Recent Advances in Biological Psychiatry: The Proceedings of the Twenty-Second Annual Convention and Scientific Program of the Society of Biological Psychiatry, Detroit, Michigan, May 5–7, 1967

340 Pages·1968·21.212 MB·English

by  Ralph W. Gerard M.D. (auth.), Joseph Wortis M.D. (eds.)

Recent Advances in
Biological Psychiatry
Officers of
SOCIETY OF BIOLOGICAL PSYCHIATRY
for 1967-1968
Hudson Hoagland, Ph.D., President
Robert G. Heath, M.D., First Vice-President
John I. Nurnberger, M.D., Second Vice-President
George N. Thompson, M.D., Secretary-Treasurer
Charles Shagass, M.D., Assistant Treasurer
Councilors
Ralph W. Gerard, M.D. (for 5 years) Amedeo S. Marrazzi, M.D. (for 3 years)
D. Ewen Cameron, M.D. (for 4 years) Paull. Yakovlev, M.D. (for 2 years)
Lauretta Bender, M.D. (for 1 year)
Committee on Public Relations
Eugene Ziskind, M.D., Chairman
Herman C. B. Denber, M.D. I Wladimir T. Liberson, M.D.
Nathan Kline, M.D.
Committee on Program
Murray GlusmanI, M .D., Chairman
Jack H. Mendelson, M.D. William Holt, M.D.
John Paul Brady, M.D. Arthur Yuwiler, Ph.D.
Committee on Publications
Joseph Wortis, IM .D., Chairman
Joel J. Elkes, M.D. Charles Shagass, M.D.
Arnold J. Mandell, M.D. Jacques S. Gottlieb, M.D.
Committee on Membership
Leo Alexander, M.D., Chairman
Leo G. Abood, Ph.D. I Enoch Callaway, M.D.
John R. Bergen, Ph.D.
Committee on Research Awards
Williamina A. Himwich, Ph.D., Chairman
D. Ewen Cameron, M.D. I George N. Thompson, M.D.
Committee on Scientific Information and Opportunities
John I. Nurnberger, M.D., Chairman
Margaret A. Kennard, M.D. I Carl C. Pfeiffer, M.D.
VOLUME X
Recent Advances in
Biological Psychiatry
THE PROCEEDINGS OF THE TWENTY-SECOND ANNUAL CON
VENTION AND SCIENTIFIC PROGRAM OF THE SOCIETY OF
BIOLOGICAL PSYCHIATRY, DETROIT, MICHIGAN, MAY 5-7, 1967
Edited by
Joseph Wortis, M.D.
Associate Clinical Professor of Psychiatry,
State University of New York, Downstate
Medical College, Brooklyn" New York
':±?
Springer Science+Business Media, LLC
Library 01 Congress Catalog Card Number 58-14190
@ 1968 Springer Science+Business Media New York
Originally published by Plenum Press in 1968
Softcover reprint of the hardcover I st edition 1968
AII rights reserved
No part 01 this publication may be reproduced in any
lorm without written permission Irom the publisher
ISBN 978-1-4684-9074-9 ISBN 978-1-4684-9072-5 (eBook)
DOI 10.1007/978-1-4684-9072-5
Contents
PRESIDENTS OF THE SOCIETY OF BIOLOGICAL PSYCHIATRY ix
CONTRmUTORS xi
Part I: PRESIDENTIAL ADDRESS
l. "BUILD THEE MORE STATELY MANSIONS, 0 My SOUL." Ralph W. Gerard ....
