Proteins and Steroids in Early Pregnancy PDF
Preview Proteins and Steroids in Early Pregnancy
Proteins and Steroids in Early Pregnancy Edited by H. M. Beier and P. Karlson With the collaboration of RJ. Aitken, M. Beato, B.M. Bhatt, D.W. Bullock, H.-W. Denker W. Elger, F. Fridlansky, J.E. Gadsby, S.R Glasser, Xi-gen Gu RB. Heap, P.W. Jungblut, C. Kirchner, C. Lambadarios Shu-xiang Li, N.K Love, S.A. McCormack, E. Milgrom c. B.O. Nilsson, Y. Nishino, J.S. Perry, J. Quatacker, Rice M. Sherman, J. de Visser, Yi-chien Yang, K Yoshinaga With 153 Figures Springer-Verlag Berlin Heidelberg New York 1982 Prof. Dr. med. Dr. rer. nat. Henning M. Beier Abteilung Anatornie und Reproduktionsbiologie Medizinische FakulHit der RWTH Aachen D-5100 Aachen, Federal Republic of Germany Prof. Dr. rer. nat. Dr. h. c. Peter Karlson Institut fUr Physiologische Chernie I Medizinische FakulHit der Philipps-UniversiUit D-3550 Marburg/Lahn, Federal Republic of Germany ISBN-13: 978-3-642-67892-9 e-ISBN-13: 978-3-642-67890-5 DOl: 10.1007/978-3-642-67890-5 Library of Congress Cataloging in Publication Data. Main entry under title: Proteins and steroids in early pregnancy. Bibliography: p. Includes index. I. Pregnancy. 2. Proteins. 3. Steroids hormones. l. Beier, H. M. II. Karlson, P. (Peter), 1918-. III. Aitken, R J. [DNLM: I. Pregnancy proteins. 2. Steroids. 3. Pregnancy. WQ 205 P967] QP281.P76 599.01'6 81-9080 This work is subject to copyright. All rights are reserved, whether the whole or part of materials is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to "Verwertungsgesellschaft Wort", Munich. © Springer-Verlag Berlin Heidelberg 1982 Softcover reprint of the hardcover 1s t edition 1982 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Preface It is about 15 years since the first presentation on uteroglobin was given to a group of developmental biologists, reproductive physiologists, and geneticists who had gathered in November 1966 at Konstanz (Germany). In the following decade so much knowledge was accumulated that a special symposium seemed appropriate. This was organized as a satellite symposium to the International Congress of Endocrinology at Hamburg and brought together 50 scientists at Aachen. These scientists, working in the field of pro teins and steroids, in early pregnancy, recognized the impact of what had been reported, and many of them later agreed to contribute to this booN. and thus to present their research d,!ta available until December 1980. The present volume covers a relatively broad spectrum of data and observations which shed some light on preimplantational embryonic life and on the supports and obstacles provided by the maternal organism with respect to final accomplishment of normal im plantation and establishment of pregnancy. The book will serve both as a textbook and as a scientific dictionary for Ph.D. students, postdoctoral fellows and advanced scientists working in this area. The course of early pregnancy depends very much on a proper balance of steroid hor mones, and the induction of protein synthesis by steroid hormones is one of the well known fundamental processes in cellular differentiation and embryonic development. This process involves the machinery of transcription and its control by steroid hormone receptor complexes, details of which are presented and discussed in this volume. We hope that the present compilation will stimulate designs for new experiments aimed at providing insight into the molecular biology of protein-steroid interactions as well as the control of gene expression. It is not unlikely that from a practical point of view there will be an explosion of interest in steroid-controlled proteins which support early pregnancy and enable the mother-to-be to provide an appropriate pregnancy milieu for the conceptus. Clinicians will desire more detailed knowledge about the significance of steroids and proteins during the