperinvestigationaldeviceregulationshavebeenfollowed.
2 phone[phone]•[email protected]•webwww.harvardapparatus.com
Harvard Bioscience companies have partnered
with leading global scientists to provide specialized
solutions for 110 years… and we are doing it again!
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treatmentsinRegenerativeMedicine.Fromoriginsin1901,Harvard Inkeepingwiththistradition,welookforwardtoworkingwithyouto
BioscienceCompanieshaveworkedcloselywithleadingglobal developandsupplythenextgenerationoftoolstosolvethenewchallenges
ofRegenerativeMedicinefromtheresearchlabbenchtothepatient.
Harvard Apparatus Provides Equipment and Expertise
for All Phases of Regenerative Medicine Applications
PHASE 1
PHASE 2
PREPARATION
ENGINEERING H
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Monitoringoforgandevelopment physiologicalconditions.
fortransplantsuitability.
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Harvard Apparatus provides advanced
solutions across the full range of Life Science
& Biomedical Research Techniques Utilized in
Regenerative Medicine
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RESEARCH:
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t -Protein-drugandprotein-proteinaffinityassays
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-Ionchannelandion transportassays,cellularelectrophysiology
-Automatedanimalfeedingstations
-Aminoacidanalysis
ORGAN FUNCTION MODELING
-Vitalsign,BloodGasandBiopotentialMonitoringandAnalysis
-Ex-vivoPhysiologyWorkstations
MOLECULAR SAMPLE PREPARATION
-DesaltingsamplesforMassSpectroscopyanalysisofcellsignalingmolecules
-Isolationofnucleicacidfrom nuclearmembranes
-TraceenrichcellmetabolicwasteproductsforIDandeventualremoval
CELL ENGINEERING AND GENETIC MODIFICATION
-Electroporation
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M
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s REGENERATIVE MEDICINE AND TISSUE ENGINEERING
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p -OrganDecellularizationandMatrix/ScaffoldRecellularization
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-CellTherapyInjector,NanoCool
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CLINICAL:
-3DHollowOrganBioreactor,InBreath
4 phone[phone]•[email protected]•webwww.harvardapparatus.com
Advanced Solutions for Regenerative Medicine & Tissue Engineering & Cell Therapy
Phase 1 Phase 2 Phase 3 Phase 4 Phase 5
Harvard
PREPARATION & ENGINEERING & CULTURING & CONDITION
Bioscience WEBSITE
HARVESTING MODIFICATIONS GROWTH MONITORING
Companies
•LiveImaging
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•Identification •FastBolusInjections •BloodGas n
Products •CellDeliverySystems •3DBioreactors Measurements web: tr
Harvard •Ventilators •Iontophoresis •Toxin&Chemical •MetabolicMonitoring www.harvardapparatus.com o
Apparatus •Anesthesia •LiposomePrep Removal •DataAquisition phone: d
•SurgicalTools •DrugDeliverySystems •PerfusionSystems andAnalysis [phone] u
•InfusionPumps •CapillaryGlass •Feedback& c
ControlSyringes t
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•SpinnerFlasks •TransfectionReagents
•SpinnerFlasks •ProteinMeasurements
•Centrifuge •LigationKits web:
•Centrifuges •ssDNA
Denville •PipettingSystems •Standards www.denvillescientific.com
•PipettingSystems •RNA
Scientific •Incubators •VisualizationKits phone:
•Incubators •Phosphorus
•Shakers •DNAPolymerase [phone]
•Shakers •EnzymeKinetics
•Sterilizers •PCR
•Electrophysiology
web:
HugoSachs •Ventilators •IsolatedOrganBaths •Cardiopulmonary www.hugo-sachs.de/
•OperatingTables •TissueBaths Mechanics
Elektronik phone:
•VitalSignalMonitors •3DBioreactors •DataAquisition
07665-9200-0
andAnalysis
•Molecular
Spectroscopy
•ProteinAnalysis
web:
•dsDNA •Molecular •Molecular
www.biochrom.co.uk/
Biochrom •Oligonucleotide Spectroscopy Spectroscopy H
Primers •MediaMonitoring •AminoAcidAnalyzers phone: a
[phone] r
•DNAMelts v
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Warner •pHMonitoring •ImagingChambers web: |
Instruments •CellImaging ••SPpeirllfuSseionnsoCrshambers •IonChannel wphwown.wea:rneronline.com Ad
Monitoring [phone] v
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Chemicals R
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BTX •Electrofusion www.btxonline.com ive
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•BehavioralApparatus:
phone:
Panlab/ -Mazes 34934750697
-RotaRods
Coulbourn web:
-Treadmills
www.coulbourn.com
-ActivityMonitors
phone:
[phone]
phone[phone]•[email protected]•webwww.harvardapparatus.com 5
Our Harvard
catalogs,
Ask about our
technical guides, application
We have Solutions for
notes and bibliographies
HarvardApparatushasthelargestglobalsupportnetworkofexperts,andbroadestrangeof
specializedproductstoassistyouinfindingthebestsolutionsforyourexperimentalresearch.
