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PRP and Microneedling in Aesthetic Medicine AmeliaK.Hausauer,MD Fellowship-TrainedCosmeticDermatologist DirectorofDermatology Aesthetx Campbell,California,USA DerekH.Jones,MD CosmeticFellowshipDirector AmericanSocietyforDermatologicSurgery MedicalDirector SkinCareandLaserPhysiciansofBeverlyHills LosAngeles,California,USA 62illustrations Thieme NewYork(cid:129)Stuttgart(cid:129)Delhi(cid:129)RiodeJaneiro ExecutiveEditor:StephanKonnry Important note: Medicine is an ever-changing science ManagingEditor:NikoleY.Connors undergoingcontinualdevelopment.Researchandclinical Director,EditorialServices:MaryJoCasey experience are continuallyexpanding ourknowledge, in ProductionEditor:TorstenScheihagen particular our knowledge of proper treatment and drug InternationalProductionDirector:AndreasSchabert therapy.Insofarasthisbookmentionsanydosageorappli- EditorialDirector:SueHodgson cation,readersmayrestassuredthattheauthors,editors, InternationalMarketingDirector:FionaHenderson andpublishershavemadeeveryefforttoensurethatsuch InternationalSalesDirector:LouisaTurrell referencesareinaccordancewiththestateofknowledgeat DirectorofInstitutionalSales:AdamBernacki thetimeofproductionofthebook. SeniorVicePresidentandChiefOperatingOfficer: Nevertheless,thisdoesnotinvolve,imply,orexpressany SarahVanderbilt guaranteeorresponsibilityonthepartofthepublishersin President:BrianD.Scanlan respecttoanydosageinstructionsandformsofapplications Printer:KingPrinting stated in the book. Every user is requested to examine carefully the manufacturers’ leaflets accompanying each LibraryofCongressCataloging-in-PublicationData drugandtocheck,ifnecessaryinconsultationwithaphy- sicianorspecialist,whetherthedosageschedulesmentioned Names:Hausauer,AmeliaK.,editor.|Jones,Derek,1965-editor. thereinorthecontraindicationsstatedbythemanufacturers Title:PRPandmicroneedlinginaestheticmedicine differfromthestatementsmadeinthepresentbook.Such /[editedby]AmeliaK.Hausauer,DerekH.Jones. examinationisparticularlyimportantwithdrugsthatare Description:Firstedition.|NewYork:Thieme,[2019]| eitherrarelyusedorhavebeennewlyreleasedonthemarket. Includesbibliographicalreferences.| Identifiers:LCCN2019001716(print)|LCCN2019005428 Everydosagescheduleoreveryformofapplicationusedis entirelyattheuser’sownriskandresponsibility.Theauthors (ebook)|ISBN9781626239050(e-book)|ISBN andpublishersrequesteveryusertoreporttothepublishers 9781626239043(print)|ISBN9781626239050(eISBN) Subjects:|MESH:CosmeticTechniques|Head–surgery| anydiscrepanciesorinaccuraciesnoticed.Iferrorsinthis workarefoundafterpublication,erratawillbepostedat Platelet-RichPlasma|Injections,Intradermal Classification:LCCRD119(ebook)|LCCRD119(print)| www.thieme.comontheproductdescriptionpage. 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Contents MenuofAccompanyingVideos......................................................... viii Preface ...................................................................................... ix Contributors................................................................................ xi I Platelet-RichPlasmaPrinciplesandPractices 1. Platelet-RichPlasma:MechanismandPracticalConsiderations.................. 3 BrianJ.AbittanandGaryGoldenberg 2. Platelet-RichPlasmaandFibrinSealantsinPlasticSurgery: ClinicalApplicationsandOnePractice’sExperience................................ 17 KamakshiZeidlerandR.LawrenceBerkowitz 3. Platelet-RichPlasmaforRejuvenationandAugmentation........................ 25 JeanetteM.BlackandLisaM.Donofrio 4. Platelet-RichPlasmaforAlopeciaandHairRestoration............................ 41 JeffreyA.Rapaport,SarahG.Versteeg,andAdityaK.Gupta II MicroneedlingPrinciplesandPractices 5. Microneedling:MechanismandPracticalConsiderations......................... 57 AmeliaK.Hausauer 6. Microneedling:ClinicalApplications................................................... 69 BrendaL.PellicaneandTinaS.Alster 7. MicroneedlingandRadiofrequency.................................................... 83 ChatchadapornChunharas,DouglasC.Wu,andMitchelP.Goldman III OtherConsiderations,Combinations,andComplications 8. ApplicationsandSafetyinSkinofColor .............................................. 103 DiAnneS.DavisandNaissanO.Wesley 9. CombinationTherapies................................................................... 125 PeterW.HashimandGaryGoldenberg 10. ComplicationsAssociatedwithPRPand MicroneedlinginAestheticMedicine.................................................. 139 TatjanaPavicicandMatthiasAust Index ................................................................................................. 149 vii Menu of Accompanying Videos Video1.1PreparationofPRP Video3.1PRPinjectionstothePeri-OrbitalAreawithaNeedle Video3.2PRPinjectionstotheInfra-OrbitalAreawithaCannula Video3.3PRPAppliedTopicallywithMicroneedling Video4.1PRPforRejuvenationandAugmentation–InjectionTechnique Video6.1Microneedling:TraySetup Video6.2PerioralMicroneedling Video6.3ScarMicroneedling Video7.1MicroneedlingandRF(CourtesyofDr.KimberlyButterwick) Video7.2MicroneedlingandRF(CourtesyofDr.KimberlyButterwick) Video8.1MNandPRP Video8.2PRPScalpInjectionsforAGA Video9.1MicroneedlingwithPlatelet-RichPlasma(Copyright2017Cutis[https://www.mdedge.com/cutis]and GaryGoldenberg,MD.Allrightsreserved.Nopartofthisvideomaybereproducedwithouttheprior writtenpermissionofFrontlineMedicalCommunicationsInc.) ProductsandDevicesusedinthevideosareproviderandpreparatorysystemspecificandmayvary.Thereisno standardprotocol;rather,thedemonstrationvideosprovidegoodexamplesbyexpertswhohaveperformed manycaseswithexcellentoutcomes. viii