Recombinant Microbes for Industrial and Agricultural Applications PDF
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RECOMBINANT MICROBES FOR INDUSTRIAL AND AGRICULTURAL APPLICATIONS BIOPROCESS TECHNOLOGY Series Editor W. Courtney McGregor Xoma Corporation Berkeley, California 1. Membrane Separations in Biotechnology, edited by W. Courtney McGregor 2. Commercial Production of Monoclonal Antibodies: A Guide for Scale-Up, edited by Saiiy S. Seaver 3. Handbook on Anaerobic Fermentations, edited by Larry E. Erickson and Daniel Yee-Chak Fung 4. Fermentation Process Development of Industrial Organisms, edited by Justin O. Neway 5. Yeast: Biotechnology and Biocatalysis, edited by Hubert Verachtert and Ren6 De Mot 6. Sensors in Bioprocess Control, edited by John V. Twork and Alexander M. Yacynych 7. Fundamentals of Protein Biotechnology, edited by Stanley Stein 8. Yeast Strain Selection, edited by Chandra J. Panchal 9. Separation Processes in Biotechnology, edited by Juan A. Asenjo 10. Large-Scale Mammalian Cell Culture Technology, edited by Anthony S. Lubiniecki 11. Extractive Byconversions, edited by Bo Mattiasson and Olle Hoist 12. Purification and Analysis of Recombinant Proteins, edited by Ramnath Seetharam and Satish K. Sharma 13. Drug Biotechnology Regulation: Scientific Basis and Practices, edited by Yuan- yuan H. Chiu and John L Gueriguian 14. Protein Immobilization: Fundamentals and Applications, edited by Richard F. Taylor 15. Biosensor Principles and Applications, edited by Loi'c J. Blum and Pierre R. Coulet 16. Industrial Application of Immobilized Biocatalysts, edited by Atsuo Tanaka, Tetsuya Tosa, and Takeshi Kobayashi 17. Insect Cell Culture Engineering, edited by Mattheus F. A. Goosen, Andrew J. Daugulis, and Peter Faulkner 18. Protein Purification Process Engineering, edited by Roger G. Harrison 19. Recombinant Microbes for Industrial and Agricultural Applications, edited by Yoshikatsu Murooka and Tadayuki Imanaka ADDITIONAL VOLUMES IN PREPARATION RECOMBINANT MICROBES FOR INDUSTRIAL AND AGRICULTURAL APPLICATIONS edited by Yoshikatsu Murooka Hiroshima University, Higashi-Hiroshima, Japan Tadayuki Imanaka Osaka University, Osaka, Japan Marcel Dekker, Inc. New York* Basel •Hong Kong Library of Congress Cataloging-in-Publication Data Recombinant microbes for industrial and agricultural applications / edited by Yoshikatsu Murooka, Tadayuki Imanaka. p. cm. — (Bioprocess technology ; 19) ISBN 0-8247-9141-X 1. Microbial biotechnology. 2. Recombinant microorganisms. I. Murooka, Yoshikatsu. II. Imanaka, Tadayuki. III. Series: Bioprocess technology ; v. 19. TP248.27.M53R43 1994 660\62-dc20 93-38282 CIP The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the address below. This book is printed on acid-free paper. Copyright © 1994 by MARCEL DEKKER, INC. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. MARCEL DEKKER, INC. 270 Madison Avenue, New York, New York 10016 Current printing (last digit): 10 9 8 7 6 5 4 3 21 PRINTED IN THE UNITED STATES OF AMERICA Series Introduction Bioprocess technology encompasses all of the basic and applied sciences as well as the engineering required to fully exploit living systems and bring their products to the marketplace. The technology that develops is eventually expressed in various methodologies and types of equipment and instruments built up along a bioprocess stream. Typically in commercial production, the stream begins at the bioreactor, which can be a classical fermentor, a cell culture perfusion system, or an enzyme bioreactor. Then comes separation of the product from the living systems and/or their components followed by an appropriate number of purification steps. The stream ends with bioproduct finishing, formulation, and packaging. A given bioprocess stream may have some tributaries or outlets and may be overlaid with a variety of monitoring devices and control systems. As with any stream, it will both shape and be shaped with time. Documenting the evolutionary shaping of bioprocess technology is the purpose of this series. Now that several products from recombinant DNA and cell fusion techniques are on the market, the new era of bioprocess technology is well established and validated. Books of this series represent developments in various segments of bioprocessing that have paralleled