establishment of pregnancy. The conditions for egg transfer and blastocyst development will be elucidated to the benefit of those patients who can only have an own child if fertilization is accomplished extracorporally and if the conceptus is re transferred to its mother within a few days. The data on our basic research on proteins and steroids controlling uterine physiology and embryonic development presented in this book could serve as a really solid basis for further clinical work. VI Preface Any success this publication achieves will be due to the contributors who wrote the manuscripts, to the patience of our families, who sacrificed so many weeks and months for the editing work, and finally to the Springer Verlag, who took over the publication of this book. Aachen and Marburg/Lahn Henning Beier May 1981 Peter Karlson Contents I. The Endocrine and Topographic Basis Proteins and Steroids in Early Pregnancy: General Considerations (P.Karlson) .... Ultrastructure of Trophoblast-Epithelium Relations During Implantation (B.O. Nilsson) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 5 Hormonal Control of Decidualization (K. Yoshinaga) ....................... 15 Ultrastructural Observations on Luteal Cells and Interstitial Gland Cells During Pseudopregnancy (J.R. Quatacker) .................................. 27 II. The Protein Secretion in Early Pregnancy Uteroglobin and Other Endometrial Proteins: Biochemistry and Biological Significance in Beginning Pregnancy (H.M. Beier) . . . . . . . . . . . . . . . . . . . . .. 39 Localization of Uteroglobin and Related Secretion Proteins in Oviducal, Uterine and Blastocyst Cells (C. Kirchner) . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 73 Uteroglobin as a Sensitive Indicator for the Biological Activity of Progestogens (Y. Nishino) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 83 Prefertilization Progesterone Treatment: Effect on Endometrium, Uteroglobin Secretion and Embryonic Development (J. de Visser). . . . .. . . . . . . . . . . . . .. 89 Evidence for the Existence of Human Uteroglobin? (C. Lambadarios) . . . . . . . .. 99 III. The Synthetic Machinery and Steroid-Protein Interactions Studies on Uteroglobin Messenger RNA (D.W. Bullock and B.M. Bhatt) ........ 117 VIII Contents Structure and Binding Properties of Rabbit Uteroglobin. Search for a Similar Protein in Human Uterine Fluid (M. Beato) . . . . . . . . . . . . . . . . . . . . . . . . .. 127 Steroid Binding to Uteroglobin (F. Fridlansky and E. Milgrom). .. . . . . . . . . . . 141 Steroid Receptors in the Gential Tract and the Monitoring of Steroid Hormone Action (p.W. Jungblut). . . . . . . . . . . . . . . . . .. . . . . . .. . . .. .. .. 147 IV. The Actions and Reactions of the Embryonic System The Synthesis of Steroids and Proteins in the Pig Blastocyst (R.B. Heap, J.E. Gadsby, C. Rice, and I.S. Perry) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 157 Steroid Hormones in Blastocyst Tissue, Uterine Flushings, and Endometrium of Pig, Sheep, and Cow (J.E. Gadsby) . . . . .. ......... . . . . . . . . . .. . . . .. 173 Proteases of the Blastocyst and of the Uterus (H.-W. Denker) ................ 183 Embryo-Associated Plasminogen Activator Prior to and During Implantation in the Mouse (M.I. Sherman) ....................................... 209 Postfertilization Activation of Stored Maternal mRNA in the One-Cell Mouse Egg (N.K. Love) ................................................... 219 The Control of Blastocyst Activity (R.J. Aitken) . . . . . . . . . . . . . . . . . . . . . . . .. 233 V. Embryo-Maternal Interactions and Exogenous Interference Cellular and Molecular Aspects of Decidualization and Implantation (S.R. Glasser and S.A. McCormack) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 245 Pharmacological Aspects of Early Pregnancy and Contraception (W. Elger and H.M. Beier) ......................................... 