Protein-Metal Interactions

685 Pages·1974·17.13 MB·English

by  Earl Frieden (auth.), Mendel Friedman (eds.)

PROTEIN-META L INTERACTIONS
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
Nathan Back State University of New York at Buffalo
N. R. Di Luzio Tulane University School of Medicine
Bernard Halpern College de France and Institute of Immuno·Biology
Ephraim Katchalski The Weizmann Institute of Science
David Kritchevsky Wistar Institute
Abel Lajtha New York State Research Institute for Neurochemistry and Drug Addiction
Rodolfo Paoletti University of Milan
Recent Volumes in this Series
Volume 40
METAL IONS IN BIOLOGICAL SYSTEMS: Studies of Some Biochemical and
Environmental Problems
Edited by Sanat K. Dahr • 1973
Volume 41A
PURINE METABOLISM IN MAN: Enzymes and Metabolic Pathways
Edited by O. Sperling, A. De Vries, and J. B. Wyngaarden' 1974
Volume 41B
PURINE METABOLISM IN MAN: Biochemistry and Pharmacology of Uric Acid Metabolism
Edited by O. Sperling, A. De Vries, and J. B. Wyngaarden • 1974
Volume 42
IMMOBILIZED BIOCHEMICALS AND AFFINITY CHROMATOGRAPHY
Edited by R. B. Dunlap' 1974
Volume 43
ARTERIAL MESENCHYME AND ARTERIOSCLEROSIS
Edited-by William D. Wagner and Thomas B. Clarkson' 1974
Volume 44
CONTROL OF GENE EXPRESSION
Edited by Alexander Kohn and Adam Shatkay • 1974
Volume 45
THE IMMUNOGLOBULIN A SYSTEM
Edited by Jiri Mestecky and Alexander R. Lawton· 1974
Volume 46
PARENTERAL NUTRITION IN INFANCY AND CHILDHOOD
Edited by Hans Henning Bode and Joseph B. Warshaw. 1974
Volume 47
CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE AGENTS
Edited by A. C. Tanquary and R. E. Lacey. 1974
Volume 48
PROTEIN-METAL INTERACTIONS
Edited by Mendel Friedman • 1974
Volume 49
NUTRITION AND MALNUTRITION: Identification and Measurement
Edited by Alexander F. Roche and Frank Falkner • 1974
Volume 50
ION·SELECTIVE MICROELECTRODES
Edited by Herbert J. Berman and Normand C. Hebert • 1974
PROTEIN-METAL
INTERACTIONS
Edited by
Mendel Friedman
Western Regional Research Laboratory
Agricultural Research Service
U. S. Department of Agriculture
Berkeley, California
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
American Chemical Society Symposium on Protein-Metal Interactions, Chicago,
1973.
Protein-metal interactions.
(Advances in experimental medicine and biology, v. 48)
Includes bibliographies.
1. Metals in the body-Congresses. 2. Metals-Physiological effect-Congresses.
3. Proteins-Congresses. I. Friedman, Mendel, ed. II. American Chemical Society.
III. Title. IV. Series. [DNLM: 1. Metals-Metabolism-Congresses. 2. Proteins
Metabolism-Congresses. WIAD559 v. 48/ QU55 S9864p 1973]
QP531.A42 1973 612'.0152 74·13406
ISBN 978-1-4684-0945-1 ISBN 978-1-4684-0943-7 (eBook)
DOl 10.1007/978-1-4684-0943-7
Proceedings of the American Chemical Society Symposium on Protein-Metal
Interactions held in Chicago, Illinois, August 27.29, 1973, with supplemental
invited contributions.
© 1974 Plenum Press, New York
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N.Y. 10011
Softcover reprint of the hardcover 15t edition 1974
United Kingdom edition published by Plenum Press, London
A Division of Plenum Publishing Company, Ltd.
4a Lower John Street, London WIR 3PD, England
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
Preface
Metal ions and proteins are ubiquitous. Therefore, not
surprisingly, new protein-metal interactions continue to be dis
covered, and their importance is increasingly recognized in both
physical and life sciences. Because the subject matter is so broad
and affects so many disciplines, in organizing this Symposium, I
sought participation of speakers with the broadest possible range
of interests. Twenty-two accepted my invitation. To supplement
the verbal presentations, the Proceedings include five closely re
lated invited contributions.
The ideas expressed are those of the various authors and are
not necessarily approved or rejected by any agency of the United
States Government. No official recommendation concerning the sub
ject matter or products discussed is implied in this book.
This book encompasses many aspects of this multifaceted field.
Topics covered represent biochemical, immunochemical, bioorganic,
biophysical, metabolic, nutritional, medical, physiological, toxi
cological, environmental, textile, and analytical interests. The
discoveries and developments in any of these areas inevitably
illumine others. I feel that a main objective of this Symposium,
bringing together scientists with widely varied experiences yet
with common interests in protein-metal interactions, so that new
understanding and new ideas would result has been realized. I hope
that the reader enjoys and benefits from reading about the fascinat
ing interactions of metal ions and proteins as much as I did.