Part II: PSYCHOPHARMACOLOGY
2. PSYCHOTOGENIC N, N-DIMETHYLATED INDOLE AMINES AND BEHAVIOR IN
SCHIZOPHRENIC PATIENTS. H. Tanimukai, R. Ginther, J. Spaide, J. R. Bueno,
and H. E. Himwich 6
3. DYNAMIC ASPECTS OF CHLORPROMAZINE METABOLISM. F. W. Grant. 16
4. IN VIVO AND IN VITRO INTERACTIONS OF CHLORPROMAZINE AND MELANIN.
Arthur G. Bolt and Irene S. Forrest. 20
5. BIOCHEMICAL DETERMINANTS IN THE EVALUATION OF MONOAMINE-OXIDASE
INHIBITORS. Sabit Gabay and Alfred J. Valcourt. 29
Part III: NEUROPHARMACOLOGY
6. ROLE OF WATER IN DRUG ACTION ON NERVE. R. I. Ludmer and H. C. Sabelli 42
7. STRUCTURAL AND HISTOCHEMICAL CHANGE IN VENTRAL-HORN CELLS RE-
SULTING FROM SENSORY DEPRIVATION. I. James Young and Wilbur F. Rowley 53
8. MOLECULAR PHARMACOLOGY OF HALLUCINOGENS. V. S. Johnston and R. J.
Bradley...................... ..... ................ 74
SUMMARY REPORTS
NEUROPHARMACOLOGY OF EARTHWORM GIANT FIBERS. James E. P. Toman
and Hector C. Sabelli ................. 100
EVIDENCE FOR BIOGENIC AMINE RECEPTORS IN TOAD SCIATIC NERVE. Hector
C. Sabelli and Marymil Gorosito . 101
Part IV: PSYCHOPHARMACOLOGY OF LEARNING
AND MEMORY
9. LEARNING AND MEMORY ENHANCEMENT BY PEMOLINE AND MAGNESIUM Hy-
DROXIDE (PMH). N. PlotnikofJ . ............. ..... ........... 102
10. DIPHENYLHYDANTOIN AND PROCAINAMIDE: NORMALIZATION OF SUBOPTIMAL
LEARNING BEHAVIOR. Paul Gordon ...... 121
1l. EFFECT OF VITAMIN B12 ON NEURONAL RNA AND ON INSTRUMENTAL CON-
DITIONING IN THE RAT. Hildegard E. Enesco . 134
v
vi CONTENTS
12. ICTUS AND AMNESIA. lver F. Small and Joyce G. Small ................................. 144
13. EFFECT OF ELECTROCONVULSIVE 'THERApy ON MEMORY IN DEPRESSIVE DIS-
OllDEllS. William W. K. Zung, Judith Rogers, and Arnold Krugman ............ 160
14. Is THERE AN ADDRESSED MEMORY IN TIlE NERVOUS SYSTEM? - ACADEMIC
ADDRESS. J. Z. Young ....... ............... 179
Part V: EEG AND NEUROPHYSIOLOGY
15. SoME ELECTROGRAPHIC DIFFERENCES BETWEEN CHRONIC SCHIZOPHRENIC
PATIENTS AND NORMAL SUBJECTS. E. Rodin, J. Grisell, and J. Gottlieb ........ 194
16. AVERAGED SoMATOSENSORY EVOKED RESPONSES IN VARIOUS PSYCHIATRIC
DISOllDERS. Charles Shaga ss ......................................... .................................... 205
17. CORRELATIVE BEHAVIORAL AND EVOKED-POTENTIAL ANALYSIS OF "INHIBI-
TORY" TEMPORAL-LoBE FUNCTION. Juhn A. Wada ........................................... 220
18. CODED STIMULATION OF TIlE EIGHTII NERVE AS A MEANS OF INVESTIGATING
AUDITORY MEMORY. B. Saltzberg, R. G. Heath, C. M. Fortner, and R. J.
Edwards ............................. ...................................... .................................... 240
19. THE ROLE OF BRAIN WAVES IN LEARNING AND OTIlER INTEGRATIVE FUNC-
TIONS. Chester W. Darrowt and Gary R. Gullickson ................................... . 249
SUMMARY REPORT
EFFECTS OF PHENOTHIAZINE DERIVATIVES ON TIlE SLEEP-WAKEFULNESS
CYCLE IN GROWING KITTENS. Akira Shimizu and Harold E. Himwich ........ 257
Part VI: NEUROCHEMISTRY
20. MATURATIONAL CHANGES IN AMINO ACIDS IN CNS OF DIFFERENT MAM
MALIAN SPECIES. Harish C. Agrawal, Jimmie M. Davis, and Williamina A.
Himwich ...................................................................................................... 258
21. EFFECTS OF EARLY WEANING ON SOME FREE AMINO ACIDS AND ACETYL
CHOLINESTERASE ACTIVITY OF RAT BRAIN. Williamina A. Himwich, Jimmie
M. Davis, and Harish C. Agrawal.................................................................... 266
22. EFFECT OF THYROID-HORMONE LEVELS ON 35S-SULFATE POOLS IN MATURE
AND SENILE RAT BRAIN. M. J. Short, W. P. Wi/son, and J. B. Sidbury, Jr. .... 271
Part VII: BEHAVIOR AND CONDITIONING
23. RECIPROCAL RELATIONS BETWEEN AUTONOMIC AND SOMATIC LEARNING:
VISCERAL AND MOTOR CONDmONING. W. Horsley Gantt ................................ 281