311 Antifertility Effect of a Long-Acting Progestin (3-Cyclopentyl Propionate of Megestrol Acetate): Prematurity of the Endometrium and Accompanying Changes of Uteroglobin and Progesterone in Uterine Fluid (Y. Yang, X. Gu, and S. Li) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335 Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 343 List of Contributors R.J. Aitken H. -W. Denker Medical Research Council Dept. of Anatomy Dept. of Reproductive Biology Rheinisch-Westfalische Technische 37, Chalmers Street Hochschule, Melatener Strasse 211 GB-Edinburgh EH3 9EW, U.K. D-5100 Aachen, W. Germany M Beato W. Elger Dept. of Physiological Chemistry Dept. Endocrine Pharmacology Philipps-UniversiHit Schering Research Laboratories Deu tschhausstrasse 1-2 Miillerstrasse 170-178 0-3550 Marburg/Lahn, W. Germany D-lOOO Berlin 65, W. Germany H.M Beier Francoise Fridlansky Dept. of Anatomy and Reproductive Bio Groupe de Recherches sur la Biochimie logy, Rheinisch-Westfalische Technische Endocrinienne et la Reproduction (INSERM Hochschule, Melatener Strasse 211 U 135) Faculte de Medecine Paris Sud D-5100 Aachen, W. Germany F-94270 Bicetre, France B.M Bhatt J.E. Gadsby Dept. of Cell Biology Reproductive Endocrinology Program Baylor College of Medicine Dept. of Pathology University of Michigan Houston, Texas 77030, USA Ann Arbor, Michigan 48109, USA D. W. Bullock S.R. Glasser Dept. of Cell Biology Dept. of Cell Biology Baylor College of Medicine Baylor College of Medicine Houston, Texas 77030, USA Houston, Texas 77030, USA x List of Contributors Xi-gen Gu Shu-xiang Li Dept. of Reproductive Physiology Dept. of Reproductive Physiology Shanghai Institute of Planned Parenthood Shanghai Institute of Planned Parenthood Research, 929 Heng Shan Road Research, 929 Heng Shan Road Shanghai, Peoples Republic of China Shanghai, Peoples Republic of China RB. Heap Nancy K. Love Dept. of Physiology Dept. of Zoology A.R.C. Institute of Animal Physiology University of Maryland Babraham College Park, Maryland 20742, USA GB-Cambridge CB2, 4AT, U.K. P. W. Jungblut Shirley A. McCormack Max-Planck-Institut fur experimentelle Dept. of Cell Biology Endokrinologie Baylor College of Medicine P.O. Box 61 0309 Houston, Texas 77030, USA D-3000 Hannover 61, W. Germany P. Karlson E. Milgrom Dept. of Physiological Chemistry Groupe de Recherches sur la Biochimie Philipps-U niversi Hi t Endocrinienne et la Reproduction (INSERM Deu tschhausstrasse 1-2 U 135) Faculte de Medecine Paris Sud D-3550 Marburg/Lahn, W. Germany F-94270 Bic~tre, France C Kirchner B.o. Nilsson Dept. of Biology Reproduction Research Unit Philipps-Universitat Dept. of Anatomy, Uppsala Universitets Lahnberge Biomedicinska Centrum, Box 571 D-3550 Marburg/Lahn, W. Germany S-751 23 Uppsala, Sweden Carol Lambadarios Y. Nishino Dept. of Obstetrics & Gynaecology Dept. of Endocrine Pharmacology University of Sheffield Schering Research Laboratories Jessop Hospital for Women Mtillerstrasse 170-178 Leavygreave Road D-lOOO Berlin 65, W. Germany GB-Sheffield 3, U.K. List of Contributors XI J.S. Perry J. de Visser Dept. of Physiology Organon Scientific Development Group A.R.C. Institute of Animal Physiology, Organon International B.Y. Babraham NL-4202 Oss, The Netherlands GB-Cambridge CB2 4AT, U.K. J.R. Quatacker Yi-chien Yang Laboratorium voor Pathologische Dept. of Renroductive Physiology Ontleedkunde, Akademisch Ziekenhuis Shanghai Institute of Planned Parenthood Rijksuniversiteit Gent, De Pintelaan 135 Research, 929 Heng Shan Road B-9000 Gent, Belgium Shanghai, Peoples Republic of China Catherine Rice K. Y oshinaga Dept. of Zoology National Institutes of Health Arizona State University Reproductive Science Branch Center for Population Research NICHD Tempe, Arizona 85281, USA Bethesda, MD 20205, USA MI Sherman Dept. of Cell Biology Roche Institute of Molecular Biology Nutley, New Jersey 07110, USA
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