Protein, Energy and Their Interaction in Critically Ill Children PDF
Preview Protein, Energy and Their Interaction in Critically Ill Children
Protein, Energy and Their Interaction in Critically Ill Children Sascha Cornelis Antonius Theodorus Verbruggen The studies as presented in this thesis were financially supported by the Sophia Children’s Hospital Fund (SSWO; grant 537; institutional grant, Erasmus MC – Sophia Children’s Hospital, Rotterdam, The Netherlands). The grant supplier had no involve- ment whatsoever in the study design, in the collection, analysis, and the interpretation of data, and in the decision to submit the reports for publication. The printing of this thesis was financially supported by Nutricia Advanced Medical Nutrition, Nestlé Nutrition and Cambridge Isotope Laboratories, Inc. ISBN: 978-90-8559-168-9 Layout: Optima Grafische Communicatie, Rotterdam, The Netherlands Cover: Sascha Verbruggen, Arnold van den Berg; www.fotoberg010.nl Printed by: Optima Grafische Communicatie, Rotterdam, The Netherlands Copyright: S.C.A.T. Verbruggen , The Netherlands, 2010 All rights reserved. No part of this book may be reproduced, stored in a retrieval sys- tem, or transmitted, in any form or by any means, electronic, mechanical, photocopy- ing, recording, or otherwise, without the prior written permission of the holder of the copyright. Protein, Energy and Their Interaction in Critically Ill Children Eiwit, Energie en Hun Interactie in Kritisch Zieke Kinderen Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof. Dr. H.G. Schmidt en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 22 december 2010 om 15.30 uur door Sascha Cornelis Antonius Theodorus Verbruggen geboren te Nijmegen Promotiecommissie: Promotor: Prof. Dr. J.B. van Goudoever Co-promotor: Dr. K.F.M. Joosten Overige leden: Prof. Dr. A.J. van der Heijden Prof. Dr. D. Tibboel Prof. Dr. P.J.J. Sauer “The less you know, the more you believe...” ‘last night on earth’ Bono, U2 Dit boek is voor mijn ouders Table of contents 11.. 22.. 33.. 44.. 55.. 66.. Chapter 1 General introduction and outline of the thesis 9 77.. Part I Glucose metabolism 88.. 99.. Chapter 2 Insulin therapy in the Pediatric Intensive Care Unit 27 1100.. Chapter 3 Efficacy and safety of a tight glucose control protocol in critically 53 1111.. ill term infants 1122.. Chapter 4 Reducing glucose intake safely prevents hyperglycemia in 65 1133.. post-surgical infants 1144.. Part II Amino Acid metabolism 1155.. 1166.. Chapter 5 Ontogeny of methionine utilization and splanchnic uptake in 85 1177.. critically ill children 1188.. Chapter 6 Parenteral amino acid intakes in critically ill children; a matter of 109 1199.. convenience 2200.. Part III Protein and Energy interactions 2211.. 2222.. Chapter 7 Current recommended parenteral protein intakes do not 133 2233.. support protein synthesis in critically ill septic, insulin resistant 2244.. adolescents with tight glucose control 2255.. Chapter 8 Albumin synthesis rates in critically ill infants and adolescents; 157 2266.. influence of amino acids, energy, and insulin 2277.. 2288.. Part IV General discussion & summary 2299.. Chapter 9 General discussion and future perspectives 177 3300.. Chapter 10 Summary 205 3311.. Chapter 11 Samenvatting voor niet-medici 211 3322.. 3333.. Dankwoord 221 3344.. Curriculum vitae 227 3355.. Affiliation of co-authors 229 3366.. 3377.. List of publications 231 3388.. Portfolio 233 3399.. 77 Chapter 1 General introduction and Outline of the thesis “In all maladies, those who are well nourished do best” Hippocrates, (460-377 BC.)
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