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PHYSIOLOGY BEHAVIORAL
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Amplifiers,imaging, electroporation andelectrofusion of Electroporation andMechanical
micromanipulation andperfusionfor mammalian,bacterial,yeast,fungi, Injectors.
theelectrophysiologicaland insectandplantcellsandtissues.
neurologicalsciences.
66 phone[phone]•[email protected]•webwww.harvardapparatus.com
Apparatus Family:
all Regenerative Medicine Research Applications
[e-mail]to
requestacatalogorTechnicalApplicationGuide.
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Specialized Tools for Model Organisms and Ex-Vivo Physiology c
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Systems, like the IH-SR for Isolated Heart Perfusion n
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MODEL ORGANISMS ISOLATED HEART
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includingDrosophila,Nematodes,XenopusandZebrafish. systemforsmallrodentheart,theIH-SR. ra
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Specialized Guides for Bioresearch d
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presentsthelargestcollection of TOOLS Workstation asafoundation fordrug in
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UssingSystemsavailable. Detailedguideforarangeoftoolsfor screeningaswellasion channel
cellbasedelectrophysiology assays. structureandfunction.
phone[phone]•[email protected]•webwww.harvardapparatus.com 77
Our Harvard
catalogs,
Ask about our
technical guides, application
We have Solutions for
notes and bibliographies
HarvardApparatushasthelargestglobalsupportnetworkofexperts,andbroadestrangeof
specializedproductstoassistyouinfindingthebestsolutionsforyourexperimentalresearch.
s
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Advanced Organ, Tissue and Cellular Engineering and Therapy Tools
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for Regenerative Medicine
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REGENERATIVE MEDICINE
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CellSuspensionsforInjection,Electrospinning.
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88 phone[phone]•[email protected]•webwww.harvardapparatus.com
Apparatus Family:
all Regenerative Medicine Research Applications
[e-mail]to
requestacatalogorTechnicalApplicationGuide.
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Molecular Biology and Assays, Sample Preparation c
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BTX: The In Vivo and In Vitro Experts in Electroporation and Electrofusion
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NEW
Systems for Regenerative
and Tissue Engineering
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Our newly developed systems are guided by break-
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scientists and surgeons to ensure performance,
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u Stem Cell Cooled Injection with high viability,
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Developedinthefield,specificallytoinject1ulto100ulofstemcellsintolive
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tissuewhilemaintainingcellviabilityinanaccurateandeasy-to-usesystem.
TheNanoCoolcools,cellsto18degreesinthesyringeduringinjections.
Fast Bolus Injection System for rapid, controlled fluid delivery (p. 17)
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n Nowasystemtodeliverpressure-controlledfluidinjection tointactorgansand
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di tissues.Thesystemdeliversrapidinjectionswhilesimultaneouslymonitoring
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transplantation ofbronchus.Producedinconjunction withPolitecnicoDiMilano
andUniversityofBarcelona,theInBreathbioreactorisideallysuitedto
regeneration oftubularhollow organssuchastrachea/bronchus,bloodvessels,
esophagusandintestines.
1100 phone[phone]•[email protected]•webwww.harvardapparatus.com