Quantitative Methods for HIV/AIDS Research

309 Pages·2017·5.3 MB·English

by  Cliburn Chan

Quantitative Methods
for
HIV/AIDS Research

Quantitative Methods
for
HIV/AIDS Research
Edited by
Cliburn Chan
Michael G. Hudgens
Shein-Chung Chow
Covercredit:PeterHraber,ThomasB.Kepler,Hua-XinLiao,BartonF.Haynes.
AdaptedfromLiaoetal.(2013)Nature496:469.
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LibraryofCongressCataloging-in-PublicationData
Title:QuantitativemethodsforHIV/AIDSresearch/CliburnChan,
MichaelG.Hudgens,Shein-ChungChow.
Description:BocaRaton:Taylor&Francis,2017.|“ACRCtitle,partofthe
Taylor&Francisimprint,amemberoftheTaylor&FrancisGroup,theacademic
divisionofT&FInformaplc.”|Includesbibliographicalreferencesandindex.
Identifiers:LCCN2017008215|ISBN9781498734233(hardback)|
ISBN9781315120805(e-book)
Subjects:LCSH:HIVinfections--Research--Methodology--Popularworks.|AIDS
(Disease)--Research--Methodology--Popularworks.
Classification:LCCRC606.64.Q362017|DDC616.97/920072--dc23LCrecord
availableathttps://lccn.loc.gov/2017008215
VisittheTaylor&FrancisWebsiteat
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Contents
Preface......................................................................................................................xi
Contributors........................................................................................................xvii
Section I Quantitative Methods for Clinical Trials
and Epidemiology
1. Statistical Issues in HIV Non-Inferiority Trials......................................3
Mimi Kim
2. Sample Size for HIV-1 Vaccine Clinical Trials with Extremely
Low Incidence Rate......................................................................................17
Shein-Chung Chow, Yuanyuan Kong, and Shih-Ting Chiu
3. Adaptive Clinical Trial Design.................................................................41
Shein-Chung Chow and Fuyu Song
4. Generalizing Evidence from HIV Trials Using Inverse
Probability of Sampling Weights.............................................................63
Ashley L. Buchanan, Michael G. Hudgens, and Stephen R. Cole
5. Statistical Tests of Regularity among Groups with HIV
Self-Test Data................................................................................................87
John Rice, Robert L. Strawderman, and Brent A. Johnson
Section II Quantitative Methods for Analysis of
Laboratory Assays
6. Estimating Partial Correlations between Logged HIV RNA
Measurements Subject to Detection Limits..........................................109
Robert H. Lyles
7. Quantitative Methods and Bayesian Models for Flow Cytometry
Analysis in HIV/AIDS Research.............................................................135
Lin Lin and Cliburn Chan
8. The Immunoglobulin Variable-Region Gene Repertoire and
Its Analysis..................................................................................................157
Thomas B. Kepler and Kaitlin Sawatzki
ix