Quantitative Neuroanatomy in Transmitter Research: Proceedings of an International Symposium held at The Wenner-Gren Center, Stockholm, May 3–4, 1984 PDF
Preview Quantitative Neuroanatomy in Transmitter Research: Proceedings of an International Symposium held at The Wenner-Gren Center, Stockholm, May 3–4, 1984
WENNER-GREN CENTER INTERNATIONAL SYMPOSIUM SERIES VOLUME42 QUANTITATIVE NEUROANATOMY IN TRANSMITTER RESEARCH QUANTITATIVE NEUROANATOMY I'N TRANSMITTER RESEARCH Proceedings of an International Symposium held at The Wenner-Gren Center, Stockholm, May 3--4, 1984 Edited by Luigi F. Agnati Department of Human Physiology, University of Modena, Modena, Italy Kjell Fuxe Department of Histology, Karolinska Institutet, Stockholm, Sweden M MACMILLAN ©The Wenner-Gren Centre 1985 Softcover reprint of the hardcover 1st edition 1985 978-0-333-39637-7 All rights reserved. No reproduction, copy or transmission of this publication may be made without written permission. No paragraph of this publication may be reproduced, copied or transmitted save with written permission or in accordance with the provisions of the Copyright Act 1956 (as amended). Any person who does any unauthorised act in relation to this publication may be liable to criminal prosecution and civil claims for damages. First published 1985 Published by THE MACMILLAN PRESS LTD Houndmills, Basingstoke, Hampshire RG21 2XS and London Companies and repre8entatives throughout the world British Library Cataloguing in Publication Data. Quantitative neuroanatomy in transmitter research: proceedings of a symposium held at the Wenner-Gren Center, Stockholm.--(Wenner-Gren Center international symposium series; v. 42) 1. Neural transmission I. Agnati, Luigi II. Fuxe, Kjell III. Series 612' .813 QP364.5 ISBN 978-1-349-08173-8 ISBN 978-1-349-08171-4 (eBook) DOI 10.1007/978-1-349-08171-4 CONTENTS The Participants ix Opening Address xii SESSION I: MORPHOMETRICAL AND MICRODENSITOMETRICAL STUDIES ON NONTRANSMITTER-IDENTIFIED NEURONS Chairman: G. Woodward Quantitative Analysis of Three-dimensional Structures in Neuroanatomy H.J.G. GUNDERSEN 3 Estimating Particle Number and Size L.-M. CRUZ-ORIVE 11 Tasks in Computer-assisted Neuroanatomy: Data Acquisition, Imaging and Database D.J. WOODWARD, W.K. SMITH, D.S. SCHLUSSELBERG, S.A. AZIZI andJ.K. CHAPIN 25 Population Characteristics of Nerve Cell Bodies Illustrated by the Postnatal Development of Cerebellar Granule Cells in the Rat V. HOWARD, R. LYNCH and P. WOODHAMS 41 Laminar Specificity of Dendritic Morphology: Examples from the Guinea Pig Hippocampal Region T.W. BLACKSTAD 55 Studies of Local Blood Flow and Glucose Utilization in Brain by Computer Assisted Autoradiography C. OWMAN and N.H. DIEMER 71 v VI Contents SESSION II: MORPHOMETRY AND MICRO DENSITOMETRY OF TRANSMITTER-IDENTIFIED NEURONS Chairmen: G. WOODWARD and G. JONSSON Morphometrical and Microdensitometrical Studies on Monoaminergic and Peptidergic Neurons in the Aging Brain L.F. AGNATI, K. FUXE, L. CALZA, L. GIARDINO, I. ZINI, G. TOFFANO, M. GOLDSTEIN, P. MARRAMA, J.-A. GUSTAFSSON, Z.-Y. YU, A.C. CUELLO, L. TERENIUS, R. LANG and D. GANTEN 91 Three-dimensional Computer Reconstructions ofCatechol aminergic Neuronal Populations in Man D.C. GERMAN, B.S. WALKER, K. MCDERMOTT, W.K. SMITH, D.S. SCHLUSSELBERG andD.J. WOODWARD 113 Topographic Distribution of Catecholamihergic Neurons in the Rat Medulla Oblongata Using Quantitative Three dimensional Reconstruction M. KALlA, D.J. WOODWARD, W.K. SMITH, K. FUXE, T. HOKFELT and M. GOLDSTEIN 127 Effects of Chronic GM1 Ganglioside Treatment on Nigral Dopamine Cell Bodies and Dendrites in Experimental Rats Using Image Analysis- Relationship to the Pharmaco kinetic Properties L.F. AGNATI, K. FUXE, G. TOFFANO, L. CALZA, I. ZINI, L. GIARDINO, F. MASCAGNI and M. GOLDSTEIN 145 Development of Quantitative Methods for the Evaluation of the Entity of Coexistence of Neuroactive Substances in Nerve Terminal Populations in Discrete Areas of the Central Nervous System: Evidence for Hormonal Regulation of Cotransmission K. FUXE, L.F. AGNATI, M. ZOLI, A. HARFSTRAND, R. GRIMALDI, P. BERNARDI, M. CAMURRI and M. GOLDSTEIN 157 Principles for the Construction of the Software for Image Analysis of Transmitter-identified Neurons P.L. FABBRI, L.F. AGNATI, K. FUXE, N. BATTISTINI, I. ZINI and M. ZOLI 175 Image Understanding and the Cell World Model L.W. TUCKER, H.J. CORNEJO and D.J. REIS 185 Contents vii Quantitative Studies of Rodent and Primate Neocortex: Central Monoamine and Peptide Neurons J.H. MORRISON and F.E. BLOOM 197 Image Analysis of Catecholamine Fluorescence and Immunofluorescence in Studies on