Recurrent Implantation Failure PDF
Preview Recurrent Implantation Failure
Recurrent Implantation Failure Etiologies and Clinical Management Jason M. Franasiak Richard T. Scott Jr. Editors 123 Recurrent Implantation Failure Jason M. Franasiak • Richard T. Scott Jr. Editors Recurrent Implantation Failure Etiologies and Clinical Management Editors Jason M. Franasiak Richard T. Scott Jr. Reproductive Medicine Associates of NJ Reproductive Medicine Associates of NJ Thomas Jefferson University Thomas Jefferson University Basking Ridge, NJ Basking Ridge, NJ USA USA ISBN 978-3-319-71966-5 ISBN 978-3-319-71967-2 (eBook) https://doi.org/10.1007/978-3-319-71967-2 Library of Congress Control Number: 2018930026 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland To my wife, Kaitlin, who is my constant. Without your love and support, this book would not have been possible. Jason M. Franasiak Preface We are fortunate to practice reproductive medicine during a time of unprecedented success when it comes to assisted reproductive technology. With the advent of com- prehensive chromosomal screening, the contribution of aneuploidy to implantation failure has been all but eliminated. Still, though, euploid embryos fail to implant. Why is that? The dwindling rate of implantation failure makes the remaining cases a particular challenge for both practitioners and their patients. The very workup for recurrent implantation failure, let alone available treatment options, often remains elusive. This text is unique in its multifaceted approach to thinking about these challeng- ing cases. It starts with a foundational look at the signaling between the embryo and endometrium, which leads to the management of embryo and endometrial syn- chrony. The pathologic nature of implantation failure is then explored with an eye toward the gamete and embryo to the maternal anatomy, immune, and hematologic system. The neuroendocrine system is considered as well as the psychological impact recurrent implantation failure has on patients. Novel theories such as the female reproductive tract microbiome are also discussed. The text is designed for clinicians and researchers in the field of reproductive endocrinology and infertility patients as a guide not only for clinical care but also for encouraging much needed research in the area. We live in an exciting time in reproductive medicine. With ever improving technology that is becoming both widely available and cost-effective, there are more tools than ever at our fingertips to address the most challenging problems that confront our patients. It is incumbent upon practitioners and researchers alike to understand the capabilities and impact of various treatments, both proven and experimental, for implantation failure. We hope this book offers some answers as well as raises unaddressed questions as we strive to better our patient care. Basking Ridge, NJ, USA Jason M. Franasiak, MD, HCLD Basking Ridge, NJ, USA Richard T. Scott Jr., MD, HCLD vii Contents 1 Signaling Between Embryo and Endometrium: Normal Implantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Chelsea Fox and Bruce A. Lessey 2 Embryo and Endometrial Synchrony in Implantation Failure . . . . . 21 Jason M. Franasiak and Richard T. Scott 3 Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure? . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Sorena Keihani, Jeremy B. Myers, and James M. Hotaling 4 Embryonic Factors Associated with Recurrent Implantation Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Daniel J. Kaser and Catherine Racowsky 5 The Genetics of Pregnancy Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 Eric J. Forman, Nathan Treff, and Rebekah S. Zimmerman 6 Immune Factors in Recurrent Implantation Failure . . . . . . . . . . . . . . 93 Diana Alecsandru and Juan A. Garcia-Velasco 7 Stress and Implantation Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 Jeffrey L. Deaton, Bonnie Patel, Erika Johnston-MacAnanny, Jie Yu, Shannon D. Whirledge, Alexandra Wilson, J. David Wininger, Yimin Shu, Robert N. Taylor, and Sarah L. Berga 8 Hematologic Disease in Implantation Failure . . . . . . . . . . . . . . . . . . . 125 Shelby A. Neal, Jason M. Franasiak, and Richard T. Scott 9 Endocrine Causes of Implantation Failure . . . . . . . . . . . . . . . . . . . . . . 135 Scott Morin, Baris Ata, and Emre Seli ix x Contents 10 Anatomic Abnormalities and Recurrent Implantation Failure . . . . . 153 Jeffrey M. Goldberg, Julian Gingold, and Natalia Llarena 11 Microbiome in Embryonic Implantation and Implantation Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175 Jason M. Franasiak, Inmaculada Moreno, and Carlos Simon 12 Psychosocial Implications of Recurrent Implantation Failure . . . . . . 197 Andrea Mechanick Braverman and Keren Sofer Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 Contributors Diana Alecsandru, MD, PhD Rey Juan Carlos University, IVI RMA-Madrid, Madrid, Spain Baris Ata, MD Department of Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkey Sarah L. Berga, MD Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, USA Andrea Mechanick Braverman, PhD Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA J. David Wininger, PhD Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, USA Jeffrey L. Deaton, MD Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, USA Eric J. Forman, MD, HCLD Reproductive Endocrinology and Infertility, Columbia University, New York, NY, USA Chelsea Fox, MD Department of Obstetrics and Gynecology, Greenville Health System, Greenville, SC, USA Jason M. Franasiak, MD, HCLD Sidney Kimmel Medical College, Thomas Jefferson University Philadelphia, PA, USA IVI-RMA of New Jersey, Basking Ridge, NJ, USA Juan A. Garcia-Velasco, MD, PhD Rey Juan Carlos University, IVI RMA- Madrid, Madrid, Spain Julian Gingold, MD Department of Gynecology and Obstetrics, Cleveland Clinic, Cleveland, OH, USA xi xii Contributors Jeffrey M. Goldberg, MD Department of Gynecology and Obstetrics, Cleveland Clinic, Cleveland, OH, USA James M. Hotaling, MD, MS, FECSM Center for Reconstructive Urology and Men’s Health, Division of Urology, University of Utah, Salt Lake City, UT, USA Erika Johnston-MacAnanny, MD Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, USA Daniel J. Kaser, MD Sidney Kimmel Medical College, Thomas Jefferson University Philadelphia, PA, USA IVI-RMA of New Jersey, Basking Ridge, NJ, USA Sorena Keihani, MD Center for Reconstructive Urology and Men’s Health, Division of Urology, University of Utah, Salt Lake City, UT, USA Bruce A. Lessey, MD, PhD Department of Obstetrics and Gynecology, Greenville Health System, Greenville, SC, USA Natalia Llarena, MD Department of Gynecology and Obstetrics, Cleveland Clinic, Cleveland, OH, USA Inmaculada Moreno, PhD Research Department, Igenomix, Valencia, Spain Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA Scott Morin, MD Sidney Kimmel Medical College, Thomas Jefferson University Philadelphia, Philadelphia, PA, USA IVI-RMA of New Jersey, Basking Ridge, NJ, USA Jeremy B. Myers, MD, FACS Center for Reconstructive Urology and Men’s Health, Division of Urology, University of Utah, Salt Lake City, UT, USA Shelby A. Neal, MD Sidney Kimmel Medical College, Thomas Jefferson University Philadelphia, PA, USA IVI-RMA of New Jersey, Basking Ridge, NJ, USA Bonnie Patel, MD Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, USA Catherine Racowsky, PhD, HCLD Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Richard T. Scott, MD, HCLD Sidney Kimmel Medical College, Thomas Jefferson University Philadelphia, PA, USA IVI-RMA of New Jersey, Basking Ridge, NJ, USA
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