Recent Advances and Future Directions in Bone Marrow Transplantation: Proceedings of a Symposium Held in Conjunction with the 16th Annual Meeting of the International Society for Experimental Hematology, August 23–28, 1987, Tokyo, Japan PDF
Preview Recent Advances and Future Directions in Bone Marrow Transplantation: Proceedings of a Symposium Held in Conjunction with the 16th Annual Meeting of the International Society for Experimental Hematology, August 23–28, 1987, Tokyo, Japan
Experimental Hematology Today-1987 Experimental Hematology Today-1987 S.J. Baum G.W Santos F. Takaku Editors Recent Advances and Future Directions in Bone Marrow Transplantation Proceedings of a Symposium Held in Conjunction with the 16th Annual Meeting of the International Society for Experimental Hematology, August 23-28, 1987, Tokyo, Japan With 36 Illustrations Springer-Verlag New York Berlin Heidelberg London Paris Tokyo S.l. Baum Department of Physiology Unifonned Services University of the Health Sciences Bethesda, MD 20817, USA G.W. Santos Department of Oncology The John Hopkins Hospital Baltimore, MD 21205, USA F. Takaku Third Department of Internal Medicine Faculty of Medicine University of Tokyo Tokyo, Japan Library of Congress Cataloging-in-Publication Data Recent advances and future directions in bone marrow transplantation. (Experimental hematology today; 1987) Includes bibliographies. I. Bone marrow-Transplantation-Congresses. I. Baum, Siegmund 1. II. Santos, G. W. (George W.) III. Takaku, Fumimaro. IV. International Society for Experimental Hematology. Meeting (16th: 1987 : Tokyo, Japan) V. Series. [DNLM: I. Bone Marrow transplantation-congresses. WI EX504P 1987/ WH 380 R2945 1987] RB145.E97 1987 612'.l1s 87-28771 [RDI23.5] [617' .44] ISBN-13: 978-1-4612-8339-3 e-ISBN-13; 978-1-4612-3762-4 DOl: 10.1007/978-1-4612-3762-4 © 1988 by Springer-Verlag New York Inc. Softcover reprint of the hardcover 1st edition 1988 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer-Verlag, 175 Fifth Avenue, New York, NY 10010, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use of general descriptive names, trade names, trademarks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Camera-ready copy provided by the editors. 9 8 7 6 5 4 3 2 1 Acknowledgments The organizers of the symposium and the International Society for Experimental Hem atology wish to acknowledge the generous assistance and grants provided by the following organizations of the United States Government: National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Public Health Service, Bethesda, Maryland 20892. Fleet Health Care Systems, Code 405, Naval Medical Research and Development Command, Naval Medical Center National Capital Region, Bethesda, Maryland 20814- 5044. The generous assistance provided by the following persons was also greatly appreciated: Dr. Alan S. Levine, National Heart, Lung, and Blood Institute, National Institutes of Health, Public Health Service, Bethesda, Maryland 20892. Commander Thomas 1. Contreras, Technology Area Manager, Biomedical/CBR, ONT- 223, Office of Naval Technology, 800 North Quincy Street, Arlington, Virginia 22217- 5000. Furthermore, the generous grant provided by the following organization was greatly appreciated: Leukemia Society of America, Inc., 733 Third Avenue, New York, New York 10017. The Editors v Contents Acknowledgments ............................................................... v Contributors ..................................................................... xiii Introduction S.J. Baum ........................................................ . Part I. Experimental Bone Marrow Transplantation Chairpersons: S.J. Baum and F. Takaku Graft-versus-Host Disease and Graft-versus-Leukemia in Experimental Systems J.P. OKunewick, D.L. Kociban, M.J. Buffo, and C.K. Young 3 2 Syngeneic Graft-versus-Host Disease: Failure of Self: Non-Self Discrimination A.D. Hess, A.e. Fischer, G.B. Vogelsang, W.E. Beschorner, and G.W. Santos.................................................. 12 3 Transfusion-Induced Allosensitization in Marrow Transplant Recipients: Mechanisms and Preventive Measures H.J. Deeg, S.J. Slichter, and R. Storb ............................ 