Although an adequate summary of the Symposium is not possible
in a brief preface, I wish to express particular interest in the
ideas reported by Professor Frieden: that the relative occurrence
and participation of the various metals as essential elements in
enzyme action and other life processes is an adaptive relationship
to their relative abundance in the ocean. Undoubtedly, this adap
tation is a continuing process. A more immediate practical concern
voiced by D. K. Darrow and H. A. Schroeder that has received wide
spread publicity and debate is that children are highly susceptible
v
vi PREFACE
to lead poisoning and that their exposure to lead nowadays comes
mainly from automobile exhaust.
Of the invited contributions supplementing the Symposium, the
paper by J. T. MacGregor and T. W. Clarkson deserves special mention.
Dr. MacGregor collaborated with Dr. Clarkson, his former major pro
fessor, in this thorough review while the latter was out of the
country dealing directly with an episode of mercury poisoning de
scribed in their paper. I believe their critical compilation of
tissue distribution and toxicity of mercury compounds will greatly
benefit the medical and other scientific communities in dealing with
this useful but dangerous element.
I am confident that the Proceedings of the Symposium on
"Protein-Metal Interactions" will be a valuable contribution to
the literature. I am particularly grateful to Dr. 1. A. Wolff,
Chairman of the Protein Subdivision of the Division of Agricultural
and Food Chemistry of the American Chemical Society, who invited me
to organize this Symposium, to all contributors and participants
for a well realized meeting of minds, and to R. N. Ubell, Editor
in-Chief, Plenum Publishing Company, for arranging publication as a
volume in the series, ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY.
Mendel Friedman
Moraga, California
April 1974
Contents
1. THE EVOLUTION OF METALS AS ESSENTIAL ELEMENTS with
special reference to iron and copper 1
Earl Frieden, Department of Chemistry, Florida
State University, Tallahassee, Florida.
2. THE FUNCTIONAL ROLES OF METALS IN METALLOENZYMES. 33
J. F. Riordan and B. L. Vallee, Biophysics Research
Laboratory, Department of Biological Chemistry,
Harvard Medical School, Boston, Massachusetts.
3. STUDIES ON CARBOXYPEPTIDASE A • . 59
E. T. Kaiser, Tai-Wah Chan and Junghun Sub,
Department of Chemistry, University of Chicago,
Chicago, Illinois.
4. ZINC-WOOL KERATIN REACTIONS IN NONAQUEOUS SOLVENTS •• 81
N. H. Koenig and Mendel Friedman, Western Regional
Research Laboratory, ARS, USDA, Berkeley, Calif.
5. HEME-PROTEIN-LIGAND INTERACTIONS. 97
J. B. Fox, Jr., M. Dymicky and A. E. Wasserman,
Eastern Regional Research Center, ARS, USDA,
Philadelphia, Pennsylvania.
6. 13C NMR STUDIES OF THE INTERACTION OF Hb AND CARBONIC
ANHYDRASE WITH 13C02• • • • • • • • • • • • • • • • • 109
Frank R. N. Gurd, Jon S. Morrow, Philip Keirn,
Ronald B. Visscher and Robert Marshall, Department
of Chemistry, Indiana University, Bloomington,
Indiana..
7. THE ANION-BINDING FUNCTIONS OF TRANSFERRIN •..•. 125
P. Aisen, A. Leibman and R. A. Pinkowitz, Depart
ments of Biophysics and Medicine, Albert Einstein
College of Medicine, Bronx, New York.
vii
viii CONTENTS
8. LACTOFERRIN CONFORMATION AND METAL BINDING PROPERTIES 141
R. M. Parry, Jr. and E. M. Brown, Eastern Regional
Research Center, ARS, USDA, Philadelphia, Penn.
9. PHYSICOCHEMICAL STUDIES OF Ca++ CONTROLLED ANTIGEN
ANTIBODY SYSTEMS • • • • • . • • • • • • • • • • • 161
P. A. Liberti, H. J. Callahan and P. H. Maurer,
Department of Biochemistry, Thomas Jefferson Uni-
versity, Philadelphia, Pennsylvania.
10. CALCIUM BINDING TO ELASTIN • • • • •• 185
Robert B. Rucker, Department of Nutrition, Univer
sity of California, Davis, California.
11. THE COORDINATION OF CALCIUM IONS BY CARP MUSCLE
CALCIUM-BINDING PROTEINS A,B, AND C. 211
0 •••••
Carole J. Coffee, Department of Biochemistry,
University of Pittsburgh, Pittsburgh, Pa., Ralph
A. Bradshaw, Department of Biological Chemistry,
Washington University School of Medicine, St.
Louis, Mo., and Robert H. Kretsinger, Department
of Biology, University of Virginia,
Charlottesville, Va.
12. FERROXIDASES AND FERRlREDUCTASES: THEIR ROLE IN
IRON METABOLISM. 235
E. Frieden and S. Osaki, Department of Chemistry,
Florida State University, Tallahassee, Florida.
