Radiation Oncology in Palliative Cancer Care

410 Pages·2013·9.923 MB·English

by  Stephen Lutz, Edward Chow, Peter Hoskin

Radiation
Oncology in
Palliative
Cancer Care

Radiation
Oncology in
Palliative
Cancer Care
Edited by
Stephen Lutz, MD MS
Radiation Oncologist
Department of Radiation Oncology
Blanchard Valley Regional Cancer Center
Findlay, OH, USA
Edward Chow, MBBS MSc PhD FRCPC
Professor, Department of Radiation Oncology
University of Toronto;
Senior Scientist, Sunnybrook Research Institute
Chair, Rapid Response Radiotherapy Program and Bone Metastases Site Group
Sunnybrook Health Sciences Centre
Toronto, ON, Canada
Peter Hoskin, MD FRCP FRCR
Professor in Clinical Oncology, University College London;
Clinical Oncologist
Mount Vernon Hospital
Northwood, London, UK
A John Wiley & Sons, Ltd., Publication
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Library of Congress Cataloging-in-Publication Data
Radiation oncology in palliative cancer care / edited by Stephen Lutz, Edward Chow,
Peter Hoskin.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-118-48415-9 (hardback : alk. paper)
I. Lutz, Stephen. II. Chow, Edward. III. Hoskin, Peter J.
[DNLM: 1. Neoplasms–radiotherapy. 2. Palliative Care–methods. 3. Radiation
Oncology–methods. 4. Radiotherapy–methods. QZ 269]
616.99’407572–dc23
2012044508
ISBN: 9781118484159
A catalogue record for this book is available from the British Library.
Wiley also publishes its books in a variety of electronic formats. Some content that appears in
print may not be available in electronic books.
Cover image: (Top) iStockphoto.com Courtesy of Simon Lo
Cover design by Modern Alchemy LLC
Set in 9.5/12pt Palatino by Toppan Best-set Premedia Limited, Hong Kong
1 2013
Contents
Contributor list, xv
Foreword, xix
Part 1: General principles of radiation oncology, 1
1 A brief history of palliative radiation oncology, 3
Joshua Jones
Introduction, 3
The early years, 3
Fractionation, 6
Advances in radiotherapy technique: the 1950s and 1960s, 7
Fractionation revisited: explicit palliation, 10
Stereotactic radiotherapy, 11
Prognostication and tailoring palliative radiotherapy to anticipated
survival, 11
Conclusion, 12
References, 13
2 The radiobiology of palliative radiation oncology, 15
Candice A. Johnstone
Introduction, 15
Radiation effect on cells, 15
Cell cycle characteristics, 18
Interaction of cell cycle and radiotherapy fractionation, 18
Radiotherapy fractionation characteristics, 19
Conclusion, 20
References, 20
3 The physics of radiation oncology, 22
Shaun Baggarley, Jiade J. Lu
Introduction, 22
The development of radiation therapy technology, 24
Process of radiation therapy, 27
Special considerations in developing countries, 28
Conclusion, 29
References, 29
v
vi  Contents
4 Curative intent versus palliative intent radiation oncology, 31
Vassilios Vassiliou, Haris Charalambous
Introduction, 31
The determination of cure plus palliation intent versus pure palliative
intent, 33
Clinical diagnoses, 35
Special considerations in developing countries, 38
Conclusion, 39
References, 39
5 Side effects of palliative radiotherapy, 43
Alysa Fairchild
Introduction, 43
Issues with interpreting palliative radiotherapy toxicity data, 44
Acute side effects, 45
Late side effects, 50
Additive toxicity, 53
Clinical advice, 53
New technologies, 55
Challenges in developing countries, 55
Conclusion, 56
References, 56
Part 2: General principles of palliation and symptom control, 61
6 A history of hospice and palliative medicine, 63
Michelle Winslow, Marcia Meldrum
Introduction, 63
Before the modern movement, 63
St. Christopher’s and the modern hospice, 64
Palliative care in the United States, 66
Global development of hospice and palliative care, 68
Continuing challenges, 69
References, 69
7 Radiation therapy and hospice care, 72
Charles F. von Gunten, Frank D. Ferris, and Arno J. Mundt
Introduction, 72
Hospice care around the world, 72
Hospice care in the United States, 73
Palliative radiation and hospice, 77
Conclusion, 79
References, 79
Contents  vii
8 The current status of palliative care and radiotherapy, 81
Thomas Smith, Susannah Batko-Yovino
What is palliative care?, 81
Who can benefit from palliative care?, 81
What are the goals of palliative care and what features of a palliative
care program help to accomplish these goals?, 83
What is the evidence regarding the benefits and risks of palliative care?
When should palliative care be introduced to a patient?, 84
Are there standards for palliative care? If so, what are the defining
measures?, 88
How does palliative care fit in with radiation oncology?, 90
References, 92
9 Palliative care in low and middle income countries: A focus on
sub-Saharan Africa, 95
Henry Ddungu, Elizabeth A. Barnes
Introduction, 95
The need for palliative care, 95
Radiotherapy, 96
Specific clinical indications for palliative radiotherapy in Africa, 97
Challenges of palliative care delivery, 98
Addressing challenges to adequate palliative care, 98
Palliative care research, 100
Delivery of palliative care, 101
Conclusion, 102
References, 102
10 Pain management, 105
Erin McMenamin
Introduction, 105
Pain assessment, 105
Analgesia ladder, 106
Primary pharmacologic interventions, 107
Adjuvant medications, 108
End-of-life considerations, 109
Conclusion, 109
References, 110
Part 3: Locally advanced or locally recurrent diseases, 113
11 Primary tumors of the central nervous system, 115
Caroline Chung, Eric L. Chang
Introduction, 115
Radiotherapy, 116
Side-effect risks, 120
viii  Contents
Radiotherapy limitations, 120
Adjuvant treatment modalities, 121
Promise of newer technologies, 121
Special considerations in developing countries, 122
Conclusion, 122
References, 122
12 The role of palliative care in head and neck cancer, 126
Albert Tiong, June Corry
Introduction, 126
Current management of head and neck squamous cell carcinomas, 126
Patient selection for palliative treatment, 127
Use of palliative radiotherapy in head and neck squamous cell
carcinomas, 130
Recurrent disease, 134
The promise of emerging technologies, 135
Chemotherapy in palliative head and neck squamous cell carcinomas, 135
Non-squamous cell carcinomas histologies, 136
Specific issues in palliation of head and neck squamous cell
carcinomas, 137
Special considerations in developing countries, 138
Conclusion, 138
References, 139
13 The role of palliative radiotherapy in breast cancer, 145
Ian H. Kunkler
Introduction, 145
Rates of palliative loco-regional radiotherapy, 148
Biologic considerations, 148
Definitions, clinical features, and multi-disciplinary approach, 148
Clinical scenarios, 150
Symptom control, 153
Palliative loco-regional radiotherapy for oligometastatic disease, 154
Radiotherapy dosing schedules, 154
Radiotherapy technique and the promise of newer technology, 156
Special considerations in developing countries, 158
Follow up, 158
Conclusion, 159
References, 159
14 Palliative radiotherapy in advanced lung cancer, 163
George Rodrigues, Benjamin Movsas
Introduction, 163
Radiotherapy treatment, 165