24. APPETITES, AVERSIONS, AND ADDICTIONS: A MODEL FOR VISCERAL MEMORY.
John Garcia and Frank R. Ervin .............. ......................... ....... ........ ..... ...... ....... 284
25. TRACE REFLEX FORMATION IN SENESCENCE AND SENILITY. L. Solyom and
T. Crowell .............. ............................................................................................ 294
26. THE EFFECT OF AROUSAL AND OF LEARNING UPON SUCKING BEHAVIOR IN
THE NEWBORN. Reuben E. Kron ........................................................................ 302
SUMMARY REPORT
BEHAVIORAL REACTIONS FOLLOWING ACUTE BRAIN DAMAGE TO CARDIAC
PATIENTS. Guy U. Motanky, Misha S. Zaks, and Kevin D. Barron ... 314
CONTENTS vii
Part VIII: SYMPOSIUM: THE BIOLOGY OF LEARNING
AND MEMORY
SUMMARY REPORTS
CHEMICALS AFFECTING MEMORY. Bernard W. AgranoD . 315
THE EFFECT OF INHIBITORS OF PROTEIN SYNTHESIS ON LEARNING AND MEM-
ORY IN THE MOUSE. Samuel H. Barondes ............... . 315
ASSOCIATIVE INTERFERENCE AND CONSOLIDATION. M. E. Jarvik and Anne
Geller. .... ................. ... ... ....... .................... 316
EFFECT OF EXPERIENCE ON THE FIRING PATTERN OF VISUAL CORTICAL NEU-
RONS. Frank Morrell. ..... ........... 317
MODELS FOR CORRELATIVE THINKING ABOUT BRAIN, BEHAVIOR, AND BIO-
CHEMISTRY. Eugene Roberts. ................ 317
CORTICAL STEADy-POTENTIAL SHIFTS IN CONDITIONED ANIMALS. Vernon
Rowland . ......... ..... ............. 318
"MEMORY": THE PARAMETER OF STIMULUS INTERRUPTION. William N.
Schoenfeld ................. ............. ....... ............................. 319
INTERACTION OF LONG-TERM AND SHORT-TERM MEMORY. Herman Buschke 320
IN MEMORIAM
Donald Ewen Cameron 321
AumOR INDEX . 323
SUBJECT INDEX ... 327
Presidents of the Society of Biological Psychiatry
1947-J. M. Nielsen
1948-Percival Bailey
1949-S. Bernard Wortis
1950-Harry C. Solomon
1951-Roland P. Mackay
] 952-Abram E. Bennett
J.
1953-Ladislas Meduna
1954-Harold E. Himwich
1955-Howard O. Fabing
1956-Margaret A. Kennard
1957-Jules H. Masserman
1958-Joseph Wortis
1959-Paul H. Hoch
1960-W. Horsley Gantt
1961-Lauretta Bender
1962-Paul I. Yakovlev
i963-Amedeo S. Marrazzi
1964-Max Rinkel
1965-0. Ewen Cameron
1966-Ralph W. Gerard
1967-Hudson Hoagland
Contributors
AGRANOFF, BERNARD W., M.D.-Department of Biological Chemistry,
University of Michigan, Ann Arbor, Michigan
AGRA WAL, HARISH C., Ph.D.-Medical Research Associate III, Thudi
chum Psychiatric Research Laboratory, Galesburg State Research
Hospital, Galesburg, Illinois
BARONDES, SAMUEL H., M.D.-Assistant Professor of Psychiatry and
Molecular Biology, Albert Einstein College of Medicine, Bronx,
New York
BARRON, KEVIN D., M.D.-Associate Professor, Department of Neurol
ogy and Psychiatry, Northwestern University Medical School,
Chicago, Illinois; Director, Neuropathology Research Section,
Veterans Administration Hospital, Hines, Illinois; Chief, Neurology
Service, Veterans Administration Hospital, Hines, Illinois
BOLT, ARTHUR G., Ph.D.-Group Section Leader, Chemical Pharma
cology and Radiobiology Department, Riker Laboratories, Hornsby,
N.S. W., Australia; Biochemical Research Laboratory, Veterans
Administration Hospital, Palo Alto, California; Department of
Psychiatry, Stanford University School of Medicine, Palo Alto,
California
BRADLEY, RONALD J., Ph.D.-Research Associate, Department ofPsy
chiatry, Yale University School of Medicine, New Haven, Connecticut
BUENO, JOAO R., M.D.-Fellow of the Conselho Nacional de Pesquisas,
Electroencephalography Department, Galesburg State Research
Hospital, Galesburg, Illinois; Thudichum Psychiatric Research
Laboratory, Galesburg State Research Hospital, Galesburg, Illinois
