Psychobiological Approaches for Anxiety Disorders: Treatment Combination Strategies

206 Pages·2012·1.38 MB·English

by  Adrian Wells(eds.)

PSYCHOBIOLOGICAL APPROACHES
FOR ANXIETY DISORDERS
Wiley Series in
CLINICAL PSYCHOLOGY
AdrianWells SchoolofPsychologicalSciences,University
(SeriesAdvisor) ofManchester,UK
Forothertitlesinthisseriespleasevisitwww.wiley.com/go/cs
PSYCHOBIOLOGICAL APPROACHES
FOR ANXIETY DISORDERS
Treatment Combination Strategies
Edited by Stefan G. Hofmann
Thiseditionfirstpublished2012
(cid:2)2012JohnWiley&Sons,Ltd.
Wiley-BlackwellisanimprintofJohnWiley&Sons,formedbythemergerofWiley’sglobal
Scientific,TechnicalandMedicalbusinesswithBlackwellPublishing.
RegisteredOffice
JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK
EditorialOffices
350MainStreet,Malden,MA02148-5020,USA
9600GarsingtonRoad,Oxford,OX42DQ,UK
TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK
Fordetailsofourglobaleditorialoffices,forcustomerservices,andforinformationabout
howtoapplyforpermissiontoreusethecopyrightmaterialinthisbookpleaseseeour
websiteatwww.wiley.com/wiley-blackwell.
TherightofStefanG.Hofmanntobeidentifiedastheauthoroftheeditorialmaterialinthis
workhasbeenassertedinaccordancewiththeUKCopyright,DesignsandPatentsAct1988.
Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,or
transmitted,inanyformorbyanymeans,electronic,mechanical,photocopying,recordingor
otherwise,exceptaspermittedbytheUKCopyright,DesignsandPatentsAct1988,
withoutthepriorpermissionofthepublisher.
Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappears
inprintmaynotbeavailableinelectronicbooks.
Designationsusedbycompaniestodistinguishtheirproductsareoftenclaimedas
trademarks.Allbrandnamesandproductnamesusedinthisbookaretradenames,service
marks,trademarksorregisteredtrademarksoftheirrespectiveowners.Thepublisherisnot
associatedwithanyproductorvendormentionedinthisbook.Thispublicationisdesignedto
provideaccurateandauthoritativeinformationinregardtothesubjectmattercovered.Itis
soldontheunderstandingthatthepublisherisnotengagedinrenderingprofessional
services.Ifprofessionaladviceorotherexpertassistanceisrequired,theservices
ofacompetentprofessionalshouldbesought.
LibraryofCongressCataloging-in-PublicationData
Psychobiologicalapproachesforanxietydisorders:treatmentcombinationstrategies/editedby
StefanG.Hofmann.
p.;cm.
Includesbibliographicalreferencesandindex.
ISBN978-0-470-97181-9(cloth)–ISBN978-0-470-97180-2(pbk.)
I.Hofmann,StefanG.
[DNLM: 1. AnxietyDisorders–therapy. 2. CombinedModalityTherapy–methods.
WM172]
616.85022–dc23
2011043015
AcataloguerecordforthisbookisavailablefromtheBritishLibrary.
Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprint
maynotbeavailableinelectronicbooks.
Setin10/12ptPalatinobyThomsonDigital,Noida,India
1 2012
CONTENTS
Aboutthe Contributors . . . . . . . . . . . . . . . . . . . . . . . . vii
Aboutthe Editor. . . . . . . . . . . . . . . . . . . . . . . . . . . . xi
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1
StefanG. Hofmann
Chapter 1 The Biologyand Efficacy of Combination
Strategiesfor Anxiety Disorders. . . . . . . . . . . .5
KeithA. Ganasen and Dan J.Stein
Chapter 2 Benzodiazepines . . . . . . . . . . . . . . . . . . . 25
BridgetA.Hearonand Michael W. Otto
Chapter 3 TricyclicAntidepressants andMonoamine
OxidaseInhibitors . . . . . . . . . . . . . . . . . . 41
FranklinR. Schneier
Chapter 4 Selective Serotonin Reuptake Inhibitors,
Reversible Inhibitors ofMonoamineOxidase-A,
andBuspirone . . . . . . . . . . . . . . . . . . . . 61
BorwinBandelow, MarkusReitt,and Dirk Wedekind
Chapter 5 D-Cycloserine. . . . . . . . . . . . . . . . . . . . . 75
AdamJ.Guastella and Gail A.Alvares
Chapter 6 Yohimbine Hydrochloride. . . . . . . . . . . . . . 91
Samantha G. Farris, Michelle L. Davis,
Lindsey B. DeBoer, Jasper A. J.Smits,
and Mark B. Powers
Chapter 7 Cortisol. . . . . . . . . . . . . . . . . . . . . . . .109
Leila Maria Soravia andDominique J.-F. de
Quervain
Chapter 8 Oxytocin . . . . . . . . . . . . . . . . . . . . . . .123
Markus Heinrichs,FrancesS. Chen,
and Gregor Domes
vi CONTENTS
Chapter 9 Dietary Supplements. . . . . . . . . . . . . . . . .145
Lindsey B. DeBoer, MichelleL. Davis,
Mark B. Powers, andJasperA. J.Smits
Chapter10 ARoadmap for the Researchand Practice
ofCombination Strategies . . . . . . . . . . . . . .181
Stefan G.Hofmann
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .195
ABOUT THE CONTRIBUTORS
Gail Alvares is a PhD student at the Brain and Mind Research Institute,
UniversityofSydney, workinginthefieldofsocialanxiety anddecision
making. Her research explores some of the fundamental ways in which
stress and anxiety influences learning and habit formation.