18 Part II. Experimental Bone Marrow Transplantation Chairpersons: J.P. OKunewick and Y. Kodera 4 Utilization of Monoclonal Antibodies for Autologous Bone Marrow Transplantation Y. Kodera, Y. Morishima, Y. Moriyama, T. Mori, A. Kanamaru, K. Shinohara, T. Ito, H. Mugishima, and T. Masaoka ................................................... 24 5 Characterization of Malignant Lymphoma in Dogs and Use as a Model for the Development of Treatment Strategies F.R. Appelbaum, P.A. Brown, T.e. Graham, B.M. Sandmaier, F.W. Schuening, and R. Storb .................................... 31 Vll viii 6 Hematopoietic Cell Transplantation in Murine Globoid Cell Leukodystrophy (The Twitcher Mouse)-A Model of a Human SphingoJipidosis (Krabbe Disease) A.M. Yeager, T. Ichioka, E. Toyoshima, Y. Kishimoto, S. Brennan, H.W. Moser, R.F. Mayer, and G.W. Santos 36 7 Experimental Basis of Bone Marrow Purging with Chemical and Photodynamic Agents A. Porcellini, A. Manna, M.T. Marchetti-Rossi, F. Centis, N. Talevi, G. Sparaventi, C. PazzagJia, A. Bocconcelli, and M. Palazzi .................................................... 45 Part III. Leukemia Chairpersons: R.P. Gale and T. Masaoka 8 Oncogenes in Acute Myelogenous Leukemia R.P. Gale and A. Butturini ........................................ 49 9 Optimal Timing of Marrow Transplantation for Patients with Acute Nonlymphoblastic and Acute Lymphoblastic Leukemia C.D. Buckner, R.A. Clift, F.R. Appelbaum, J.E. Sanders, K. Doney, and E.D. Thomas...................................... 53 10 Perspectives in Treatment of Adult Leukemia with High Dose Cytoreductive Therapy and Autologous Bone Marrow Treated Ex Vivo L.J. Horwitz, K.A. Dicke, S. Jagannath, and G. Spitzer.......... 58 Part IV. Autologous and Allogeneic Marrow Transplants in Leukemia and Lymphoma (Session A) Chairpersons: G. W. Santos annd J. Goldman 11 Allogeneic and Autologous Marrow Transplants in Acute Nonlymphoblastic Leukemia (ANLL) G.W. Santos, A.M. Yeager, R. Saral, W.H. Burns, J.R. Wingard, R. Jones, R.F. Ambinder, S.D. Rowley, W.S. May, G.B. Vogelsang, A.D. Donnenberg, W.E. Beschorner, J.E. Wagner, Jr., and A.D. Hess.............. 74 12 Allogeneic Transplantation for Acute Lymphoblastic Leukemia A.J. Barrett........................................................ 82 13 Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia-Mafosfamide Italian Study Group V. Rizzoli, L. Mangoni, A.M. Carella, G. Torlontano, M. Aglietta, L. Resegotti, E. Madon, R. Mozzana, A. Porcellini, and P. Coleselli ................................................... 89 14 Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia J. Goldman ........................................................ 94 ix Part V. Autologous and Allogeneic Marrow Transplants in Leukemia and Lymphoma (Session B) Chairpersons: R.H. Herzig and S. Asano 15 Autologous Marrow Transplantation for Hodgkin's and Non-Hodgkin's Lymphoma: Preliminary Results Using New Conditioning Regimens R.H. Herzig, G.L. Phillips, S.N. Wolff, J.W. Fay, c.F. LeMaistre, D.E. Reece, D. Frei-Lahr, J.N. Lowder, and G.P. Herzig................................................... 99 16 Long-Term Bone Marrow Culture in Autologous Transplantation: An In Vitro Biological System for Purging Leukemic Cells L.H. Coutinho, A. Will, J. Chang, N.G. Testa, and T.M. Dexter....................................................... 106 17 Allogeneic Bone Marrow Transplantation for Leukemia-Japanese Experience T. Masaoka ........................................................ 114 Part VI. Aplastic Anemia Chairpersons: R. Storb and M.M. Bortin 18 Allogeneic and Syngeneic Marrow Transplantation for Aplastic Anemia: Overview of Seattle Results R. Storb, K. Doney, E.D, Thomas, C. Anasetti, F.R. Appelbaum, P. Beatty, W. Bensinger, C.D. Buckner, R. A. Clift, A. Fefer, J. Hansen, R. Hill, P. Martin, R. McGuffin, J. Sanders, J. Singer, P. Stewart, K. Sullivan, and R. Witherspoon ............................................... 119 19 Recent Advances and Future Trends in Bone Marrow Transplantation for Severe Aplastic Anemia E.C. Gordon-Smith................................................ 125 20 Allogeneic Bone Marrow Transplantation in Leukemia B. Speck, A. Gratwohl, A. Tichelli, and C. Nissen............... 130 Part VII. Acute Graft-versus-Host Disease Chairpersons: B. Speck and D. H. Pluznik 21 Bone Marrow Transplantation: The Difficulties Ahead M.M. Bortin, M.M. Horowitz, and A.A. Rimm .................. 