Blood Vessel Innervation T. COWEN and G. BURNSTOCK 213 Image Analysis of Transmitter Identified Neurons Using the IBAS System 0. JOHANSSON and H. HALLMAN 231 Image Analysis of Neuronal and Glial Markers: Fluorescence Micros£opical Applications L.OLSON,H.BJORKLUND,M.ERIKSDOTTER NILSSON, A. HENSCHEN and I. STROMBERG 251 SESSION III: QUANTITATIVE IMMUNOCYTO CHEMISTRY AND AMINE FLUORESCENCE HISTOCHEMISTRY Chairman: C. Owman The Use of Quantitative Immunocytochemistry to Study the Regulation of Tyrosine Hydroxylase in Noradrenergic and Dopaminergic Neural Systems R.H. BENNO, L.W. TUCKER, T.H. JOH and D.J. REIS 269 Quantitative Cytochemical Studies on Catecholaminergic and Peptidergic Nerve Terminals J. SCHIPPER 287 Quantitation of Nerve Terminal Networks of Transmitter identified Neurons after Selective Neurotoxic Lesions G. JONSSON, H. HALLMAN andJ. LUTHMAN 301 Cytofluorimetric Scanning: A Quantitative Method to Study Axonal Transport A. DAHLSTROM and P.-A. LARSSON 317 Quantitative Microfluorimetry and Semiquantitative Immunocytochemistry as Tools in the Analysis of Transmitter Identified Neurons K. FUXE, L.F. AGNATI, K. ANDERSSON, M. ZOLI, F. BENFENATI, P. ENEROTH and C. CUELLO 331 viii Contents SESSION IV: QUANTITATIVE RECEPTOR AND 2-DEOXYGLUCOSE AUTORADIOGRAPHY Chairman: J.M. Palacios Quantitative Autoradiographic Localization of Dopamine Receptors and Uptake Sites in the Rat and Human CNS B. SCATTON, A. DUBOIS, A. CAMUS, F. JAVOY AGID, N.R. ZAHNISER, M.L. DUBOCOVICH and A. CUDENNEC 351 The Use of Quantitative Autoradiographic Techniques on the Study of Drug Action in the Brain: Receptor Autoradiography and 2-Deoxyglucose Technique J.M. PALACIOS and K.-H. WIEDERHOLD 365 Quantitative Autoradiography as a Tool to Study Receptors in Neural Tissue. Studies on 3H-Oubain Binding Sites and Correlation with Synaptic Protein Phosphorylation in Different Brain Areas F. BENFENATI, L.F. AGNATI, K. FUXE, M. CIMINO, N. BATTISTINI, E.M. PICH, C. FARABEGOLI and!. ZINI 381 Quantitative Autoradiography of Drug Binding Sites: Methodological Considerations G.F. WOOTEN and W.A. GEARY 397 Recent Advances in the Visualization and Quantification of Benzodiazepine Receptor~ G. RICHARDS and H. MOHLER 407 Index 417 THE PARTICIPANTS Luigi F. Agnati Tim Cowen Department of Human Physiology Department of Anatomy & Embryology University of Modena University College London Via Campi 287 Gower Street I-41100 MODENA IDNDON W:::: 1E 6BT Italy U.K. Kurt Andersson Luis-M. Cruz-Orive Department of Histology Department of Anatomy Karolinska Institutet University of Bern S-1 04 01 S'IOCKHOIM P 0 Box 139 Sweden CH-3000 BERN Switzerland Fabio Benfenati Department of Human Physiology Annica DahlstrOm University of Modena Department of Histology Via Campi 287 University of GOteborg I -411 00 MODENA S-400 33 GOTEBoRG Italy Sweden Robert Benno Pier Luigi Fabbri The New York Hospital The Center for Instruments Cornell Medical Center University of Modena 1300 York Avenue Via Campi 213 NEW YORK, N.Y. 10021 I -41100 MODENA USA Italy Theodor Blackstad Kjell Fuxe Department of Anatomy Department of Histology University of Oslo Karolinska Institutet Karl Johans gate 47 S-1 04 0 1 STOCKHOlM OLSO 1 Sweden Norway ix The Participants X Dwight Gernan John Morrison Department of Physiology Scripps Clinic and Research University of Texas Health Foundation Science Center IA JOIJ.A DALLAS California 92037 Texas 75235 USA USA Lars Olsson Hans J0rgen Gundersen Department of Histology Department of Medicine Karolinska Institutet University of Aarhus S-1 04 01 STOCKHOLM DK-8000 AARHUS Sweden Denmark Christer Owman Vyvyan Howard Department of Histology Department of Anatomy University of Lund University of Liverpool Biskopsgatan 5 POBox147 S-223 62 LUND LIVERPOOL L69 3BK Sweden U.K. Jos~ Maria Palacios Tanas HOkfelt Preclinical Research Department of Histology Sandoz Ltd Karolinska Institutet CH-4002 BASEL S-104 01 STOCKHOLM Switzerland Sweden Thomas Rainl:x:>w Olle Johansson Department of Pharnacology Department of Histology Medical School Karolinska Institutet University of Pennsylvania S-1 04 01 STOCKHOLM PHilADELPHIA Sweden Pennsylvania 19104 USA GOsta Jonsson Department of Histology Grayson Richards Karolinska Institutet Pharnaceutical Research Department S-104 01 STOCKHOLM F. Roffman-LaRoche & Co. Ltd. Sweden CH-4002 BASEL Switzerland Madhu Kalia Department of Neurosurgery Bernhard Scatton Thomas Jefferson University Department of Biology 1025 walnut Street Synth~labo - L.E.R.S. PHilADELPHIA 31 Avenue Paul Vaillant Couturier Pennsylvania 19107 F-92220 BAGNEUX USA France
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