BUSCHKE, HERMAN, M.D.-Assistant Professor of Medicine (Neurology),
Department of Medicine, Division of Neurology, Stanford University
School of Medicine, Palo Alto, California
CROWELL, TED, B.Sc.-Summer Research Assistant, Psychiatry De
partment, Allan Memorial Institute, McGill University, Montreal,
Canada
t DARROW, CHESTER W., Ph.D.-Division of Psychophysiology, Institute
for Juvenile Research, Chicago, Illinois
DAVIS, JAMES M, B.Sc.-Medical Research Associate I, Thudichum
Psychiatric Research Laboratory, Galesburg State Research Hos
pital, Galesburg, Illinois
EDWARDS, R. J., Jr., M.S.E.E.-Instructor, Psychiatry and Neurology
Department, Tulane University School of Medicine, New Orleans,
Louisiana; Science Service Division, Texas Instruments, Inc.,
Dallas, Texas
ENESCO, HILDEGARD E., Ph.D.-Research Associate, Psychiatry De
partment, Allan Memorial Institute, McGill University, Montreal,
Canada
xi
xii CONTRlBuroRS
ERVIN, FRANK R., MD.-Director, Stanley Cobb Laboratories for
Psychiatric 'Research, Department of Psychiatry, Massachusetts
General Hospital, Harvard Medical School, Boston, Massachusetts
FORREST, IRENE S., Ph.D.-Chief, Biochemistry Research Laboratory,
MPD, Veterans Administration Hospital, Palo Alto, California;
Research Associate in Psychiatry, Stanford University School of
Medicine, Palo Alto, California
FORTNER, C. M, MS.-Department of Psychiatry and Neurology, Tulane
University School of Medicine, New Orleans, Louisiana
GABAY, SABIT, Ph.D.-Chief, Biochemical Research Laboratory, Vet
erans Administration Hospital, Brockton, Massachusetts; Assistant
Research Professor, Department of Biochemistry, Boston University
School of Medicine, Boston, Massachusetts
GANTT, W. HORSLEY, M.D.-Pavlovian Laboratories, Veterans Adminis
tration Hospital, Perry Point, Maryland; johns Hopkins University
School of Medicine, Baltimore, Maryland
GARCIA, JOHN, Ph.D.-Lecturer, Surgery Department, Harvard Medical
School; Associate Biologist, Neurosurgical Service, Massachusetts
General Hospital, Boston, Massachusetts; Stanley Cobb Laboratories
for Psychiatric Research, Harvard Medical School, Massachusetts
General Hospital, Boston, Massachusetts
GELLER, A., MD.-Albert Einstein College of Medicine, Bronx, New York
GERARD, RALPH W., M.D.-Dean of the Graduate Division, University
of California, Irvine, California
GINTHER, ROWENA, B.S.-Thudichum Psychiatric Research Laboratory,
Galesburg State Research Hospital, Galesburg, illinois
GORDON, PAUL, Ph.D.-Assistant Professor, Department of Pharma
cology, Chicago Medical School, Chicago, illinois
GOROSITO, MARYMIL, Ph.D.-Instituto de Farmacologia, University of
Litoral, Rosario, Argentina
GOTTLIEB, JACQUES S., M.D.-Director, Lafayette Chnic (an agency of
the Michigan Department of Mental Health), Professor and Chairman,
Department of Psychiatry, Wayne State University School of Medi
cine, Lafayette Clinic, Detroit, Michigan
GRANT, FREDERICK W., Ph.D.-Associate Research Scientist, Research
Division, Marcy State Hospital, Marcy, New York
GRISELL, JAMES L., Ph.D.-Head, Computing Laboratory, Mental Health
Department, Wayne State University School of Medicine, Lafayette
Clinic, Detroit, Michigan
GU LLiCKSON, GARY R., M.A. - Acting Division Chief, Division of Psycho
physiology, Institute for juvenile Research, Chicago, illinois
HEA TH, ROBERT G., MD., D. MSc.-Professor and Chairman, Psychiatry
and Neurology Department, Tulane University School of Medicine,
New Orl eans, Louisiana
HIMWICH, HAROLD E., MD.-Research Director, ThudichumPsychiatric
Research Laboratory, Galesburg State Research Hospital, Gales
burg, lllinois