Psychiatry, Psychoanalysis, And The New Biology Of Mind

441 Pages·2005·5.998 MB·English

by  Eric R. Kandel

PSYCHIATRY,
PSYCHOANALYSIS, AND
THE NEW BIOLOGY OF
MIND
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PSYCHIATRY,
PSYCHOANALYSIS, AND
THE NEW BIOLOGY OF
MIND
By
Eric R. Kandel, M.D.
With commentaries by
Arnold M. Cooper, M.D.
Steven E. Hyman, M.D.
Thomas R. Insel, M.D.
Donald F. Klein, M.D.
Joseph LeDoux, Ph.D.
Eric J. Nestler, M.D., Ph.D.
John M. Oldham, M.D.
Judith L. Rapoport, M.D.
Charles F. Zorumski, M.D.
Washington, DC
London, England
Note: The authors have worked to ensure that all information in this book is accu-
rate at the time of publication and consistent with general psychiatric and medical
standards, and that information concerning drug dosages, schedules, and routes of
administration is accurate at the time of publication and consistent with standards
set by the U.S. Food and Drug Administration and the general medical community.
As medical research and practice continue to advance, however, therapeutic stan-
dards may change. Moreover, specific situations may require a specific therapeutic re-
sponse not included in this book. For these reasons and because human and
mechanical errors sometimes occur, we recommend that readers follow the advice of
physicians directly involved in their care or the care of a member of their family.
Books published by American Psychiatric Publishing, Inc., represent the views and
opinions of the individual authors and do not necessarily represent the policies and
opinions of APPI or the American Psychiatric Association.
Copyright © 2005 American Psychiatric Publishing, Inc.
ALL RIGHTS RESERVED
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Library of Congress Cataloging-in-Publication Data
Kandel, Eric R.
Psychiatry, psychoanalysis, and the new biology of mind / by Eric R. Kandel ; with
commentaries by Arnold M. Cooper ... [et al.].—1st ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 1-58562-199-4 (alk. paper)
1. Psychiatry. 2. Psychoanalysis. 3. Neurobiology. 4. Molecular biology.
[DNLM: 1. Psychoanalysis—Collected works. 2. Mental Processes—physiology—
Collected Works. 3. Molecular Biology—methods—Collected Works. 4. Psychia-
try—methods—Collected Works. WM 460 K16p 2005] I. Title.
RC435.2.K36 2005
616.89—dc22 2004029916

British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
For
Paul and Minouche,
who have taught me much
about the
biology of mind
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CONTENTS
CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . XI
FOREWORD . . . . . . . . . . . . . . . . . . . . . . . . . . . XIII
Herbert Pardes, M.D.
INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . .XVII
1
PSYCHOTHERAPY AND THE SINGLE SYNAPSE:
THE IMPACT OF PSYCHIATRIC THOUGHT
ON NEUROBIOLOGIC RESEARCH . . . . . . . . . . . . . . 1
Eric R. Kandel, M.D.
With commentary by Judith L. Rapoport, M.D.
2
A NEW INTELLECTUAL FRAMEWORK FOR
PSYCHIATRY . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Eric R. Kandel, M.D.
With commentary by Thomas R. Insel, M.D.
3
BIOLOGY AND THE FUTURE OF PSYCHOANALYSIS:
A NEW INTELLECTUAL FRAMEWORK
FOR PSYCHIATRY REVISITED. . . . . . . . . . . . . . . . 59
Eric R. Kandel, M.D.
With commentary by Arnold M. Cooper, M.D.
4
FROM METAPSYCHOLOGY TO
MOLECULAR BIOLOGY: EXPLORATIONS
INTO THE NATURE OF ANXIETY. . . . . . . . . . . . . 107
Eric R. Kandel, M.D.
With commentaries by Donald F. Klein, M.D.,
and Joseph LeDoux, Ph.D.
5
NEUROBIOLOGY AND MOLECULAR BIOLOGY:
THE SECOND ENCOUNTER . . . . . . . . . . . . . . . . 157
Eric R. Kandel, M.D.
With commentary by Eric J. Nestler, M.D., Ph.D.
6
NEURAL SCIENCE: A CENTURY OF PROGRESS
AND THE MYSTERIES THAT REMAIN. . . . . . . . . .199
Thomas D. Albright, Ph.D.
Thomas M. Jessell, Ph.D.
Eric R. Kandel, M.D.
Michael I. Posner, Ph.D.
With commentary by Steven E. Hyman, M.D.
7
THE MOLECULAR BIOLOGY OF MEMORY
STORAGE: A DIALOGUE BETWEEN GENES
AND SYNAPSES . . . . . . . . . . . . . . . . . . . . . . . .337
Eric R. Kandel, M.D.
With commentary by Charles F. Zorumski, M.D.
8
GENES, BRAINS, AND SELF-UNDERSTANDING:
BIOLOGY’S ASPIRATIONS FOR A NEW
HUMANISM. . . . . . . . . . . . . . . . . . . . . . . . . . .373
Eric R. Kandel, M.D.
With commentary by John M. Oldham, M.D.
AFTERWORD . . . . . . . . . . . . . . . . . . . . . . . . . .385
INDEX. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .389
CONTRIBUTORS
Thomas D. Albright, Ph.D.
Professor, The Salk Institute for Biological Studies, San Diego, California; In-
vestigator, Howard Hughes Medical Institute, Chevy Chase, Maryland
Arnold M. Cooper, M.D.
Stephen P. Tobin and Dr. Arnold M. Cooper Professor Emeritus in Consulta-
tion-Liaison Psychiatry, Weill Cornell Medical College; Training and Super-
vising Analyst, Columbia University Center for Psychoanalytic Training and
Research, New York, New York
Steven E. Hyman, M.D.
Provost, Harvard University; Professor of Neurobiology, Harvard Medical
School, Cambridge, Massachusetts
Thomas R. Insel, M.D.
Director, National Institute of Mental Health, Bethesda, Maryland
Thomas M. Jessell, Ph.D.
Investigator, Howard Hughes Medical Institute, Chevy Chase, Maryland;
Professor of Biochemistry and Molecular Biophysics, Columbia University
Medical Center, New York, New York
Donald F. Klein, M.D.
Professor of Psychiatry, Columbia University College of Physicians and Sur-
geons, New York, New York
Joseph LeDoux, Ph.D.
Henry and Lucy Moses Professor of Science, Center for Neural Science, New
York University, New York, New York
ix