Dr Borwin Bandelow is Professor at the Department of Psychiatry and
€
Psychotherapy at the University of Gottingen, Germany. He is the
Managing Director of the clinic and head of the Anxiety Disorders Unit.
As a psychiatry and neurology specialist, a psychologist, and a psycho-
therapist,BorwinBandelowspecializesinanxietydisorders(panicdisor-
der, generalized anxiety disorder, and social phobia), schizophrenia,
depression, psychotherapy, and psychopharmacology. He has authored
or co-authored over 200 publications internationally in both books and
scientificjournals.BorwinBandelowisPresidentoftheGermanSocietyfor
AnxietyResearch.HeisEditor-in-ChiefoftheGermanJournalofPsychi-
atry, one of thefirst on-line psychiatric journals.
Frances S. Chen, PhD, is a postdoctoral fellow at the University of
Freiburg, Germany. She completed her PhD in psychology at Stanford
University.From2009to2010,shewasaVisitingProfessorofPsychology
atDeepSpringsCollegeinCalifornia.Shecurrentlyconductsresearchat
the University of Freiburg as a Fulbright Scholar and Alexander von
Humboldt Postdoctoral Fellow. Her research focuses on neurobiological
and psychological factors influencing social relationships, in particular
attachmentbehaviorandbehaviorwithinnegotiationandconflictsettings.
Michelle L. Davis is a research assistant for the Anxiety Research and
TreatmentProgramatSouthernMethodistUniversity.ShereceivedaBSc
inBiologyatTexasTechUniversity.Sheiscurrentlyaprojectcoordinator
for a study funded by the National Institute of Drug Abuse examining
exercise as an augment to cognitive behavioral treatment for smoking
cessation.
LindseyB.DeBoerisaclinicalpsychologydoctoralcandidateatSouthern
Methodist University. She received a BA in Psychology and in Child
Developmentat The University of Texas at Dallas and an MA in clinical
psychology at SMU. Ms. DeBoer is currently a research assistant for the
viii ABOUTTHECONTRIBUTORS
AnxietyResearchandTreatmentProgramatSMU.Herresearchfocuseson
the interplay between anxiety and health behaviors including eating
behavior,exercise,andsubstanceuse,aswellasaugmentingempirically
supported psychotherapy with exercise and dietary interventions.
DrDominiquedeQuervainisafullprofessorattheFacultyofMedicine
and Faculty of Psychology and Director of the Division of Cognitive
Neuroscience, University of Basel, Switzerland. He studied medicine at
theUniversityofBerne,Switzerland,andwasaPostdoctoralFellowatthe
UniversityofCaliforniaIrvine,USA,andattheuniversitiesofBaseland
Zurich, Switzerland. He is interested in the effects of stress hormones
on memory in health and disease and in the identification of memory-
related genes in humans using behavioral genetics approaches together
with neuroimaging techniques.
DrGregorDomescompletedhisPhDinpsychologyattheUniversityof
€
Tubingen, Germany, and his postdoctoral research at the University of
Rostock, Germanyandthe Universityof Zurich, Switzerland.Currently,
heisanassistantprofessorattheUniversityofFreiburg,Germanyanda
memberoftheFreiburgBrainImagingCenter.Hisresearchfocusesonthe
behavioral and neural effects of steroid hormones and neuropeptides in
health and mentaldisorders.
Samantha G. Farris is a clinical psychology doctoral student at the
UniversityofHouston.ShereceivedherBachelor’sdegreeinpsychology
fromRutgersUniversity,whileworkingattheCenterofAlcoholStudies.
Aftercompletingherdegree,MsFarrisworkedasaresearchcoordinatorat
the Center for the Treatment and Study of Anxiety, at the University of
Pennsylvania. Her current research interests include the relationship
between anxiety and substance use disorders, and dissemination of
empirically-supported treatments.
KeithGanasen,MD,isaresidentinpsychiatry.Hehas,duringhistraining
in psychiatry, embarked on research in the anxiety disorders, and is
planning a career in academic psychiatry.
Dr Adam Guastella is Associate Professor, a clinical psychologist, and
principal research fellow at the Brain and Mind Research Institute, Uni-
versityofSydney.Hemanagestheyouthanxietyservicesattheinstitute.