progress in the life sciences. For obvious proprietary reasons, some developments in industry, although validated, may be published only later, if at all. Therefore, our continuing series will follow the growth of this field as it is available from both academia and industry. W. Courtney McGregor Hi Preface The dramatic increase in the number of new journals and books that focus on aspects of biotechnology reflects the extensive developments in this field and the continued growth in stature and maturity of bioindustries. However, a gap seems to be developing between laboratory observations and industrial practices. To help bridge this gap, this book presents an overview of biotechnology's use of recombinant microorganisms, combining within a single volume detailed fundamental information about recombinant microorganisms and their application to both industry and agriculture. Because of the language barriers, nonnative English speakers, for the most part, have been hesitant to contribute their scientific and technical knowledge to international publications. However, in spite of my pessimistic expectations, most of the scientists who were asked to contribute to this book accepted my invitation with pleasure, irrespective of their native tongues. Their support encouraged me to edit the book, and I am convinced that the contents are a timely and welcome contribution, even though there are already many books that deal with genetic engineering in bacteria, plants, and animal cells. I am particularly proud of the contributors who are nonnative English speakers who have overcome this potential handicap and provided expert reviews of their respective fields as well as summaries of original research. Additional excellent reviews provided by authorities from Europe and the United States add further luster to this text. The overriding aim of this book is to combine in a single text detailed information on pharmacologically active agents and health care; enzyme production; the processing of foods and beverages; the application of biotechnology in agriculture; biofuels and chemicals; waste treatment; and regulation and safety. It provides a reference source for graduate students taking courses in biotechnology, microbiology, genetics and molecular biology, and also for industrial, pharmacological, and agrochemical specialists who seek further information on practical ex- amples. Research using recombinant microorganisms advances with each passing day. However, I am sure this book, because of its wide scope, will still be useful a decade from now. Thanks are due to Mr. Russell Dekker for his invitation to produce this book and for his encouragement and also to Mr. Simon J. Yates and Ms. Deirdre Griese at Marcel Dekker, Inc., for coordinating the entire effort. Yoshikatsu Murooka V Contents Series Introduction Hi Preface v Contributors xi 1. Introduction: Exploitation of Conventional and Industrial Microorganisms 1 Yoshikatsu Murooka 2. Regulation and Safety of Recombinant Microorganisms 15 Fusao Tomita 3. Contributions of Recombinant Microbes and Their Potential 27 Arnold L. Demain, Akira Kimura, and Atsuhiko Shinmyo I. Pharmacologically Active Agents and Health Care 4. Overproduction of Heterologous Proteins in Escherichia coli 49 Hisashi Yasueda and Hiroshi Matsui 5. Extremely Efficient Protein Secretion System in Bacillus brevis 71 Shigezo Udaka and Hideo Yamagata 6. Secretory Production of Homologous and Heterologous Proteins by Recombinant Streptomyces: What Has Been Accomplished? 81 Istvdn Molndr 7. Antibiotics Produced by Streptomyces Host-Vector Systems 105 Masanori Sugiyama 8. /3-Lactam Antibiotics Produced by Genetically Engineered Filamentous Fungi 119 T. Vichitsoonthonkul, Y, W. Chu, H. S. Sodhi, and G. Saunders 9. Heterologous Protein Production by Yeast Host-Vector Systems 137 Satoshi Harashima 10. Glutathione and Its Derivatives: Produced by Recombinant Escherichia coli and Saccharomyces cerevisiae 159 Kousaku Murata 11. Recombinant Microbial ADP-Ribosylating Toxins of Bordetella pertussis, Vibiro cholerae, and Enterotoxigenic Escherichia coli: Structure, Function, and Toxoid Vaccine Development 185 W. Neal Burnette, Witold Cieplak, Jr., Harvey R. Kaslow, Rino Rappuoli, and Elaine /. Tuomanen vil
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