Regenerative Medicine and Cell Therapy

321 Pages·2013·3.19 MB·English

by  Ilyas Singec (auth.)

Stem Cell Biology and Regenerative Medicine
Series Editor
Kursad Turksen
For furthervolumes:
http://www.springer.com/series/7896
Hossein Baharvand Nasser Aghdami
•
Editors
Regenerative Medicine and
Cell Therapy
Editors
Hossein Baharvand Nasser Aghdami
Cell and DevelopmentalBiology RoyanCell TherapyCenter
Cell Science Research Center Cell Science Research Center
RoyanInstitutefor StemCell Biology RoyanInstitutefor StemCell Biology
and Technology and Technology
ACECR,Tehran ACECR,Tehran
Iran Iran
and and
Department of Developmental Biology Department of Regenerative Medicine
Universityof Science andCulture Cell Science Research Center
ACECR,Tehran RoyanInstitutefor StemCell Biology
Iran and Technology
ACECR,Tehran
Iran
ISBN 978-1-62703-097-7 ISBN 978-1-62703-098-4 (eBook)
DOI 10.1007/978-1-62703-098-4
SpringerNewYorkHeidelbergDordrechtLondon
LibraryofCongressControlNumber:2012943371
(cid:2)SpringerScience+BusinessMediaNewYork2013
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To the memory of Dr. Saeid Kazemi Ashtiani,
a wonderful colleague, a great stem cell
biologist, and an inspirational advocate
for stem cell research in Iran.
To our professors, teachers, students, and
families.
Preface
There are numerous promising researches that show that science and medicine of
the future will likely be based upon regenerative medicine and cellular therapies.
Regenerative medicine is devoted to the replacement of diseased cells, tissues, or
organs in congenital or acquired disease, or the repair of tissues in vivo by aug-
mentation of natural or induction of latent regenerative processes. This new
interdisciplinary field of research and clinical therapies that focus on stem cells
andregenerative biology isjustbeginning atthe dawn ofthetwenty-first century.
In our previous book, Advances in Stem Cell Research (2012, Springer), we have
addressed and discussed current advances and topics pertaining to stem cells,
covering topics such as stem cell nano-engineering, pluripotent stem cells, and
cellular reprogramming. In this book, Regenerative Medicine and Cell Therapy,
weaimtoexplainclinicalapplicationsandexperiencesofstemcelltherapy,taking
into consideration neurological, ocular surface, skin, cardiac, musculoskeletal,
liver and gastrointestinal diseases, and diabetes, in addition to germline and cord
bloodstemcells.Thecontributionstothisbook,allwrittenbyrenownedexpertsin
their respective disciplines, describe and explore various facets of regenerative
medicine and cell therapy. This book will be an especially valuable resource for
biomedical researchers and clinicians.
Wewanttosincerelythankalltheauthorswhohavecontributedtothisvolume
for their devoted efforts and their excellent contributions. We hope that you, as a
reader, will enjoy this book. We are also grateful to Drs. Hamid Gourabi, Abdol-
hosseinShahverdi,andAhmadVosoughDizajforhavingfaithinandsupportingus
throughoutthisproject.Wealsowishtoacknowledgethegreatsupportprovidedby
many at Humana Press. A special thank you goes to our dedicated colleagues at
Royan Institute for Stem Cell Biology and Technology who, with their tireless
commitment for stem cell research and therapy, have become crucial factors in
encouragingustoeditthisRegenerativeMedicineandCellTherapy.Wearegrateful
toZahraMaghariforherassistancewithcollectingthechaptersandinfollow-up.
