Recent Advances in Synthesis and Chemical Biology XI Symposium PDF
Preview Recent Advances in Synthesis and Chemical Biology XI Symposium
Recent Advances in Synthesis and Chemical Biology XI Symposium 14th December 2012 ’ O Flanagan Lecture Theatre Royal College of Surgeons in Ireland ’ 123 St. Stephen s Green Dublin 2 ‘Recent Advances in Synthesis and Chemical Biology XI’ 14th December 2012 The Centre for Synthesis and Chemical Biology wishes to thank the following sponsors for their support for this symposium: Centre for Synthesis & Chemical Biology “Recent Advances in Synthesis and Chemical Biology XI” Friday, 14th December, 2012 Royal College of Surgeons in Ireland (RCSI), 123 St Stephens Green, Dublin 2 PROGRAMME 08.50am‐9.00am Opening session Introduction by Professor Kevin B. Nolan, RCSI Welcome by Professor Patrick J. Broe, President, RCSI 9.00am‐09.45am Chairperson: Dr Celine Marmion, RCSI Professor Nick Farrell, Virginia Commonwealth University, USA ‘How Does Platinum Enter Cells? A Role for Heparan Sulfate Proteoglycan (HSPG) mediation’ 09.45am‐10.30am ELI LILLY LECTURE Chairperson: Professor Stefan Oscarson, UCD Professor Ben G. Davis, University of Oxford, UK ‘Sugars & Proteins’ 10.30am‐11.00am Coffee/Tea Break 11.00am‐11.45am WATERS LECTURE Chairperson: Professor Stephen Connon, TCD Professor Jeffrey Bode, ETH‐Zürich, Switzerland ‘Chemical Protein Synthesis with the KAHA Ligation’ 11.45am‐12.30pm Chairperson: Dr Marc Devocelle, RCSI Professor Jonathan Clayden, University of Manchester, UK 'Conformational Communication' 12.30pm‐13.45pm Lunch Break 13.45pm‐14.30pm INSTITUT DE RECHERCHES SERVIER LECTURE Chairperson: Professor Isabel Rozas, TCD Dr Sophie Jackson, University of Cambridge, UK ‘A Tangled Problem: The Structure, Function and Folding of Knotted Proteins’ 14.30pm‐16.00pm Poster Session. Coffee/Tea Break 16.00pm‐16.45pm GLAXOSMITHKLINE LECTURE Chairperson: Professor Pat Guiry, UCD Professor Wilfred A. van der Donk, University of Illinois at Urbana‐Champaign, USA ‘Posttranslational modifications in natural product biosynthesis’ 16.45pm‐17.00pm Closing Remarks Professor Pat Guiry, Director, Centre for Synthesis and Chemical Biology 17.00pm‐18.00pm Wine Reception Investing in your future Invited Speakers: Profiles Professor Nicholas Farrell, Virginia Commonwealth University, USA Dr. Nicholas P. Farrell is a graduate of University College Dublin. He obtained his PhD from Sussex University and completed postdoctoral fellowships at Simon Fraser University and The University of British Columbia. He is currently Professor of Chemistry at Virginia Commonwealth University (VCU). His research interests are in the broad area of bioinorganic chemistry. Specifically his interest is in the medicinal uses of inorganic compounds and his work has included development of antiviral and antiparasitic drugs. His major research is on platinum-based anticancer agents, which are an important part of the anticancer drug armamentarium. Professor The first genuinely structurally novel platinum drug to enter clinical trials in thirty years Nicholas Farrell, (BBR3464) arose from his laboratory research. BBR3464 remains the only “non- Virginia classical” platinum compound to undergo human testing. Commonwealth Professor Farrell has written or co-edited three books in the area of platinum anticancer University, USA agents and medicinal inorganic chemistry. He is the author of over 200 refereed papers and thirty review chapters. He and his collaborators have received over sixty patents world wide from his inventions. He was honored as Distinguished Research Scholar of Virginia Commonwealth University for 2003-2004. He was instrumental in development of a graduate program in Chemical Biology at VCU and is strongly interested in helping build scientific expertise and collaboration amongst developing countries. He was the Chair of the first Gordon Research Conference on Metals in Medicine and in October 2003 chaired the Ninth International Symposium on Platinum Compounds in Cancer Chemotherapy, a meeting which unites chemists, biochemists, pharmacologists and cancer clinicians. He was Jefferson Science Fellow in The US Department of State 2010-2011. He is co-founder and President of The Wild Geese Network of Irish Scientists, devoted to fostering collaborations between scientists in Ireland and the rest of the world and highlighting the success of