PPuullmmoonnaarryy AABBIIMM CCeerrttiiffiiccaattiioonn EExxaamm RReevviieeww CCoouurrssee Robert M. Jasmer, M.D. Associate Clinical Professor of Medicine, UCSF Leslie Zimmerman, MD Professor of Clinical Medicine, UCSF ICU Director, SFVAMC RReellaattiivvee VVaalluuee?? Medical Content (cid:132) CV 14% • Pulmonary 10% • ID 9%; GI 9% • Cross Content (cid:132) Critical Care 10% • Geriatrics 10% • Prevention 6%; Women’s Health 6% • RReellaattiivvee VVaalluuee?? Pulmonary: ½ is (cid:132) Obstructive disease • Occupational and Environmental • Restrictive & Interstitial • Pulmonary vascular disease • LLeeccttuurree OOuuttlliinnee PFTs (cid:132) Cough (cid:132) Asthma (cid:132) Solitary Pulmonary Nodule (cid:132) PVD (cid:132) ILDs (cid:132) TB (cid:132) Etc. (cid:132) QQuueessttiioonn 11 A 65 year-old woman with known COPD has spirometry. Which values can be obtained from the following graph? QQuueessttiioonn 11 4 Liters 3 2 1 1 2 3 4 5 6 Seconds A. FEV1 B. FEV1/FVC C. FEF 25%-75% D. Maximal flow rate at 25% of FVC E. Maximal flow rate at 50% of FVC SSppiirroommeettrryy FEV1 All you need to know is: FEV1 (F)VC TLC FEV1/FVC (FEV1%) TLC (and DLCO) RV Time SSppiirroommeettrryy (F)VC Obstructive disease TLC Restrictive disease RV Time QQuueessttiioonn 22 Which of the following diseases typically has a normal DLCO? A. Asthma B. Emphysema C. Idiopathic pulmonary arterial hypertension D. Idiopathic pulmonary fibrosis E. Pneumocystis jiroveci pneumonia DDLLCCOO Destroy alveoli or capillaries (cid:198) CO DLCO: integrity Low DLCO of the alveolar– capillary membrane CO CO DDLLCCOO Just narrow airways (cid:198) CO DLCO: integrity Normal DLCO of the alveolar– capillary membrane CO CO QQuueessttiioonn 22 Which of the following diseases typically has a normal DLCO? A. Asthma B. Emphysema Air “sac” C. Idiopathic pulmonary arterial problem hypertension D. Idiopathic pulmonary fibrosis E. Pneumocystis jiroveci pneumonia Capillary problem PPFFTTss Obstructive Disease: Low FEV1% - normal DLCO: asthma and chronic bronchitis - low DLCO: emphysema Restrictive Disease: Low TLC - normal or mildly decreased DLCO: obesity - low DLCO: ILD QQuueessttiioonn 33 A 72 year-old man with 5 years of progressive DOE has the following CXR QQuueessttiioonn 33 And has the following PFTs: FVC 2.4L (52%) FEV1 1.02L (38%) FEV1/FVC 41% TLC 5.0L (77%) RV 2.6L (120%) DLCO 12 (48%) QQuueessttiioonn 33 You should order which of the following? A. Body box plethysmography B. CT Angiogram C. HRCT D. Negative inspiratory pressure E. Pulmonary exercise testing PPuullmmoonnaarryy FFuunnccttiioonn TTeessttss Spirometry (cid:132) Diagnose obstruction if FEV1/FVC < 70% Flow-volume loop (cid:132) Diagnose restriction if Lung volumes (cid:132) TLC < 80% Diffusing capacity (cid:132) Non-specific, but sensitive for alveolar capillary wall integrity Low in emphysema, ILDs, PVD TTLLCC mmeeaassuurreemmeennttss iinn CCOOPPDD CCaann bbee uunnddeerreessttiimmaatteedd bbyy ggaass ddiilluuttiioonn tteecchhnniiqquuee Body box plethysmography estimates entire Standard thoracic cage C1V1= C2(V1+V2) KKeeyy:: CCXXRR wwaass hhyyppeerriinnffllaatteedd,, ddiiddnn’’tt mmaakkee sseennssee tthhaatt TTLLCC wwaass llooww.. Large blebs don’t equilibrate 22000044:: WWoorrllddwwiiddee LLeeaaddiinngg CCaauusseess ooff DDeeaatthh 10 9 Affects 9% of 8 World Population 7 By 2020, will s move to 3rd n 6 o leading Milli 5 cause of death 4 3 2 1 0 Heart Disease CVA Pneumonia COPD Diarrhea http://www.who.int/mediacentre/factsheets/fs310_2008.pdf In US, only common disease with RISING mortality In US, the increase in COPD deaths is driven by very large increase in deaths by women
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