Hossein Baharvand
Nasser Aghdami
vii
Contents
1 Cell Therapy for Neurodegenerative Disorders . . . . . . . . . . . . . . 1
Ilyas Singec
2 New Prospects for Neural Stem Cell Therapies of Nervous
System Diseases Toward the Establishment
of Atypical Ectopic Perivascular Stem Cell Niches. . . . . . . . . . . . 23
Clara Alfaro-Cervello, Chiara Cossetti, Elena Giusto,
Matteo Donegà and Stefano Pluchino
3 Cultured Limbal Epithelial Stem Cell Therapy
for Ocular Surface Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Hannah J. Levis, Julie T. Daniels and Sajjad Ahmad
4 Keratinocyte Stem Cells: Biology and Clinical Applications. . . . . 57
Carlo Pincelli and Alessandra Marconi
5 Cardiac Regeneration with Stem Cells . . . . . . . . . . . . . . . . . . . . 65
Beatriz Pelacho, Manuel Mazo, Sheyla Montori,
Ana Maria Simon-Yarza, Juan Jose Gavira,
Maria J. Blanco-Prieto and Felipe Prósper
6 Development of Biological Approaches to Improve
Muscle Healing After Injury and Disease . . . . . . . . . . . . . . . . . . 113
Jonathan D. Proto and Johnny Huard
7 Mesenchymal Stem Cells in Bone and Cartilage Regeneration . . . 131
Mohamadreza Baghaban Eslaminejad, Elham Zomorodian
and Fatemeh Bagheri
ix
x Contents
8 Pancreatic Reprogramming . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155
Juan Domínguez-Bendala
9 Pancreatic Regeneration in the Face of Diabetes . . . . . . . . . . . . . 169
Zeeshan Ahmad
10 Regenerative Therapies for Liver Diseases . . . . . . . . . . . . . . . . . 203
Amar Deep Sharma, Ina Rittelmeyer, Tobias Cantz and Michael Ott
11 Clinical Studies of Cell Therapy for Liver Cirrhosis . . . . . . . . . . 233
James A. Thomas and Stuart J. Forbes
12 Stem Cell Applications for the Treatment of Gastrointestinal
System Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Jacobo Trebol Lopez, Tihomir Georgiev-Hristov,
Mariano García-Arranz and Damián García-Olmo
13 Germ Line Stem Cells: A Promising Alternative Source
for Stem-Cell-Based Therapies in Regenerative Medicine. . . . . . . 279
Ellen Goossens and Herman Tournaye
14 Cord Blood Stem Cells and Regenerative Medicine . . . . . . . . . . . 301
David T. Harris
About the Editors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315
Contributors
Sajjad Ahmad Department of Ophthalmology, Royal Victoria Infirmary, Clare-
mont Wing, Newcastle Upon Tyne, UK
Zeeshan Ahmad Department of Molecular Cell Biology, Max-Planck Institute
for Biophysical Chemistry, Göttingen, Germany
ClaraAlfaro-Cervello DepartmentofClinicalNeurosciences,CambridgeCentre
for Brain Repair and Stem Cell Initiative, University of Cambridge, Cambridge,
UK
Mohamadreza Baghaban Eslaminejad Department of Stem Cell and Devel-
opmental Biology, Cell Science Research Center, Royan Institute for Stem Cell
Biology and Technology, ACECR, Tehran, Iran
Fatemeh Bagheri Department of Stem Cell and Developmental Biology, Cell
Science Research Center,RoyanInstitutefor StemCellBiologyandTechnology,
ACECR, Tehran, Iran
Maria J. Blanco-Prieto Pharmacy and Pharmaceutical Technology Department,
School of Pharmacy, University of Navarra, Pamplona, Spain
Tobias Cantz Junior Research Group ‘‘Stem Cell Biology’’, Cluster of Excel-
lence REBIRTH Hannover Medical School, Hannover, Germany
Chiara Cossetti Department of Clinical Neurosciences, Cambridge Centre for
Brain Repair and Stem Cell Initiative, University of Cambridge, Cambridge, UK
Julie T. Daniels Moorfields Eye Hospital Cells for Sight Stem Cell Research -
Unit, Department of Ocular Biology and Therapeutics, UCL Institute of Oph-
thalmology, London, UK
Juan Domínguez-Bendala Diabetes Research Institute, University of Miami,
Miami, FL, USA
xi
xii Contributors
Matteo Donegà Department of Clinical Neurosciences, Cambridge Centre for
Brain Repair and Stem Cell Initiative, University of Cambridge, Cambridge, UK
Ellen Goossens Biology of the Testis (BITE), Vrije Universiteit Brussel, Brus-
sels, Belgium
Stuart J. Forbes MRC Centre for Inflammation Research/MRC Centre for
Regenerative Medicine, University of Edinburgh, Edinburgh, UK; Scottish Liver
Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, UK
Mariano García-Arranz Surgery Department, Cell Therapy Laboratory, Inves-
tigation Institute IdiPAZ, Autonomous University from Madrid, Madrid, Spain
DamiánGarcía-Olmo ColoproctologyUnit,GeneralandDigestiveTractSurgery
Department, University Hospital ‘‘La Paz’’, Madrid, Spain; Surgery Department,
Cell Therapy Laboratory, Investigation Institute IdiPAZ, Autonomous University
from Madrid, Madrid,Spain
Juan Jose Gavira Service and Area of Cell Therapy, Clínica Universidad de
Navarra, Foundation for Applied Medical Research, University of Navarra,
Pamplona, Spain
Tihomir Georgiev-Hristov General and Digestive Tract Surgery Department,
University Hospital ‘‘La Paz’’, Madrid, Spain; Surgery Department, Cell Therapy
Laboratory, Investigation Institute IdiPAZ, Autonomous University from Madrid,
Madrid, Spain
ElenaGiusto DepartmentofClinicalNeurosciences,CambridgeCentreforBrain
Repair and Stem Cell Initiative, University of Cambridge, Cambridge, UK
DavidT.Harris DepartmentofImmunobiology,UniversityofArizona,Tucson,
AZ, USA; Cord Blood Registry Inc., San Bruno, CA, USA
Herman Tournaye Centre for Reproductive Medicine, UZ Brussel, Brussels,
Belgium
JohnnyHuard DepartmentofOrthopaedic Surgery,StemCellResearch Center,
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
HannahJ.Levis DepartmentofOcularBiologyandTherapeutics,UCLInstitute
of Ophthalmology, London, UK
AlessandraMarconi DepartmentofMedicine,LaboratoryofCutaneousBiology,
EmergencyMedicineandMedicalSpecialties,InstituteofDermatology, University
ofModenaandReggioEmilia,Modena,Italy
Manuel Mazo Hematology and Cardiology Service and Area of Cell Therapy,
Clínica Universidad de Navarra, Foundation for Applied Medical Research,
University of Navarra, Pamplona, Spain
Contributors xiii
Sheyla Montori Hematology and Cardiology Service and Area of Cell Therapy,
Clínica Universidad de Navarra, Foundation for Applied Medical Research,
University of Navarra, Pamplona, Spain
Michael Ott Department of Gastroenterology Hepatology and Endocrinology,
Hannover Medical School, Hannover, Germany; TWINCORE, Centre for
Experimental and Clinical Infection Research, A joint venture between the Han-
nover Medical School (MHH) and the Helmholtz Centre for Infection Research
(HZI), Hannover, Germany
Beatriz Pelacho Hematology and Cardiology Service and Area of Cell Therapy,
Clínica Universidad de Navarra, Foundation for Applied Medical Research,
University of Navarra, Pamplona, Spain
Carlo Pincelli Department of Medicine, Laboratory of Cutaneous Biology,
EmergencyMedicineandMedicalSpecialties,InstituteofDermatology, University
ofModenaandReggioEmilia,Modena,Italy
Stefano Pluchino Department of Clinical Neurosciences, Cambridge Centre for
Brain Repair and Stem Cell Initiative, University of Cambridge, Cambridge, UK
Felipe Prósper Hematology and Cardiology Service and Area of Cell Therapy,
Clínica Universidad de Navarra, Foundation for Applied Medical Research,
University of Navarra, Pamplona, Spain
Jonathan D. Proto Department of Orthopaedic Surgery, Stem Cell Research
Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Ina Rittelmeyer Department of Gastroenterology Hepatology and Endocrinol-
ogy, Hannover Medical School, Hannover, Germany; TWINCORE, Centre for
Experimental and Clinical Infection Research, A joint venture between the Han-
nover Medical School (MHH) and the Helmholtz Centre for Infection Research
(HZI), Hannover, Germany
Amar Deep Sharma Junior Research Group ‘‘Stem Cell Biology’’, Cluster of
Excellence REBIRTH Hannover Medical School, Hannover, Germany
Ana MariaSimón-Yarza Hematology andCardiologyService andArea ofCell
Therapy, Clínica Universidad de Navarra, Foundation for Applied Medical
Research, University of Navarra, Pamplona, Spain
Ilyas Singec Sanford-Burnham Medical Research Institute, La Jolla, CA, USA
James A. Thomas MRC Centre for Inflammation Research/MRC Centre for
Regenerative Medicine, University of Edinburgh, Edinburgh, UK; Scottish Liver
Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, UK