13. COPPER AND AMINE OXIDASES IN CONNECTIVE TISSUE
METABOLISM • • • • • 267
0 • • 0 • 0 • • • • • 0 •
E. D. Harris and Bo L. O'Dell, Department of
Agricultural Chemistry, University of Missouri,
Columbia, Mo.
14. COPPER- AND ZINC-BINDING COMPONENTS IN RAT INTESTINE 285
Gary Wo Evans, USDA, ARS Human Nutrition Labora-
tory, Grand Forks, North Dakota, and Carole J.
Hahn, Department of Biochemistry, University of
North Dakota, Grand Forks, North Dakota.
15. METAL-ALBUMIN-AMINO ACID INTERACTIONS: CHEMICAL AND
PHYSIOLOGICAL INTERRELATIONSHIPS • 299
0 •
R. Io Henkin, Section of Neuroendocrinology,
National Heart and Lung Institute, Bethesda,
Maryland.
CONTENTS ix
16. THE EFFECT OF ZINC DEPRIVATION ON THE BRAIN •..• 329
G. J. Fosmire, Y. Y. Al-Ubaidi, E. Halas and
H. H. Sanstead, USDA, ARS Human Nutrition Labora
tory, Grank Forks, North Dakota and Department of
Psychology, University of North Dakota, Grand
Forks, North Dakota.
17. BIOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES OF RAT
SKIN DURING ZINC DEFICIENCY • • . • . • . . • • • . 347
J. M. Hsu, K. M. Kim and W. L. Anthony, Veterans
Administration Hospital, Department of Pathology,
University of Maryland School of Medicine and
Department of Biochemical Sciences, The Johns
Hopkins University, Baltimore, Maryland.
18. NICKEL DEFICIENCY IN CHICKS AND RATS: EFFECTS ON
LIVER MORPHOLOGY, FUNCTIONAL AND POLYSOMAL INTEGRITY. 389
F. H. Nielsen, D. A. Ollerich, G. J. Fosmire and
H. H. Sanstead, USDA, ARS, Human Nutrition Labora-
tory, Grand Forks, North Dakota and Department of
Anatomy, University of North Dakota, Granq Forks,
North Dakota.
19. SELENIUM CATALYSIS OF SWELLING OF RAT LIVER
MITOCHONDRIA AND REDUCTION OF CYTOCHROME c BY SULFUR
COMPOUNDS • • • • • • . • • • . . • • . • . • 405
o. A. Levander, V. C. Morris and D. J. Higgs,
Agricultural Research Service, USDA, Beltsville,
Maryland.
20. CHILDHOOD EXPOSURE TO ENVIRONMENTAL LEAD ..•• 425
D. K. Darrow and H. A. Schroeder, M.D., Trace
Element Laboratory, Department of Physiology,
Dartmouth Medical School, Hanover, New Hampshire.
21. CELLULAR EFFECTS OF LEAD. • 447
R. A. Goyer and J. F. Moore, Department of
Pathology, University of North Carolina at Chapel
Hill, N.C.
22. DISTRIBUTION, TISSUE BINDING AND TOXICITY OF
MERCURIAL S • . • • . • . . • . . • • • • . • . 463
J. T. MacGregor, Western Regional Research Labora
tory, ARS, USDA, Berkeley, California and
T. W. Clarkson, The University of Rochester, School
of Medicine and Dentistry, Rochester, New York.
x CONTENTS
23. INTERACTIONS OF MERCURY COMPOUNDS WITH WOOL AND
RELATED BIOPOLYMERS • • . • . . 505
Mendel Friedman and Merle Sid Hasri, Western
Regional Research Laboratory, ARS, USDA, Berkeley,
Ca lifornia.
24. INTERACTIONS OF KERATINS WITH METAL IONS:
UPTAKE PROFILES, MODE OF BINDING, AND EFFECTS
ON PROPERTIES OF WOOL . • . • . . . . . • . • . . . . 551
Merle Sid Masri and Mendel Friedman, Western
Regional Research Laboratory, ARS, USDA, Berkeley,
California.
25. X-RAY PHOTOELECTRON SPECTROSCOPIC STUDIES OF BIOLOGI
CAL MATERIALS. METAL ION PROTEIN BINDING AND OTHER
ANALYTICAL APPLICATIONS . . . • • • . . • . . • . . 589
M. H. Millard, Western Regional Research Labora-
tory, ARS, USDA, Berkeley, California.
26. METAL ANALYSIS IN BIOLOGICAL HATERIAL BY ENERGY
DISPERSIVE X-RAY FLUORESCENCE SPECTROSCOPY 621
F. William Reuter, Western Regional Research
Laboratory, ARS, USDA, Berkeley, California and
William L. Raynolds, Department of Nutritional
Sciences, University of California, Berkeley,
California.
27. THE APPLICATION OF PERTURBED DIRECTIONAL CORRELA
TION OF GAHMA RAYS TO THE STUDY OF PROTEIN-METAL
INTERACT IONS ••••• • • • • • • • • • • • 639
G. Graf, J. C. Glass, and L. L. Richer, Depart
ments of Biochemistry and Physics, North Dakota
State University, Fargo, North Dakota.
. . . . . . . . . . . . . . . . .
INDEX ••• 681