RECENT ADVANCES IN AEROSPACE MEDICINE RECENT ADVANCES IN AEROSPACE MEDICINE PROCEEDINGS XVIII INTERNATIONAL CONGRESS OF AVIATION AND SPACE MEDICINE AMSTERDAM 1969 Edited by DOUGLAS E. BUSBY Continental Airlines. Los Angeles. California. U.S.A. D. REIDEL PUBLISHING COMPANY DORDRECHT-HOLLAND Library of Congress Catalog Card Number 74-131264 ISB-13: 978-94-010-3319-0 e-1SB-13: 978-94-010-3317-6 DOT: 10.1007/978-94-010-3317-6 All Rights Reserved Copyright © 1970 by D. Reidel Publishing Company, Dordrecht, Holland Softcover reprint of the hardcover 1s t edition 1970 No part of this book may be reproduced in any form, by print, photoprint, microfilm, or any other means, without written permission from the publisher PREFACE This book is a collection of scientific papers presented at the XVIII International Congress of Aviation and Space Medicine held in Amsterdam, The Netherlands, from 15-18 September 1969. It is dedicated to General E. de Vries and Dr. K. Vaan drager, President and Vice-President of the Congress, who wished that this unsur passed exchange of scientific information by distinguished authorities of the inter national aerospace medical community be made readily available to all as a valuable source of information. I am deeply grateful to the Congress Committee for honoring me with this editorship, to the authors for submitting generally excellent manuscripts and to the publisher for compiling a book of such high quality. This book contains both Main Theme papers, given by invited lecturers, and selected Free Communications at the Congress. Main Themes were 'physiology of atmospheric pressure' (papers by Ernsting, Meijne, Sluijter, Behnke), 'vestibular problems in aviation medicine' (papers by Melvill Jones, Benson, Oosterveld, Groen, Guedry and Benson, Brandt, Henriksson and Nilsson), 'aviation and cardiology' (papers by Blackburn, Wood) and 'space medicine' (paper by Berry). The Free Communications herein focus on many areas of continuing and timely interest to clinicians and investigators in aerospace medicine. Selection and health maintenance of pilots, medical problems in airline passengers, use of the centrifuge as a therapeutic device, and circadian rhythm effects on man's psychophysiological state receive particular attention. Although the diversity of collected papers in aerospace medicine presents problems in arrangement for both broad and reference reading, the papers in this book fit well into sections dealing with man in the exploration of space, clinical aviation medicine, and man's responses to the various stresses imposed by the aerospace environment. D. E. BUSBY TABLE OF CONTENTS PREFACE v SECTION 1/ MAN IN THE EXPLORATION OF SPACE BERR Y, C. A. / Summary of Medical Experience in the Apollo 7 through 11 Manned Spaceflights 3 KAKURIN, L. I., SHADRINTSEV, I. S., and ZERENIN, A. G. / Physiological In- formation Monitoring Techniques for the Soyuz Spacecraft 42 KRUPINA, T. N., MATSNEV, E. I., YAKOVLEVA, I. Ya., VYTCHIKOVA, M. A., and LEVANOV, v. Ya. / Peculiarities of Responses of the Acoustic Analyzer of Man Exposed to Prolonged Noise Effects During a Year-Long Medico- Engineering Experiment 45 SCHWARTZ, A. W. / Exobiology 48 SECTION II / CLINICAL AVIATION MEDICINE BLACKBURN, H. / Coronary Risk Factors and Prevention 55 CARRE, R., RICHAR T, J. C., SAL VA G NIAC, J., et PLAS, F. / Expertise cardiolo- gique et personnel navigant: ses principales difficultes 68 CARRE, R., RICHAR T, J. C., SALVAGNIAC, J., et PLAS, F. / Syndrome de Wolff- Parkinson et White et aptitude au personnel navigant 75 RIJLANT, P., RUTTKAY-NEDECKY, I., CERNOHORSKY, J., and ALLARD, A. / Norms for Quantitative Vectorcardiography with Special Emphasis on the Medical Evaluation of Flying Personnel 80 HELAM, B. L., PITSCHUGIN, I. M., STRONGIN, G. L., KUZNETSOVA, L. I., and SHISHOVA, A. A. / The Diagnostics of Early Forms of Atherosclerosis and La- tent Coronary Insufficiency in Flight Crews 90 BENNETT, G. and O'CONNER, P. J. / Medical Wastage of Military and Civil Aircrew in Great Britain 1963-68 93 PESQUIES, P., PINGANNA UD, P. M., NATHIE, J., et BORSARELLO, J. / Les a malaises en vol dans l'armee de l'air franc;:aise: etude analytique de 1961 1968 100 GARTMANN, H. / Selection of Airline Transport Pilots: Psychiatric and Psycho- logical Approach 106 PASQUET, J. et LAVERNHE, J. / A propos des recommandations de l'O.A.C.I. sur les normes auditives du personnel navigant technique 113 VIII TABLE OF CONTENTS HARPER, C. R., KIDERA, G. J., and