His research focuses on using translational models to improve social
function in disorders of social deficit and to develop novel methods to
reduce anxiety.
BridgetA.Hearon, MA, isa doctoral student intheClinicalPsychology
ProgramatBostonUniversity.Herresearchinterestsincludethetreatment
ABOUTTHECONTRIBUTORS ix
ofanxietyandsubstanceusedisordersaswellasfactorswhichinfluence
health behaviors.
DrMarkusHeinrichsisafullProfessorattheFacultyofEconomicsand
Behavioral Sciences and at the Faculty of Medicine, Director of the
LaboratoryforBiologicalandPersonalityPsychology,andDirectorofthe
Outpatient Clinic for Stress-Related Disorders at the University of
Freiburg, Germany. He received his PhD from the University of Trier,
Germany, where he began his studies on oxytocin and social behavior.
PriortohispositionattheUniversityofFreiburg,hespent10yearsatthe
University of Zurich, Switzerland, where he was a professor of clinical
psychology and psychobiology from 2007 to 2009. His research topics
include experimental therapy research on mental disorders with social
deficits, neurobiology of social interaction, and stress- and anxiety-
protective factors.
Michael W. Otto, PhD, is Professor of Psychology at Boston University.
MichaelOttospecializesinthecognitive-behavioraltreatmentofanxiety,
mood, and substance use disorders. An enduring theme across these
disorders is the role of exposure-based emotional tolerance/acceptance
strategies in improving mental health and activity levels. His research
focuses on difficult-to-treat populations, including interventions for pa-
tientswhohavefailedtorespondtoprevioustreatments.Healsofocuses
on health behavior promotion ranging from medication adherence to
engagement in exercise, and has published over 300 articles, chapters,
and books spanning his research interests.
Mark B. Powers, PhD, is Assistant Professor and Co-Director of the
AnxietyResearchandTreatmentProgramatSouthernMethodistUniver-
sity.HereceivedaBAattheUniversityofCaliforniaatSantaBarbara,an
MA at Pepperdine University, and a PhD from the University of Texas
at Austin. He also completed a pre-doctoral fellowship at Boston and
Harvard universities and a residency at the University of Washington.
Hehasover70publicationsandhiscurrentresearchfocusesonmechan-
ismsof changein anxiety disorders.
Markus Reitt is a clinical psychologist at the Department of Psychiatry
€
and Psychotherapy at the University of Gottingen. He is trained in
Cognitive Behavioral Therapy. In his research, he cooperates with the
EastChinaNormalUniversity,Shanghai,China.Heiscurrentlyworking
with the Task Force for Germany National Guidelines for Anxiety
Disorders.
Franklin R. Schneier, MD, is Professor of Clinical Psychiatry at the
Department of Psychiatry at Columbia University in New York and
x ABOUTTHECONTRIBUTORS
Research Psychiatrist in the Anxiety Disorders Clinic of New York State
Psychiatric Institute. His research has focused on psychobiology, and
cognitive-behavioral and pharmacological treatments for anxiety and
mood disorders.
Jasper J. A. Smits, PhD, is Associate Professor and Co-director of the
AnxietyResearchandTreatmentProgramatSouthernMethodistUniver-
sity. He is a federally funded investigator of intervention strategies to
improveoutcomesforadultssufferingfromanxietyandrelateddisorders.
Dr Leila Maria Soravia is a Postdoctoral Fellow at the Department of
Psychiatric Neurophysiology of the University Hospital of Psychiatry,
UniversityofBerne,Switzerland.ShestudiedPsychologyattheUniversity
ofBerne,andobtainedherPhDattheDepartmentofClinicalPsychology
€
and Psychotherapy of the University of Zurich, Switzerland. She has
focusedontheinvestigationoftheneuroendocrinologicalmechanismsof
anxiety disorders and the development of new treatment approaches,
especiallyforsocialphobiaandspiderphobia.Hermaininterestisinthe
explorationoftheHPA-axis,theglucocorticoidcortisol,anditsinfluence
on fear memory inphobic patients.
DanJ.Stein’sMD,PhD,isProfessorandChairmanoftheDepartmentof
Psychiatry at the University of CapeTown in South Africa. His research
focuses on the psychobiology of anxiety disorders, ranging from animal
models,through clinical research,and on to epidemiological work.
DrDirkWedekindisaseniorconsultantpsychiatristattheDepartmentof
€
PsychiatryattheUniversityofGottingen,Germany.Heattendedmedical
€
school in Gottingen, Germany and studied affective neuroscience in
Maastricht, The Netherlands. His scientific work has focused on the
neurobiology and neuropharmacology of anxiety disorders. He also
workedonclinical andbiologicalaspectsofaddictiondisordersanddid
researchonpersonality-andsomatoformdisorders.Hehasauthoredand
co-authoredmorethan60articlesinscientificjournalsandbooksandisa
frequent nationalspeakeron pharmacological and clinical topics.