Irish scientists abroad. Professor Benjamin G. Davis, University of Oxford, UK Professor Ben Davis got his B.A. (1993) and D.Phil. (1996) from the University of Oxford. He then spent 2 years as a postdoctoral fellow in the laboratory of Professor Bryan Jones at the University of Toronto, exploring protein chemistry and biocatalysis. In 1998 he returned to the U.K. to take up a lectureship at the University of Durham. In the autumn of 2001 he moved to the Dyson Perrins Laboratory, University of Oxford and received a fellowship at Pembroke College, Oxford. Professor Benjamin G. His group's research centers on chemical biology with an emphasis on Davis, carbohydrates and proteins. In particular, the group's interests encompass University of synthesis and methodology, inhibitor design, protein engineering, drug delivery, Oxford, UK molecular modeling, molecular biology, and glycoscience. This work has received the 1999 RSC Meldola medal and prize, the 2001 RSC Carbohydrate Award sponsored by Syngenta, an AstraZeneca Strategic Research Award, a DTI Smart Award, a Mitzutani Foundation for Glycoscience Award, the 2002 Philip Leverhulme Prize, the 2005 Royal Society Mullard Prize and Medal, the RSC 2005 Corday-Morgan Medal, the 2006 International Association for Protein Structure Analysis and Proteomics Young Investigator Award, the 2008 Wain Medal for Chemical Biology, and in 2008 he was the first UK recipient of the American Chemical Society's Horace S. Isbell Award. Professor Jeffrey Bode, ETH-Zürich, Switzerland Professor Jeffrey Bode was born in 1974 near Los Angeles, California. He studied Chemistry (B.S., 1996) and Philosophy (B.A., 1996) at Trinity University in San Antonio, Texas. He began his graduate work at the California Institute of Technology and moved with his research advisor, Prof. Erick Carreira, to ETH– Zürich in 1998, where he received his Dok. Nat. Sci. in 2001. From 2001–2003, he was a JSPS Postdoctoral Fellowship at the Tokyo Institute of Technology with Prof. Keisuke Suzuki. In 2003, he joined the University of California, Santa Barbara as an Assistant Professor of Chemistry and Biochemistry. In 2007, he Professor moved to the University of Pennsylvania in Philadelphia as an Associate Jeffrey Bode, Professor before joining ETH-Zürich in 2010 as Professor of Synthetic Organic ETH-Zürich, Chemisty. Switzerland Professor Bode’s research group works on the development of new reactions and their application to the synthesis of small molecules and peptides, shapeshifting organic molecules, molecular diagnostics, and novel materials. His research and teaching have been recognized by several awards including the Camille and Henry Dreyfus New Faculty Award (2003), NSF Career Award (2004), Beckman Young Investigator Award (2006), Research Corporation Cottrell Scholar Award (2006), David and Lucille Packard Foundation Fellowship (2006), Alfred P. Sloan Fellowship (2007), the ACS Cope Scholar Award (2008), and the Hirata Gold Medal (2009). He has received awards from pharmaceutical companies including Amgen, Astrazeneca, Bristol Myers Squibb, Eli Lilly, and Roche and was listed among the “Top 20 under 40 Brains in Science” by Discover Magazine (2008). Professor Jonathan Clayden, The University of Manchester, UK Jonathan Clayden obtained his first degree and PhD from the University of Cambridge, where he worked with Dr Stuart Warren on asymmetric synthesis using phosphine oxide chemistry. He spent 18 months as a Royal Society Western European Research Fellow in the laboratories of Prof. Marc Julia in Paris, before moving in 1994 to Manchester as a Lecturer. In 2001 he was promoted to a personal chair in Organic Chemistry. He has been awarded the Royal Society of Chemistry's Meldola and Corday- Morgan Medals, Hickinbottom Fellowship and Merck Prize, and he has received Professor research prizes from GlaxoWellcome, AstraZeneca, Pfizer and Novartis. He is Jonathan author of the undergraduate textbook "Organic Chemistry" (Clayden, Greeves, Clayden, The and Warren, 2nd edn pub OUP 2012) and of "Organolithiums, Selectivity for University of Synthesis" (pub Pergamon Press 2002). Manchester, UK Jonathan Clayden and his research group work on the construction of molecules with defined shapes – in particular those where control of conformation and limitation of flexibility is important.
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