CULLEN, J. F. / A Study of Simulated Air- line Pilot Incapacitation. Phase I: Obvious and Maximal Loss of Function 116 HOOGENDOORN, J. and MOSSEL, D. A. A. / Prevention of Food-Borne Diseases in Civil Aviation 123 SCHOCKEN, v. and LEDERER, L. G. / Unscheduled Landings for Medical Rea- sons: A Five-year Survey of the Experience at American Airlines 126 REIGHARD, H. L. / U.S. Aircraft Hijackings - Epidemiological Considerations 130 BULEY, L. E. / Experience with a Physiologically-Based Formula for Deter- mining Rest Periods on Long-Distance Air Travel 135 SNYDER, J. / Hypnotics and Jet-Age Travel 142 BLANC, C. J. et DIGO, R. J. / Psychotherapies et chimiotherapies en medecine aeronautique 146 DELAHAYE, R. P., GUEFFIER, G., SERIS, H., et AUFFRET, R. / La part de la radiologie dans l'enquete medicale apres ejection des pilotes militaires d'avions it reaction 150 PELLIGRA, R., STEIN, S., MARKHAM, J., LIPPE, P., NOYES, J., DICKSON, J., and SKRETTINGLAND, K. / The Centrifuge as a Therapeutic Device 158 DOESSCHA TE, J. TEN, HOPPENBROUWERS, R., and LANSBERG, M. P. / Selec- tive g-Force Application in the Treatment of Retinal Detachment 169 SECTION 111/ MAN IN HIS GASEOUS ENVIRONMENT ERNSTING, J. / Decompression Sickness in Aviation 177 MEIJNE, N. G. / Decompression Sickness and the Cardiovascular System 188 GAUME, J. G. / Factors Influencing the Time of Safe Unconsciousness (TSU) for Commercial Jet Passengers Following Cabin Decompression 198 SLUIJTER, M. E. / Gas Exchange at Low Ambient Pressure 204 BEHNKE, A. R. / Oxygen Tolerances and Adverse Reactions 208 GLAISTER, D. H. / Oscillations in Expiratory Gas Flow During Performance of Forced Vital Capacity 226 SECTION IV / MAN IN HIS KINETIC ENVIRONMENT MELVILL JONES, G. / Dynamic Cross-Coupling in the Semicircular Canals 235 BENSON, A. J. / Interactions between Semicircular Canals and Gravireceptors 249 OOSTERVELD, w. J. / The Threshold Value for Stimulation of the Horizontal Semicircular Canals 262 GROEN, J. J. / Central Regulation of Vestibular Function 269 GUEDR Y, JR., F. E. and BENSON, A. J. / Tracking Performance During Sinusoidal Stimulation of the Vertical and Horizontal Semicircular Canals 276 BRANDT, U. / Un nouveau test de des orientation spatiale avec quelques resul- tats concernant Ie role des otolithes dans Ie mecanisme de reorientation 289 HENRIKSSON, N. G. and NILSSON, A. / Importance of Labyrinthine and Other Sensory Information for Normal Driving 301 TABLE OF CONTENTS IX WOOD, E. H. / Studies of Effects of Variations in the Direction and Magnitude of the Gravitational-Inertial Force Environment on the Cardiovascular and Respiratory Systems 309 DEMANGE, J. M. R. / Effets des accelerations positives prolongees (+ 3 Gz) sur les variations du debit cardiaque humain. (Mesure par plethysmographie electrique aortique transthoracique: influence du vetement anti-G) 315 AUFFRET, R., SERIS, H., DEMANGE, J., et DELAHAYE, R. P. / Resistance du corps humain aux accelerations elevees de courte duree: effets mecaniques et hemo-dynamiques 319 DEBIJADJI, R., PEROVIC, L., and VARAGIC, v. / The Effect of Supersonic Flying on the Urinary Catecholamine Excretion in Pilots 323 SECTION V / MAN IN HIS THERMAL ENVIRONMENT COLIN, 1., BOUTELIER, C., et TIMBAL, J. / Tolerance al a chaleur dans Ie cas de panne de la climatisation sur avion de transport supersonique 331 TIMBAL, J., COLIN, J., et BOUTELIER, C. / Influence de l'altitude sur les echanges thermiques de l'homme 337 SECTION VI/MAN IN HIS TEMPORAL ENVIRONMENT ASCHOFF, J. C., GIEDKE, G., and POPPEL, H. / Circadian Periodicity of Reac- tion-Times 343 VAN ZOEREN, M., PANNEKOEK, L., and THIJSSEN, T. H. H. / Circadian Rhythm and Performance 348 STRENGERS, T. / The Urinary Excretion of Hormonal Metabolites Before, During and After Intercontinental Flights 353 GERRITZEN, F. / Methods for the Study of the Behaviour of Human Circadian Rhythms in Kidney Function Before, During and After Global Flights 356 SECTION I MAN IN THE EXPLORATION OF SPACE SUMMARY OF MEDICAL EXPERIENCE IN THE APOLLO 7 THROUGH 11 MANNED SPACEFLIGHTS C. A. BERRY National Aeronautics and Space Administration, Manned Spacecraft Center, Houston, Tex., U.S.A. 1. Introduction The goal of the Apollo Program was to land men on the Moon and return them safely to Earth. This goal was achieved in the Apollo 11 mission, with two astronauts stepping onto the lunar soil on July 20, 1969. A number of similar missions for further exploration of the Moon are planned. The Apollo Program was a series of