134 22 Predictive Models of Graft-versus-Host Disease G.B. Vogelsang, A.D. Hess, M. Silanskis, K. Friedman, E. Farmer, and G.W. Santos...................................... 141 23 Prevention of Severe GVHD Employing Cyclosporine in HLA-Matched Marrow Transplant for Leukemia P.J. Tutschka and E.A. Copelan .................................. 145 x Part VIII. Chronic Graft-versus-Host Disease Chairpersons: P.J. Tutschka and R. Parkman 24 Chronic Graft-versus-Host Disease: Pathogenesis, Diagnosis, Treatment and Prognostic Factors K. Sullivan, R. Witherspoon, R. Storb, F.R. Appelbaum, P. Beatty, W. Bensinger, C. Bigelow, C.D. Buckner, M. Cheever, R. A. Clift, K. Doney, A. Fefer, P. Greenberg, J. Hansen, P. Martin, D. Matthews, G. McDonald, J. Meyers, F.B. Petersen, J.E. Sanders, H. Shulman, J. Singer, P. Stewart, and E.D. Thomas ..................................... 150 25 The Role of Autoreactive T Lymphocytes in Graft-versus-Host Disease (GVHD) R. Parkman, J. Champagne, M. Cooper, V. Draper, Y. DeClerck, and S. Walker ...................................... 158 26 Predictive Factors for Chronic Graft-versus-Host Disease and Leukemic Relapse After Allogeneic Bone Marrow Transplantation N. Jacobsen, J.H. Badsberg, B. Lbnnqvist, O. Ringden, L. Volin, T. Ruutu, J. Rajantie, M.A. Siimes, J. Nikoskelainen, A. Toivanen, H.K. Andersen, N. Keiding, and G. Gahrton for the Nordic Bone Marrow Transplantation Group ...................... 161 Part IX. Infections After Bone Marrow Transplants Chairpersons: W. Burns and V. Rizzoli 27 Viral Infection Following Bone Marrow Transplantation W.H. Burns and J.R. Wingard.................................... 165 28 Bacterial, Fungal, and Protozoan Infection After Marrow Transplantation J. Meyers, F.B. Petersen, G.W. Counts, E.C. Reed, S.J. Skerrett, R.A. Bowden, K. Sullivan, and C.D. Buckner 171 29 Prevention and Treatment of Infections after Bone Marrow Transplantation D.J. Winston, W.G. Ho, R.P. Gale, and R.E. Champlin 177 Part X. Metabolic and Genetic Disorders Chairpersons: H. Mizoguchi and W. Krivit 30 Bone Marrow Transplantation for Thalassemia: 156 Cases Transplanted in Pesaro G. Lucarelli, C. Giardini, M. Galimberti, P. Polchi, E. Angelucci, D. Baronciani, F. Manenti, P. Politi, D. Marchionni, M. Donati, O. Paradisi, C. Giorgi, M. Manna, and F. Agostinelli..................................... 187 31 Improvement of Clinical Expression of Central Nervous System Manifestation in Lysosomal Storage Diseases Treated By Bone Marrow Transplantation W. Krivit, C.B. Whitley, G. Lund, N.K.C. Ramsay, and J.H. Kersey ................................................... 189 Xl 32 Bone Marrow Transplantation Following Nuclear Accidents R.P. Gale.......................................................... 195 Conclusions G.W. Santos....................................................... 200 Contributors Massimo Aglietta, M.D., Associate Professor, University of Torino, School of Medicine, Torino, Italy Fabrizio Agostinelli, Biologist, Assistant in Hematology, Divisione di Ematologia, Os pedale Civile, Pesaro, Italy Richard F. Ambinder, M.D., Instructor of Oncology, The Johns Hopkins Hospital, Bal timore, Maryland, USA Claudio Anasetti, M.D., Assistant Member, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Hans Kerzel Andersen, D. V .M., Associate Professor, Institute of Medical Microbiology, University of Aarhus, Aarhus, Denmark Emanuele Angelucci, M.D., Assistant in Hematology, Divisione di Ematologia, Ospe dale Civile, Pesaro, Italy Frederick R. Appelbaum, M.D., Associate Professor of Medicine, University of Wash ington, and Associate Member, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Shigetaku Asano, M.D., University of Tokyo, Institute of Medical Science, Tokyo, Japan Jens Henrik Badsberg, Ph.D., Assistant Professor and Statistician, Statistical Research Unit, University of Copenhagen, Copenhagen, Denmark Donatella Baronciani, M.D., Assistant in Hematology, Divisione di Ematologia, Ospedale Civile, Pesaro, Italy A.J. Barrett, M.D., F.R.C. Path., Department of Hematology, Westminster Hospital, London, United Kingdom Siegmund J. Baum, Ph.D., Department of Physiology, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland, USA Xlll
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