unmanned and manned spaceflights in both earth and lunar orbits, first to check out the operational safety of spacecraft compo nents, and then to land on the Moon. Apollo manned spaceflights, summarized in Table I, gave a spaceflight experience of 3105 man-hours, including extravehicular lunar surface times of 2 hr, 14 min for astronaut Armstrong and 1 hr, 42 min for astronaut Aldrin. The total American spaceflight experience, including 54 man-hours in the Mercury Program and 1939 man-hours in the Gemini Program, is now 5098 man-hours. Medical information gained especially in the Gemini Program (Gooch and Berry, 1969) was utilized extensively in planning the medical support and investigations (Graybiel et al., 1967) conducted during the Apollo manned spaceflights (Berry and Catterson, 1967). Such significant biomedical observations in the Gemini Program as high energy cost of extravehicular activity, cardiovascular deconditioning, diminished exercise capacity and loss of red cell mass (Anon, 1966; Berry et aI., 1966; Fischer et al., 1967; Kelly and Coons, 1967) had to receive thorough consideration, particularly with respect to their possible effect on astronaut performance during proposed lunar surface activity (Berry, 1968). Although the contribution of confinement per se to the deteriorative physiologic changes observed after flights of long duration in the small Mercury and Gemini spacecraft cabins could not be determined, it was thought that the freedom of movement and exercising allowed in the Apollo spacecraft would maintain the astronauts in optimum physical condition for the duration of the Apollo 11 mission. 2. Medical Objectives for Apollo Program The following medical objectives were established for the Apollo Program: (1) Assurance of crew safety. (2) Assurance of mission completion and those activities contributing to mission management. (3) Prevention of back contamination of the earth's biosphere. D. E. Busby (ed.). Recent Advances in Aerospace Medicine. 3-41. All Rights Reserved. Copyright © 1970 by D. Reidel Publishing Company. Dordrecht-Holland. 4 C.A.BERRY TABLE I Apollo manned spaceflights Flight Flights Astronauts Launch dates Descriptions durations (hr: min: sec) Apollo 7 Schirra Oct. 11, 1968 Earth orbital checkout of the command 260:09:45 Eisele and service modules (CSM) Cunningham Apollo 8 Borman Dec. 21, 1968 First lunar orbit (10 orbits) flight for 147:00:11 Lovell checkout of the CSM at lunar Anders distance Apollo 9 McDivitt Mar. 3, 1969 First manned earth-orbital checkout 241:00:54 Scott of the lunar module (LM), CSMjLM Schweikart rendezvous, and extravehicular activity (EYA ) Apollo 10 Stafford May 18,1969 First lunar orbit rendezvous and 192:03:23 Young low pass over lunar surface Ceman Apollo 11 Armstrong July 16, 1969 First lunar landing and EYA on the 195:18:35 Collins lunar surface Aldrin (4) Continuance of the understanding of the biomedical changes incident to manned spaceflight. To meet these objectives it was necessary to prepare a medical requirements document detailing a pre- and postflight medical evaluation program which would provide information to assure capability for the proper support of lunar landing. This program (Berry, 1967) was particularly important for the reason that all inflight medical and other experiments in the Apollo program were deleted after the fatal spacecraft fire in order to concentrate on the operational complexity of the Apollo missions. Areas of concern in planning the lunar mission have been summarized (Berry, 1969a). Comparison of biomedical data obtained in the Gemini Program with that from Apollo missions prior to the lunar mission was vital to predicting the physiologic state of the astronauts at the time oflunar surface activity (Berry, 1969; Berry and Catterson, 1967). The provision of a microbial baseline for lunar quarantine operations and the further documentation of spaceflight effects on man were also valuable objectives. The medical procedures conducted were developed by a multidisciplinary team in the Medical Research and Operations Directorate of the National Aeronautics and Space Administration Manned Spacecraft Center at Houston, Texas (Berry, 1969b). In addition to detailed physical examinations, exhaustive studies were performed in the areas of hematology, immunology, biochemistry, bone densitometry, cardio vascular functions, exercise capacity and microbiology. These evaluations were
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